메뉴 건너뛰기




Volumn 49, Issue 1, 2010, Pages 78-85

In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: Protection by melatonin and pinoline

Author keywords

carbon tetrachloride; melatonin; membrane fluidity; oxidative stress; pinoline

Indexed keywords

4 HYDROXYALKENAL; ALKENE DERIVATIVE; CARBON TETRACHLORIDE; MALONALDEHYDE; MELATONIN; PINOLINE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; 6-METHOXYTRYPTOLINE; CARBOLINE DERIVATIVE;

EID: 77954339411     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00769.x     Document Type: Article
Times cited : (25)

References (60)
  • 2
    • 0015687156 scopus 로고
    • Carbon tetrachloride hepatotoxicity: An example of lethal cleavage
    • Recknagel RO, Glende EA. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. Crit Rev Toxicol 1973 2 : 263 297.
    • (1973) Crit Rev Toxicol , vol.2 , pp. 263-297
    • Recknagel, R.O.1    Glende, E.A.2
  • 3
    • 0020077751 scopus 로고
    • Evidence for carbon tetrachloride-induced lipid peroxidation in mouse liver
    • Lee PY, Mccay PB, Hornbrook KR. Evidence for carbon tetrachloride-induced lipid peroxidation in mouse liver. Biochem Pharmacol 1982 31 : 405 409.
    • (1982) Biochem Pharmacol , vol.31 , pp. 405-409
    • Lee, P.Y.1    McCay, P.B.2    Hornbrook, K.R.3
  • 4
    • 0025758136 scopus 로고
    • Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
    • Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991 12 : 151 180.
    • (1991) Endocr Rev , vol.12 , pp. 151-180
    • Reiter, R.J.1
  • 5
    • 0002979059 scopus 로고
    • Melatonin: A potent, endogenous hydroxyl radical scavenger
    • Tan DX, Chen LD, Poeggeler B et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993 1 : 57 60.
    • (1993) Endocr J , vol.1 , pp. 57-60
    • Tan, D.X.1    Chen, L.D.2    Poeggeler, B.3
  • 6
    • 53749104127 scopus 로고    scopus 로고
    • Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment mice: Ameliorative potential of the melatonin metabolite, AFMK
    • Manda K, Ueno M, Anzai K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment mice: ameliorative potential of the melatonin metabolite, AFMK. J Pineal Res 2008 45 : 430 438.
    • (2008) J Pineal Res , vol.45 , pp. 430-438
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 7
    • 51649122293 scopus 로고    scopus 로고
    • Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species
    • Peyrot F, Ducrocq C. Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 2008 45 : 235 246.
    • (2008) J Pineal Res , vol.45 , pp. 235-246
    • Peyrot, F.1    Ducrocq, C.2
  • 8
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009 47 : 109 126.
    • (2009) J Pineal Res , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 9
    • 1642562820 scopus 로고    scopus 로고
    • Regulation of antioxidant enzymes: A significant role for melatonin
    • Rodríguez C, Mayo JC, Sainz RM et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004 36 : 1 9.
    • (2004) J Pineal Res , vol.36 , pp. 1-9
    • Rodríguez, C.1    Mayo, J.C.2    Sainz, R.M.3
  • 10
    • 0030135215 scopus 로고    scopus 로고
    • Melatonin reduces nitric oxide synthase activity in rat hypothalamus
    • Bettahi I, Pozo D, Osuna C et al. Melatonin reduces nitric oxide synthase activity in rat hypothalamus. J Pineal Res 1996 20 : 205 210.
    • (1996) J Pineal Res , vol.20 , pp. 205-210
    • Bettahi, I.1    Pozo, D.2    Osuna, C.3
  • 11
    • 0029382404 scopus 로고
    • Permeability of pure lipid bilayers to melatonin
    • Costa EJ, Lopes RH, Lamy-Freund MT. Permeability of pure lipid bilayers to melatonin. J Pineal Res 1995 19 : 123 126.
