Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrrioxamine (desferoxamine) in rat liver homogenates

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 10, 2001, Pages 1393-1401

  Gitto, E ^a   Tan, D X ^a   Reiter, R J ^a   Karbownik, M ^b   Manchester, L C ^a   Cuzzocrea, S ^c   Fulia, F ^c   Barberi, I ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; ALPHA TOCOPHEROL; ASCORBIC ACID; DEFEROXAMINE; FERROUS SULFATE; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; MALONALDEHYDE; MELATONIN;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CELL PROTECTION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENTIATION; DRUG SCREENING; IC 50; INHIBITION KINETICS; LIPID PEROXIDATION; LIVER HOMOGENATE; MALE; MEMBRANE DAMAGE; METABOLIC INHIBITION; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL MEMBRANE; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLUTATHIONE; LIPID PEROXIDATION; LIPIDS; MALONDIALDEHYDE; MELATONIN; PROTEINS; RATS; VITAMIN E;

EID: 0034763416     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011777747     Document Type: Article

References (45)

1. Glutathione and glutathione delivery compounds
2. On the antioxidant activity of melatonin
3. Free radicals: Dietary advantages and disadvantages
4. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical
5. Mechanism of anti-neuroblastoma activity of desferoxamine in vitro
6. Comparison of activity of desferoxamine with that of oral iron chelators against human neuroblastoma cell lines
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Scavenging effect of melatonin on hydroxyl radicals generated by alloxan
9. Oxygen-radical absorbance capacity assay for antioxidant
10. Tissue injury by free radicals
11. Retinal lipid peroxidation in vitro in inhibited by melatonin
12. Melatonin protects against gastric ischemia-reperfusion injury in rats
13. Melatonin and vitamin E limit oxide-induced lipid peroxidation in rat brain homogenates
14. Mechanisms of cell injury by activated oxygen species
15. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation
16. Longitudinal studies of the neurobiology of vitamin E and other antioxidant systems, and neurological function in the vitamin E deficient rat
17. Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats
18. New actions of melatonin and their relevance to biometeorology
19. On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photoxidation, and scavenging of free radicals
20. Does mega-C do more good than harm, or more harm than good?
21. Brain iron delocalization and lipid peroxidation following cardiac arrest
22. Effect of desferoxamine on late deaths following CPR in rats
23. The role of metabolism in the antioxidant function of vitamin E
24. The importance of vitamin E in human nutrition
25. Antioxidant properties of melatonin: A pulse radiolysis study
26. Melatonin: A peroxyl radical scavenger more effective than vitamin E
27. Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate, trolox, and glutathione
28. Chromium (III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: Comparative effects of melatonin, ascorbate and vitamin E
29. Biological antioxidant defences
30. Interaction of vitamin E, ascorbic acid, and glutathione in protection against oxidative damage
31. Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
32. Oxidative damage in the central nervous system: Protection by melatonin
33. Pharmacological actions of melatonin in free radical pathophysiology
34. Actions of melatonin in the reduction of oxidative stress: A review
35. Potential of iron chelator as effective antiproliferative agents
36. Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin
37. 2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin
38. The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates
39. Antioxidant defense: Vitamins E and C and carotenoids
40. Melatonin: A potent, endogenous hydroxyl radical scavenger
41. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of melatonin interaction with hydroxyl radicals
42. Significance of melatonin in antioxidative system: Reactions and products
43. Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation
44. Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells