메뉴 건너뛰기




Volumn 156, Issue 7, 2015, Pages 2470-2481

Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; BETA ADRENERGIC RECEPTOR; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NORADRENALIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FIBROBLAST GROWTH FACTOR; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

EID: 84937604339     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-2001     Document Type: Article
Times cited : (177)

References (70)
  • 1
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415-425.
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3
  • 2
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5(6):426-437.
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 4
    • 84858311217 scopus 로고    scopus 로고
    • Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
    • De Sousa-Coelho AL, Marrero PF, Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J. 2012;443(1):165-171.
    • (2012) Biochem J , vol.443 , Issue.1 , pp. 165-171
    • De Sousa-Coelho, A.L.1    Marrero, P.F.2    Haro, D.3
  • 5
    • 34249697012 scopus 로고    scopus 로고
    • βKlotho is required for metabolic activity of fibroblast growth factor 21
    • Ogawa Y, Kurosu H, Yamamoto M, et al. βKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA. 2007;104(18):7432-7437.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.18 , pp. 7432-7437
    • Ogawa, Y.1    Kurosu, H.2    Yamamoto, M.3
  • 6
    • 39149091423 scopus 로고    scopus 로고
    • FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho
    • Kharitonenkov A, Dunbar JD, Bina HA, et al. FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho. J Cell Physiol. 2008;215(1):1-7.
    • (2008) J Cell Physiol , vol.215 , Issue.1 , pp. 1-7
    • Kharitonenkov, A.1    Dunbar, J.D.2    Bina, H.A.3
  • 7
    • 41649109108 scopus 로고    scopus 로고
    • βKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    • Suzuki M, Uehara Y, Motomura-Matsuzaka K, et al. βKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008;22(4):1006-1014.
    • (2008) Mol Endocrinol , vol.22 , Issue.4 , pp. 1006-1014
    • Suzuki, M.1    Uehara, Y.2    Motomura-Matsuzaka, K.3
  • 8
    • 84863338708 scopus 로고    scopus 로고
    • Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
    • Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One. 2012;7(3):e33870.
    • (2012) PLoS One , vol.7 , Issue.3
    • Yang, C.1    Jin, C.2    Li, X.3    Wang, F.4    McKeehan, W.L.5    Luo, Y.6
  • 10
    • 84865741904 scopus 로고    scopus 로고
    • βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
    • Ding X, Boney-Montoya J, Owen BM, et al. βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012;16(3):387-393.
    • (2012) Cell Metab , vol.16 , Issue.3 , pp. 387-393
    • Ding, X.1    Boney-Montoya, J.2    Owen, B.M.3
  • 12
    • 57349098220 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 corrects obesity in mice
    • Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149(12):6018-6027.
    • (2008) Endocrinology , vol.149 , Issue.12 , pp. 6018-6027
    • Coskun, T.1    Bina, H.A.2    Schneider, M.A.3
  • 13
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    • Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26(3):271-281.
    • (2012) Genes Dev , vol.26 , Issue.3 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3
  • 14
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem. 2011;286(15):12983-12990.
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3
  • 15
    • 84893849860 scopus 로고    scopus 로고
    • Interplay between FGF21 and insulin action in the liver regulates metabolism
    • Emanuelli B, Vienberg SG, Smyth G, et al. Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest. 2014;124(2):515-527.
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 515-527
    • Emanuelli, B.1    Vienberg, S.G.2    Smyth, G.3
  • 16
    • 84872070199 scopus 로고    scopus 로고
    • Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: Relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
    • Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, Celi FS. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab. 2012;98(1):102.
    • (2012) J Clin Endocrinol Metab , vol.98 , Issue.1 , pp. 102
    • Lee, P.1    Brychta, R.J.2    Linderman, J.3    Smith, S.4    Chen, K.Y.5    Celi, F.S.6
  • 18
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med. 2013;19(10):1252-1263.
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 19
    • 84875835392 scopus 로고    scopus 로고
    • Pharmacological and nutritional agents promoting browning of white adipose tissue
    • Bonet ML, Oliver P, Palou A. Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochim Biophys Acta. 2013;1831(5):969-985.