    • (1995) J Pineal Res , vol.19 , pp. 123-126
    • Costa, E.J.1    Lopes, R.H.2    Lamy-Freund, M.T.3
  • 12
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
    • Menéndez-Peláez A, Reiter RJ. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 1993 15 : 59 69.
    • (1993) J Pineal Res , vol.15 , pp. 59-69
    • Menéndez-Peláez, A.1    Reiter, R.J.2
  • 13
    • 49049147437 scopus 로고
    • 6-methoxy-1,2,3,4-tetrahydro-beta-carboline in pineal gland of chicken and cock
    • Kari I. 6-methoxy-1,2,3,4-tetrahydro-beta-carboline in pineal gland of chicken and cock. FEBS Lett 1981 127 : 277 280.
    • (1981) FEBS Lett , vol.127 , pp. 277-280
    • Kari, I.1
  • 15
    • 0028227812 scopus 로고
    • The Pictet-Spengler reaction and biogenic triptamines: Formation of tetrahydro-b-carbolines at physiological pH
    • Callaway JC, Gynther J, Poso A et al. The Pictet-Spengler reaction and biogenic triptamines: formation of tetrahydro-b-carbolines at physiological pH. J Heterocycl Chem 1994 31 : 431 435.
    • (1994) J Heterocycl Chem , vol.31 , pp. 431-435
    • Callaway, J.C.1    Gynther, J.2    Poso, A.3
  • 16
    • 0032913239 scopus 로고    scopus 로고
    • Pharmacological aspects of N-acetyl-5-methoxytryptamine (melatonin) and 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (pinoline) as antioxidants: Reduction of oxidative damage in brain region homogenates
    • Pless G, Frederiksen TJ, García JJ et al. Pharmacological aspects of N-acetyl-5-methoxytryptamine (melatonin) and 6-methoxy-1,2,3,4-tetrahydro- beta-carboline (pinoline) as antioxidants: reduction of oxidative damage in brain region homogenates. J Pineal Res 1999 26 : 236 246.
    • (1999) J Pineal Res , vol.26 , pp. 236-246
    • Pless, G.1    Frederiksen, T.J.2    García, J.J.3
  • 17
    • 0034634732 scopus 로고    scopus 로고
    • Protective effect of beta-carbolines and other antioxidants on lipid peroxidation due to hydrogen peroxide in rat brain homogenates
    • García JJ, Martínez-Ballarín E, Robinson M et al. Protective effect of beta-carbolines and other antioxidants on lipid peroxidation due to hydrogen peroxide in rat brain homogenates. Neurosci Lett 2000 294 : 1 4.
    • (2000) Neurosci Lett , vol.294 , pp. 1-4
    • García, J.J.1    Martínez-Ballarín, E.2    Robinson, M.3
  • 18
    • 33746514547 scopus 로고    scopus 로고
    • Protective effect of melatonin and pinoline on nitric oxide-induced lipid and protein peroxidation in rat brain homogenates
    • Piñol-Ripoll G, Fuentes-Broto L, Millán-Plano S et al. Protective effect of melatonin and pinoline on nitric oxide-induced lipid and protein peroxidation in rat brain homogenates. Neurosci Lett 2006 405 : 89 93.
    • (2006) Neurosci Lett , vol.405 , pp. 89-93
    • Piñol-Ripoll, G.1    Fuentes-Broto, L.2    Millán-Plano, S.3
  • 19
    • 0032882717 scopus 로고    scopus 로고
    • Pineal indoleamines and vitamin e reduce nitric oxide-induced lipid peroxidation in rat retinal homogenates
    • Siu AW, Reiter RJ, To CH. Pineal indoleamines and vitamin E reduce nitric oxide-induced lipid peroxidation in rat retinal homogenates. J Pineal Res 1999 27 : 122 128.
