FGF21 signalling pathway and metabolic traits- genetic association analysis

European Journal of Human Genetics

Volumn 18, Issue 12, 2010, Pages 1344-1348

  Kaess, Bernhard M ^a,b   Barnes, Timothy A ^a   Stark, Klaus ^b   Charchar, Fadi J ^c   Waterworth, Dawn ^d   Song, Kijoung ^d   Wang, William Y S ^a,e   Vollenweider, Peter ^f   Waeber, Gerard ^f   Mooser, Vincent ^d   Zukowska Szczechowska, Ewa ^g   Samani, Nilesh J ^a,h   Hengstenberg, Christian ^b   Tomaszewski, MacIej ^a,h  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c UNIVERSITY OF BALLARAT   (Australia)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^g MEDICAL UNIVERSITY OF SILESIA   (Poland)

^h GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

cholesterol; fibroblast growth factor 21; fibroblast growth factor receptor 2; genome wide association studies; single nucleotide polymorphism

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KLOTHO BETA PROTEIN; KLOTHO PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BODY MASS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BASE SEQUENCE; FEMALE; FIBROBLAST GROWTH FACTORS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTENSION; MALE; METABOLIC NETWORKS AND PATHWAYS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 78549284595     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.130     Document Type: Article

References (29)

1. Moore DD: Physiology. Sister act. Science 2007; 316: 1436-1438.
2. Kharitonenkov A, Shiyanova TL, Koester A et al: FGF-21 as a novel metabolic regulator. J Clin Invest 2005; 115: 1627-1635.
3. Inagaki T, Dutchak P, Zhao G et al: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007; 5: 415-425.
4. Kurosu H, Choi M, Ogawa Y et al: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 2007; 282: 26687-26695.
5. Ogawa Y, Kurosu H, Yamamoto M et al: BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA 2007; 104: 7432-7437.
6. Suzuki M, Uehara Y, Motomura-Matsuzaka K et al: bet}Klotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 2008; 22: 1006-1014.
7. Kharitonenkov A, Dunbar JD, Bina HA et al: FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J Cell Physiol 2008; 215: 1-7.
8. Tomaszewski M, Charchar FJ, Lynch MD et al: Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation 2007; 116: 1915-1924.
9. Firmann M, Mayor V, Vidal PM et al: The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 2008; 8: 6.
10. Tobin MD, Sheehan NA, Scurrah KJ, Burton PR: Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med 2005; 24: 2911-2935.
11. Broeckel U, Hengstenberg C, Mayer B et al: A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 2002; 30: 210-214.
12. Tomaszewski M, Charchar FJ, Samani NJ: Association studies in current cardiovascular genetics - functional variants, tags or both? J Hum Hypertens 2007; 21: 425-426.
13. Horvath S, Xu X, Laird NM: The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001; 9: 301-306.
14. Yan J: Yet another package for Generalized Estimating Equations. R-News 2002; 2/3: 12-14.
15. Cupples LA, Arruda HT, Benjamin EJ et al: The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet 2007; 8 (Suppl 1): S1.
16. Samani NJ, Erdmann J, Hall AS et al: Genomewide association analysis of coronary artery disease. N Engl J Med 2007; 357: 443-453. (Pubitemid 47204873)
17. Erdmann J, Grosshennig A, Braund PS et al: New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009; 41: 280-282.
18. Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100: 9440-9445.
19. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
20. Tomaszewski M, Brain NJ, Charchar FJ et al: Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension 2002; 40: 286-291.
21. Kharitonenkov A, Wroblewski VJ, Koester A et al: The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 2007; 148: 774-781.
22. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E: Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007; 5: 426-437.
23. Potthoff MJ, Inagaki T, Satapati S et al: FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA 2009; 106: 10853-10858.
24. Christodoulides C, Dyson P, Sprecher D, Tsintzas K, Karpe F: Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. J Clin Endocrinol Metab 2009; 94: 3594-3601.
25. Moyers JS, Shiyanova TL, Mehrbod F et al: Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling. J Cell Physiol 2007; 210: 1-6.
26. Hughes SE: Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. J Histochem Cytochem 1997; 45: 1005-1019.
27. Yie J, Hecht R, Patel J et al: FGF21 N- and C-termini play different roles in receptor interaction and activation. FEBS Lett 2009; 583: 19-24.
28. Katoh M: Cancer genomics and genetics of FGFR2 (Review). Int J Oncol 2008; 33: 233-237.
29. de Bakker PI, Ferreira MA, Jia X, Neale BM, Raychaudhuri S, Voight BF: Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet 2008; 17 (R2): R122-R128.