메뉴 건너뛰기




Volumn 61, Issue 4, 2015, Pages 1239-1250

Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; EZETIMIBE; LOW DENSITY LIPOPROTEIN; PLACEBO; AZETIDINE DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT;

EID: 84925339397     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27647     Document Type: Article
Times cited : (299)

References (35)
  • 1
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012; 55:2005-2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 2
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    • Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011; 140:124-131.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3    Torres, D.M.4    Shaw, J.5    Contreras, M.6
  • 4
    • 84924938800 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies
    • Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. doi: 10.1016/j.cgh.2014.04.014.
    • Clin Gastroenterol Hepatol
    • Singh, S.1    Allen, A.M.2    Wang, Z.3    Prokop, L.J.4    Murad, M.H.5    Loomba, R.6
  • 7
    • 84865545850 scopus 로고    scopus 로고
    • Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
    • Loomba R, Abraham M, Unalp A, Wilson L, Lavine J, Doo E, et al. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 2012; 56:943-951.
    • (2012) Hepatology , vol.56 , pp. 943-951
    • Loomba, R.1    Abraham, M.2    Unalp, A.3    Wilson, L.4    Lavine, J.5    Doo, E.6
  • 9
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 2010; 51:1961-1971.
    • (2010) Hepatology , vol.51 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3    Unalp-Arida, A.4    Colvin, R.5    Johnson, R.J.6
  • 11
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355:2297-2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 12
    • 84867574634 scopus 로고    scopus 로고
    • The emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease
    • Zarrinpar A, Loomba R. The emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012; 36:909-921.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 909-921
    • Zarrinpar, A.1    Loomba, R.2
  • 13
    • 84861975560 scopus 로고    scopus 로고
    • Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
    • Savard C, Tartaglione EV, Kuver R, Haigh WG, Farrell GC, Subramanian S, et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology 2013; 57:81-92.
    • (2013) Hepatology , vol.57 , pp. 81-92
    • Savard, C.1    Tartaglione, E.V.2    Kuver, R.3    Haigh, W.G.4    Farrell, G.C.5    Subramanian, S.6
  • 14
    • 84859929103 scopus 로고    scopus 로고
    • Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease
    • de Bari O, Neuschwander-Tetri BA, Liu M, Portincasa P, Wang DQ. Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease. J Lipids 2012; 2012:302847.
    • (2012) J Lipids , vol.2012 , pp. 302847
    • de Bari, O.1    Neuschwander-Tetri, B.A.2    Liu, M.3    Portincasa, P.4    Wang, D.Q.5
  • 15
    • 36549013633 scopus 로고    scopus 로고
    • Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
    • Deushi M, Nomura M, Kawakami A, Haraguchi M, Ito M, Okazaki M, et al. Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett 2007; 581:5664-5670.
    • (2007) FEBS Lett , vol.581 , pp. 5664-5670
    • Deushi, M.1    Nomura, M.2    Kawakami, A.3    Haraguchi, M.4    Ito, M.5    Okazaki, M.6
  • 17
    • 78651473467 scopus 로고    scopus 로고
    • Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
    • Park H, Shima T, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, et al. Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol 2011; 46:101-107.
    • (2011) J Gastroenterol , vol.46 , pp. 101-107
    • Park, H.1    Shima, T.2    Yamaguchi, K.3    Mitsuyoshi, H.4    Minami, M.5    Yasui, K.6
  • 18
    • 84865569519 scopus 로고    scopus 로고
    • Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial
    • Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, et al. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 2012; 56:922-932.
    • (2012) Hepatology , vol.56 , pp. 922-932
    • Le, T.A.1    Chen, J.2    Changchien, C.3    Peterson, M.R.4    Kono, Y.5    Patton, H.6
  • 19
    • 84888298670 scopus 로고    scopus 로고
    • Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
    • Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 2013; 58:1930-1940.
    • (2013) Hepatology , vol.58 , pp. 1930-1940
    • Noureddin, M.1    Lam, J.2    Peterson, M.R.3    Middleton, M.4    Hamilton, G.5    Le, T.A.6
  • 20
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 21
    • 55149115873 scopus 로고    scopus 로고
    • Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials
    • Loomba R, Wesley R, Pucino F, Liang TJ, Kleiner DE, Lavine JE. Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials. Clin Gastroenterol Hepatol 2008; 6:1243-1248.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1243-1248
    • Loomba, R.1    Wesley, R.2    Pucino, F.3    Liang, T.J.4    Kleiner, D.E.5    Lavine, J.E.6
  • 22
    • 84866605548 scopus 로고    scopus 로고
    • Effect of multipeak spectral modeling of fat for liver iron and fat quantification: correlation of biopsy with MR imaging results
    • Kuhn JP, Hernando D, Munoz del Rio A, Evert M, Kannengiesser S, Volzke H, et al. Effect of multipeak spectral modeling of fat for liver iron and fat quantification: correlation of biopsy with MR imaging results. Radiology 2012; 265:133-142.