    • (1999) J Pineal Res , vol.27 , pp. 122-128
    • Siu, A.W.1    Reiter, R.J.2    To, C.H.3
  • 20
    • 0033949540 scopus 로고    scopus 로고
    • 2: Protection by melatonin and related molecules
    • 2: protection by melatonin and related molecules. J Pineal Res 2000 29 : 54 61.
    • (2000) J Pineal Res , vol.29 , pp. 54-61
    • Qi, W.1    Reiter, R.J.2    Tan, D.X.3
  • 21
    • 0038071527 scopus 로고    scopus 로고
    • Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes
    • Millán-Plano S, García JJ, Martínez-Ballarín E et al. Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes. J Trace Elem Med Biol 2003 17 : 39 44.
    • (2003) J Trace Elem Med Biol , vol.17 , pp. 39-44
    • Millán-Plano, S.1    García, J.J.2    Martínez-Ballarín, E.3
  • 22
    • 68249112961 scopus 로고    scopus 로고
    • Melatonin down-regulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model
    • Jung KH, Hong SW, Zheng HM et al. Melatonin down-regulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J Pineal Res 2009 47 : 173 183.
    • (2009) J Pineal Res , vol.47 , pp. 173-183
    • Jung, K.H.1    Hong, S.W.2    Zheng, H.M.3
  • 23
    • 64649093159 scopus 로고    scopus 로고
    • Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats
    • Tahan V, Atug O, Akin H et al. Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J Pineal Res 2009 46 : 401 407.
    • (2009) J Pineal Res , vol.46 , pp. 401-407
    • Tahan, V.1    Atug, O.2    Akin, H.3
  • 24
    • 0029349115 scopus 로고
    • Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose-6 phosphatase activity
    • Daniels WM, Reiter RJ, Melchiorri D et al. Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose-6 phosphatase activity. J Pineal Res 1995 19 : 1 6.
    • (1995) J Pineal Res , vol.19 , pp. 1-6
    • Daniels, W.M.1    Reiter, R.J.2    Melchiorri, D.3
  • 25
    • 0034468737 scopus 로고    scopus 로고
    • Preventive effect of melatonin on the progression of carbon tetrachloride-induced acute liver injury in rats
    • Ohta Y, Kongo M, Sasaki E et al. Preventive effect of melatonin on the progression of carbon tetrachloride-induced acute liver injury in rats. Adv Exp Med Biol 1999 467 : 327 332.
    • (1999) Adv Exp Med Biol , vol.467 , pp. 327-332
    • Ohta, Y.1    Kongo, M.2    Sasaki, E.3
  • 26
    • 1642562815 scopus 로고    scopus 로고
    • Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride
    • Ohta Y, Kongo-Nishimura M, Matsura T et al. Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride. J Pineal Res 2004 36 : 10 17.
    • (2004) J Pineal Res , vol.36 , pp. 10-17
    • Ohta, Y.1    Kongo-Nishimura, M.2    Matsura, T.3
  • 27
    • 0035146116 scopus 로고    scopus 로고
    • Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats
    • Calvo JR, Reiter RJ, García JJ et al. Characterization of the protective effects of melatonin and related indoles against alpha- naphthylisothiocyanate-induced liver injury in rats. J Cell Biochem 2001 80 : 461 470.
    • (2001) J Cell Biochem , vol.80 , pp. 461-470
    • Calvo, J.R.1    Reiter, R.J.2    García, J.J.3
  • 28
    • 71449123049 scopus 로고    scopus 로고
    • Effects of tryptophan and 5-hydroxytryptophan on the hepatic cell membrane rigidity due to oxidative stress
    • Reyes-Gonzales MC, Fuentes-Broto L, Martínez-Ballarín E et al. Effects of tryptophan and 5-hydroxytryptophan on the hepatic cell membrane rigidity due to oxidative stress. J Membr Biol 2009 231 : 93 99.
    • (2009) J Membr Biol , vol.231 , pp. 93-99
    • Reyes-Gonzales, M.C.1    Fuentes-Broto, L.2    Martínez-Ballarín, E.3
  • 30
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 72 : 248 254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 31
    • 0025697262 scopus 로고
    • Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
    • Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990 9 : 515 540.