    • (2013) Biochim Biophys Acta , vol.1831 , Issue.5 , pp. 969-985
    • Bonet, M.L.1    Oliver, P.2    Palou, A.3
  • 20
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 2010;11(3):206-212.
    • (2010) Cell Metab , vol.11 , Issue.3 , pp. 206-212
    • Hondares, E.1    Rosell, M.2    Gonzalez, F.J.3    Giralt, M.4    Iglesias, R.5    Villarroya, F.6
  • 22
    • 0031843809 scopus 로고    scopus 로고
    • Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue
    • Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ. Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol. 1998;275(1 pt 2):R291-R299.
    • (1998) Am J Physiol , vol.275 , Issue.1 , pp. R291-R299
    • Bamshad, M.1    Aoki, V.T.2    Adkison, M.G.3    Warren, W.S.4    Bartness, T.J.5
  • 23
    • 36148970418 scopus 로고    scopus 로고
    • The fasting polypeptide FGF21 can enter brain from blood
    • Hsuchou H, Pan W, Kastin AJ. The fasting polypeptide FGF21 can enter brain from blood. Peptides. 2007;28(12):2382-2386.
    • (2007) Peptides , vol.28 , Issue.12 , pp. 2382-2386
    • Hsuchou, H.1    Pan, W.2    Kastin, A.J.3
  • 24
    • 80755168936 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: Relationship with plasma FGF21 and body adiposity
    • Tan BK, Hallschmid M, Adya R, Kern W, Lehnert H, Randeva HS. Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity. Diabetes. 2011;60(11):2758-2762.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2758-2762
    • Tan, B.K.1    Hallschmid, M.2    Adya, R.3    Kern, W.4    Lehnert, H.5    Randeva, H.S.6
  • 25
    • 84883778996 scopus 로고    scopus 로고
    • FGF21 regulates metabolism and circadian behavior by acting on the nervous system
    • Bookout AL, de Groot MH, Owen BM, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med. 2013;19(9):1147-1152.
    • (2013) Nat Med , vol.19 , Issue.9 , pp. 1147-1152
    • Bookout, A.L.1    De Groot, M.H.2    Owen, B.M.3
  • 26
    • 84883763046 scopus 로고    scopus 로고
    • FGF21 contributes to neuroendocrine control of female reproduction
    • Owen BM, Bookout AL, Ding X, et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat Med. 2013;19(9):1153-1156.
    • (2013) Nat Med , vol.19 , Issue.9 , pp. 1153-1156
    • Owen, B.M.1    Bookout, A.L.2    Ding, X.3
  • 27
    • 77957376253 scopus 로고    scopus 로고
    • Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    • Fon Tacer K, Bookout AL, Ding X, et al. Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol. 2010;24(10):2050-2064.
    • (2010) Mol Endocrinol , vol.24 , Issue.10 , pp. 2050-2064
    • Fon Tacer, K.1    Bookout, A.L.2    Ding, X.3
  • 28
    • 0027518628 scopus 로고
    • The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues
    • Yazaki N, Fujita H, Ohta M, Kawasaki T, Itoh N. The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues. Biochim Biophys Acta. 1993;1172(1-2):37-42.
    • (1993) Biochim Biophys Acta , vol.1172 , Issue.1-2 , pp. 37-42
    • Yazaki, N.1    Fujita, H.2    Ohta, M.3    Kawasaki, T.4    Itoh, N.5
  • 29
    • 77954277205 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
    • Sarruf DA, Thaler JP, Morton GJ, et al. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes. 2010;59(7):1817-1824.
    • (2010) Diabetes , vol.59 , Issue.7 , pp. 1817-1824
    • Sarruf, D.A.1    Thaler, J.P.2    Morton, G.J.3
  • 30
    • 0037008157 scopus 로고    scopus 로고
    • βAR signaling required for diet-induced thermogenesis and obesity resistance
    • Bachman ES, Dhillon H, Zhang CY, et al. βAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002;297(5582):843-845.
