-
1
-
-
84861591910
-
The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association American Association for the Study of Liver Diseases, and American College of Gastroenterology
-
Chalasani N., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012, 142:1592-1609.
-
(2012)
Gastroenterology
, vol.142
, pp. 1592-1609
-
-
Chalasani, N.1
-
2
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
-
Browning J.D., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, J.D.1
-
3
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
-
Williams C.D., et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011, 140:124-131.
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, C.D.1
-
4
-
-
84945544435
-
Trends in burden of cirrhosis and hepatocellular carcinoma by underlying liver disease in US veterans, 2001-2013
-
Beste L.A., et al. Trends in burden of cirrhosis and hepatocellular carcinoma by underlying liver disease in US veterans, 2001-2013. Gastroenterology 2015, 149:1471-1482.
-
(2015)
Gastroenterology
, vol.149
, pp. 1471-1482
-
-
Beste, L.A.1
-
5
-
-
84255162259
-
Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States
-
Afzali A., et al. Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States. Liver Transpl. 2012, 18:29-37.
-
(2012)
Liver Transpl.
, vol.18
, pp. 29-37
-
-
Afzali, A.1
-
6
-
-
0033038672
-
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
-
Matteoni C.A., et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.A.1
-
7
-
-
0036302288
-
Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
-
Bugianesi E., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002, 123:134-140.
-
(2002)
Gastroenterology
, vol.123
, pp. 134-140
-
-
Bugianesi, E.1
-
8
-
-
33747517955
-
The epidemiology of nonalcoholic fatty liver disease in adults
-
Clark J.M. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006, 40(Suppl. 1):S5-S10.
-
(2006)
J Clin Gastroenterol
, vol.40
, pp. S5-S10
-
-
Clark, J.M.1
-
9
-
-
84887319657
-
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms
-
Wree A., et al. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat. Rev. Gastroenterol. Hepatol. 2013, 10:627-636.
-
(2013)
Nat. Rev. Gastroenterol. Hepatol.
, vol.10
, pp. 627-636
-
-
Wree, A.1
-
10
-
-
77955690182
-
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
-
Neuschwander-Tetri B.A. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 2010, 52:774-788.
-
(2010)
Hepatology
, vol.52
, pp. 774-788
-
-
Neuschwander-Tetri, B.A.1
-
11
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
Yamaguchi K., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45:1366-1374.
-
(2007)
Hepatology
, vol.45
, pp. 1366-1374
-
-
Yamaguchi, K.1
-
12
-
-
77049094855
-
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
-
Wouters K., et al. Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice. FEBS Lett. 2010, 584:1001-1005.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1001-1005
-
-
Wouters, K.1
-
13
-
-
84880683621
-
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease
-
Scorletti E., Byrne C.D. Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. Annu. Rev. Nutr. 2013, 33:231-248.
-
(2013)
Annu. Rev. Nutr.
, vol.33
, pp. 231-248
-
-
Scorletti, E.1
Byrne, C.D.2
-
14
-
-
84872493396
-
Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
-
Musso G., et al. Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid Res. 2013, 52:175-191.
-
(2013)
Prog. Lipid Res.
, vol.52
, pp. 175-191
-
-
Musso, G.1
-
15
-
-
84930632138
-
Recent insights on the role of cholesterol in non-alcoholic fatty liver disease
-
Arguello G., et al. Recent insights on the role of cholesterol in non-alcoholic fatty liver disease. Biochim. Biophys. Acta 2015, 1852:1765-1778.
-
(2015)
Biochim. Biophys. Acta
, vol.1852
, pp. 1765-1778
-
-
Arguello, G.1
-
16
-
-
84899117631
-
Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis
-
Hendrikx T., et al. Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis. Obes. Rev. 2014, 15:424-433.
-
(2014)
Obes. Rev.
, vol.15
, pp. 424-433
-
-
Hendrikx, T.1
-
17
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
Kumashiro N., et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:16381-16385.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 16381-16385
-
-
Kumashiro, N.1
-
18
-
-
84942103324
-
Ceramides - lipotoxic inducers of metabolic disorders
-
Chaurasia B., Summers S.A. Ceramides - lipotoxic inducers of metabolic disorders. Trends Endocrinol. Metab. 2015, 26:538-550.
