Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review

Pharmacological Research

Volumn 105, Issue , 2016, Pages 108-120

  Esteban Zubero, Eduardo ^a   Alatorre Jiménez, Moisés Alejandro ^b   López Pingarrón, Laura ^a   Reyes Gonzales, Marcos César ^a   Almeida Souza, Priscilla ^a   Cantín Golet, Amparo ^a   Ruiz Ruiz, Francisco José ^a   Tan, Dun Xian ^b   García, José Joaquín ^a   Reiter, Russel J ^b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Chemotherapeutic; Lipid peroxidation; Liver toxicity; Melatonin; Oxidative stress; Sepsis

Indexed keywords

AFLATOXIN B1; ALPHA TOCOPHEROL; AMITRIPTYLINE; ANTINEOPLASTIC AGENT; BERGAPTEN; CADMIUM; CARBON TETRACHLORIDE; CARNITINE; CISPLATIN; COPPER; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIAZEPAM; DIMETHYL SULFOXIDE; DOXORUBICIN; ENDOTOXIN; ETHINYLESTRADIOL; FLUVOXAMINE; GRISEOFULVIN; IRON; LETROZOLE; MELATONIN; MERCURY; N ACETYLSEROTONIN; NICOTINE; PARACETAMOL; PENTOXIFYLLINE; TAMOXIFEN; THIOACETAMIDE; UNINDEXED DRUG; AFLATOXIN; ANTIOXIDANT; HEAVY METAL; PROTECTIVE AGENT;

AFLATOXICOSIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANTIBODY RESPONSE; ANTIOXIDANT ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CAUSE OF DEATH; DNA DAMAGE; ENZYME ACTIVATION; GENOTOXICITY; HEMAGGLUTINATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MULTIPLE ORGAN FAILURE; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; OSTEOPOROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SEPSIS; TERATOGENICITY; ANIMAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; COMPLICATION; DRUG EFFECTS; LIVER; LIVER DISEASES; METABOLISM; PATHOLOGY;

AFLATOXINS; ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; CHEMICAL AND DRUG INDUCED LIVER INJURY; HUMANS; LIVER; LIVER DISEASES; MELATONIN; METALS, HEAVY; NICOTINE; PROTECTIVE AGENTS; SEPSIS;

EID: 84956717504     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.01.018     Document Type: Review

References (206)

1. D.X. Tan, L.C. Manchester, R.J. Reiter, W.B. Qi, M. Zhang, S.T. Weintraub, J. Cabrera, R.M. Sainz, and J.C. Mayo Identification of highly elevated levels of melatonin in bone marrow: its origin and significance Biochim. Biophys. Acta. 1472 1999 206 214
2. D. Acuña-Castroviejo, G. Escames, C. Venegas, M.E. Díaz-Casado, E. Lima-Cabello, L.C. López, S. Rosales-Corral, D.X. Tan, and R.J. Reiter Extrapineal melatonin: sources, regulation, and potential functions Cell. Mol. Life. Sci. 71 2014 2997 3025
3. H.M. Zhang, and Y. Zhang Melatonin: a well-documented antioxidant with conditional pro-oxidant actions J. Pineal Res. 57 2014 131 146
4. L.C. Manchester, A. Coto-Montes, J.A. Boga, L.P. Andersen, Z. Zhou, A. Galano, J. Vriend, D.X. Tan, and R.J. Reiter Melatonin: an ancient molecule that makes oxygen metabolically tolerable J. Pineal Res. 14 295 2015 403 419 59
5. R.J. Reiter Pineal melatonin: cell biology of its synthesis and of its physiological interactions Endocr. Rev. 12 1991 151 180
6. I. Bejarano, F. Monllor, A.M. Marchena, A. Ortiz, G. Lozano, M.I. Jiménez, P. Gaspar, J.F. García, J.A. Pariente, A.B. Rodríguez, and J. Espino Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa J. Pineal Res. 57 2014 333 339
7. D.X. Tan, L.C. Manchester, M.P. Terron, L.J. Flores, and R.J. Reiter One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 42 2007 28 42
8. E.A. Herrera, R. Macchiavello, C. Montt, G. Ebensperger, M. Díaz, S. Ramírez, J.T. Parer, M. Serón-Ferré, R.V. Reyes, and A.J. Llanos Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs J. Pineal Res. 57 2014 33 42
9. C. Rodriguez, J.C. Mayo, R.M. Sainz, I. Antolín, F. Herrera, V. Martín, and R.J. Reiter Regulation of antioxidant enzymes: a significant role for melatonin J. Pineal Res. 36 2004 1 9
10. A. Galano, M.E. Medina, D.X. Tan, and R.J. Reiter Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis J. Pineal Res. 58 2015 107 116
11. T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239 247
12. R.P. Patel, J. McAndrew, H. Sellak, C.R. White, H. Jo, B.A. Freeman, and V.M. Darley-Usmar Biological aspects of reactive nitrogen species Biochim. Biophys. Acta. 1411 1999 385 400
13. A. Korkmaz, R.J. Reiter, T. Topal, L.C. Manchester, S. Oter, and D.X. Tan Melatonin: an established antioxidant worthy of use in clinical trials Mol. Med. 15 2009 43 50
14. J.J. García, L. López-Pingarrón, P. Almeida-Souza, A. Tres, P. Escudero, F.A. García-Gil, D.X. Tan, R.J. Reiter, J.M. Ramírez, and M. Bernal-Pérez Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review J. Pineal Res. 56 2014 225 237
15. R.J. Reiter, D.X. Tan, C. Osuna, and E. Gitto Actions of melatonin in the reduction of oxidative stress: a review J. Biomed. Sci. 7 2000 444 458
