Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Slack, Cathy ^a   Foley, Andrea ^a   Partridge, Linda ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; FEEDING; FEMALE; FEMALE FERTILITY; HOMEOSTASIS; INTESTINE FLUID; INTESTINE FUNCTION; LIFESPAN; LIPID METABOLISM; LIPID STORAGE; LONGEVITY; MALE; MOUSE; NONHUMAN; SURVIVAL RATE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIET; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FERTILITY; GENE EXPRESSION; LIPID METABOLISM; LONGEVITY; MALE; METFORMIN; PHOSPHORYLATION;

EID: 84867621125     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047699     Document Type: Article

References (49)

1. Fontana L, Partridge L, Longo VD, (2010) Extending healthy life span-from yeast to humans. Science 328: 321-326.
2. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, et al. (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
3. Masoro EJ (2002) Caloric restriction: a key to understanding and modulating aging. Amsterdam: Elsevier.
4. Holloszy JO, Fontana L, (2007) Caloric restriction in humans. Exp Gerontol 42: 709-712.
5. Redman LM, Martin CK, Williamson DA, Ravussin E, (2008) Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes. Physiol Behav 94: 643-648.
6. Dhahbi JM, Mote PL, Fahy GM, Spindler SR, (2005) Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics 23: 343-350.
7. Klip A, Leiter LA, (1990) Cellular mechanism of action of metformin. Diabetes Care 13: 696-704.
8. Cusi K, Consoli A, DeFronzo RA, (1996) Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81: 4059-4067.
9. Verma S, Bhanot S, McNeill JH, (1994) Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats. Am J Physiol 267: H1250-1253.
10. Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ, (2006) Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle. Am J Physiol Endocrinol Metab 291: E182-189.
11. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, et al. (2005) Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 40: 685-693.
12. Anisimov VN, Egormin PA, Bershtein LM, Zabezhinskii MA, Piskunova TS, et al. (2005) Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. Bull Exp Biol Med 139: 721-723.
13. Ma TC, Buescher JL, Oatis B, Funk JA, Nash AJ, et al. (2007) Metformin therapy in a transgenic mouse model of Huntington's disease. Neurosci Lett 411: 98-103.
14. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, et al. (2008) Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 7: 2769-2773.
15. Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, et al. (2010) Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle 9: 188-197.
16. Anisimov VN, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, et al. (2010) Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. Aging (Albany NY) 2: 945-958.
17. Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, et al. (2011) If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) 3: 148-157.
18. Ruiter R, Visser LE, van Herk-Sukel MP, Coebergh JW, Haak HR, et al. (2012) Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care 35: 119-124.
19. Smith DL Jr, Elam CF Jr, Mattison JA, Lane MA, Roth GS, et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J Gerontol A Biol Sci Med Sci 65: 468-474.
20. Onken B, Driscoll M, (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5: e8758.
21. Zhou G, Myers R, Li Y, Chen Y, Shen X, et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174.
22. Kahn BB, Alquier T, Carling D, Hardie DG, (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25.
23. Zong H, Ren JM, Young LH, Pypaert M, Mu J, et al. (2002) AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A 99: 15983-15987.
24. Fryer LG, Parbu-Patel A, Carling D, (2002) The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277: 25226-25232.
25. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646.
26. El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, et al. (2000) Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 275: 223-228.
27. Ouyang J, Parakhia RA, Ochs RS, (2011) Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem 286: 1-11.
28. Johnson EC, Kazgan N, Bretz CA, Forsberg LJ, Hector CE, et al. (2010) Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PLoS One 5.
29. Tohyama D, Yamaguchi A, (2010) A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster. Biochem Biophys Res Commun 394: 112-118.
30. Funakoshi M, Tsuda M, Muramatsu K, Hatsuda H, Morishita S, et al. (2011) A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. Biochem Biophys Res Commun 405: 667-672.
31. Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R, (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev 18: 3004-3009.
32. Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, et al. (2007) An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17: 1646-1656.
33. Greer EL, Brunet A, (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8: 113-127.
34. Wilcock C, Bailey CJ, (1994) Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 24: 49-57.
35. Drenos F, Kirkwood TB, (2005) Modelling the disposable soma theory of ageing. Mech Ageing Dev 126: 99-103.
36. Cognigni P, Bailey AP, Miguel-Aliaga I, (2011) Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. Cell Metab 13: 92-104.
37. Skorupa DA, Dervisefendic A, Zwiener J, Pletcher SD, (2008) Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell 7: 478-490.
38. Bass TM, Grandison RC, Wong R, Martinez P, Partridge L, et al. (2007) Optimization of dietary restriction protocols in Drosophila. J Gerontol A Biol Sci Med Sci 62: 1071-1081.
39. Jafari M, Khodayari B, Felgner J, Bussel, II, Rose MR, et al. (2007) Pioglitazone: an anti-diabetic compound with anti-aging properties. Biogerontology 8: 639-651.
40. Kalender A, Selvaraj A, Kim SY, Gulati P, Brule S, et al. (2010) Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 11: 390-401.
41. Bhalla K, Hwang BJ, Dewi RE, Twaddel W, Goloubeva OG, et al. (2012) Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev Res (Phila) 5: 544-552.
42. van Herrewege JDJR, (1997) Starvation and desiccation tolerances in Drosophila: Comparison of species from different climatic origins. Ecoscience 4: 151-157.
43. Klachko D W-CA (2011) Use of Metformin in Patients with Kidney and Cardiovascular Diseases. Cardiorenal Medicine 1.
44. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890.
45. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, et al. (2009) 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139: 149-160.
46. Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L, (2002) Dietary restriction in long-lived dwarf flies. Science 296: 319.
47. Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A, (2007) PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
48. Giannakou ME, Goss M, Partridge L, (2008) Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7: 187-198.
49. Spindler SR, (2012) Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. Age (Dordr) 34: 111-120.