-
(2015)
Trends Endocrinol. Metab.
, vol.26
, pp. 538-550
-
-
Chaurasia, B.1
Summers, S.A.2
-
19
-
-
0036790413
-
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
-
Tabas I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 2002, 110:905-911.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 905-911
-
-
Tabas, I.1
-
20
-
-
84905637866
-
Comparative proteomic study reveals 17beta-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
-
Su W., et al. Comparative proteomic study reveals 17beta-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:11437-11442.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 11437-11442
-
-
Su, W.1
-
22
-
-
79957889560
-
The role of lipid droplets in metabolic disease in rodents and humans
-
Greenberg A.S., et al. The role of lipid droplets in metabolic disease in rodents and humans. J. Clin. Invest. 2011, 121:2102-2110.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2102-2110
-
-
Greenberg, A.S.1
-
23
-
-
0037113954
-
The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition
-
Tauchi-Sato K., et al. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J. Biol. Chem. 2002, 277:44507-44512.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44507-44512
-
-
Tauchi-Sato, K.1
-
24
-
-
84888367601
-
The biophysics and cell biology of lipid droplets
-
Thiam A.R., et al. The biophysics and cell biology of lipid droplets. Nat. Rev. Mol. Cell Biol. 2013, 14:775-786.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 775-786
-
-
Thiam, A.R.1
-
25
-
-
84866143955
-
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
-
Hsieh K., et al. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J. Cell Sci. 2012, 125:4067-4076.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4067-4076
-
-
Hsieh, K.1
-
26
-
-
64949147821
-
Central nervous system: cholesterol turnover, brain development and neurodegeneration
-
Dietschy J.M. Central nervous system: cholesterol turnover, brain development and neurodegeneration. Biol. Chem. 2009, 390:287-293.
-
(2009)
Biol. Chem.
, vol.390
, pp. 287-293
-
-
Dietschy, J.M.1
-
27
-
-
56449110891
-
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance
-
Radhakrishnan A., et al. Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab. 2008, 8:512-521.
-
(2008)
Cell Metab.
, vol.8
, pp. 512-521
-
-
Radhakrishnan, A.1
-
28
-
-
0037462815
-
The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
-
Lambert G., et al. The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J. Biol. Chem. 2003, 278:2563-2570.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2563-2570
-
-
Lambert, G.1
-
29
-
-
84860469242
-
Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
-
Min H.K., et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012, 15:665-674.
-
(2012)
Cell Metab.
, vol.15
, pp. 665-674
-
-
Min, H.K.1
-
30
-
-
78649632998
-
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
-
Simonen P., et al. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. J. Hepatol. 2011, 54:153-159.
-
(2011)
J. Hepatol.
, vol.54
, pp. 153-159
-
-
Simonen, P.1
-
31
-
-
61849095626
-
Enhanced free cholesterol SREBP-2 and StAR expression in human NASH
-
Caballero F., et al. Enhanced free cholesterol SREBP-2 and StAR expression in human NASH. J. Hepatol. 2009, 50:789-796.
-
(2009)
J. Hepatol.
, vol.50
, pp. 789-796
-
-
Caballero, F.1
-
32
-
-
84861975560
-
Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
-
Savard C., et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology 2013, 57:81-92.
-
(2013)
Hepatology
, vol.57
, pp. 81-92
-
-
Savard, C.1
-
33
-
-
80051826073
-
Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
-
Subramanian S., et al. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J. Lipid Res. 2011, 52:1626-1635.
-
(2011)
J. Lipid Res.
, vol.52
, pp. 1626-1635
-
-
Subramanian, S.1
-
34
-
-
80053612479
-
Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis
-
Van Rooyen D.M., et al. Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology 2011, 141:1393-1403.
-
(2011)
Gastroenterology
, vol.141
, pp. 1393-1403
-
-
Van Rooyen, D.M.1
-
35
-
-
67651148531
-
Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population
-
Ioannou G.N., et al. Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population. Hepatology 2009, 50:175-184.
-
(2009)
Hepatology
, vol.50
, pp. 175-184
-
-
Ioannou, G.N.1
-
36
-
-
84876803994
-
Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis
-
Ioannou G.N., et al. Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J. Lipid Res. 2013, 54:1326-1334.
-
(2013)
J. Lipid Res.
, vol.54
, pp. 1326-1334
-
-
Ioannou, G.N.1
-
37
-
-
84921905230
-
Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH
-
Ioannou G.N., et al. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH. J. Lipid Res. 2015, 56:277-285.
-
(2015)
J. Lipid Res.
, vol.56
, pp. 277-285
-
-
Ioannou, G.N.1
-
38
-
-
41149120450
-
Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
-
Zheng S., et al. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur. J. Pharmacol. 2008, 584:118-124.
-
(2008)
Eur. J. Pharmacol.
, vol.584
, pp. 118-124
-
-
Zheng, S.1
-
39
-
-
77954366025
-
Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study
-
Yoneda M., et al. Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study. Hepatol. Res. 2010, 40:613-621.
-
(2010)
Hepatol. Res.
, vol.40
, pp. 613-621
-
-
Yoneda, M.1
-
40
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
Puri P., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
-
(2007)
Hepatology
, vol.46
, pp. 1081-1090
-
-
Puri, P.1
-
41
-
-
0037382071
-
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
-
Musso G., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003, 37:909-916.
-
(2003)
Hepatology
, vol.37
, pp. 909-916
-
-
Musso, G.1
-
42
-
-
67049114700
-
Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol
-
Yasutake K., et al. Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. Scand. J. Gastroenterol. 2009, 44:471-477.
-
(2009)
Scand. J. Gastroenterol.
, vol.44
, pp. 471-477
-
-
Yasutake, K.1
-
43
-
-
84939268765
-
Statin use and non-alcoholic steatohepatitis in at risk individuals
-
Dongiovanni P., et al. Statin use and non-alcoholic steatohepatitis in at risk individuals. J. Hepatol. 2015, 63:705-712.
-
(2015)
J. Hepatol.
, vol.63
, pp. 705-712
-
-
Dongiovanni, P.1
-
44
-
-
78649890465
-
Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
-
Athyros V.G., et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet 2010, 376:1916-1922.
-
(2010)
Lancet
, vol.376
, pp. 1916-1922
-
-
Athyros, V.G.1
-
45
-
-
33745046866
-
Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study
-
Athyros V.G., et al. Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study. Curr. Med. Res. Opin. 2006, 22:873-883.
-
(2006)
Curr. Med. Res. Opin.
, vol.22
, pp. 873-883
-
-
Athyros, V.G.1
-
46
-
-
78650971903
-
Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial
-
Foster T., et al. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am. J. Gastroenterol. 2011, 106:71-77.
-
(2011)
Am. J. Gastroenterol.
, vol.106
, pp. 71-77
-
-
Foster, T.1
-
47
-
-
74949102941
-
A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial
-
Nelson A., et al. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial. J. Clin. Gastroenterol. 2009, 43:990-994.
-
(2009)
J. Clin. Gastroenterol.
, vol.43
, pp. 990-994
-
-
Nelson, A.1
-
48
-
-
78651473467
-
Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
-
Park H., et al. Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J. Gastroenterol. 2011, 46:101-107.
-
(2011)
J. Gastroenterol.
, vol.46
, pp. 101-107
-
-
Park, H.1
-
49
-
-
77952674608
-
Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet
-
Chan D.C., et al. Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet. Diabetes Care 2010, 33:1134-1139.
-
(2010)
Diabetes Care
, vol.33
, pp. 1134-1139
-
-
Chan, D.C.1
-
50
-
-
84898600580
-
The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial
-
Takeshita Y., et al. The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial. Diabetologia 2014, 57:878-890.
-
(2014)
Diabetologia
, vol.57
, pp. 878-890
-
-
Takeshita, Y.1
-
51
-
-
84925339397
-
Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel MRI and MRE in a randomized trial (MOZART Trial)
-
Loomba R., et al. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel MRI and MRE in a randomized trial (MOZART Trial). Hepatology 2014, 61:1239-1250.