    • (1990) Free Radic Biol Med , vol.9 , pp. 515-540
    • Janero, D.R.1
  • 32
    • 0025102226 scopus 로고
    • Determination of carbonyl content in oxidatively modified proteins
    • Levine RL, Gardeland D, Oliver CN et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990 186 : 464 478.
    • (1990) Methods Enzymol , vol.186 , pp. 464-478
    • Levine, R.L.1    Gardeland, D.2    Oliver, C.N.3
  • 33
    • 73449099589 scopus 로고    scopus 로고
    • Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies
    • Pradeep HA, Khan S, Ravikumar K et al. Hepatoprotective evaluation of Anogeissus latifolia: in vitro and in vivo studies. World J Gastroenterol 2009 15 : 4816 4822.
    • (2009) World J Gastroenterol , vol.15 , pp. 4816-4822
    • Pradeep, H.A.1    Khan, S.2    Ravikumar, K.3
  • 34
    • 18844400550 scopus 로고    scopus 로고
    • Protective effects of melatonin against carbon tetrachloride-induced hepatotoxicity in rats: A light microscopic and biochemical study
    • Kus I, Ogeturk M, Oner H et al. Protective effects of melatonin against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Cell Biochem Funct 2005 23 : 169 174.
    • (2005) Cell Biochem Funct , vol.23 , pp. 169-174
    • Kus, I.1    Ogeturk, M.2    Oner, H.3
  • 35
    • 73449105395 scopus 로고    scopus 로고
    • Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation
    • Dong MX, Jia Y, Zhang YB et al. Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol 2009 15 : 4753 4762.
    • (2009) World J Gastroenterol , vol.15 , pp. 4753-4762
    • Dong, M.X.1    Jia, Y.2    Zhang, Y.B.3
  • 37
    • 0029855034 scopus 로고    scopus 로고
    • 4 and ketone treatment on hepatic membrane integrity
    • 4 and ketone treatment on hepatic membrane integrity. J Toxicol Environ Health 1996 49 : 285 300.
    • (1996) J Toxicol Environ Health , vol.49 , pp. 285-300
    • Raymond, P.1    Plaa, G.L.2
  • 38
    • 0027404311 scopus 로고
    • Disruption effects of carbon tetrachloride on rat liver microsomes
    • Lissi EA, Rosenbluth H. Disruption effects of carbon tetrachloride on rat liver microsomes. J Photochem Photobiol B 1993 17 : 33 40.
    • (1993) J Photochem Photobiol B , vol.17 , pp. 33-40
    • Lissi, E.A.1    Rosenbluth, H.2
  • 39
    • 0021143795 scopus 로고
    • Lipid composition of liver plasma membranes from rats intoxicated with carbon tetrachloride
    • Camacho J, Rubalcava B. Lipid composition of liver plasma membranes from rats intoxicated with carbon tetrachloride. Biochim Biophys Acta 1984 776 : 97 104.
    • (1984) Biochim Biophys Acta , vol.776 , pp. 97-104
    • Camacho, J.1    Rubalcava, B.2
  • 40
    • 0019861038 scopus 로고
    • Effect of diabetes and insulin replacement on the lipid properties of hepatic smooth endoplasmic reticulum
    • Holloway CT, Gardfield SA. Effect of diabetes and insulin replacement on the lipid properties of hepatic smooth endoplasmic reticulum. Lipids 1981 16 : 525 532.
    • (1981) Lipids , vol.16 , pp. 525-532
    • Holloway, C.T.1    Gardfield, S.A.2
  • 41
    • 0026703851 scopus 로고
    • Abnormal lipid composition of microsomes from cirrhotic rat liver - Does it contribute to decreased microsomal function?
    • Reichen J, Buters JT, Sojcic Z et al. Abnormal lipid composition of microsomes from cirrhotic rat liver - does it contribute to decreased microsomal function? Experientia 1992 48 : 482 486.
