Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21

Gastroenterology

Volumn 146, Issue 2, 2014, Pages

  Li, Yu ^a   Wong, Kimberly ^a   Giles, Amber ^a   Jiang, Jianwei ^a   Lee, Jong Woo ^a   Adams, Andrew C ^b   Kharitonenkov, Alexei ^b   Yang, Qin ^c   Gao, Bin ^d   Guarente, Leonard ^e   Zang, Mengwei ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Hepatocyte Derived Hormone; Liver Specific Disruption of Sirt1; Metabolic Homeostasis; Obesity

Indexed keywords

3 HYDROXYBUTYRATE DEHYDROGENASE; ACETYL COENZYME A ACETYLTRANSFERASE; ACYL COENZYME A DESATURASE 1; ADENOVIRUS VECTOR; ADIPONECTIN; CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; CYTOCHROME C OXIDASE; FIBROBLAST GROWTH FACTOR 21; HYDROXYMETHYLGLUTARYL COENZYME A LYASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RESVERATROL; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CALORIMETRY; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; EMBRYO; ENERGY BALANCE; ENERGY EXPENDITURE; ENERGY RESOURCE; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; KETOGENESIS; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LIVER; LIVER CELL; LIVER PROTECTION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WHITE ADIPOSE TISSUE;

AD; ADENOVIRUS; BAT; BROWN ADIPOSE TISSUE; CARBON DIOXIDE PRODUCTION; CARNITINE PALMITOYLTRANSFERASE 1Α; CPT1Α; FAS; FATTY ACID SYNTHASE; FGF21; FIBROBLAST GROWTH FACTOR 21; HEPATOCYTE-DERIVED HORMONE; LIVER-SPECIFIC DISRUPTION OF SIRT1; LIVER-SPECIFIC SIRT1 KNOCKOUT MICE; MCAD; MEDIUM-CHAIN ACYL-COA DEHYDROGENASE; MEF; MESSENGER RNA; METABOLIC HOMEOSTASIS; MOUSE EMBRYONIC FIBROBLAST; MRNA; NAD; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1; NICOTINAMIDE ADENINE DINUCLEOTIDE; OBESITY; OXYGEN CONSUMPTION; PEROXISOME PROLIFERATOR ACTIVATED RECEPTORΑ; PPARΑ; SIRT1; SIRT1 LKO MICE; SREBP-1; STEROL REGULATORY ELEMENT BINDING PROTEIN-1; VCO(2); VO(2); WAT; WHITE ADIPOSE TISSUE; WILD-TYPE; WT;

ANIMALS; BIOLOGICAL MARKERS; CALORIMETRY, INDIRECT; ENERGY METABOLISM; FASTING; FATTY LIVER; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION PROFILING; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; LIVER; MICE; MICE, KNOCKOUT; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; SIRTUIN 1; UP-REGULATION;

EID: 84892721345     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.059     Document Type: Article

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