-
(2014)
Hepatology
, vol.61
, pp. 1239-1250
-
-
Loomba, R.1
-
52
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo S., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 2008, 40:1461-1465.
-
(2008)
Nat. Genet.
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
-
53
-
-
77956630787
-
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
-
Speliotes E.K., et al. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 2010, 52:904-912.
-
(2010)
Hepatology
, vol.52
, pp. 904-912
-
-
Speliotes, E.K.1
-
54
-
-
77956636268
-
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
-
Rotman Y., et al. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010, 52:894-903.
-
(2010)
Hepatology
, vol.52
, pp. 894-903
-
-
Rotman, Y.1
-
55
-
-
84869224701
-
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148 M (rs738409) affects hepatic VLDL secretion in humans and in vitro
-
Pirazzi C., et al. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148 M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J. Hepatol. 2012, 57:1276-1282.
-
(2012)
J. Hepatol.
, vol.57
, pp. 1276-1282
-
-
Pirazzi, C.1
-
56
-
-
80054806707
-
Expression and characterization of a PNPLA3 protein isoform (I148 M) associated with nonalcoholic fatty liver disease
-
Huang Y., et al. Expression and characterization of a PNPLA3 protein isoform (I148 M) associated with nonalcoholic fatty liver disease. J. Biol. Chem. 2011, 286:37085-37093.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 37085-37093
-
-
Huang, Y.1
-
57
-
-
84921487729
-
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
-
Dongiovanni P., et al. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology 2015, 61:506-514.
-
(2015)
Hepatology
, vol.61
, pp. 506-514
-
-
Dongiovanni, P.1
-
58
-
-
84881025772
-
A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia
-
Cefalu A.B., et al. A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia. Arterioscler. Thromb. Vasc. Biol. 2013, 33:2021-2025.
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 2021-2025
-
-
Cefalu, A.B.1
-
59
-
-
78049457761
-
Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease
-
Chalasani N., et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology 2010, 139:1567-1576.
-
(2010)
Gastroenterology
, vol.139
, pp. 1567-1576
-
-
Chalasani, N.1
-
60
-
-
84941312383
-
A Phase 3 trial of sebelipase alfa in lysosomal acid lipase deficiency
-
Burton B.K., et al. A Phase 3 trial of sebelipase alfa in lysosomal acid lipase deficiency. N. Engl. J. Med. 2015, 373:1010-1020.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 1010-1020
-
-
Burton, B.K.1
-
61
-
-
77953745493
-
Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death
-
Montero J., et al. Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death. Biochim. Biophys. Acta 2010, 1797:1217-1224.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1217-1224
-
-
Montero, J.1
-
62
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
-
Mari M., et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab. 2006, 4:185-198.
-
(2006)
Cell Metab.
, vol.4
, pp. 185-198
-
-
Mari, M.1
-
63
-
-
79955947558
-
Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways
-
Li L., et al. Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways. J. Biol. Chem. 2011, 286:17809-17820.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 17809-17820
-
-
Li, L.1
-
64
-
-
84862021619
-
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
-
Hager L., et al. Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. J. Biol. Chem. 2012, 287:20755-20768.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 20755-20768
-
-
Hager, L.1
-
65
-
-
84904012910
-
Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice
-
Legry V., et al. Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice. Clin. Sci. (Lond.) 2014, 127:507-518.
-
(2014)
Clin. Sci. (Lond.)
, vol.127
, pp. 507-518
-
-
Legry, V.1
-
66
-
-
77949524635
-
Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets
-
Hodges B.D., Wu C.C. Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets. J. Lipid Res. 2010, 51:262-273.
-
(2010)
J. Lipid Res.
, vol.51
, pp. 262-273
-
-
Hodges, B.D.1
Wu, C.C.2
-
67
-
-
84902975099
-
Lipid droplets as signaling platforms linking metabolic and cellular functions
-
Arrese E.L., et al. Lipid droplets as signaling platforms linking metabolic and cellular functions. Lipid Insights 2014, 7:7-16.