    • (2012) Radiology , vol.265 , pp. 133-142
    • Kuhn, J.P.1    Hernando, D.2    Munoz del Rio, A.3    Evert, M.4    Kannengiesser, S.5    Volzke, H.6
  • 23
    • 80052996528 scopus 로고    scopus 로고
    • Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy
    • Reeder SB, Cruite I, Hamilton G, Sirlin CB. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 2011; 34:729-749.
    • (2011) J Magn Reson Imaging , vol.34 , pp. 729-749
    • Reeder, S.B.1    Cruite, I.2    Hamilton, G.3    Sirlin, C.B.4
  • 24
    • 85027925485 scopus 로고    scopus 로고
    • Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease-MRI accurately quantifies hepatic steatosis in NAFLD
    • Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, et al. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease-MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther 2012; 36:22-29.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 22-29
    • Permutt, Z.1    Le, T.A.2    Peterson, M.R.3    Seki, E.4    Brenner, D.A.5    Sirlin, C.6
  • 25
    • 84888290605 scopus 로고    scopus 로고
    • Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis
    • Reeder SB. Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis. Hepatology 2013; 58:1877-1880.
    • (2013) Hepatology , vol.58 , pp. 1877-1880
    • Reeder, S.B.1
  • 26
    • 84880649809 scopus 로고    scopus 로고
    • Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography
    • Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL. Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography. Radiology 2013; 268:411-419.
    • (2013) Radiology , vol.268 , pp. 411-419
    • Kim, D.1    Kim, W.R.2    Talwalkar, J.A.3    Kim, H.J.4    Ehman, R.L.5
  • 27
    • 84911948591 scopus 로고    scopus 로고
    • Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study
    • Loomba R, Wolfson T, Ang B, Booker J, Behling C, Peterson M, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology 2014; 60:1920-1928.
    • (2014) Hepatology , vol.60 , pp. 1920-1928
    • Loomba, R.1    Wolfson, T.2    Ang, B.3    Booker, J.4    Behling, C.5    Peterson, M.6
  • 28
    • 79956292596 scopus 로고    scopus 로고
    • Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography
    • Chen J, Talwalkar JA, Yin M, Glaser KJ, Sanderson SO, Ehman RL. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology 2011; 259:749-756.
    • (2011) Radiology , vol.259 , pp. 749-756
    • Chen, J.1    Talwalkar, J.A.2    Yin, M.3    Glaser, K.J.4    Sanderson, S.O.5    Ehman, R.L.6
  • 29
    • 84874226671 scopus 로고    scopus 로고
    • Magnetic resonance elastography of liver: technique, analysis, and clinical applications
    • Venkatesh SK, Yin M, Ehman RL. Magnetic resonance elastography of liver: technique, analysis, and clinical applications. J Magn Reson Imaging 2013; 37:544-555.
    • (2013) J Magn Reson Imaging , vol.37 , pp. 544-555
    • Venkatesh, S.K.1    Yin, M.2    Ehman, R.L.3
  • 30
    • 84890829992 scopus 로고    scopus 로고
    • Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease
    • Xanthakos SA, Podberesky DJ, Serai SD, Miles L, King EC, Balistreri WF, et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr 2014; 164:186-188.
    • (2014) J Pediatr , vol.164 , pp. 186-188
    • Xanthakos, S.A.1    Podberesky, D.J.2    Serai, S.D.3    Miles, L.4    King, E.C.5    Balistreri, W.F.6
  • 32
    • 84925304127 scopus 로고    scopus 로고
    • Effect of weight loss on MRI estimation of liver fat and volume in patients with nonalcoholic steatohepatitis
    • Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, et al. Effect of weight loss on MRI estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2014. doi: 10.1016/j.cgh.2014.08.039.
    • (2014) Clin Gastroenterol Hepatol
    • Patel, N.S.1    Doycheva, I.2    Peterson, M.R.3    Hooker, J.4    Kisselva, T.5    Schnabl, B.6
  • 33
    • 84903850162 scopus 로고    scopus 로고
    • Efficacy of ezetimibe for reducing serum low-density lipoprotein cholesterol levels resistant to lifestyle intervention in patients with non-alcoholic fatty liver disease
    • Oza N, Takahashi H, Eguchi Y, Kitajima Y, Kuwashiro T, Ishibashi E, et al. Efficacy of ezetimibe for reducing serum low-density lipoprotein cholesterol levels resistant to lifestyle intervention in patients with non-alcoholic fatty liver disease. Hepatol Res 2014; 44:812-817.
    • (2014) Hepatol Res , vol.44 , pp. 812-817
    • Oza, N.1    Takahashi, H.2    Eguchi, Y.3    Kitajima, Y.4    Kuwashiro, T.5    Ishibashi, E.6
  • 34
    • 84898600580 scopus 로고    scopus 로고
    • The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial
    • Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato K, et al. The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial. Diabetologia 2014; 57:878-890.
    • (2014) Diabetologia , vol.57 , pp. 878-890
    • Takeshita, Y.1    Takamura, T.2    Honda, M.3    Kita, Y.4    Zen, Y.5    Kato, K.6
  • 35
    • 84908093531 scopus 로고    scopus 로고
    • Serum alanine aminotransferase as a biomarker of treatment response in nonalcoholic steatohepatitis
    • Loomba R. Serum alanine aminotransferase as a biomarker of treatment response in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2014; 12:1731-1732.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1731-1732
    • Loomba, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.