메뉴 건너뛰기




Volumn 78, Issue , 2016, Pages 223-241

Understanding the Physiology of FGF21

Author keywords

Adipose; Diet; Fat; Liver; Obesity; klotho

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; FATTY ACID; FIBROBLAST GROWTH FACTOR;

EID: 84958620673     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021115-105339     Document Type: Review
Times cited : (641)

References (114)
  • 1
    • 84958617461 scopus 로고    scopus 로고
    • Appetite regulation and thermogenesis
    • ed. J Jamson, pp. 457-78. Philadelphia, PA: Elsevier/Saunders
    • Maratos-Flier E. 2016. Appetite regulation and thermogenesis. In Endocrinology: Adult and Pediatric, Vol. 1, ed. J Jamson, pp. 457-78. Philadelphia, PA: Elsevier/Saunders
    • (2016) Endocrinology: Adult and Pediatric , vol.1
    • Maratos-Flier, E.1
  • 3
    • 38149134409 scopus 로고    scopus 로고
    • Functional evolutionary history of the mouse Fgf gene family
    • Itoh N, Ornitz DM. 2008. Functional evolutionary history of the mouse Fgf gene family. Dev. Dyn. 237:18-27
    • (2008) Dev. Dyn , vol.237 , pp. 18-27
    • Itoh, N.1    Ornitz, D.M.2
  • 4
    • 84875922294 scopus 로고    scopus 로고
    • Genome-wide metaanalysis of observational studies shows common genetic variants associated with macronutrient intake
    • Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, et al. 2013. Genome-wide metaanalysis of observational studies shows common genetic variants associated with macronutrient intake. Am. J. Clin. Nutr. 97:1395-402
    • (2013) Am. J. Clin. Nutr , vol.97 , pp. 1395-1402
    • Tanaka, T.1    Ngwa, J.S.2    Van Rooij, F.J.3    Zillikens, M.C.4    Wojczynski, M.K.5
  • 6
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N. 2000. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta 1492:203-6
    • (2000) Biochim. Biophys. Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 9
    • 70350455732 scopus 로고    scopus 로고
    • Acute glucose-lowering and insulinsensitizing action of FGF21 in insulin resistant mouse models-association with liver and adipose tissue effects
    • Xu J, Stanislaus S,Chinookoswong N, Lau YY, HagerT, et al. 2009. Acute glucose-lowering and insulinsensitizing action of FGF21 in insulin resistant mouse models-association with liver and adipose tissue effects. Am. J. Physiol. Endocrinol. Metab. 297:E1105-14
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , pp. E1105-E1114
    • Xu, J.1    Stanislaus, S.2    Chinookoswong, N.3    Lau, Y.Y.4    Hager, T.5
  • 11
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. 2007. Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5:426-37
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 12
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, et al. 2007. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 5:415-25
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5
  • 15
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of βklotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, et al. 2007. Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282:26687-95
    • (2007) J. Biol. Chem , vol.282 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3    Dickson, A.S.4    Goetz, R.5
  • 16
    • 84862782796 scopus 로고    scopus 로고
    • Understanding the physical interactions in the FGF21/FGFR/ β-Klotho complex: Structural requirements and implications in FGF21 signaling
    • Yie J,WangW, Deng L, Tam LT, Stevens J, et al. 2012. Understanding the physical interactions in the FGF21/FGFR/ β-Klotho complex: structural requirements and implications in FGF21 signaling. Chem. Biol. Drug Des. 79:398-410
    • (2012) Chem. Biol. Drug des , vol.79 , pp. 398-410
    • Yie, J.1    Wang, W.2    Deng, L.3    Tam, L.T.4    Stevens, J.5
  • 18
    • 57849155278 scopus 로고    scopus 로고
    • FGF21 N-and C-termini play different roles in receptor interaction and activation
    • Yie J, Hecht R, Patel J, Stevens J,WangW, et al. 2009. FGF21 N-and C-termini play different roles in receptor interaction and activation. FEBS Lett. 583:19-24
    • (2009) FEBS Lett , vol.583 , pp. 19-24
    • Yie, J.1    Hecht, R.2    Patel, J.3    Stevens, J.4    Wang, W.5
  • 19
    • 84865741904 scopus 로고    scopus 로고
    • βklotho is required for fibroblast growth factor 21 effects on growth and metabolism
    • Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, et al. 2012. βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 16:387-93
    • (2012) Cell Metab , vol.16 , pp. 387-393
    • Ding, X.1    Boney-Montoya, J.2    Owen, B.M.3    Bookout, A.L.4    Coate, K.C.5
  • 21
    • 79960726293 scopus 로고    scopus 로고
    • Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    • Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, et al. 2011. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology 152:2996-3004
    • (2011) Endocrinology , vol.152 , pp. 2996-3004
    • Fisher, F.M.1    Estall, J.L.2    Adams, A.C.3    Antonellis, P.J.4    Bina, H.A.5
  • 22
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, et al. 2009. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58:250-59
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3    Stanislaus, S.4    Chen, M.5
  • 23
    • 70350093621 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
    • Johnson CL, Weston JY, Chadi SA, Fazio EN, Huff MW, et al. 2009. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Gastroenterology 137:1795-804
    • (2009) Gastroenterology , vol.137 , pp. 1795-1804
    • Johnson, C.L.1    Weston, J.Y.2    Chadi, S.A.3    Fazio, E.N.4    Huff, M.W.5
  • 24
    • 33750587755 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
    • WenteW, Efanov AM, BrennerM, Kharitonenkov A, Koster A, et al. 2006. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55:2470-78
    • (2006) Diabetes , vol.55 , pp. 2470-2478
    • Wente, W.1    Efanov, A.M.2    Brenner, M.3    Kharitonenkov, A.4    Koster, A.5
  • 25
    • 84883778996 scopus 로고    scopus 로고
    • FGF21 regulates metabolism and circadian behavior by acting on the nervous system
    • Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, et al. 2013. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat. Med. 19:1147-52
    • (2013) Nat. Med , vol.19 , pp. 1147-1152
    • Bookout, A.L.1    De Groot, M.H.2    Owen, B.M.3    Lee, S.4    Gautron, L.5
  • 26
    • 84911917770 scopus 로고    scopus 로고
    • FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting
    • Liang Q, Zhong L, Zhang J,Wang Y, Bornstein SR, et al. 2014. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 63:4064-75
    • (2014) Diabetes , vol.63 , pp. 4064-4075
    • Liang, Q.1    Zhong, L.2    Zhang, J.3    Wang, Y.4    Bornstein, S.R.5
  • 28
    • 79958092986 scopus 로고    scopus 로고
    • A Klotho β variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea
    • Wong BS, Camilleri M, Carlson PJ, Guicciardi ME, Burton D, et al. 2011. A Klotho β variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea. Gastroenterology 140:1934-42
    • (2011) Gastroenterology , vol.140 , pp. 1934-1942
    • Wong, B.S.1    Camilleri, M.2    Carlson, P.J.3    Guicciardi, M.E.4    Burton, D.5
  • 29
    • 41649109108 scopus 로고    scopus 로고
    • βklotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    • Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, et al. 2008. βKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22:1006-14
    • (2008) Mol. Endocrinol , vol.22 , pp. 1006-1014
    • Suzuki, M.1    Uehara, Y.2    Motomura-Matsuzaka, K.3    Oki, J.4    Koyama, Y.5
  • 30
    • 84862017269 scopus 로고    scopus 로고
    • Dynamics and distribution of Klotho β (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
    • Ming AY, Yoo E, Vorontsov EN, Altamentova SM, Kilkenny DM, Rocheleau JV. 2012. Dynamics and distribution of Klotho β (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex. J. Biol. Chem. 287:19997-20006
    • (2012) J. Biol. Chem , vol.287 , pp. 19997-20006
    • Ming, A.Y.1    Yoo, E.2    Vorontsov, E.N.3    Altamentova, S.M.4    Kilkenny, D.M.5    Rocheleau, J.V.6
  • 31
    • 84905679771 scopus 로고    scopus 로고
    • The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
    • Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, et al. 2012. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol. Metab. 2:31-37
    • (2012) Mol. Metab , vol.2 , pp. 31-37
    • Adams, A.C.1    Yang, C.2    Coskun, T.3    Cheng, C.C.4    Gimeno, R.E.5
  • 32
    • 34848866633 scopus 로고    scopus 로고
    • Liver-specific activities of FGF19 require Klotho β
    • Lin BC, Wang M, Blackmore C, Desnoyers LR. 2007. Liver-specific activities of FGF19 require Klotho β. J. Biol. Chem. 282:27277-84
    • (2007) J. Biol. Chem , vol.282 , pp. 27277-27284
    • Lin, B.C.1    Wang, M.2    Blackmore, C.3    Desnoyers, L.R.4
  • 33
    • 84858719733 scopus 로고    scopus 로고
    • Klotho-βoverexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
    • PohW,WongW,Ong H, Aung MO, Lim SG, et al. 2012. Klotho-βoverexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma. Mol. Cancer 11:14
    • (2012) Mol. Cancer , vol.11 , pp. 14
    • Poh, W.1    Wong, W.2    Ong, H.3    Aung, M.O.4    Lim, S.G.5
  • 34
    • 84939482520 scopus 로고    scopus 로고
    • First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway
    • HagelM,Miduturu C, SheetsM, RubinN,WengW, et al. 2015. First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway. Cancer Discov. 5:424-37
    • (2015) Cancer Discov , vol.5 , pp. 424-437
    • Hagel, M.1    Miduturu, C.2    Sheets, M.3    Rubin, N.4    Weng, W.5
  • 35
    • 83655165300 scopus 로고    scopus 로고
    • Amelioration of type 2 diabetes by antibodymediated activation of fibroblast growth factor receptor 1
    • Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, et al. 2011. Amelioration of type 2 diabetes by antibodymediated activation of fibroblast growth factor receptor 1. Sci. Transl. Med. 3:113ra26
    • (2011) Sci. Transl. Med , vol.3 , pp. 113ra26
    • Wu, A.L.1    Kolumam, G.2    Stawicki, S.3    Chen, Y.4    Li, J.5
  • 36
  • 37
    • 80053428117 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    • Ge X, Chen C, Hui X, Wang Y, Lam KS, Xu A. 2011. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J. Biol. Chem. 286:34533-41
    • (2011) J. Biol. Chem , vol.286 , pp. 34533-34541
    • Ge, X.1    Chen, C.2    Hui, X.3    Wang, Y.4    Lam, K.S.5    Xu, A.6
  • 38
  • 39
    • 47949111205 scopus 로고    scopus 로고
    • Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor γ and altered metabolic states
    • Muise ES, Azzolina B, Kuo DW, El-Sherbeini M, Tan Y, et al. 2008. Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor γ and altered metabolic states. Mol. Pharmacol. 74:403-12
    • (2008) Mol. Pharmacol , vol.74 , pp. 403-412
    • Muise, E.S.1    Azzolina, B.2    Kuo, D.W.3    El-Sherbeini, M.4    Tan, Y.5
  • 41
    • 84865422329 scopus 로고    scopus 로고
    • TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: Involvement of JNK1 in the FGF21 pathway
    • Diaz-Delfin J, Hondares E, Iglesias R, Giralt M, Caelles C, Villarroya F. 2012. TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology 153:4238-45
    • (2012) Endocrinology , vol.153 , pp. 4238-4245
    • Diaz-Delfin, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 42
    • 84891684837 scopus 로고    scopus 로고
    • High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: Involvement of peroxisome proliferator-activated receptor γsignaling
    • So WY, Cheng Q, Chen L, Evans-Molina C, Xu A, et al. 2013. High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γsignaling. Diabetes 62:3751-59
    • (2013) Diabetes , vol.62 , pp. 3751-3759
    • So, W.Y.1    Cheng, Q.2    Chen, L.3    Evans-Molina, C.4    Xu, A.5
  • 43
    • 84455199475 scopus 로고    scopus 로고
    • Lack of overt FGF21resistance in two mouse models of obesity and insulin resistance
    • Hale C, ChenMM,Stanislaus S,Chinookoswong N, HagerT, et al. 2012. Lack of overt FGF21resistance in two mouse models of obesity and insulin resistance. Endocrinology 153:69-80
    • (2012) Endocrinology , vol.153 , pp. 69-80
    • Hale, C.1    Chen, M.M.2    Stanislaus, S.3    Chinookoswong, N.4    Hager, T.5
  • 44
    • 82455212124 scopus 로고    scopus 로고
    • Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial
    • Samson SL, Sathyanarayana P, Jogi M, Gonzalez EV, Gutierrez A, et al. 2011. Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. Diabetologia 54:3093-100
