Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP

Diabetes

Volumn 57, Issue 2, 2008, Pages 306-314

  Kim, Yong Deuk ^a   Park, Keun Gyu ^b   Lee, Yong Soo ^a   Park, Yun Yong ^a   Kim, Don Kyu ^a   Nedumaran, Balachandar ^a   Jang, Won Gu ^c   Cho, Won Jea ^a   Ha, Joohun ^d   Lee, In Kyu ^c   Lee, Chul Ho ^e   Choi, Hueng Sik ^a  

^a Chonnam National University   (South Korea)

^b Keimyung University   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Kyung Hee University Hospital   (South Korea)

^e Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CELL NUCLEUS RECEPTOR; DEXAMETHASONE; GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; METFORMIN; NUCLEAR FACTOR; NUCLEAR FACTOR ALPHA; ORPHAN NUCLEAR RECEPTOR SHP; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AMP ACTIVATED PROTEIN KINASES; AMP-ACTIVATED PROTEIN KINASES; ANTIDIABETIC AGENT; CELL RECEPTOR; MULTIENZYME COMPLEX; PROTEIN SERINE THREONINE KINASE; SMALL HETERODIMER PARTNER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ASSAY; DIABETES CONTROL; DRUG INHIBITION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RAT; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; DRUG EFFECT; GENETICS; LIVER; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GLUCONEOGENESIS; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; LIVER; LIVER NEOPLASMS; MALE; METFORMIN; MULTIENZYME COMPLEXES; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 40749116561     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-0381     Document Type: Article

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