Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells

Journal of Hepatology

Volumn 61, Issue 1, 2014, Pages 98-106

  Tomita, Kengo ^a,b   Teratani, Toshiaki ^b   Suzuki, Takahiro ^b   Shimizu, Motonori ^a   Sato, Hirokazu ^a   Narimatsu, Kazuyuki ^a   Usui, Shingo ^a   Furuhashi, Hirotaka ^a   Kimura, Akifumi ^a   Nishiyama, Kiyoshi ^a   Maejima, Tadashi ^a   Okada, Yoshikiyo ^a   Kurihara, Chie ^a   Shimamura, Katsuyoshi ^b   Ebinuma, Hirotoshi ^b   Saito, Hidetsugu ^c   Yokoyama, Hirokazu ^b   Watanabe, Chikako ^a   Komoto, Shunsuke ^a   Nagao, Shigeaki ^a   Sugiyama, Kazuo ^b   Aosasa, Suefumi ^a   Hatsuse, Kazuo ^a   Yamamoto, Junji ^a   Hibi, Toshifumi ^b   Miura, Soichiro ^a   Hokari, Ryota ^a   Kanai, Takanori ^b   more..

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Acyl coenzyme A:cholesterol acyltransferase; Bone morphogenetic protein and activin membrane bound inhibitor; Free cholesterol; Hepatic stellate cell; Toll like receptor 4; Transforming growth factor

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; BAMBI PROTEIN; CARBON TETRACHLORIDE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE 1; CLODRONIC ACID; COLLAGEN TYPE 1; PROTEIN; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CHOLESTEROL ESTER; STEROL O-ACYLTRANSFERASE 1; TLR4 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DISEASE EXACERBATION; HEPATITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KUPFFER CELL; LIVER CELL; LIVER CELL DAMAGE; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STELLATE CELL; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE COURSE; GENETICS; KNOCKOUT MOUSE; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL ESTERS; DISEASE PROGRESSION; HEPATIC STELLATE CELLS; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; STEROL O-ACYLTRANSFERASE; TOLL-LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA;

EID: 84902685435     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.03.018     Document Type: Article

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