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Volumn 291, Issue 1, 2006, Pages

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

Author keywords

Adenosine 5 monophosphate activated protein kinase; Diabetes; Lipid; Obesity

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MALONYL COENZYME A; METFORMIN; PALMITIC ACID; TRIACYLGLYCEROL;

EID: 33745822416     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00272.2005     Document Type: Article
Times cited : (127)

References (35)
  • 1
    • 21344457450 scopus 로고    scopus 로고
    • Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1
    • Al-Khalili L, Forsgren M, Kannisto K, Zierath JR, Lonnqvist F, and Krook A. Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. Diabetologia 48: 1173-1179, 2005.
    • (2005) Diabetologia , vol.48 , pp. 1173-1179
    • Al-Khalili, L.1    Forsgren, M.2    Kannisto, K.3    Zierath, J.R.4    Lonnqvist, F.5    Krook, A.6
  • 2
    • 0032529121 scopus 로고    scopus 로고
    • Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle
    • Alam N and Saggerson ED. Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle. Biochem J 334: 233-241, 1998.
    • (1998) Biochem J , vol.334 , pp. 233-241
    • Alam, N.1    Saggerson, E.D.2
  • 3
    • 0022472905 scopus 로고
    • Effect of metformin on glucose metabolism in mouse soleus muscle
    • Bailey CJ and Puah JA. Effect of metformin on glucose metabolism in mouse soleus muscle. Diabete Metab 12: 212-218, 1986.
    • (1986) Diabete Metab , vol.12 , pp. 212-218
    • Bailey, C.J.1    Puah, J.A.2
  • 4
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • Bonen A, Parolin ML, Steinberg GR, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ, and Dyck DJ. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J 18: 1144-1146, 2004.
    • (2004) FASEB J , vol.18 , pp. 1144-1146
    • Bonen, A.1    Parolin, M.L.2    Steinberg, G.R.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.6    Luiken, J.J.7    Heigenhauser, G.J.8    Dyck, D.J.9
  • 10
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, and Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277: 25226-25232, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 11
    • 0013772833 scopus 로고
    • Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation on pyruvate metabolism and on lactate/pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscle
    • Garland PB, Newsholme EA, and Randle PJ. Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation on pyruvate metabolism and on lactate/pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscle. Biochem J 93: 665-678, 1964.
    • (1964) Biochem J , vol.93 , pp. 665-678
    • Garland, P.B.1    Newsholme, E.A.2    Randle, P.J.3
  • 12
    • 0013773447 scopus 로고
    • Regulation of glucose uptake by muscle. 10. Effects of alloxan-diabetes, starvation, hypothysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acylcoenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles
    • Garland PB and Randle PJ. Regulation of glucose uptake by muscle. 10. Effects of alloxan-diabetes, starvation, hypothysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acylcoenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles. Biochem J 93: 678-687, 1964.
    • (1964) Biochem J , vol.93 , pp. 678-687
    • Garland, P.B.1    Randle, P.J.2
  • 13
    • 0042321037 scopus 로고    scopus 로고
    • Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    • Goodpaster BH, Katsiaras A, and Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52: 2191-2197, 2003.
    • (2003) Diabetes , vol.52 , pp. 2191-2197
    • Goodpaster, B.H.1    Katsiaras, A.2    Kelley, D.E.3
  • 14
    • 0042321037 scopus 로고    scopus 로고
    • Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    • Goodpaster BH, Katsiaras A, and Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52: 2191-2197, 2003.
    • (2003) Diabetes , vol.52 , pp. 2191-2197
    • Goodpaster, B.H.1    Katsiaras, A.2    Kelley, D.E.3
  • 16
    • 2942735492 scopus 로고    scopus 로고
    • The molecular mechanism linking muscle fat accumulation to insulin resistance
    • Hulver MW and Dohm GL. The molecular mechanism linking muscle fat accumulation to insulin resistance. Proc Nutr Soc 63: 375-380, 2004.
    • (2004) Proc Nutr Soc , vol.63 , pp. 375-380
    • Hulver, M.W.1    Dohm, G.L.2
  • 19
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR, and Kahn BB. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes 51: 443-448, 2002.
    • (2002) Diabetes , vol.51 , pp. 443-448
    • Kim, Y.B.1    Ciaraldi, T.P.2    Kong, A.3    Kim, D.4    Chu, N.5    Mohideen, P.6    Mudaliar, S.7    Henry, R.R.8    Kahn, B.B.9
  • 20
    • 0032765396 scopus 로고    scopus 로고
    • 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
    • Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, and Winder WW. 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48: 1667-1671, 1999.
    • (1999) Diabetes , vol.48 , pp. 1667-1671
    • Kurth-Kraczek, E.J.1    Hirshman, M.F.2    Goodyear, L.J.3    Winder, W.W.4
  • 21
    • 0037734282 scopus 로고    scopus 로고
    • Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: Relationship to glucose disposal
    • Mathieu-Costello O, Kong A, Ciaraldi TP, Cui L, Ju Y, Chu N, Kim D, Mudaliar S, and Henry RR. Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal. Metabolism 52: 540-546, 2003.
    • (2003) Metabolism , vol.52 , pp. 540-546
    • Mathieu-Costello, O.1    Kong, A.2    Ciaraldi, T.P.3    Cui, L.4    Ju, Y.5    Chu, N.6    Kim, D.7    Mudaliar, S.8    Henry, R.R.9
  • 22
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG, and Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273: E1107-E1112, 1997.
    • (1997) Am J Physiol Endocrinol Metab , vol.273
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 25
    • 0033559856 scopus 로고    scopus 로고
    • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
    • Muoio DM, Seefeld K, Witters LA, and Coleman RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338: 783-791, 1999.
    • (1999) Biochem J , vol.338 , pp. 783-791
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 29
    • 21044447666 scopus 로고    scopus 로고
    • AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle
    • Smith AC, Bruce CR, and Dyck DJ. AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle. J Physiol 565: 537-546, 2005.
    • (2005) J Physiol , vol.565 , pp. 537-546
    • Smith, A.C.1    Bruce, C.R.2    Dyck, D.J.3
  • 30
    • 0033638542 scopus 로고    scopus 로고
    • Development of leptin resistance in rat soleus muscle in response to high-fat diets
    • Steinberg GR and Dyck DJ. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279: E1374-E1382, 2000.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Steinberg, G.R.1    Dyck, D.J.2
  • 31
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • Stumvoll M, Nurjhan N, Perriello G, Dailey G, and Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333: 550-554, 1995.
    • (1995) N Engl J Med , vol.333 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 32
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF, and Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 99: 16309-16313, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang, Cc.C.5    Itani, S.I.6    Lodish, H.F.7    Ruderman, N.B.8
  • 34
    • 9144271181 scopus 로고    scopus 로고
    • AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    • Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, and Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem 279: 47898-47905, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 47898-47905
    • Zang, M.1    Zuccollo, A.2    Hou, X.3    Nagata, D.4    Walsh, K.5    Herscovitz, H.6    Brecher, P.7    Ruderman, N.B.8    Cohen, R.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.