-
(2014)
Lipid Insights
, vol.7
, pp. 7-16
-
-
Arrese, E.L.1
-
68
-
-
84923046255
-
Cholesterol, inflammation and innate immunity
-
Tall A.R., Yvan-Charvet L. Cholesterol, inflammation and innate immunity. Nat. Rev. Immunol. 2015, 15:104-116.
-
(2015)
Nat. Rev. Immunol.
, vol.15
, pp. 104-116
-
-
Tall, A.R.1
Yvan-Charvet, L.2
-
69
-
-
0033613147
-
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
-
Brown M.S., Goldstein J.L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:11041-11048.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 11041-11048
-
-
Brown, M.S.1
Goldstein, J.L.2
-
71
-
-
0346037268
-
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
-
Kunjathoor V.V., et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 2002, 277:49982-49988.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49982-49988
-
-
Kunjathoor, V.V.1
-
72
-
-
0031821192
-
Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network
-
Jerome W.G., et al. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network. J. Lipid Res. 1998, 39:1362-1371.
-
(1998)
J. Lipid Res.
, vol.39
, pp. 1362-1371
-
-
Jerome, W.G.1
-
73
-
-
17344370810
-
Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation
-
Li W., et al. Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler. Thromb. Vas. Biol. 1998, 18:177-184.
-
(1998)
Arterioscler. Thromb. Vas. Biol.
, vol.18
, pp. 177-184
-
-
Li, W.1
-
74
-
-
84865551517
-
Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice
-
Bieghs V., et al. Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice. Hepatology 2012, 56:894-903.
-
(2012)
Hepatology
, vol.56
, pp. 894-903
-
-
Bieghs, V.1
-
75
-
-
84880178234
-
Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation
-
Bieghs V., et al. Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. Liver Int. 2013, 33:1056-1061.
-
(2013)
Liver Int.
, vol.33
, pp. 1056-1061
-
-
Bieghs, V.1
-
76
-
-
77952717393
-
Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
-
Bieghs V., et al. Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology 2010, 138:2477-2486.
-
(2010)
Gastroenterology
, vol.138
, pp. 2477-2486
-
-
Bieghs, V.1
-
77
-
-
84859081972
-
Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
-
Bieghs V., et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS ONE 2012, 7:e34378.
-
(2012)
PLoS ONE
, vol.7
-
-
Bieghs, V.1
-
78
-
-
84871330823
-
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
-
167-178. e1
-
Bieghs V., et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology 2013, 144:167-178. e1.
-
(2013)
Gastroenterology
, vol.144
-
-
Bieghs, V.1
-
79
-
-
77951073185
-
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid
-
Liu B., et al. Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid. J. Lipid Res. 2010, 51:933-944.
-
(2010)
J. Lipid Res.
, vol.51
, pp. 933-944
-
-
Liu, B.1
-
80
-
-
33846264060
-
Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens
-
Targher G. Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens. Diabet. Med. 2007, 24:1-6.
-
(2007)
Diabet. Med.
, vol.24
, pp. 1-6
-
-
Targher, G.1
-
81
-
-
84922367724
-
Formation of 3D cholesterol crystals from 2D nucleation sites in lipid bilayer membranes: implications for atherosclerosis
-
Varsano N., et al. Formation of 3D cholesterol crystals from 2D nucleation sites in lipid bilayer membranes: implications for atherosclerosis. J. Am. Chem. Soc. 2015, 137:1601-1607.
-
(2015)
J. Am. Chem. Soc.
, vol.137
, pp. 1601-1607
-
-
Varsano, N.1
-
82
-
-
0042165989
-
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein A.E., et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125:437-443.
-
(2003)
Gastroenterology
, vol.125
, pp. 437-443
-
-
Feldstein, A.E.1
-
83
-
-
33745904468
-
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
-
Wieckowska A., et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006, 44:27-33.
-
(2006)
Hepatology
, vol.44
, pp. 27-33
-
-
Wieckowska, A.1
-
84
-
-
73949150306
-
Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins
-
Haka A.S., et al. Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins. Mol. Biol. Cell 2009, 20:4932-4940.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 4932-4940
-
-
Haka, A.S.1
-
85
-
-
84860280502
-
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis
-
Dixon L.J., et al. Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab. Invest. 2012, 92:713-723.