16. D. Pozo, R.J. Reiter, J.R. Calvo, and J.M. Guerrero Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum Life Sci. 55 1994 PL455 PL460
17. I. Bettahi, D. Pozo, C. Osuna, R.J. Reiter, D. Acuña-Castroviejo, and J.M. Guerrero Melatonin reduces nitric oxide synthase activity in rat hypothalamus J. Pineal Res. 20 1996 205 210
18. S. Rodriguez-Reynoso, C. Leal, E. Portilla, N. Olivares, and J. Muniz Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: possible role of tumor necrosis factor- α and nitric oxide J. Surg. Res. 100 2001 141 149
19. M. Martín, M. Macías, G. Escames, R.J. Reiter, M.T. Agapito, G.G. Ortiz, and D. Acuña-Castroviejo Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo J. Pineal Res. 28 2000 242 248
20. G. Paradies, G. Petrosillo, V. Paradies, R.J. Reiter, and F.M. Ruggiero Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease J. Pineal Res. 48 2010 297 310
21. N. Mohan, K. Sadeghi, R.J. Reiter, and M.L. Meltz The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B Biochem. Mol. Biol. Int. 37 1995 1063 1070
22. J.I. Chuang, N. Mohan, M.L. Meltz, and R.J. Reiter Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen Cell. Biol. Int. 20 1996 687 692
23. R. Bruck, H. Aeed, Y. Avni, H. Shirin, Z. Matas, M. Shahmurov, I. Avinoach, G. Zozulya, N. Weizman, and A. Hochman Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats J. Hepatol. 40 2004 86 93
24. E. Talero, S. Garcia-Maurino, and V. Motilva Melatonin, autophagy and intestinal bowel disease Curr. Pharm. Des. 20 2014 4816 4827
25. H.S. Hussein, and J.M. Brasel Toxicity, metabolism and impact of mycotoxins on humans and animals Toxicology 167 2001 101 134
26. C.P. Wild, and P.C. Turner The toxicology of aflatoxins as a basis for public health decisions Mutagenesis 17 2002 471 481
27. H.S. Ramsdell, A. Parkinson, A.C. Eddy, and D.L. Eaton Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P-450 IIIA enzymes Toxicol. Appl. Pharmacol. 108 1991 436 447
28. H.A. Awney, A.A. Amara, M.H. El-masry, and H.H. Baghdadi Effect of 12 plant extracts on the hepatic microsomal B(a) p hydroxylation and H2O2 production in mice treated with lindane J. Environ. Nutr. Interact. 1 1997 129 142
29. Y.H. Shi, Z.R. Xu, J.L. Feng, and C.Z. Wang Efficacy of modified montmorillonite nanocomposite to reduce the toxicity of aflatoxin in broiler chicks Anim. Feed Sci. Technol. 129 2006 138 148
30. J.P. Kolb Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia Leukemia 14 2000 1685 1694
31. D.W. Nicholson Caspase structure, proteolytic substrates and function during apoptotic cell death Cell. Death Differ. 6 1999 1028 1042
32. M. Akerfelt, R.I. Morimoto, and L. Sistonen Heat shock factors: integrators of cell stress, development and lifespan Nat. Rev. Mol. Cell. Biol. 11 2010 545 555
33. T.E. Massey, R.K. Stewart, J.M. Daniels, and L. Liu Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B1 carcinogenicity Proc. Soc. Exp. Biol. Med. 208 1995 213 227
34. H.M. Shen, C.N. Ong, and C.Y. Shi Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes Toxicology 99 1995 115 123
35. H.A. Awney, A.M. Attih, S.L. Habib, and M.H. Mostafa Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1) Toxicology 172 2002 143 148
36. G.M. Kirby, C.R. Wolf, G.E. Neal, D.J. Judah, C.J. Henderson, P. Srivatanakul, and P. Wild In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand Carcinogenesis 14 1993 2613 2620
37. A.R.M.A. Meki, E.E.D.F. Esmail, A.A. Hussein, and H.M. Hassanein Caspase-3 and heat shock protein-70 in rat liver treated with aflatoxin B1: effect of melatonin Toxicon 43 2004 93 100
38. O. Goldbaum, and L.C. Richter Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress J. Neurochem. 78 2001 1233 1242
39. S. Xanthoudakis, and D.W. Nicholson Heat-shock proteins as death determinants Nat. Cell Biol. 2 2000 163 165
40. L.P. Weber, and D.M. Janz Effect of beta-naphtholflavone and dimethylbenz (a) anthracene on apoptosis and hsp70 expression in juvenile channel catfish Ictalurus punctatus ovary Aquat. Toxicol. 54 2001 39 50
41. A.R.M.A. Meki, S. Abdel-Ghaffar, and I. El-Gabaly Aflatoxin B1 induces apoptosis in rat liver: protective effect of melatonin Neuroendocrinol. Lett. 22 2001 417 426
42. H. Ozen, M. Karaman, Y. Ciʇremiş, M. Tuzcu, K. Ozcan, and D. Erdaʇ Effectiveness of melatonin on aflatoxicosis in chicks Res. Vet. Sci. 86 2009 485 489
43. M. Sirajudeen, K. Gopi, J.S. Tyagi, R.P. Moudgal, J. Mohan, and R. Singh Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxinB1-contaminateddiets in young chicks Environ. Toxicol. 26 2011 153 160
44. I. El-Gibaly, A.M. Meki, and S.K. Abdel-Ghaffar Novel B melatonin-loaded chitosan microcapsules: in vitro characterization and antiapoptosis efficacy for aflatoxinB1-inducedapoptosis in rat liver Int. J. Pharm. 260 2003 5 22
