Liposomal NAD+ prevents diminished O2 consumption by immunostimulated Caco-2 cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 5 26-5, 2002, Pages

  Khan, Abrar U ^a   Delude, Russell L ^a   Han, Yong Y ^a   Sappington, Penny L ^a   Han, Xianonan ^a   Carcillo, Joseph A ^a   Fink, Mitchell P ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b 616 Scaife Hall ^*  (United States)

Author keywords

Enterocyte; Epithelium; Intestinal; Nitric oxide; Peroxynitrite; Poly(ADP ribose) polymerase

Indexed keywords

3 AMINOBENZAMIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOSOME; N (6 OXO 5,6 DIHYDROPHENANTHRIDIN 2 YL) N,N DIMETHYLACETAMIDE HYDROCHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXIDIZING AGENT; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SCAVENGER; TIRON; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URATE;

ARTICLE; CELL CULTURE; CELL HYPOXIA; CELL RESPIRATION; CELL STRAIN CACO 2; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INCUBATION TIME; INTESTINE CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REDUCTION; SEPSIS;

EID: 0036087218     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00358.2001     Document Type: Article

References (45)

1. Antagonist action of imidazolineoxyl N-oxides against endothelium derived relaxing factor/NO through a radical reaction
2. Negatively charged liposomes inhibit tyrosine phosphorylation of 41-kDa protein in murine macrophages stimulated with LPS
3. An improved cycling assay for nicotinamide adenine dinucleotide
4. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia
5. Skeletal muscle partial pressure of oxygen in patients with sepsis
6. Rapid reduction of nitric oxide by mitochondria and reversible inhibition of mitochondrial respiration by nitric oxide
7. Unilamellar liposomes modulate secretion of tumor necrosis factor by lipopolysaccharide-stimulated macrophages
8. Aconitase is readily inactivated by peroxynitrite, but not its precursor, nitric oxide
9. Cytokine-induced epithelial hyperpermeability: Role of nitric oxide
10. Poly- (ADP-ribosyl)ation reactions in the regulation of nuclear functions
11. Evaluation of free radical scavengers in studies of lymphocyte-mediated cytolysis
12. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells
13. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells
14. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure
15. Cytopathic hypoxia: Mitochondrial dysfunction as a mechanism contributing to organ dysfunction in sepsis
16. Rapid separation of low molecular weight solutes from liposomes without dilution
17. Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation
18. Interferon-γ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
19. Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration
20. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
21. L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
22. Oxidative metabolism in rat hepatocytes and mitochondria during sepsis
23. Poly(ADP-ribose) synthetase activation mediates increased intestinal epithelial permeability induced by peroxynitrite in Caco-2BBe cells
24. Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases
25. Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine
26. Peroxynitrite-mediated oxidation of dihydrorhodamine
27. BBe cultured intestinal epithelial monolayers
28. Preparation of liposomes
29. A simple ultramicro method for determination of pyridine nucleotides in tissues
30. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1-deficient mice
31. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
32. Inhibition of mitochondrial electron transport by peroxynitrite
33. Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis
34. Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage
35. Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
36. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase
37. Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication
38. Peroxynitrite causes energy depletion and increases permeability via activation of poly(ADP-ribose) synthetase in pulmonary epithelial cells
39. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite
40. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite
41. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 μm) by a combination of reverse-phase evaporation and extrusion through polycarbonate membranes
42. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock
43. Modified microassay for serum nitrate and nitrite
44. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
45. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide