-
1
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
-
Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology. 2011;140:124-131.
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, C.D.1
Stengel, J.2
Asike, M.I.3
-
2
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002; 346:1221-1231.
-
(2002)
N Engl J Med.
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
3
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
-
Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679-689.
-
(2010)
Hepatology
, vol.51
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
4
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009;58:250-259.
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
Lloyd, D.J.2
Hale, C.3
-
5
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesityinduced insulin resistance
-
Holland WL, Brozinick JT, Wang LP, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesityinduced insulin resistance. Cell Metab. 2007;5:167-179.
-
(2007)
Cell Metab.
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
-
6
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance
-
Jornayvaz FR, Shulman GI. Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metab. 2012;15:574-584.
-
(2012)
Cell Metab.
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.I.2
-
7
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000;106:171-176.
-
(2000)
J Clin Invest.
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
8
-
-
79960969204
-
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice
-
Birkenfeld AL, Lee HY, Guebre-Egziabher F, et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 2011;14:184-195.
-
(2011)
Cell Metab.
, vol.14
, pp. 184-195
-
-
Birkenfeld, A.L.1
Lee, H.Y.2
Guebre-Egziabher, F.3
-
9
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and β-cells function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cells function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
10
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
-
(1959)
Can J Biochem Physiol.
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
11
-
-
79954996869
-
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
-
Jornayvaz FR, Birkenfeld AL, Jurczak MJ, et al. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc Natl Acad Sci USA. 2011;108:5748-5752.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 5748-5752
-
-
Jornayvaz, F.R.1
Birkenfeld, A.L.2
Jurczak, M.J.3
-
12
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002;277:50230-50236.
-
(2002)
J Biol Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
13
-
-
77956534963
-
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
-
Ayala JE, Samuel VT, Morton GJ, et al. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech. 2010;3:525-534.
-
(2010)
Dis Model Mech.
, vol.3
, pp. 525-534
-
-
Ayala, J.E.1
Samuel, V.T.2
Morton, G.J.3
-
14
-
-
0027316021
-
Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats
-
Youn JH, Buchanan TA. Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 1993;42:757-763.
-
(1993)
Diabetes
, vol.42
, pp. 757-763
-
-
Youn, J.H.1
Buchanan, T.A.2
-
15
-
-
80055057797
-
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
-
Lee HY, Birkenfeld AL, Jornayvaz FR, et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology. 2011;54:1650-1660.
-
(2011)
Hepatology
, vol.54
, pp. 1650-1660
-
-
Lee, H.Y.1
Birkenfeld, A.L.2
Jornayvaz, F.R.3
-
16
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
Choi CS, Savage DB, Kulkarni A, et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J Biol Chem. 2007;282:22678-22688.
-
(2007)
J Biol Chem.
, vol.282
, pp. 22678-22688
-
-
Choi, C.S.1
Savage, D.B.2
Kulkarni, A.3
-
17
-
-
78349242167
-
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
-
Jornayvaz FR, Jurczak MJ, Lee HY, et al. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am J Physiol Endocrinol Metab. 2010;299:E808-E815.
-
(2010)
Am J Physiol Endocrinol Metab.
, vol.299
-
-
Jornayvaz, F.R.1
Jurczak, M.J.2
Lee, H.Y.3
-
18
-
-
84874607649
-
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
-
Camporez JP, Jornayvaz FR, Lee HY, et al. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology. 2013;154:1021-1028.
-
(2013)
Endocrinology
, vol.154
, pp. 1021-1028
-
-
Camporez, J.P.1
Jornayvaz, F.R.2
Lee, H.Y.3
-
19
-
-
82355161907
-
High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
-
Pesta D, Gnaiger E. High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol. 2012;810:25-58.
-
(2012)
Methods Mol Biol.
, vol.810
, pp. 25-58
-
-
Pesta, D.1
Gnaiger, E.2
-
20
-
-
84856442945
-
A guide to analysis of mouse energy metabolism
-
Tschöp MH, Speakman JR, Arch JR, et al. A guide to analysis of mouse energy metabolism. Nat Methods. 2012;9:57-63.
-
(2012)
Nat Methods
, vol.9
, pp. 57-63
-
-
Tschöp, M.H.1
Speakman, J.R.2
Arch, J.R.3
-
21
-
-
84863011453
-
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
-
Mu J, Pinkstaff J, Li Z, et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes. 2012;61:505-512.
-
(2012)
Diabetes
, vol.61
, pp. 505-512
-
-
Mu, J.1
Pinkstaff, J.2
Li, Z.3
-
22
-
-
84873178604
-
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER- preventing diacylg- lycerol-mediated hepatic insulin resistance
-
Cantley JL, Yoshimura T, Camporez JP, et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylg- lycerol-mediated hepatic insulin resistance. Proc Natl Acad SciUSA. 2013;110:1869-1874.
-
(2013)
Proc Natl Acad SciUSA
, vol.110
, pp. 1869-1874
-
-
Cantley, J.L.1
Yoshimura, T.2
Camporez, J.P.3
-
23
-
-
78649497300
-
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance
-
Lee HY, Choi CS, Birkenfeld AL, et al. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab. 2010;12: 668-674.
-
(2010)
Cell Metab.
, vol.12
, pp. 668-674
-
-
Lee, H.Y.1
Choi, C.S.2
Birkenfeld, A.L.3
-
24
-
-
58149401189
-
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
-
Choi CS, Befroy DE, Codella R, et al. Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci USA. 2008;105:19926-19931.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19926-19931
-
-
Choi, C.S.1
Befroy, D.E.2
Codella, R.3
-
25
-
-
84862907611
-
Thyroid hormone receptor- α gene knockout mice are protected from diet-induced hepatic insulin resistance
-
Jornayvaz FR, Lee HY, Jurczak MJ, et al. Thyroid hormone receptor- α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology. 2012;153:583-591.
-
(2012)
Endocrinology
, vol.153
, pp. 583-591
-
-
Jornayvaz, F.R.1
Lee, H.Y.2
Jurczak, M.J.3
-
26
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149:6018-6027.
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
Bina, H.A.2
Schneider, M.A.3
-
28
-
-
33846418834
-
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor- 21
-
Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor- 21. Endocrinology. 2007;148:774-781.
-
(2007)
Endocrinology
, vol.148
, pp. 774-781
-
-
Kharitonenkov, A.1
Wroblewski, V.J.2
Koester, A.3
-
29
-
-
69249093921
-
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
-
Berglund ED, Li CY, Bina HA, et al. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology. 2009;150:4084-4093.
-
(2009)
Endocrinology
, vol.150
, pp. 4084-4093
-
-
Berglund, E.D.1
Li, C.Y.2
Bina, H.A.3
-
30
-
-
84865741904
-
Klotho is required for fibroblast growth factor 21 effects on growth and metabolism
-
Ding X, Boney-Montoya J, Owen BM, et al. Klotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012;16:387-393.
-
(2012)
Cell Metab.
, vol.16
, pp. 387-393
-
-
Ding, X.1
Boney-Montoya, J.2
Owen, B.M.3
-
32
-
-
68149091653
-
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
-
Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care. 2009;32:1542-1546.
-
(2009)
Diabetes Care
, vol.32
, pp. 1542-1546
-
-
Chavez, A.O.1
Molina-Carrion, M.2
Abdul-Ghani, M.A.3
Folli, F.4
Defronzo, R.A.5
Tripathy, D.6
-
33
-
-
77957359658
-
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
-
Li H, Fang Q, Gao F, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol. 2010;53:934-940.
-
(2010)
J Hepatol.
, vol.53
, pp. 934-940
-
-
Li, H.1
Fang, Q.2
Gao, F.3
-
34
-
-
77957361851
-
Fibroblast growth factor 21 as a biomarker for NAFLD: Integrating pathobiology into clinical practice
-
Morris-Stiff G, Feldstein AE. Fibroblast growth factor 21 as a biomarker for NAFLD: integrating pathobiology into clinical practice. J Hepatol. 2010;53:795-796.
-
(2010)
J Hepatol.
, vol.53
, pp. 795-796
-
-
Morris-Stiff, G.1
Feldstein, A.E.2
-
35
-
-
84877272187
-
An FGF21-adiponectin- ceramide axis controls energy expenditure and insulin action in mice
-
Holland WL, Adams AC, Brozinick JT, et al. An FGF21-adiponectin- ceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 2013;17:790-797.
-
(2013)
Cell Metab.
, vol.17
, pp. 790-797
-
-
Holland, W.L.1
Adams, A.C.2
Brozinick, J.T.3
-
36
-
-
84877260638
-
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
-
Lin Z, Tian H, Lam KS, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 2013;17:779-789.
-
(2013)
Cell Metab.
, vol.17
, pp. 779-789
-
-
Lin, Z.1
Tian, H.2
Lam, K.S.3
-
37
-
-
78651260799
-
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
-
Holland WL, Miller RA, Wang ZV, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med. 2011;17:55-63.
-
(2011)
Nat Med.
, vol.17
, pp. 55-63
-
-
Holland, W.L.1
Miller, R.A.2
Wang, Z.V.3
-
38
-
-
84874406268
-
Adiponectin corrects high-fat dietinduced disturbances in muscle metabolomic profile and wholebody glucose homeostasis
-
Liu Y, Turdi S, Park T, et al. Adiponectin corrects high-fat dietinduced disturbances in muscle metabolomic profile and wholebody glucose homeostasis. Diabetes. 2013;62:743-752.
-
(2013)
Diabetes
, vol.62
, pp. 743-752
-
-
Liu, Y.1
Turdi, S.2
Park, T.3
-
39
-
-
45649085226
-
Inhibition of growth hormone signaling by the fastinginduced hormone FGF21
-
Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA. Inhibition of growth hormone signaling by the fastinginduced hormone FGF21. Cell Metab. 2008;8:77-83.
-
(2008)
Cell Metab.
, vol.8
, pp. 77-83
-
-
Inagaki, T.1
Lin, V.Y.2
Goetz, R.3
Mohammadi, M.4
Mangelsdorf, D.J.5
Kliewer, S.A.6
-
40
-
-
67749142348
-
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes
-
Samuel VT, Beddow SA, Iwasaki T, et al. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes. Proc Natl Acad Sci USA. 2009;106: 12121-12126.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12121-12126
-
-
Samuel, V.T.1
Beddow, S.A.2
Iwasaki, T.3
-
41
-
-
77249099832
-
Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
-
Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 2010;11:206-212.
-
(2010)
Cell Metab.
, vol.11
, pp. 206-212
-
-
Hondares, E.1
Rosell, M.2
Gonzalez, F.J.3
Giralt, M.4
Iglesias, R.5
Villarroya, F.6
-
42
-
-
77955434383
-
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPKSIRT1- PGC-1α pathway
-
Chau MD, Gao J, Yang Q, Wu Z, Gromada J. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPKSIRT1- PGC-1α pathway. Proc Natl Acad Sci USA. 2010;107: 12553-12558.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12553-12558
-
-
Chau, M.D.1
Gao, J.2
Yang, Q.3
Wu, Z.4
Gromada, J.5
-
43
-
-
77954277205
-
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
-
Sarruf DA, Thaler JP, Morton GJ, et al. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes. 2010;59:1817-1824.
-
(2010)
Diabetes
, vol.59
, pp. 1817-1824
-
-
Sarruf, D.A.1
Thaler, J.P.2
Morton, G.J.3
|