45. Y. Murata, N. Sasaki, E. Miyamoto, and S. Kawashima Use of floating alginate gel beads for stomach-specific drug delivery Eur. J. Pharm. Biopharm. 50 2000 221 226
46. A. Gesing, and M. Karbownik-Lewinska Protective effects of melatonin and N-acetylserotonin on aflatoxin B1-induced lipid peroxidation in rats Cell. Biochem. Funct. 26 2008 314 319
47. J.R. Calvo, R.J. Reiter, J.J. Garcia, G.G. Ortiz, D.X. Tan, and M. Karbownik Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats J. Cell. Biochem. 80 2001 461 470
48. S.S. Leonard, G.K. Harris, and X. Shi Metal-induced oxidative stress and signal transduction Free Radic. Biol. Med. 37 2004 1921 1942
49. W. Bal, and K.S. Kasprzak Induction of oxidative DNA damage by carcinogenic metals Toxicol. Lett. 127 2002 55 62
50. F. Chen, and X. Shi Intracellular signal transduction of cells in response to carcinogenic metals Crit. Rev. Oncol. Hematol. 42 2002 105 121
51. R.J. Reiter, L.C. Manchester, and D.X. Tan Neurotoxins: free radical mechanisms and melatonin protection Curr. Neuropharmacol. 8 2010 194 210
52. R.J. Reiter, D.X. Tan, and A. Galano Melatonin: exceeding expectations Physiology (Bethesda) 29 2014 325 333
53. A. Romero, E. Ramos, C. de Los Ríos, J. Egea, J. Del Pino, and R.J. Reiter A review of metal-catalyzed molecular damage: protection by melatonin J. Pineal Res. 56 2014 343 370
54. T.S. Nawrot, J.A. Staessen, H.A. Roels, E. Munters, A. Cuypers, T. Richart, A. Ruttens, K. Smeets, H. Clijsters, and J. Vangronsveld Cadmium exposure in the population: from health risks to strategies of prevention Biometals 23 2010 769 782
55. M.J. Berridge, M.D. Bootman, and H.L. Roderick Calcium signalling: dynamics, homeostasis and remodeling Nat. Rev. Mol. Cell. Biol. 4 2003 517 529
56. A. Hartwig Cadmium and cancer Met. Ions Life Sci. 11 2013 491 507
57. A. Fernández, R. Ordóñez, R.J. Reiter, J. González-Gallego, and J.L. Mauriz Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis J. Pineal Res. 59 2015 292 307
58. P.M. Ferraro, S. Costanzi, A. Naticchia, A. Sturniolo, and G. Gambaro Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006 BMC Public Health 304 2010 10.1186/1471-2458-10-304
59. D. Trachootham, W. Lu, M.A. Ogasawara, R.D. Nilsa, and P. Huang Redox regulation of cell survival Antioxid. Redox. Signal. 10 2008 1343 1374
60. M.J. Berridge Calcium signaling remodelling and disease Biochem. Soc. Trans. 40 2012 297 309
61. E.M. del Carmen, V. Souza, L. Bucio, E. Hernandez, P. Damian-Matsumura, V. Zaga, and M. Gutierrez-Ruiz Cadmium induces α1 collagen (I) and metallothionein II gene and alters the antioxidant system in rat hepatic stellate cells Toxicology 170 2002 63 73
62. E. Casalino, C. Sblano, G. Calzaretti, and C. Landriscina Acute cadmium intoxication induces alpha-class glutathione S-transferase protein synthesis and enzyme activity in rat liver Toxicology 217 2006 240 245
63. Y.H. Huang, C.M. Shih, C.J. Huang, C.M. Lin, C.M. Chou, M.L. Tsai, T.P. Liu, J.F. Chiu, and C.T. Chen Effects of cadmium on structure and enzymatic activity of Cu, Zn-SOD and oxidative status in neural cells J. Cell. Biochem. 98 2006 577 589
64. M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem. Biol. Interact. 160 2006 1 40
65. F. Thévenod, and W.K. Lee Cadmium and cellular signaling cascades: interactions between cell death and survival pathways Arch. Toxicol. 87 2013 1743 1786
66. G.H. El-Sokkary, A.A. Nafady, and E.H. Shabash Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat Ecotoxicol. Environ. Saf. 73 2010 456 463
67. J. Bokori, S. Fekete, R. Glavits, I. Kadar, J. Konez, and L. Kovari Complex study of the physiological role of cadmium: effects of prolonged dietary exposure of broiler chickens to cadmium Acta Vet. Hung. 44 1996 57 74
68. Y.O. Kim, Y.K. Ahn, and J.H. Kim Influence of melatonin on immunotoxicity of cadmium Int. J. Immunopharmacol. 22 2000 275 284
69. M.C. Caroleo, G. Doria, and G. Nistico Melatonin restores immunodepression in aged and cyclophosphamide-treated mice Ann. N.Y. Acad. Sci. 719 1994 343 352
70. H. Fujimaki Suppression of primary antibody response by a single exposure to cadmium in mice Toxicol. Lett. 25 1985 69 74
71. S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
72. R.C. Scarpulla Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network Biochim. Biophys. Acta 1813 2011 1269 1278
73. P. Guo, H. Pi, S. Xu, L. Zhang, Y. Li, M. Li, Z. Cao, L. Tian, J. Xie, R. Li, M. He, Y. Lu, C. Liu, W. Duan, Z. Yu, and Z. Zhou Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro Toxicol. Sci. 142 2014 182 195