    • (1992) Experientia , vol.48 , pp. 482-486
    • Reichen, J.1    Buters, J.T.2    Sojcic, Z.3
  • 43
    • 0033382517 scopus 로고    scopus 로고
    • Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress
    • García JJ, Reiter RJ, Pié J et al. Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress. J Bioenerg Biomembr 1999 31 : 609 616.
    • (1999) J Bioenerg Biomembr , vol.31 , pp. 609-616
    • García, J.J.1    Reiter, R.J.2    Pié, J.3
  • 44
    • 0031587041 scopus 로고    scopus 로고
    • Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation
    • García JJ, Reiter RJ, Guerrero JM et al. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett 1997 408 : 297 300.
    • (1997) FEBS Lett , vol.408 , pp. 297-300
    • García, J.J.1    Reiter, R.J.2    Guerrero, J.M.3
  • 45
    • 0042591064 scopus 로고    scopus 로고
    • Melatonin protects against lipid peroxidation and membrane rigidity in erythrocytes from patients undergoing cardiopulmonary bypass surgery
    • Ochoa JJ, Vílchez MJ, Palacios MA et al. Melatonin protects against lipid peroxidation and membrane rigidity in erythrocytes from patients undergoing cardiopulmonary bypass surgery. J Pineal Res 2003 35 : 104 108.
    • (2003) J Pineal Res , vol.35 , pp. 104-108
    • Ochoa, J.J.1    Vílchez, M.J.2    Palacios, M.A.3
  • 46
    • 0033681047 scopus 로고    scopus 로고
    • Melatonin reduces phenylhydrazine-induced oxidative damage to cellular membranes: Evidence for the involvement of iron
    • Karbownik M, Reiter RJ, García JJ et al. Melatonin reduces phenylhydrazine-induced oxidative damage to cellular membranes: evidence for the involvement of iron. Int J Biochem Cell Biol 2000 32 : 1045 1054.
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 1045-1054
    • Karbownik, M.1    Reiter, R.J.2    García, J.J.3
  • 47
    • 0034684174 scopus 로고    scopus 로고
    • Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by delta-aminolevulinic acid
    • Karbownik M, Reiter RJ, García JJ et al. Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by delta-aminolevulinic acid. Biochim Biophys Acta 2000 1523 : 140 146.
    • (2000) Biochim Biophys Acta , vol.1523 , pp. 140-146
    • Karbownik, M.1    Reiter, R.J.2    García, J.J.3
  • 48
    • 0033798101 scopus 로고    scopus 로고
    • Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation
    • Karbownik M, Reiter RJ, Qi W et al. Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation. Mol Cell Biochem 2000 211 : 137 144.
    • (2000) Mol Cell Biochem , vol.211 , pp. 137-144
    • Karbownik, M.1    Reiter, R.J.2    Qi, W.3
  • 49
    • 0027189788 scopus 로고
    • Free radical-lipid interactions and their pathological consequences
    • Rice-Evans C, Burdon R. Free radical-lipid interactions and their pathological consequences. Prog Lipid Res 1993 32 : 71 110.
    • (1993) Prog Lipid Res , vol.32 , pp. 71-110
    • Rice-Evans, C.1    Burdon, R.2
  • 50
    • 0027944443 scopus 로고
    • Alterations in mitochondrial membrane fluidity by lipid peroxidation products
    • Chen JJ, Yu BP. Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med 1994 17 : 411 418.
    • (1994) Free Radic Biol Med , vol.17 , pp. 411-418
    • Chen, J.J.1    Yu, B.P.2
  • 51
    • 33644749146 scopus 로고    scopus 로고
    • Therapeutic value of melatonin in an experimental model of liver injury and regeneration
    • Sigala F, Theocharis S, Sigalas K et al. Therapeutic value of melatonin in an experimental model of liver injury and regeneration. J Pineal Res 2006 40 : 270 279.
    • (2006) J Pineal Res , vol.40 , pp. 270-279
    • Sigala, F.1    Theocharis, S.2    Sigalas, K.3
  • 52
    • 33749262660 scopus 로고    scopus 로고
    • Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice
    • Noyan T, Kömüròlu U, Bayram I et al. Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice. Cell Biol Toxicol 2006 22 : 381 391.
    • (2006) Cell Biol Toxicol , vol.22 , pp. 381-391
    • Noyan, T.1    Kömüròlu, U.2    Bayram, I.3
  • 53
    • 57049122890 scopus 로고    scopus 로고
    • Inhibition of carbon tetrachloride-mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis
    • Ogeturk M, Kus I, Pekmez H et al. Inhibition of carbon tetrachloride-mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis. Toxicol Ind Health 2008 24 : 201 208.
    • (2008) Toxicol Ind Health , vol.24 , pp. 201-208
    • Ogeturk, M.1    Kus, I.2    Pekmez, H.3
  • 54
    • 0036215805 scopus 로고    scopus 로고
    • The protective effect of melatonin on renal ischemia-reperfusion injury in the rat
    • Sener G, Sehirli AO, Keyer-Uysal M et al. The protective effect of melatonin on renal ischemia-reperfusion injury in the rat. J Pineal Res 2002 32 : 120 126.
    • (2002) J Pineal Res , vol.32 , pp. 120-126
    • Sener, G.1    Sehirli, A.O.2    Keyer-Uysal, M.3
  • 55
    • 0038008675 scopus 로고    scopus 로고
    • Protective effects of melatonin, vitamin e and N-acetylcysteine against acetaminophen toxicity in mice: A comparative study
    • Sener G, Sehirli AO, Ayanoglu-Dulger G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. J Pineal Res 2003 35 : 61 68.
    • (2003) J Pineal Res , vol.35 , pp. 61-68
    • Sener, G.1    Sehirli, A.O.2    Ayanoglu-Dulger, G.3
  • 57
    • 0031981238 scopus 로고    scopus 로고
    • Comparison of the antioxidant activity of melatonin and pinoline in vitro
    • Pähkla R, Zilmer M, Kullisaar T et al. Comparison of the antioxidant activity of melatonin and pinoline in vitro. J Pineal Res 1998 24 : 96 101.
    • (1998) J Pineal Res , vol.24 , pp. 96-101
    • Pähkla, R.1    Zilmer, M.2    Kullisaar, T.3
  • 58
    • 0030914428 scopus 로고    scopus 로고
    • Pharmacological actions of melatonin in free radical pathophysiology
    • Reiter RJ, Tang L, García JJ et al. Pharmacological actions of melatonin in free radical pathophysiology. Life Sci 1997 60 : 2255 2271.
    • (1997) Life Sci , vol.60 , pp. 2255-2271
    • Reiter, R.J.1    Tang, L.2    García, J.J.3
  • 59
    • 34848844459 scopus 로고    scopus 로고
    • -) with the melatonin metabolite N1-acetyl-5- methoxykynuramine
    • -) with the melatonin metabolite N1-acetyl-5-methoxykynuramine. J Pineal Res 2007 43 : 382 388.
    • (2007) J Pineal Res , vol.43 , pp. 382-388
    • Hardeland, R.1    Backhaus, C.2    Fadavi, A.3
  • 60
    • 0017870178 scopus 로고
    • Major pharmacological effects of 6-methoxytetrahydro-b-carboline, a drug elevating the tissue 5-hydroxytryptamine level
    • Airaksinen MM, Ho BT, An R et al. Major pharmacological effects of 6-methoxytetrahydro-b-carboline, a drug elevating the tissue 5-hydroxytryptamine level. Arzneimittelforschung 1978 28 : 42 46.
    • (1978) Arzneimittelforschung , vol.28 , pp. 42-46
    • Airaksinen, M.M.1    Ho, B.T.2    An, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.