    • (2011) Diabetologia , vol.54 , pp. 3093-3100
    • Samson, S.L.1    Sathyanarayana, P.2    Jogi, M.3    Gonzalez, E.V.4    Gutierrez, A.5
  • 45
    • 84883260199 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
    • Adams AC, Coskun T, Cheng CC, O'Farrell LS, Dubois SL, Kharitonenkov A. 2013. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. Mol. Metab. 2:205-14
    • (2013) Mol. Metab , vol.2 , pp. 205-214
    • Adams, A.C.1    Coskun, T.2    Cheng, C.C.3    O'Farrell, L.S.4    Dubois, S.L.5    Kharitonenkov, A.6
  • 46
    • 84920702690 scopus 로고    scopus 로고
    • Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptormachinery for endocrine FGFs in obese patients
    • Gallego-Escuredo JM, Gomez-Ambrosi J, Catalan V, Domingo P, Giralt M, et al. 2015. Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptormachinery for endocrine FGFs in obese patients. Int. J. Obes. 39:121-29
    • (2015) Int. J. Obes , vol.39 , pp. 121-129
    • Gallego-Escuredo, J.M.1    Gomez-Ambrosi, J.2    Catalan, V.3    Domingo, P.4    Giralt, M.5
  • 50
    • 84925253746 scopus 로고    scopus 로고
    • Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
    • Lees EK, Krol E, Grant L, Shearer K, Wyse C, et al. 2014. Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. Aging Cell 13:817-27
    • (2014) Aging Cell , vol.13 , pp. 817-827
    • Lees, E.K.1    Krol, E.2    Grant, L.3    Shearer, K.4    Wyse, C.5
  • 51
    • 84858311217 scopus 로고    scopus 로고
    • Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
    • De Sousa-Coelho AL, Marrero PF,HaroD. 2012. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem. J. 443:165-71
    • (2012) Biochem. J , vol.443 , pp. 165-171
    • De Sousa-Coelho, A.L.1    Marrero, P.F.2    Haro, D.3
  • 52
    • 84926291653 scopus 로고    scopus 로고
    • A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling
    • Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, et al. 2015. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nat. Commun. 6:6693
    • (2015) Nat. Commun , vol.6 , pp. 6693
    • Shimizu, N.1    Maruyama, T.2    Yoshikawa, N.3    Matsumiya, R.4    Ma, Y.5
  • 53
    • 84908291960 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation inmice on methionine and choline-deficient diets
    • e6
    • Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, et al. 2014. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation inmice on methionine and choline-deficient diets. Gastroenterology 147:1073-83.e6
    • (2014) Gastroenterology , vol.147 , pp. 1073-1083
    • Fisher, F.M.1    Chui, P.C.2    Nasser, I.A.3    Popov, Y.4    Cunniff, J.C.5
  • 54
    • 84925778793 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine-and choline-deficient diet
    • Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, et al. 2015. Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine-and choline-deficient diet. Biochim. Biophys. Acta 1852:1242-52
    • (2015) Biochim. Biophys. Acta , vol.1852 , pp. 1242-1252
    • Tanaka, N.1    Takahashi, S.2    Zhang, Y.3    Krausz, K.W.4    Smith, P.B.5
  • 55
    • 84911917697 scopus 로고    scopus 로고
    • Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
    • Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, et al. 2014. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes 63:4057-63
    • (2014) Diabetes , vol.63 , pp. 4057-4063
    • Markan, K.R.1    Naber, M.C.2    Ameka, M.K.3    Anderegg, M.D.4    Mangelsdorf, D.J.5
  • 56
    • 69249093921 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
    • Berglund ED, Li CY, BinaHA, Lynes SE, MichaelMD, et al. 2009. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology 150:4084-93
    • (2009) Endocrinology , vol.150 , pp. 4084-4093
    • Berglund, E.D.1    Li, C.Y.2    Bina, H.A.3    Lynes, S.E.4    Michael, M.D.5
  • 57
    • 84903477340 scopus 로고    scopus 로고
    • FGF21 inhibits apolipoprotein(a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway
    • Lin X, Li G, He X,Ma X, Zhang K, et al. 2014. FGF21 inhibits apolipoprotein(a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway. Mol. Cell. Biochem. 393:33-42