74. S. Cuesta, R. Kireev, C. Garcia, L. Rancan, E. Vara, and J.A.F. Tresguerres Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence accelerated prone male mice (SAMP8) Age (Dordr.) 35 2013 659 671
75. A.S. Bause, and M.C. Haigis SIRT3 regulation of mitochondrial oxidative stress Exp. Gerontol. 48 2013 634 639
76. Q.L. Liang, G.A. Benavides, A. Vassilopoulos, D. Gius, V. Darley-Usmar, and J.H. Zhang Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts Biochem. J. 454 2013 249 257
77. W. Shen, C. Tian, H. Chen, Y. Yang, D. Zhu, P. Gao, and J. Liu Oxidative stress mediates chemerin-induced autophagy in endothelial cells Free Radic. Biol. Med. 55 2013 73 82
78. H. Pi, S. Xu, R.J. Reiter, P. Guo, L. Zhang, Y. Li, M. Li, Z. Cao, L. Tian, J. Xie, R. Zhang, M. He, Y. Lu, C. Liu, W. Duan, Z. Yu, and Z. Zhou SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin Autophagy 11 2015 1037 1051
79. V. Eybl, D. Kotyzová, and M. Bludovská The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice Toxicol. Lett. 151 2004 79 85
80. S. Lopez-Burillo, D.X. Tan, J.C. Mayo, R.M. Sainz, L.C. Manchester, and R.J. Reiter Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions J. Pineal Res. 34 2003 269 277
81. V. Eybl, D. Kotyzova, and J. Koutensky Comparative study of natural antioxidants-curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice Toxicology 225 2006 150 156
82. M. Valko, H. Morris, and M.T. Cronin Metals, toxicity and oxidative stress Curr. Med. Chem. 12 2005 1161 1208
83. M. Nishida, T. Yamamoto, Y. Yoshimura, and J. Kawada Subacute toxicity of methylmercuric chloride and mercuric chloride on mouse thyroid J. Pharmacobiodyn. 9 1986 331 338
84. T. Ando, I. Wakisaka, T. Yanagihashi, T. Tomari, and H. Hatano Mercury concentration in gray hair Nihon Eiseigaku Zasshi 43 1989 1063 1068
85. A.T. Khan, A. Atkinson, T.C. Graham, S.J. Thompson, S. Ali, and K.F. Shireen Effects of inorganic mercury on reproductive performance of mice Food Chem. Toxicol. 42 2004 571 577
86. M. Aschner, T. Syversen, D.O. Souza, J.B. Rocha, and M. Farina Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity Braz. J. Med. Biol. Res. 40 2007 285 291
87. S. Ceccatelli, E. Dare, and M. Moors Methylmercury-induced neurotoxicity and apoptosis Chem. Biol. Interact. 188 2010 301 308
88. M. Jindal, G.R. Garg, P.K. Mediratta, and M.I. Fahim Protective role of melatonin in myocardial oxidative damage induced by mercury in murine model Hum. Exp. Toxicol. 30 2011 1489 1500
89. B. van de Water, M. de Graauw, S. Le Dévédec, and M. Alderlieste Cellular stress responses and molecular mechanisms of nephrotoxicity Toxicol. Lett. 162 2006 83 93
90. A.R. Purohit, and M.V. Rao Mitigative role of melatonin and alpha-tocopherol against mercury-induced genotoxicity Drug Chem. Toxicol. 37 2014 221 226
91. M. Mahboob, K.F. Shireen, A. Atkinson, and A.T. Khan Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury J. Environ. Sci. Health. B. 36 2001 687 697
92. G. Sener, A.O. Sehirli, and G. Ayanoglu-Dulger Melatonin protects against mercury(II)-induced oxidative tissue damage in rats Pharmacol. Toxicol. 93 2003 290 296
93. G. Sener, A.O. Sehirli, and G. Ayanoglu-Dulger Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study J. Pineal Res. 35 2003 61 68
94. S. Fahn, and G. Cohen The oxidant stress hypothesis in Parkinson's disease: evidence supporting it Ann. Neurol. 32 1992 804 812
95. J.P. Kehrer The Haber-Weiss reaction and mechanisms of toxicity Toxicology 149 2000 43 50
96. H. Wiseman, and B. Halliwell Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem. J. 313 1996 17 29
97. F. Aktan iNOS-mediated nitric oxide production and its regulation Life Sci. 75 2004 639 654
98. Z.D. Liu, and R.C. Hider Design of clinically useful iron (III)- selective chelators Med. Res. Rev. 22 2002 26 64
99. D.B. Lovejoy, and D.R. Richardson Iron chelators as antineoplastic agents: current developments and promise of the PIH class of chelators Curr. Med. Chem. 10 2003 1035 1049
100. W. Qi, R.J. Reiter, D.X. Tan, L.C. Manchester, and J.R. Calvo Melatonin prevents deltaaminolevulinic acid-induced oxidative DNA damage in the presence of Fe2+ Mol. Cell. Biochem. 218 2001 87 92
101. E. Gitto, D.X. Tan, R.J. Reiter, M. Karbownik, L.C. Manchester, S. Cuzzocrea, F. Fulia, and I. Barberi Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates J. Pharm. Pharmacol. 53 2001 1393 1401
102. M. Arredondo, and N.T. Núñez Iron and copper metabolism Mol. Aspects Med. 26 2005 313 327
103. S.I. Liochev, and I. Fridovich The Haber-Weiss cycle -70 years later: an alternative view Redox. Rep. 7 2002 59 60
104. O.I. Aruoma, B. Halliwell, E. Gajewski, and M. Dizdaroglu Copper-ion dependent damage to the bases in DNA in the presence of hydrogen peroxide Biochem. J. 273 1991 601 604
105. H. Speisky, M. Gomez, F. Burgos-Bravo, C. López-Alarcón, C. Julian, C. Olea-Azar, and M.E. Aliaga Generation of superoxide radicals by copper-glutathione complexes: redox-consequences associated with their interaction with reduced glutathione Bioorg. Med. Chem. 17 2009 1803 1810
106. V. Brezova, M. Valko, M. Breza, H. Morris, J. Telser, D. Dvoranova, K. Kaiserova, L. Varecka, M. Mazur, and D. Leibfritz Role of radicals and singlet oxygen in photoactivated dna cleavage by the anticancer drug camptothecin: an electron paramagnetic resonance study J. Phys. Chem. B. 107 2003 2415 2425
107. P. Parmar, J. Limson, T. Nyokong, and S. Daya Melatonin protects against copper-mediated free radical damage J. Pineal Res. 32 2002 237 242
108. A. Wakatsuki, Y. Okatani, N. Ikenoue, C. Izumiya, and C. Kaneda Melatonin inhibits oxidative modification of low-density lipoprotein particles in normolipidemic post-menopausal women J. Pineal Res. 28 2000 136 142
109. J.C. Mayo, D.X. Tan, R.M. Sainz, M. Natarajan, S. Lopez-Burillo, and R.J. Reiter Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants Biochim. Biophys. Acta 1620 2003 139 150
110. G. Sener, H.Z. Toklu, and S. Cetinel β-Glucan protects against chronic nicotine induced oxidative damage in rat kidney and bladder Environ. Toxicol. Pharmacol. 23 2007 25 32
111. E. Siktar, D. Ekinci, E. Siktar, S. Beydemir, I. Gulcin, and M. Gunay Protective role of L-carnitine supplementation against exhaustive exercise induced oxidative stress in rats Eur. J. Pharmacol. 668 2011 407 413
112. S. Mercan, and B. Eren Protective role of melatonin supplementation against nicotine-induced liver damage in mouse Toxicol. Ind. Health 29 2013 888 896
113. R.H. Liu, M. Mizuta, and S. Matsuruka Long-term oral nicotine administration reduces insulin resistance in obese rats Eur. J. Pharmacol. 458 2002 227 234
114. P. Czekaj, A. Palasz, T. Lebda-Wyborny, G. Nowaczyk-Dura, W. Karczewska, E. Florek, and M. Kaminski Morphological changes in lungs placenta, liver and kidneys of pregnant rats exposed to cigarette smoke Int. Arch. Occup. Environ. Health 75 2002 27 35
115. M. Ogeturk, I. Kus, A. Kavakli, I. Zararsiz, N. Ilhan, and M. Sarsilmaz Effects of melatonin on carbon tetrachloride-induced changes in rat serum J. Physiol. Biochem. 60 2004 205 210
116. P. Abraham, G. Wilfred, and S.P. Cathrine Clin. Chirn. Acta 289 1999 177 179
117. W.J. Brattin, E.A. Glende Jr., and R.O. Recknagel Pathological mechanisms in carbon tetrachloride hepatotoxicity J. Free Radic. Biol. Med. 1 1985 27 38
118. M.X. Dong, Y. Jia, Y.B. Zhang, C.C. Li, Y.T. Geng, L. Zhou, X.Y. Li, J.C. Liu, and Y.C. Niu Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation World J. Gastroenterol. 15 2009 4753 4762
119. M. Sreepriya, T. Devaki, and M. Nayeem Protective effects of Indigoferatinctoria L. against D-Galactosamine and carbon tetrachloride challenge on 'in situ' perfused rat liver Indian J. Physiol. Pharmacol. 45 2001 428 434
120. F.A. Fahim, A.Y. Esmat, H.M. Fadel, and K.F. Hassan Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis Int. J. Food Sci. Nutr. 50 1999 413 427
121. Y. Ohta, M. Kongo, E. Sasaki, K. Nishida, and I. Ishiguro Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats J. Pineal Res. 28 2000 119 126
122. J. Camacho, and B. Rubalcava Lipid composition of liver plasma membranes from rats intoxicated with carbon tetrachloride Biochim. Biophys. Acta 776 1984 97 104
123. 4-injured hepatocytes Zhongguo Yao Li XueBao 17 1996 348 350
124. A. Güven, A. Güven, and M. Gülmez The effect of kefir on the activities of GSH-Px, GST CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissues J. Vet. Med. B. Infect. Dis. Vet. Public Health 50 2003 412 416
125. W.M. Daniels, R.J. Reiter, D. Melchiorri, E. Sewerynek, M.I. Pablos, and G.G. Ortiz Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose-6 phosphatase activity J. Pineal Res. 19 1995 1 6
126. R.T. Hong, J.M. Xu, and Q. Mei Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats World J. Gastroenterol. 15 2009 1452 1458
127. S.C. Cunnane Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: Interactions with essential fatty acids and prostaglandins Alcohol. Clin. Exp. Res. 1 1987 25 31
128. I. Kus, M. Ogeturk, H. Oner, S. Sahin, H. Yekeler, and M. Sarsilmaz Protective effects of melatonin against carbontetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study Cell. Biochem. Funct. 23 2005 169 174
129. L.B. Zavodnik, I.B. Zavodnik, E.A. Lapshina, E.B. Belonovskaya, D.I. Martinchik, R.I. Kravchuk, M. Bryszewska, and R.J. Reiter Protective effects of melatonin against carbon tetrachloride hepatotoxicity in rats Cell Biochem. Funct. 23 2005 353 359
