Mitochondrial function and dysfunction in sepsis

Wiener Medizinische Wochenschrift

Volumn 160, Issue 5-6, 2010, Pages 118-123

  Wendel, Martina ^a   Heller, Axel R ^b  

^a Fachklinik Prinzregent Luitpold ^*  (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Cytokines; Mitochondria; Nitric oxide; Reactive nitrogen species; Reactive oxygen species; Sepsis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CYTOCHROME C OXIDASE; GLUTATHIONE; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SS 31; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; SUCCINIC ACID DIMETHYL ESTER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; XJB 5131;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CARDIOMYOPATHY; CELL ENERGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA STRAND BREAKAGE; DRUG TARGETING; ENDOTOXEMIA; ENERGY METABOLISM; HEART MUSCLE CONTRACTILITY; HEMORRHAGIC SHOCK; HUMAN; INFLAMMATION; INTESTINE EPITHELIUM CELL; LIVER MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATIENT MONITORING; RESPIRATORY CHAIN; REVIEW; SEPSIS; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA REPAIR; ENERGY METABOLISM; HUMANS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL MEMBRANES; MYOCARDIAL CONTRACTION; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SEPSIS;

EID: 77952495086     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-010-0766-5     Document Type: Review

References (36)

1. Clayton DA. Transcription and replication of animal mitochondrial DNAs. Int Rev Cytol, 141: 217-232, 1992.
2. Crimi E, Sica V, Williams-Ignarro S, et al. The role of oxidative stress in adult critical care. Free Radic Biol Med, 40: 398-406, 2006.
3. Biolo G, Antonione R, De Cicco M. Glutathione metabolism in sepsis. Crit Care Med, 35(Suppl.): S591-S595, 2007.
4. Suliman HB, Carraway MS, Piantadosi CA. Postlipopolysaccharide oxidative damage of mitochondrial DNA. Am J Respir Crit Care Med, 167: 570-579, 2007.
5. Suliman HB, Welty-Wolf KE, Carraway M, et al. Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res, 64: 279-288, 2004.
6. Svistunenko DA, Davies N, Brealey D, et al. Mitochondrial dysfunction in patients with severe sepsis: An EPR interrogation of individual respiratory chain components. Biochim Biopyhs Acta, 1757: 262-272, 2006.
7. Garcia-Ruiz C, Colell A, Mari M, et al. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. J Biol Chem, 272: 11369-11377, 1997.
8. Crouser ED, Julian MW, Dorinsky PM. Ileal VO2-DO2 alterations induced by endotoxin correlate with severity of mitochondrial injury. Am J Resp Crit Care Med, 160: 1347-1353, 1999.
9. Crouser ED, Julian MW, Blaho DV, Pfeiffer DR. Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med, 30: 276-284, 2002.
10. Tatsumi T, Akashi K, Keira N, et al. Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts. J Mol Cell Cardiol, 37: 775-784, 2004.
11. Welty-Wolf KE, Simonson SG, Huang YC, et al. Ultrastructural changes in skeletal muscle mitochondria in Gram-negative sepsis. Shock, 5: 378-384, 1996.
12. Soriano FG, Nogueira AC, Caldini EG, et al. Potential role of poly(adenosine 50-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial dysfunction associated with septic shock. Crit Care Med, 34: 1073-1079, 2006.
13. Vanhorebeek I, De Vos R, Mesotten D, et al. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet, 365: 53-69, 2005.
14. Baumgarten G, Knuefermann P, Schuhmacher G, et al. Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock, 25: 43-49, 2006.
15. Nemoto S, Vallejo JG, Knuefermann P, et al. Escherichia coli LPSinduced LV dysfunction: role of Toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol, 282: H2316-H2323, 2002.
16. Levy RJ, Deutschmann CS. Cytochrome c oxidase dysfunction in sepsis. Crit Care Med, 35(Suppl.): S468-S475, 2007.
17. Larche J, Lancel S, Hassoun SM, Favory R, et al. Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol, 48: 377-385, 2006.
18. Kurose I, Miura S, Higuchi H, et al. Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles of tumor necrosis factor alpha. Hepatology, 24: 1185-1192, 1996.
19. Tu W, Satoi S, Zhang Z, et al. Hepatocellular dysfunction induced by nitric oxide production in hepatocytes isolated from rats with sepsis. Shock, 19: 373-377, 2003.
20. Satoi S, Kamiyama Y, Kitade H, et al. Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. Clin Exp Pharmacol Physiol, 27: 197-201, 2000.
21. Berg S, Sappington PL, Guzik LJ, et al. Proinflammatory cytokines increase the rate of glycolysis and adenosine-50-triphosphate turnover in cultured rat enterocytes. Crit Care Med, 31: 1203-1212, 2003.
22. Khan AU, Delude RL, Han YH, et al. Liposomal NAD consumption prevents diminished O2 consumption by immunostimulated Caco-2 cells. Am J Physiol Lung Cell Mol Physiol, 282: L1082-L1091, 2002.
23. Cho S, Szeto HH, Kim E, et al. A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36. J Biol Chem, 282: 4634-4642, 2007.
24. Fink MP, Macias CA, Xiao J, et al. Hemigramicidin-TEMPO conjugates: Novel mitochondria-targeted antioxidants. Crit Care Med, 35(Suppl.): S461-S467, 2007. (Pubitemid 47312180)
25. King CJ, Tytgat S, Delude RL, Fink MP. Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med, 27: 2518-2524, 1999.
26. Matejovic M, Krouzecky A, Martinkova V, et al. Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock, 21: 458-465, 2004.
27. Lopez A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med, 32: 21-30, 2004.
28. Gerö D, Szabo C. Poly(ADP-ribose) polymerase: a new therapeutic target? Curr Opin Anaesthesiol, 21: 111-121, 2008.
29. Wang H, Zhu S, Zhou R, et al. Therapeutic potential of HMGB1- targeting agents in sepsis. Expert Rev Mol Med, 10: e32, 2008.
30. Cairns CB, Ferroggiaro AA, Walther JM, et al. Post-ischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury. Circulation, 96(9 Suppl.): II260-II265, 1997.
31. Ferreira FL, Ladriere L, Vincent JL, Malaisse WJ. Prolongation of survival time by infusion of succinic acid dimethyl ester in a caecal liagtion and perforation model of sepsis. Horm Metab Res, 32: 335-336, 2000.
32. Malaisse WJ, Nadi AB, Ladriere L, Zhang TM. Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia. Nutrition, 13: 330-341, 1997.
33. Schaefer CF, Lerner MR, Biber B. Dose-related reduction of intestinal cytochrome aa3 induced by endotoxin in rats. Circ Shock, 33: 17-25, 1991.
34. Kobayashi A, Okayama Y, Yamazaki N. 31P-NMR magnetization transfer study of reperfused rat heart. Mol Cell Biochem, 119: 121-127, 1993.
35. Rivers E, Nguyen B, Havstad S, et al. Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New Engl J Med, 345: 1368-1377, 2001.
36. Rivers EP, Kruse JA, Jacobsen G, et al. The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock. Crit Care Med, 35: 2016-2024, 2007.