    • (2014) Mol. Cell. Biochem , vol.393 , pp. 33-42
    • Lin, X.1    Li, G.2    He, X.3    Ma, X.4    Zhang, K.5
  • 58
    • 84892721345 scopus 로고    scopus 로고
    • Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
    • Li Y, Wong K, Giles A, Jiang J, Lee JW, et al. 2014. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology 146:539-49.e7
    • (2014) Gastroenterology , vol.146 , pp. 539e7-549e7
    • Li, Y.1    Wong, K.2    Giles, A.3    Jiang, J.4    Lee, J.W.5
  • 59
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1αand regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, et al. 2009. FGF21 induces PGC-1αand regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. PNAS 106:10853-58
    • (2009) PNAS , vol.106 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3    Ding, X.4    He, T.5
  • 60
    • 79960947880 scopus 로고    scopus 로고
    • Paradoxical regulation of human FGF21 by both fasting and feeding signals: Is FGF21 a nutritional adaptation factor
    • Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, et al. 2011. Paradoxical regulation of human FGF21 by both fasting and feeding signals: Is FGF21 a nutritional adaptation factor? PLOS ONE 6:e22976
    • (2011) PLOS ONE , vol.6 , pp. e22976
    • Uebanso, T.1    Taketani, Y.2    Yamamoto, H.3    Amo, K.4    Ominami, H.5
  • 61
    • 69249238074 scopus 로고    scopus 로고
    • Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
    • Iizuka K, Takeda J, Horikawa Y. 2009. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett. 583:2882-86
    • (2009) FEBS Lett , vol.583 , pp. 2882-2886
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 62
    • 71949094496 scopus 로고    scopus 로고
    • Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: Striking effects on fibroblast growth factor-21 induction
    • Sanchez J, Palou A, Pico C. 2009. Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction. Endocrinology 150:5341-50
    • (2009) Endocrinology , vol.150 , pp. 5341-5350
    • Sanchez, J.1    Palou, A.2    Pico, C.3
  • 64
    • 70349472910 scopus 로고    scopus 로고
    • Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
    • Li X, Ge H, Weiszmann J, Hecht R, Li YS, et al. 2009. Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett. 583:3230-34
    • (2009) FEBS Lett , vol.583 , pp. 3230-3234
    • Li, X.1    Ge, H.2    Weiszmann, J.3    Hecht, R.4    Li, Y.S.5
  • 65
    • 43549110007 scopus 로고    scopus 로고
    • FGF21 attenuates lipolysis in human adipocytes-A possible link to improved insulin sensitivity
    • Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Ryden M. 2008. FGF21 attenuates lipolysis in human adipocytes-A possible link to improved insulin sensitivity. FEBS Lett. 582:1725-30
    • (2008) FEBS Lett , vol.582 , pp. 1725-1730
    • Arner, P.1    Pettersson, A.2    Mitchell, P.J.3    Dunbar, J.D.4    Kharitonenkov, A.5    Ryden, M.6
  • 66
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • Hotta Y, Nakamura H, KonishiM,Murata Y,TakagiH, et al. 2009. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 150:4625-33
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3    Murata, Y.4    Takagi, H.5
  • 67
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARαin response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. 2010. Hepatic FGF21 expression is induced at birth via PPARαin response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11:206-12
    • (2010) Cell Metab , vol.11 , pp. 206-212
    • Hondares, E.1    Rosell, M.2    Gonzalez, F.J.3    Giralt, M.4    Iglesias, R.5    Villarroya, F.6
  • 68
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, et al. 2011. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286:12983-90
    • (2011) J. Biol. Chem , vol.286 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3    Gonzalez, F.J.4    Giralt, M.5
  • 70
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    • Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, et al. 2012. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26:271-81
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5