130. R.J. Reiter, D.X. Tan, R.M. Sainz, J.C. Mayo, and S. Lopez-Burillo Melatonin: reducing the toxicity and increasing the efficacy of drugs J. Pharm. Pharmacol. 54 2002 1299 1321
131. H. Wang, W. Wei, N.P. Wang, S.Y. Gui, L. Wu, W.Y. Sun, and S.Y. Xu Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress Life Sci. 77 2005 1902 1915
132. M. Aranda, C.D. Albendea, F. Lostalé, L. López-Pingarrón, L. Fuentes-Broto, E. Martínez-Ballarín, R.J. Reiter, M.C. Pérez-Castejón, and J.J. García In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline J. Pineal Res. 49 2010 78 85
133. T. Noyan, U. Kömüroʇlu, I. Bayram, and M.R. Sekeroʇlu Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice Cell. Biol. Toxicol. 22 2006 381 391
134. M.E. Shaker, M.E. Houssen, E.M. Abo-Hashem, and T.M. Ibrahim Comparison of vitamin E, L-carnitine and melatonin in ameliorating carbontetrachloride and diabetes induced hepatic oxidative stress J. Physiol. Biochem. 65 2009 225 233
135. M. Boll, L.W. Weber, E. Becker, and A. Stampfl Mechanism of carbon tetrachloride induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites Z. Naturforsch. 56 2001 649 659
136. K. Demirdag, I.H. Bahcecioglu, I.H. Ozercan, M. Ozden, S. Yilmaz, and A. Kalkan Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats J. Gastroenterol. Hepatol. 19 2004 333 338
137. M.C. Wallace, K. Hamesch, M. Lunova, Y. Kim, R. Weiskirchen, P. Strnad, and S.L. Friedman Standard operating procedures in experimental liver research: thioacetamide model in mice and rats Lab. Anim. 49 2015 21 29
138. J. Peeling, L. Shoemaker, T. Gauthier, A. Benarroch, G.R. Sutherland, and G.Y. Minuk Cerebral metabolic and histological effects of thioacetamide-induced liver failure Am. J. Physiol. 265 1993 G572 G578
139. R.F. Butterworth, M.D. Norenberg, V. Felipo, P. Ferenci, J. Albrecht, and A.T. Blei Members of the ISHEN Commission on Experimental Models of HE, Experimental models of hepatic encephalopathy: ISHEN guidelines Liver Int. 29 2009 783 788
140. H. Hajovsky, G. Hu, Y. Koen, D. Sarma, W. Cui, D.S. Moore, J.L. Staudinger, and R.P. Hanzlik Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes Chem. Res. Toxicol. 25 2012 1955 1963
141. J. Chilakapati, M.C. Korrapati, K. Shankar, R.A. Hill, A. Warbritton, J.R. Latendresse, and H.M. Mehendale Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: effects of diet restriction and Phenobarbital Toxicol. Appl. Pharmacol. 219 2007 72 84
142. A. Fernández-Martínez, N.A. Callejas, M. Casado, L. Boscá, and P. Martín-Sanz Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes J. Hepatol. 40 2004 963 970
143. P. Stanková, O. Kucera, H. Lotková, T. Rousar, R. Endlicher, and Z. Cervinková The toxic effect of thioacetamide on rat liver in vitro Toxicol. In Vitro 24 2010 2097 2103
144. Y.M. Koen, D. Sarma, H. Hajovsky, N.A. Galeva, T.D. Williams, J.L. Staudinger, and R.P. Hanzlik Protein targets of thioacetamide metabolites in rat hepatocytes Chem. Res. Toxicol. 26 2013 564 574
145. C.J. Chu, S.S. Wang, F.Y. Lee, F.Y. Chang, H.C. Lin, M.C. Hou, C.C. Chan, S.L. Wu, C.T. Chen, H.C. Huang, and S.D. Lee Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure Eur. J. Clin. Invest. 31 2001 156 163
146. M.L. Mesa, R. Carrizosa, C. Martínez-Honduvilla, M. Benito, and I. Fabregat Changes in rat liver gene expression induced by thioacetamide: Protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism Hepatology 23 1996 600 606
147. A. Al-Bader, T.C. Mathew, H. Abul, H. Al-Sayer, P.K. Singal, and H.M. Dashti Cholangiocarcinoma and liver cirrhosis in relation to changes due to thioacetamide Mol. Cell. Biochem. 208 2000 1 10
148. W. Laleman, I. Vander Elst, M. Zeegers, R. Servaes, L. Libbrecht, T. Roskams, J. Fevery, and F. Nevens A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited Eur. J. Clin. Invest. 36 2006 242 249
149. R. Bruck, H. Aeed, R. Schey, Z. Matas, R. Reifen, G. Zaiger, A. Hochman, and Y. Avni Pyrrolidinedithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats J. Hepatol. 36 2002 370 377
150. G. Czechowska, K. Celinski, A. Korolczuk, G. Wojcicka, J. Dudka, A. Bojarska, and R.J. Reiter Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats J. Physiol. Pharmacol. 66 2015 567 579
151. I. Túnez, M.C. Muñoz, M.A. Villavicencio, F.J. Medina, E.P. de Prado, I. Espejo, M. Barcos, M. Salcedo, M. Feijóo, and P. Montilla Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide Pharmacol. Res. 52 2005 223 228
152. M.W. Church, B.W. Blakley, D.L. Burgio, and A.K. Gupta WR-2721 (Amifostine) ameliorates cisplatin-induced hearing loss but causes neurotoxicity in hamsters: dose-dependent effects J. Assoc. Res. Otolaryngol. 5 2004 227 237
153. P.S. Steeg, and D. Theodorescu Metastasis: a therapeutic target for cancer Nat. Clin. Pract. Oncol. 5 2008 206 219