    • (2002) Science , vol.297 , Issue.5582 , pp. 843-845
    • Bachman, E.S.1    Dhillon, H.2    Zhang, C.Y.3
  • 31
    • 34447132204 scopus 로고    scopus 로고
    • Catecholaminergic control of mitogen-activated protein kinase signaling in paraventricular neuroendocrine neurons in vivo and in vitro: A proposed role during glycemic challenges
    • Khan AM, Ponzio TA, Sanchez-Watts G, Stanley BG, Hatton GI, Watts AG. Catecholaminergic control of mitogen-activated protein kinase signaling in paraventricular neuroendocrine neurons in vivo and in vitro: a proposed role during glycemic challenges. J Neurosci. 2007;27(27):7344-7360.
    • (2007) J Neurosci , vol.27 , Issue.27 , pp. 7344-7360
    • Khan, A.M.1    Ponzio, T.A.2    Sanchez-Watts, G.3    Stanley, B.G.4    Hatton, G.I.5    Watts, A.G.6
  • 32
    • 77749310482 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus
    • Chee MJ, Myers MG Jr, Price CJ, Colmers WF. Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. J Neurosci. 2010;30(9):3380-3390.
    • (2010) J Neurosci , vol.30 , Issue.9 , pp. 3380-3390
    • Chee, M.J.1    Myers, M.G.2    Price, C.J.3    Colmers, W.F.4
  • 34
    • 0002385575 scopus 로고
    • Blockade of endogenous norepinephrine synthesis by α-methyl-tyrosine, an inhibitor of tyrosine hyxroxylase
    • Spector S, Sjoerdsma A, Udenfriend S. Blockade of endogenous norepinephrine synthesis by α-methyl-tyrosine, an inhibitor of tyrosine hyxroxylase. J Pharmacol Exp Ther. 1965;147:86-95.
    • (1965) J Pharmacol Exp Ther , vol.147 , pp. 86-95
    • Spector, S.1    Sjoerdsma, A.2    Udenfriend, S.3
  • 36
    • 84893206164 scopus 로고    scopus 로고
    • Analysis and measurement of the sympathetic and sensory innervation of white and brown adipose tissue
    • Vaughan CH, Zarebidaki E, Ehlen JC, Bartness TJ. Analysis and measurement of the sympathetic and sensory innervation of white and brown adipose tissue. Methods Enzymol. 2014;537:199-225.
    • (2014) Methods Enzymol , vol.537 , pp. 199-225
    • Vaughan, C.H.1    Zarebidaki, E.2    Ehlen, J.C.3    Bartness, T.J.4
  • 37
    • 0028951399 scopus 로고
    • Catecholaminergic innervation of white adipose tissue in Siberian hamsters
    • Youngstrom TG, Bartness TJ. Catecholaminergic innervation of white adipose tissue in Siberian hamsters. Am J Physiol. 1995;268(3 pt 2):R744-R751.
    • (1995) Am J Physiol , vol.268 , Issue.3 , pp. R744-R751
    • Youngstrom, T.G.1    Bartness, T.J.2
  • 38
    • 0019510756 scopus 로고
    • Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: Measurement of catecholamines, serotonin and metabolites in rat brain
    • Mefford IN. Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain. J Neurosci Methods. 1981;3(3):207-224.
    • (1981) J Neurosci Methods , vol.3 , Issue.3 , pp. 207-224
    • Mefford, I.N.1
  • 39
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • Potthoff MJ, Inagaki T, Satapati S, et al. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA. 2009;106(26):10853-10858.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.26 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3
  • 40
    • 79960726293 scopus 로고    scopus 로고
    • Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    • Fisher FM, Estall JL, Adams AC, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011;152(8):2996-3004.
    • (2011) Endocrinology , vol.152 , Issue.8 , pp. 2996-3004
    • Fisher, F.M.1    Estall, J.L.2    Adams, A.C.3
  • 41
    • 84875844782 scopus 로고    scopus 로고
    • UCP1 mRNA does not produce heat
    • Nedergaard J, Cannon B. UCP1 mRNA does not produce heat. Biochim Biophys Acta. 2013;1831(5):943-949.