-
(2012)
Lab. Invest.
, vol.92
, pp. 713-723
-
-
Dixon, L.J.1
-
86
-
-
84873573078
-
Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis
-
Dixon L.J., et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS ONE 2013, 8:e56100.
-
(2013)
PLoS ONE
, vol.8
-
-
Dixon, L.J.1
-
87
-
-
84896709837
-
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
-
Wree A., et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 2014, 59:898-910.
-
(2014)
Hepatology
, vol.59
, pp. 898-910
-
-
Wree, A.1
-
88
-
-
84942820675
-
Inflammasome activation in the liver: focus on alcoholic and non-alcoholic steatohepatitis
-
Szabo G., Iracheta-Vellve A. Inflammasome activation in the liver: focus on alcoholic and non-alcoholic steatohepatitis. Clin. Res. Hepatol. Gastroenterol. 2015, 39(Suppl 1):S18-S23.
-
(2015)
Clin. Res. Hepatol. Gastroenterol.
, vol.39
, pp. S18-S23
-
-
Szabo, G.1
Iracheta-Vellve, A.2
-
89
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010, 464:1357-1361.
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
-
90
-
-
77955356552
-
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
-
Rajamaki K., et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE 2010, 5:e11765.
-
(2010)
PLoS ONE
, vol.5
, pp. e11765
-
-
Rajamaki, K.1
-
91
-
-
47849132947
-
The Nalp3 inflammasome is essential for the development of silicosis
-
Cassel S.L., et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:9035-9040.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 9035-9040
-
-
Cassel, S.L.1
-
92
-
-
77950362382
-
The inflammasomes
-
Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
93
-
-
80052179138
-
Caspase-1-induced pyroptotic cell death
-
Miao E.A., et al. Caspase-1-induced pyroptotic cell death. Immunol. Rev. 2011, 243:206-214.
-
(2011)
Immunol. Rev.
, vol.243
, pp. 206-214
-
-
Miao, E.A.1
-
94
-
-
58449083290
-
Pyroptosis: host cell death and inflammation
-
Bergsbaken T., et al. Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 2009, 7:99-109.
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, pp. 99-109
-
-
Bergsbaken, T.1
-
95
-
-
84925060829
-
Fibrosis-a common pathway to organ injury and failure
-
Rockey D.C., et al. Fibrosis-a common pathway to organ injury and failure. N. Engl. J. Med. 2015, 372:1138-1149.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1138-1149
-
-
Rockey, D.C.1
-
96
-
-
84929310290
-
Emerging and disease-specific mechanisms of hepatic stellate cell activation
-
Wallace M.C., et al. Emerging and disease-specific mechanisms of hepatic stellate cell activation. Semin. Liver Dis. 2015, 35:107-118.
-
(2015)
Semin. Liver Dis.
, vol.35
, pp. 107-118
-
-
Wallace, M.C.1
-
97
-
-
83755163159
-
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
-
Teratani T., et al. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 2012, 142:152-164.
-
(2012)
Gastroenterology
, vol.142
, pp. 152-164
-
-
Teratani, T.1
-
98
-
-
84894875873
-
Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
-
Tomita K., et al. Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 2014, 59:154-169.
-
(2014)
Hepatology
, vol.59
, pp. 154-169
-
-
Tomita, K.1
-
99
-
-
80053176429
-
Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis
-
Musso G., et al. Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis. Am. J. Clin. Nutr. 2011, 94:1033-1042.
-
(2011)
Am. J. Clin. Nutr.
, vol.94
, pp. 1033-1042
-
-
Musso, G.1
-
100
-
-
70350662973
-
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
-
Kang Q., Chen A. Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. Lab. Invest. 2009, 89:1275-1290.
-
(2009)
Lab. Invest.
, vol.89
, pp. 1275-1290
-
-
Kang, Q.1
Chen, A.2
-
101
-
-
84902685435
-
Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells
-
Tomita K., et al. Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells. J. Hepatol. 2014, 61:98-106.
-
(2014)
J. Hepatol.
, vol.61
, pp. 98-106
-
-
Tomita, K.1
|