154. O. Ciftci, I. Ozdemir, N. Vardi, and N. Gurbuz Novel platinum-N heterocyclic carbene complex is more cardiotoxic than cisplatin in rats Hum. Exp. Toxicol. 30 2011 1342 1349
155. E. Papagiannidou, D.J. Skene, and C. Ioannides Potential drug interactions with melatonin Physiol. Behav. 131 2014 17 24
156. S. Taziki, M.R. Sattari, S. Dastmalchi, and M.A. Eghbal Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes Adv. Pharm. Bull. 5 2015 329 334
157. V. Rapozzi, S. Zorzet, M. Comelli, I. Mavelli, L. Perissin, and T. Giraldi Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in micebearing TLX5 lymphoma Life Sci. 63 1998 1701 1713
158. A. Catalá, A. Zvara, L.G. Puskás, and K. Kitajka Melatonin-induced gene expression changes and its preventive effects on adriamycin-induced lipid peroxidation in rat liver J. Pineal Res. 21 2007 43 49
159. A.I. Othman, M.A. El-Missiry, M.A. Amer, and M. Arafa Melatonin controls oxidative stress and modulates iron, ferritin, and transferring levels in adriamycin treated rats Life Sci. 83 2008 563 568
160. E. Oz, and M.N. Ilhan Effects of melatonin in reducing the toxic effects of doxorubicin Mol. Cell. Biochem. 286 2006 11 15
161. S. Kanno, A. Tomizawa, T. Hiura, Y. Osanai, M. Kakuta, Y. Kitajima, K. Koiwai, T. Ohtake, M. Ujibe, and M. Ishikawa Melatonin protects on toxicity by acetaminophen but not on pharmacological effects in mice Biol. Pharm. Bull. 29 2006 472 476
162. T. Matsura, T. Nishida, A. Togawa, S. Horie, C. Kusumoto, S. Ohata, J. Nakada, Y. Ishibe, K. Yamada, and Y. Ohta Mechanisms of protection by melatonin against acetaminophen-induced liver injury in mice J. Pineal Res. 41 2006 211 219
163. Y.L. Liang, Z.H. Zhang, Z.J. Liu, Z.Q. Liu, L. Tao, Y.F. Zhang, H. Wang, C. Zhang, X. Chen, and D.X. Xu Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure PLoS One 7 2012 10.1371/journal.pone.0051911
164. P. Madhu, K.P. Reddy, and P.S. Reddy Melatonin reduces oxidative stress and restores mitochondrial function in the liver of rats exposed to chemotherapeutics J. Exp. Zool. A. Ecol. Genet. Physiol. 323 2015 301 308
165. M. Shokrzadeh, A. Ahmadi, F. Naghshvar, A. Chabra, and M. Jafarinejhad Prophylactic efficacy of melatonin on cyclophosphamide-induced liver toxicity in mice Biomed. Res. Int. 470425 2014 10.1155/2014/470425
166. C.S. Kwak, and K.C. Mun The beneficial effect of melatonin for cyclosporine hepatotoxicity in rats Transplant. Proc. 32 2000 2009 2010
167. R. Rezzani, B. Buffoli, L. Rodella, A. Stacchiotti, and R. Bianchi Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver Int. Immunopharmacol. 5 2005 1397 1405
168. M. Kurus, M. Esrefoglu, G. Sogutlu, and A. Atasever Melatonin prevents cyclosporine-induced hepatotoxicity in rats Med. Princ. Pract. 18 2009 407 410
169. S. Akbulut, H. Elbe, C. Eris, Z. Dogan, G. Toprak, E. Yalcin, E. Otan, and Y. Turkoz Effects of antioxidant agents against cyclosporine-induced hepatotoxicity J. Surg. Res. 193 2015 658 666
170. G.H. El-Sokkary Melatonin and vitamin C administration ameliorate diazepam-induced oxidative stress and cell proliferation in the liver of rats Cell. Prolif. 41 2008 168 176
171. C. Mdel, S.G. Martinez, A.M. Afonso, and A. Batlle Buzaleh Protective action of antioxidants on hepatic damage induced by griseofulvin Sci. World J. 982358 2014 10.1155/2014/982358
172. M. Aydin, S. Oktar, O.V. Ozkan, E. Alçin, O.H. Oztürk, and A. Nacar Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin Gynecol. Endocrinol. 27 2011 209 215
173. F. Mauviard, F. Raynaud, M. Geoffriau, B. Claustrat, and P. Pevet 5-Methoxypsoralen inhibits 6-hydroxylation of melatonin in the rat Biol. Signals 4 1995 32 41
174. S. Härtter, M. Grozinger, H. Weigmann, J. Roschke, and C. Hiemke Increased bioavailability of oral melatonin after fluvoxamine coadministration Clin. Pharmacol. Ther. 67 2000 1 6
175. S. Ono, T. Hanataka, S. Miyazawa, M. Tsutsui, T. Ayoama, F.J. Gonzalez, and T. Satoh Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily Xenobiotica 26 1996 1155 1166
176. A. Allameh, E.Y. Vansoun, and A. Zarghi Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity Mech. Ageing Dev. 95 1997 71 79
177. K.P.J.R. Wright, and P. Badia Effects of menstrual cycle phase and oral contraceptives on alertness cognitive performance, and circadian rhythms during sleep deprivation Behav. Brain. Res. 103 1999 185 194
178. H.K. Crew, L.M. Notley, R.M. Wunsch, M.S. Lennard, and E.M. Gillam Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4′-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen Drug Metab. Dispos. 30 2002 869 874