    • (2013) Biochim Biophys Acta , vol.1831 , Issue.5 , pp. 943-949
    • Nedergaard, J.1    Cannon, B.2
  • 43
    • 33846136443 scopus 로고    scopus 로고
    • Thermoregulation: Some concepts have changed. Functional architecture of the thermoregulatory system
    • Romanovsky AA. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R37-R46.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292 , Issue.1 , pp. R37-R46
    • Romanovsky, A.A.1
  • 44
    • 78449285575 scopus 로고    scopus 로고
    • Sympathetic and sensory innervation of brown adipose tissue
    • Bartness TJ, Vaughan CH, Song CK. Sympathetic and sensory innervation of brown adipose tissue. Int J Obes. 2010;34(suppl 1):S36-S42.
    • (2010) Int J Obes , vol.34 , pp. S36-S42
    • Bartness, T.J.1    Vaughan, C.H.2    Song, C.K.3
  • 46
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25(3):426-457.
    • (2004) Endocr Rev , vol.25 , Issue.3 , pp. 426-457
    • Van Der Lely, A.J.1    Tschöp, M.2    Heiman, M.L.3    Ghigo, E.4
  • 47
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131-2157.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 48
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414(6865):799-806.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 49
    • 84913586856 scopus 로고    scopus 로고
    • The browning of white adipose tissue: Some burning issues
    • Nedergaard J, Cannon B. The browning of white adipose tissue: some burning issues. Cell Metab. 2014;20(3):396-407.
    • (2014) Cell Metab , vol.20 , Issue.3 , pp. 396-407
    • Nedergaard, J.1    Cannon, B.2
  • 50
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest. 1995;96(6):2914-2923.
    • (1995) J Clin Invest , vol.96 , Issue.6 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerbäck, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 51
    • 0031959232 scopus 로고    scopus 로고
    • Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
    • Stefl B, Janovská A, Hodný Z, et al. Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice. Am J Physiol. 1998;274(3 pt 1):33.
    • (1998) Am J Physiol , vol.274 , Issue.3 , pp. 33
    • Stefl, B.1    Janovská, A.2    Hodný, Z.3
  • 52
    • 78650945931 scopus 로고    scopus 로고
    • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    • Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011;121(1):96-105.
    • (2011) J Clin Invest , vol.121 , Issue.1 , pp. 96-105
    • Seale, P.1    Conroe, H.M.2    Estall, J.3
  • 53
    • 84862000905 scopus 로고    scopus 로고
    • Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
    • Kiefer FW, Vernochet C, O'Brien P, et al. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med. 2012;18(6):918-925.
    • (2012) Nat Med , vol.18 , Issue.6 , pp. 918-925
    • Kiefer, F.W.1    Vernochet, C.2    O'Brien, P.3
  • 54
    • 51449123610 scopus 로고    scopus 로고
    • Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice
    • Toh SY, Gong J, Du G, et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One. 2008;3(8):e2890.
    • (2008) PLoS One , vol.3 , Issue.8
    • Toh, S.Y.1    Gong, J.2    Du, G.3
  • 55
    • 0034770191 scopus 로고    scopus 로고
    • Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
    • Tsukiyama-Kohara K, Poulin F, Kohara M, et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med. 2001;7(10):1128-1132.
    • (2001) Nat Med , vol.7 , Issue.10 , pp. 1128-1132
    • Tsukiyama-Kohara, K.1    Poulin, F.2    Kohara, M.3
  • 57
    • 2942532305 scopus 로고    scopus 로고
    • Nuclear receptor corepressor RIP140 regulates fat accumulation
    • Leonardsson G, Steel JH, Christian M, et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci USA. 2004;101(22):8437-8442.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.22 , pp. 8437-8442
    • Leonardsson, G.1    Steel, J.H.2    Christian, M.3
  • 58
    • 31044432605 scopus 로고    scopus 로고
    • Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
    • Powelka AM, Seth A, Virbasius JV, et al. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006;116(1):125-136.
