Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

Diabetologia

Volumn 54, Issue 12, 2011, Pages 3101-3110

  Stephenne, X ^a   Foretz, M ^b,c,d   Taleux, N ^a,e   Van Der Zon, G C ^f   Sokal, E ^a   Hue, L ^a   Viollet, B ^b,c,d   Guigas, B ^a,f  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b INSTITUT COCHIN   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e INSERM   (France)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

AMP:ATP ratio; AMPK; Hepatocytes; Human; Metformin; Mitochondria; Respiratory chain complex 1

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE GAMMA; MESSENGER RNA; METFORMIN; OXYGEN; PROTEIN SERINE THREONINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ENERGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ADENINE NUCLEOTIDES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; ISOENZYMES; MALE; METFORMIN; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; OXYGEN CONSUMPTION; RATS;

EID: 82455209029     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2311-5     Document Type: Article

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