  • 71
    • 84872070199 scopus 로고    scopus 로고
    • Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: Relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
    • Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, Celi FS. 2013. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J. Clin. Endocrinol. Metab. 98:E98-102
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. E98-102
    • Lee, P.1    Brychta, R.J.2    Linderman, J.3    Smith, S.4    Chen, K.Y.5    Celi, F.S.6
  • 72
    • 77955434383 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1αpathway
    • Chau MD, Gao J, Yang Q, Wu Z, Gromada J. 2010. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1αpathway. PNAS 107:12553-58
    • (2010) PNAS , vol.107 , pp. 12553-12558
    • Chau, M.D.1    Gao, J.2    Yang, Q.3    Wu, Z.4    Gromada, J.5
  • 73
  • 75
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue
    • Véniant MM, Sivits G, Helmering J, Komorowski, et al. 2015. Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue. Cell Metab. 21:731-38
    • (2015) Cell Metab , vol.21 , pp. 731-738
    • Véniant, M.M.1    Sivits, G.2    Helmering, J.3    Komorowski4
  • 76
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    • Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, et al. 2013. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat. Med. 19:83-92
    • (2013) Nat. Med , vol.19 , pp. 83-92
    • Kim, K.H.1    Jeong, Y.T.2    Oh, H.3    Kim, S.H.4    Cho, J.M.5
  • 77
    • 84890431558 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) and bone: Is there a relationship in humans
    • Lee P, Linderman J, Smith S, Brychta RJ, Perron R, et al. 2013. Fibroblast growth factor 21 (FGF21) and bone: Is there a relationship in humans? Osteoporos. Int. 24:3053-57
    • (2013) Osteoporos. Int , vol.24 , pp. 3053-3057
    • Lee, P.1    Linderman, J.2    Smith, S.3    Brychta, R.J.4    Perron, R.5
  • 78
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, et al. 2014. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 19:302-9
    • (2014) Cell Metab , vol.19 , pp. 302-309
    • Lee, P.1    Linderman, J.D.2    Smith, S.3    Brychta, R.J.4    Wang, J.5
  • 79
    • 84894058844 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
    • Hondares E, Gallego-Escuredo JM, Flachs P, Frontini A, Cereijo R, et al. 2014. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. Metabolism 63:312-17
    • (2014) Metabolism , vol.63 , pp. 312-317
    • Hondares, E.1    Gallego-Escuredo, J.M.2    Flachs, P.3    Frontini, A.4    Cereijo, R.5
  • 80
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγactivity and the antidiabetic actions of thiazolidinediones
    • Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, et al. 2012. Fibroblast growth factor-21 regulates PPARγactivity and the antidiabetic actions of thiazolidinediones. Cell 148:556-67
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5
  • 81
    • 84877272187 scopus 로고    scopus 로고
    • An FGF21-adiponectinceramide axis controls energy expenditure and insulin action in mice
    • Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, et al. 2013. An FGF21-adiponectinceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 17:790-97
    • (2013) Cell Metab , vol.17 , pp. 790-797
    • Holland, W.L.1    Adams, A.C.2    Brozinick, J.T.3    Bui, H.H.4    Miyauchi, Y.5
  • 82
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, et al. 2013. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17:779-89
    • (2013) Cell Metab , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3    Lin, S.4    Hoo, R.C.5
  • 83
    • 36148970418 scopus 로고    scopus 로고
    • The fasting polypeptide FGF21 can enter brain from blood
    • Hsuchou H, Pan W, Kastin AJ. 2007. The fasting polypeptide FGF21 can enter brain from blood. Peptides 28:2382-86
    • (2007) Peptides , vol.28 , pp. 2382-2386
    • Hsuchou, H.1    Pan, W.2    Kastin, A.J.3
  • 84
    • 80755168936 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: Relationship with plasma FGF21 and body adiposity
    • Tan BK, Hallschmid M, Adya R, Kern W, Lehnert H, Randeva HS. 2011. Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity. Diabetes 60:2758-62