    • (2006) J Clin Invest , vol.116 , Issue.1 , pp. 125-136
    • Powelka, A.M.1    Seth, A.2    Virbasius, J.V.3
  • 59
    • 79959933148 scopus 로고    scopus 로고
    • Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
    • Yadav H, Quijano C, Kamaraju AK, et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 2011;14(1):67-79.
    • (2011) Cell Metab , vol.14 , Issue.1 , pp. 67-79
    • Yadav, H.1    Quijano, C.2    Kamaraju, A.K.3
  • 60
    • 84862740201 scopus 로고    scopus 로고
    • Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation
    • Lu X, Ji Y, Zhang L, et al. Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. Endocrinology. 2012;153(7):3123-3132.
    • (2012) Endocrinology , vol.153 , Issue.7 , pp. 3123-3132
    • Lu, X.1    Ji, Y.2    Zhang, L.3
  • 61
    • 84887200977 scopus 로고    scopus 로고
    • Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis
    • Bi S. Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis. Physiol Behav. 2013;121:56-60.
    • (2013) Physiol Behav , vol.121 , pp. 56-60
    • Bi, S.1
  • 62
    • 79955635264 scopus 로고    scopus 로고
    • Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
    • Chao PT, Yang L, Aja S, Moran TH, Bi S. Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab. 2011;13(5):573-583.
    • (2011) Cell Metab , vol.13 , Issue.5 , pp. 573-583
    • Chao, P.T.1    Yang, L.2    Aja, S.3    Moran, T.H.4    Bi, S.5
  • 63
    • 34249666642 scopus 로고    scopus 로고
    • A high-fat, ketogenic diet induces a unique metabolic state in mice
    • Kennedy AR, Pissios P, Otu H, et al. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab. 2007;292(6):E1724-E1739.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.6 , pp. E1724-E1739
    • Kennedy, A.R.1    Pissios, P.2    Otu, H.3
  • 64
    • 70350322694 scopus 로고    scopus 로고
    • Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
    • Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009;150(11):4931-4940.
    • (2009) Endocrinology , vol.150 , Issue.11 , pp. 4931-4940
    • Badman, M.K.1    Koester, A.2    Flier, J.S.3    Kharitonenkov, A.4    Maratos-Flier, E.5
  • 65
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • Owen BM, Ding X, Morgan DA, et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 2014;20(4):670-677.
    • (2014) Cell Metab , vol.20 , Issue.4 , pp. 670-677
    • Owen, B.M.1    Ding, X.2    Morgan, D.A.3
  • 66
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • Dutchak PA, Katafuchi T, Bookout AL, et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell. 2012;148(3):556-567.
    • (2012) Cell , vol.148 , Issue.3 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3
  • 67
    • 84883260199 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
    • Adams AC, Coskun T, Cheng CC, O Farrell LS, Dubois SL, Kharitonenkov A. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. Mol Metab. 2013;2(3):205-214.
    • (2013) Mol Metab , vol.2 , Issue.3 , pp. 205-214
    • Adams, A.C.1    Coskun, T.2    Cheng, C.C.3    O Farrell, L.S.4    Dubois, S.L.5    Kharitonenkov, A.6
  • 68
    • 84865422329 scopus 로고    scopus 로고
    • TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: Involvement of JNK1 in the FGF21 pathway
    • Díaz-Delfín J, Hondares E, Iglesias R, Giralt M, Caelles C, Villarroya F. TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology. 2012;153(9):4238-4245.
    • (2012) Endocrinology , vol.153 , Issue.9 , pp. 4238-4245
    • Díaz-Delfín, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 69
    • 78049297991 scopus 로고    scopus 로고
    • Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    • Fisher FM, Chui PC, Antonellis PJ, et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010;59(11):2781-2789.
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2781-2789
    • Fisher, F.M.1    Chui, P.C.2    Antonellis, P.J.3
  • 70
    • 84880679205 scopus 로고    scopus 로고
    • Fat cells directly sense temperature to activate thermogenesis
    • Ye L, Wu J, Cohen P, et al. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci USA. 2013;110(30):12480-12485.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.30 , pp. 12480-12485
    • Ye, L.1    Wu, J.2    Cohen, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.