179. J.C. Marshall, J.L. Vincent, G. Guyatt, D.C. Angus, E. Abraham, G. Bernard, C. Bombardier, T. Calandra, H.S. Jørgensen, R. Sylvester, and M. Boers Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum Crit. Care Med. 33 2005 1708 1716
180. F.B. Mayr, S. Yende, and D.C. Angus Epidemiology of severe sepsis Virulence 5 2014 4 11
181. D. Brealey, and M. Singer Mitochondrial dysfunction in sepsis Curr. Infect. Dis. Rep. 5 2003 365 371
182. N. Nesseler, Y. Launey, C. Aninat, C. Morel, Y. Malledant, and P. Seguin Clinical review: the liver in sepsis Crit. Care. 16 2012 10.1186/cc11381
183. M. Singer, and D. Brealey Mitochondrial dysfunction in sepsis Biochem. Soc. Symp. 66 1999 149 166
184. A.U. Khan, R.L. Delude, Y.Y. Han, P.L. Sappington, X. Han, J.A. Carcillo, and M.P. Fink Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells Am. J. Physiol. Lung Cell. Mol. Physiol. 282 2002 1082 1091
185. M.C. Exline, and E.D. Crouser Mitochondrial mechanisms of sepsis induced organ failure Front. Biosci. 13 2008 5031 5041
186. T. Regueira, M. Andresen, and S. Djafarzadeh Mitochondrial dysfunction during sepsis, impact and possible regulating role of hypoxia-inducible factor-1alpha Med. Int. 33 2009 385 392
187. M. Wendel, and A.R. Heller Mitochondrial function and dysfunction in sepsis Wien. Med. Wochenschr. 160 2010 118 123
188. G.C. Brown Nitric oxide and mitochondrial respiration Biochim. Biophys. Acta 1411 1999 351 369
189. L.C. López, G. Escames, F. Ortiz, E. Ros, and D. Acuña-Castroviejo Melatonin restores the mitochondrial production of ATP in septic mice Neuro. Endocrinol. Lett. 27 2006 623 630
190. N. Apostolova, R. Garcia-Bou, A. Hernandez-Mijares, R. Herance, M. Rocha, and V.M. Victor Mitochondrial antioxidants alleviate oxidative and nitrosative stress in a cellular model of sepsis Pharm. Res. 28 2011 2910 2919
191. P. Bochud, and T. Calandra Pathogenesis of sepsis: new concepts and implications for future treatment Br. Med. J. 326 2003 262 266
192. A. Ozdulger, I. Cinel, O. Koksel, L. Cinel, D. Avlan, A. Unlu, H. Okcu, M. Dikmengil, and U. Oral The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model Shock 19 2003 366 372
193. C. Thiemermann Membrane-permeable radical scavenger (tempol) for shock ischemia-reperfusion injury, and inflammation Crit. Care Med. 31 2003 76 84
194. E. Crespo, M. Macías, D. Pozo, G. Escames, M. Martin, F. Vives, J.M. Guerrero, and D. Acuña-Castroviejo Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide induced multiple organ dysfunction in rats FASEB J. 13 1999 1537 1546
195. G. Sener, H. Toklu, C. Kapucu, F. Ercan, G. Erkanli, A. Kaçmaz, M. Tilki, and B.C. Yeʇen Melatonin protects against oxidative organ injury in a rat model of sepsis Surg. Today 35 2005 52 59
196. J.Y. Wu, M.Y. Tsou, T.H. Chen, S.J. Chen, C.M. Tsao, and C.C. Wu Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats J. Pineal Res. 45 2008 106 116
197. A. Kleber, D. Kubulus, D. Rössler, B. Wolf, T. Volk, T. Speer, and T. Fink Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response Exp. Mol. Pathol. 97 2014 565 571
198. M.W. Hung, G.M. Kravtsov, C.F. Lau, A.M. Poon, G.L. Tipoe, and M.L. Fung Melatonin ameliorates endothelial dysfunction vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia J. Pineal Res. 55 2013 247 256
199. Z. Zhou, M.C. Connell, and D.J. MacEwan TNFR1-induced NF-kappaB but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells Cell. Signal. 19 2007 1238 1248
200. S.J. Jiang, S.Y. Hsu, C.R. Deng, H.C. Huang, S.L. Liu, G.Y. Shi, and H.L. Wu Dextromethorphan attenuates LPS-induced adhesion molecule expression in human endothelial cells Microcirculation 20 2013 190 201
201. E. Gitto, M. Karbownik, R.J. Reiter, D.X. Tan, S. Cuzzocrea, P. Chiurazzi, S. Cordaro, G. Corona, G. Trimarchi, and I. Barberi Effects of melatonin treatment in septic newborn Pediatr. Res. 50 2001 756 760
202. M. El Frargy, H.M. El-Sharkawy, and G.F. Attia Use of melatonin as an adjuvant therapy in neonatal sepsis J. Neonatal Perinatal Med. 2015 [Epub ahead of print]
203. C. Doerrier, J.A. García, H. Volt, M.E. Díaz-Casado, E. Lima-Cabello, F. Ortiz, M. Luna-Sánchez, G. Escames, L.C. López, and D. Acuña-Castroviejo Identification of mitochondrial deficits and melaton in targets in liver of septic mice by high-resolution respirometry Life Sci. 121 2015 158 165
204. M.D. Brand, and T.C. Esteves Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3 Cell. Metab. 2 2005 85 93
205. D.A. Lowes, N.R. Webster, M.P. Murphy, and H.F. Galley Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis Br. J. Anaesth. 110 2013 472 480
206. T. Mitchell, D. Rotaru, H. Saba, R.A.J. Smith, M.P. Murphy, and L.A. MacMillan-Crow The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cellsand rat kidneys J. Pharmacol. Exp. Ther. 336 2011 682 692