Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

Gastroenterology

Volumn 137, Issue 5, 2009, Pages 1795-1804

  Johnson, Charis L ^a,b   Weston, Jacqueline Y ^a,b   Chadi, Sami A ^a,b   Fazio, Elena N ^a,b   Huff, Murray W ^b   Kharitonenkov, Alexei ^c   Köester, Anja ^c   Pin, Christopher L ^a,b  

^a CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CERULETIDE; EARLY GROWTH RESPONSE FACTOR 1; FIBROBLAST GROWTH FACTOR 21; MITOGEN ACTIVATED PROTEIN KINASE 1; RECOMBINANT FIBROBLAST GROWTH FACTOR; THAPSIGARGIN; TRIACYLGLYCEROL;

ACINAR CELL; AMYLASE BLOOD LEVEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME PURIFICATION; GENE DELETION; GENE FUNCTION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PANCREAS ACINUS; PANCREATITIS; PRIORITY JOURNAL; STELLATE CELL; TISSUE INJURY; WILD TYPE;

ANIMALS; CAERULEIN; CELL CULTURE TECHNIQUES; EARLY GROWTH RESPONSE PROTEIN 1; FIBROBLAST GROWTH FACTORS; MICE; MICE, INBRED C57BL; PANCREAS, EXOCRINE; PANCREATITIS; RATS; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER;

EID: 70350093621     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.07.064     Document Type: Article

References (38)

1. Hofbauer B., Saluja A.K., Lerch M.M., et al. Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rats. Am J Physiol 275 (1998) G352-G362
2. Chang Y.T., Chang M.C., Su T.C., et al. Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. J Clin Gastroenterol 43 (2008) 591-596
3. Dawra R., Sharif R., Phillips P., et al. Development of a new mouse model of acute pancreatitis induced by administration of L-arginine. Am J Physiol Gastrointest Liver Physiol 292 (2007) G1009-G1018
4. Ji B., Chen X.Q., Misek D.E., et al. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Physiol Genomics 14 (2003) 59-72
5. Madro A., Celinski K., and Slomka M. The role of pancreatic stellate cells and cytokines in the development of chronic pancreatitis. Med Sci Monit 10 (2004) RA166-RA170
6. Kowalik A.S., Johnson C.L., Chadi S.A., et al. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 292 (2007) G1123-G1132
7. Fukumoto S. Actions and mode of actions of FGF19 subfamily members. Endocr J 55 (2008) 23-31
8. Kharitonenkov A., Shiyanova T.L., Koester A., et al. FGF-21 as a novel metabolic regulator. J Clin Invest 115 (2005) 1627-1635
9. Wang H., Qiang L., and Farmer S.R. Identification of a domain within peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol 28 (2008) 188-200
10. Moyers J.S., Shiyanova T.L., Mehrbod F., et al. Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARγ signaling. J Cell Physiol 210 (2007) 1-6
11. Muise E.S., Azzolina B., Kuo D.W., et al. Adipose fibroblast growth factor 21 is up-regulated by PPAR{γ} and altered metabolic states. Mol Pharmacol 74 (2008) 403-412
12. Badman M.K., Pissios P., Kennedy A.R., et al. Hepatic fibroblast growth factor 21 is regulated by PPARγ and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5 (2007) 426-437
13. Inagaki T., Dutchak P., Zhao G., et al. Endocrine regulation of the fasting response by PPARγ-mediated induction of fibroblast growth factor 21. Cell Metab 5 (2007) 415-425
14. Griesbacher T., Pommer V., Schuligoi R., et al. Anti-inflammatory actions of perfluorooctanoic acid and peroxisome proliferator-activated receptors (PPAR) α and γ in experimental acute pancreatitis. Int Immunopharmacol 8 (2008) 325-329
15. Folch-Puy E., Granell S., Iovanna J.L., et al. Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats. World J Gastroenterol 12 (2006) 6458-6463
16. Konturek P.C., Dembinski A., Warzecha Z., et al. Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-γ, protects pancreas against acute cerulein-induced pancreatitis. World J Gastroenterol 11 (2005) 6322-6329
17. Pin C.L., Rukstalis J.M., Johnson C., et al. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol 155 (2001) 519-530
18. Maratos-Flier E. Molecular insights from the study of ketogenic diets: the role of FGF21 in metabolism. Keystone Symposia on Molecular and Cellular Biology-Type 2 Diabetes and Insulin (2009) Banff, Alberta, Canada
19. Telford D.E., Sutherland B.G., Edwards J.Y., et al. The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin. J Lipid Res 48 (2007) 699-708
20. Yule D.I., and Williams J.A. U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem 267 (1992) 13830-13835
21. Wallace V.A., and Raff M.C. A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 126 (1999) 2901-2909
22. Fazio E.N., Everest M., Colman R., et al. Altered Glut-2 accumulation and β-cell function in mice lacking the exocrine-specific transcription factor, Mist1. J Endocrinol 187 (2005) 407-418
23. Niederau C., Luthen R., Klonowski-Stumpe H., et al. The role of calcium in pancreatitis. Hepatogastroenterology 46 (1999) 2723-2730
24. Rollins M.D., Sudarshan S., Firpo M.A., et al. Anti-inflammatory effects of PPAR-γ agonists directly correlate with PPAR-γ expression during acute pancreatitis. J Gastrointest Surg 10 (2006) 1120-1130
25. Kaiser A.M., Saluja A.K., Sengupta A., et al. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 269 (1995) C1295-C1304
26. Zenz R., Eferl R., Scheinecker C., et al. Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Res Ther 10 (2008) 201
27. Gong L.B., He L., Liu Y., et al. Expression of early growth response factor-1 in rats with cerulein-induced acute pancreatitis and its significance. World J Gastroenterol 11 (2005) 5022-5924
28. Chen S.J., Ning H., Ishida W., et al. The early-immediate gene EGR-1 is induced by transforming growth factor-β and mediates stimulation of collagen gene expression. J Biol Chem 281 (2006) 21183-21197
29. Cho S.J., Kang M.J., Homer R.J., et al. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J Biol Chem 281 (2006) 8161-8168
30. Friedrich B., Janessa A., Artunc F., et al. DOCA and TGF-β induce early growth response gene-1 (Egr-1) expression. Cell Physiol Biochem 22 (2008) 465-474
31. Ishiwata T., Naito Z., Lu Y.P., et al. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Exp Mol Pathol 73 (2002) 181-190
32. Menke A., Yamaguchi H., Giehl K., et al. Hepatocyte growth factor and fibroblast growth factor 2 are overexpressed after cerulein-induced acute pancreatitis. Pancreas 18 (1999) 28-33
33. Ebert M., Yokoyama M., Ishiwata T., et al. Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans. Pancreas 18 (1999) 240-246
34. Midgley V.C., and Khachigian L.M. Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1. J Biol Chem 279 (2004) 40289-40295
35. Luttenberger T., Schmid-Kotsas A., Menke A., et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 80 (2000) 47-55
36. Fu M., Zhang J., Lin Y., et al. Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-γ 1 gene expression in human aortic smooth muscle cells. J Biol Chem 277 (2002) 26808-26814
37. Zhang X., Cui Y., Fang L., et al. Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas 37 (2008) e31-e38
38. Yu J.H., Kim K.H., and Kim H. SOCS 3 and PPAR-γ ligands inhibit the expression of IL-6 and TGF-β1 by regulating JAK2/STAT3 signaling in pancreas. Int J Biochem Cell Biol 40 (2008) 677-688