    • (2011) Diabetes , vol.60 , pp. 2758-2762
    • Tan, B.K.1    Hallschmid, M.2    Adya, R.3    Kern, W.4    Lehnert, H.5    Randeva, H.S.6
  • 85
    • 77954277205 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
    • Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, et al. 2010. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 59:1817-24
    • (2010) Diabetes , vol.59 , pp. 1817-1824
    • Sarruf, D.A.1    Thaler, J.P.2    Morton, G.J.3    German, J.4    Fischer, J.D.5
  • 86
    • 84883763046 scopus 로고    scopus 로고
    • FGF21 contributes to neuroendocrine control of female reproduction
    • Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, et al. 2013. FGF21 contributes to neuroendocrine control of female reproduction. Nat. Med. 19:1153-56
    • (2013) Nat. Med , vol.19 , pp. 1153-1156
    • Owen, B.M.1    Bookout, A.L.2    Ding, X.3    Lin, V.Y.4    Atkin, S.D.5
  • 87
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • Lein ES,Hawrylycz MJ, AoN, Ayres M, Bensinger A, et al. 2007. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-76
    • (2007) Nature , vol.445 , pp. 168-176
    • Lein, E.S.1    Hawrylycz, M.J.2    Ao, N.3    Ayres, M.4    Bensinger, A.5
  • 88
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, et al. 2014. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 20:670-77
    • (2014) Cell Metab , vol.20 , pp. 670-677
    • Owen, B.M.1    Ding, X.2    Morgan, D.A.3    Coate, K.C.4    Bookout, A.L.5
  • 89
    • 84937604339 scopus 로고    scopus 로고
    • Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice
    • Douris N, Stevanovic D, Fisher FM, Cisu TI, Chee MJ, et al. 2015. Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice. Endocrinology 156:2470-81
    • (2015) Endocrinology , vol.156 , pp. 2470-2481
    • Douris, N.1    Stevanovic, D.2    Fisher, F.M.3    Cisu, T.I.4    Chee, M.J.5
  • 91
    • 77957028948 scopus 로고    scopus 로고
    • FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model
    • Uonaga T, Toyoda K, Okitsu T, Zhuang X, Yamane S, et al. 2010. FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model. Islets 2:247-51
    • (2010) Islets , vol.2 , pp. 247-251
    • Uonaga, T.1    Toyoda, K.2    Okitsu, T.3    Zhuang, X.4    Yamane, S.5
  • 93
    • 73249138414 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
    • Hojman P, Pedersen M, Nielsen AR, Krogh-Madsen R, Yfanti C, et al. 2009. Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes 58:2797-801
    • (2009) Diabetes , vol.58 , pp. 2797-2801
    • Hojman, P.1    Pedersen, M.2    Nielsen, A.R.3    Krogh-Madsen, R.4    Yfanti, C.5
  • 94
    • 84877149547 scopus 로고    scopus 로고
    • Acute exercise induces FGF21 expression in mice and in healthy humans
    • Kim KH, Kim SH,Min YK, YangHM, Lee JB, LeeMS. 2013. Acute exercise induces FGF21 expression in mice and in healthy humans. PLOS ONE 8:e63517
    • (2013) PLOS ONE , vol.8 , pp. e63517
    • Kim, K.H.1    Kim, S.H.2    Min, Y.K.3    Yang, H.M.4    Lee, J.B.5    Lee, M.S.6
  • 96
  • 97
    • 84933056402 scopus 로고    scopus 로고
    • FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
    • Yan X, Chen J, Zhang C, Zhou S, Zhang Z, et al. 2015. FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation. J. Cell. Mol. Med. 19:1557-68
    • (2015) J. Cell. Mol. Med , vol.19 , pp. 1557-1568
    • Yan, X.1    Chen, J.2    Zhang, C.3    Zhou, S.4    Zhang, Z.5
  • 98
    • 39449127028 scopus 로고    scopus 로고
    • Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes mellitus
    • Chen WW, Li L, Yang GY, Li K, Qi XY, et al. 2008. Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes mellitus. Exp. Clin. Endocrinol. Diabetes 116:65-68
    • (2008) Exp. Clin. Endocrinol. Diabetes , vol.116 , pp. 65-68
    • Chen, W.W.1    Li, L.2    Yang, G.Y.3    Li, K.4    Qi, X.Y.5
  • 99
    • 67650263853 scopus 로고    scopus 로고
    • Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    • Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, et al. 2009. Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes 58:1532-38
    • (2009) Diabetes , vol.58 , pp. 1532-1538
    • Mai, K.1    Andres, J.2    Biedasek, K.3    Weicht, J.4    Bobbert, T.5
  • 100
    • 69949107891 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man
    • Christodoulides C, Dyson P, Sprecher D, Tsintzas K, Karpe F. 2009. Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. J. Clin. Endocrinol. Metab. 94:3594-601
    • (2009) J. Clin. Endocrinol. Metab , vol.94 , pp. 3594-3601
    • Christodoulides, C.1    Dyson, P.2    Sprecher, D.3    Tsintzas, K.4    Karpe, F.5
  • 101
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA,TripathyD. 2009. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care 32:1542-46
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 102
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X, Yeung DC, KarpisekM, StejskalD, Zhou ZG, et al. 2008. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 57:1246-53
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5
  • 103
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, Fan J, Zhou J, et al. 2010. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J. Hepatol. 53:934-40
    • (2010) J. Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3    Fan, J.4    Zhou, J.5
  • 104
    • 77956519052 scopus 로고    scopus 로고
    • Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
    • Yilmaz Y, Eren F, Yonal O, Kurt R, Aktas B, et al. 2010. Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. Eur. J. Clin. Investig. 40:887-92
    • (2010) Eur. J. Clin. Investig , vol.40 , pp. 887-892
    • Yilmaz, Y.1    Eren, F.2    Yonal, O.3    Kurt, R.4    Aktas, B.5
  • 105
    • 84874767867 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
    • Kralisch S, Tonjes A, Krause K, Richter J, Lossner U, et al. 2013. Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans. J. Endocrinol. 216:135-43
    • (2013) J. Endocrinol , vol.216 , pp. 135-143
    • Kralisch, S.1    Tonjes, A.2    Krause, K.3    Richter, J.4    Lossner, U.5
  • 106
    • 84924082369 scopus 로고    scopus 로고
    • Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females
    • Hanks LJ, Casazza K, Ashraf AP, Wallace S, Gutierrez OM. 2015. Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. Clin. Endocrinol. 82:550-56
    • (2015) Clin. Endocrinol , vol.82 , pp. 550-556
    • Hanks, L.J.1    Casazza, K.2    Ashraf, A.P.3    Wallace, S.4    Gutierrez, O.M.5
  • 107
    • 84861996283 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: A longitudinal analysis
    • Reinehr T,Woelfle J,Wunsch R, Roth CL. 2012. Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis. J. Clin. Endocrinol. Metab. 97:2143-50
    • (2012) J. Clin. Endocrinol. Metab , vol.97 , pp. 2143-2150
    • Reinehr, T.1    Woelfle, J.2    Wunsch, R.3    Roth, C.L.4
  • 111
    • 84903984107 scopus 로고    scopus 로고
    • Serum FGF21 levels in adult m 3243A > G carriers: Clinical implications
    • Koene S, de Laat P, van Tienoven DH, Vriens D, Brandt AM, et al. 2014. Serum FGF21 levels in adult m.3243A > G carriers: clinical implications. Neurology 83:125-33
    • (2014) Neurology , vol.83 , pp. 125-133
    • Koene, S.1    De Laat, P.2    Van Tienoven, D.H.3    Vriens, D.4    Brandt, A.M.5
  • 112
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, et al. 2013. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 18:333-40
    • (2013) Cell Metab , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3    Glass, L.C.4    Deeg, M.A.5
  • 113
    • 84897109882 scopus 로고    scopus 로고
    • Inventing new medicines: The FGF21 story
    • Kharitonenkov A, Adams AC. 2014. Inventing new medicines: the FGF21 story. Mol. Metab. 3:221-29
    • (2014) Mol. Metab , vol.3 , pp. 221-229
    • Kharitonenkov, A.1    Adams, A.C.2
  • 114
    • 84901821975 scopus 로고    scopus 로고
    • FGF21-based pharmacotherapy-potential utility for metabolic disorders
    • Gimeno RE, Moller DE. 2014. FGF21-based pharmacotherapy-potential utility for metabolic disorders. Trends Endocrinol. Metab. 25:303-11
    • (2014) Trends Endocrinol. Metab , vol.25 , pp. 303-311
    • Gimeno, R.E.1    Moller, D.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.