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Volumn 17, Issue 6, 2002, Pages 471-481

The toxicology of aflatoxins as a basis for public health decisions

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; AFLATOXIN B1; ALDEHYDE REDUCTASE; BIOLOGICAL MARKER; CARCINOGEN; CHLOROPHYLL; DNA; GLUTATHIONE TRANSFERASE; OLTIPRAZ; PLACEBO; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; MUTAGENIC AGENT;

EID: 0036856464     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/17.6.471     Document Type: Review
Times cited : (390)

References (153)
  • 3
    • 0033854662 scopus 로고    scopus 로고
    • Effects of carcinogen-induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HepG2 cells and its implication on hepatocellular carcinomas
    • Banerjee, R., Caruccio, L., Zhang, Y.J., McKercher, S. and Santella, R.M. (2000) Effects of carcinogen-induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HepG2 cells and its implication on hepatocellular carcinomas. Hepatology, 32, 367-374.
    • (2000) Hepatology , vol.32 , pp. 367-374
    • Banerjee, R.1    Caruccio, L.2    Zhang, Y.J.3    McKercher, S.4    Santella, R.M.5
  • 4
    • 0029096455 scopus 로고
    • Synergistic hepatocarcinogenic effect of hepadnaviral infection and dietary aflatoxin B1 in woodchucks
    • Bannasch, P., Khoshkhou, N.I., Hacker, H.J. et al. (1995) Synergistic hepatocarcinogenic effect of hepadnaviral infection and dietary aflatoxin B1 in woodchucks. Cancer Res., 55, 3318-3330.
    • (1995) Cancer Res. , vol.55 , pp. 3318-3330
    • Bannasch, P.1    Khoshkhou, N.I.2    Hacker, H.J.3
  • 6
    • 0022258515 scopus 로고
    • Prostaglandin H synthase-dependent epoxidation of aflatoxin B1
    • Battista, J.R. and Marnett, L.J, (1985) Prostaglandin H synthase-dependent epoxidation of aflatoxin B1. Carcinogenesis, 6, 1227-1229.
    • (1985) Carcinogenesis , vol.6 , pp. 1227-1229
    • Battista, J.R.1    Marnett, L.J.2
  • 7
    • 0023829781 scopus 로고
    • Mapping the binding site of aflatoxin B1 in DNA: Systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences
    • Benasutti, M., Ejadi, S., Whitlow, M.D. and Loechler, E.L. (1988) Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences. Biochemistry, 27, 472-481.
    • (1988) Biochemistry , vol.27 , pp. 472-481
    • Benasutti, M.1    Ejadi, S.2    Whitlow, M.D.3    Loechler, E.L.4
  • 8
    • 0032972555 scopus 로고    scopus 로고
    • Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain. A study of 129 archival tumour samples
    • Boix-Ferrero, J., Pellin, A., Blesa, R., Adrados, M. and Llombart-Bosch, A. (1999) Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain. A study of 129 archival tumour samples. Virchows Arch., 434, 497-501.
    • (1999) Virchows Arch. , vol.434 , pp. 497-501
    • Boix-Ferrero, J.1    Pellin, A.2    Blesa, R.3    Adrados, M.4    Llombart-Bosch, A.5
  • 9
    • 0028988112 scopus 로고
    • p53 protein accumulation in European hepatocellular-carcinoma is not always dependent on p53 gene mutation
    • Bourdon, J.C., Derrico, A., Paterlini, P., Grigioni, W., May, E. and Debuire, B. (1995) p53 protein accumulation in European hepatocellular-carcinoma is not always dependent on p53 gene mutation. Gastroenterology, 108, 1176-1182.
    • (1995) Gastroenterology , vol.108 , pp. 1176-1182
    • Bourdon, J.C.1    Derrico, A.2    Paterlini, P.3    Grigioni, W.4    May, E.5    Debuire, B.6
  • 10
    • 0033566210 scopus 로고    scopus 로고
    • Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms
    • Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J. and Bailey, G. (1999) Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: an evaluation of reduced bioavailability vs. target organ protective mechanisms. Toxicol. Appl. Pharmacol., 158, 141-151.
    • (1999) Toxicol. Appl. Pharmacol. , vol.158 , pp. 141-151
    • Breinholt, V.1    Arbogast, D.2    Loveland, P.3    Pereira, C.4    Dashwood, R.5    Hendricks, J.6    Bailey, G.7
  • 11
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac, B., Kew, M., Wands, J. and Ozturk, M. (1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature, 350, 429-431.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 12
    • 0026546972 scopus 로고
    • Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues
    • Buetler, T.M. and Eaton, D.L. (1992) Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues. Cancer Res., 52, 314-318.
    • (1992) Cancer Res. , vol.52 , pp. 314-318
    • Buetler, T.M.1    Eaton, D.L.2
  • 14
    • 0028093279 scopus 로고
    • In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene
    • Cariello, N.F., Cui, L. and Skopek, T.R. (1994) In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene. Cancer Res., 54, 4436-4441.
    • (1994) Cancer Res. , vol.54 , pp. 4436-4441
    • Cariello, N.F.1    Cui, L.2    Skopek, T.R.3
  • 15
    • 0026448806 scopus 로고
    • Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain
    • Challen, C., Lunec, J., Warren, W., Collier, J. and Bassendine, M.F. (1992) Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain. Hepatology, 16, 1362-1366.
    • (1992) Hepatology , vol.16 , pp. 1362-1366
    • Challen, C.1    Lunec, J.2    Warren, W.3    Collier, J.4    Bassendine, M.F.5
  • 16
    • 0029844863 scopus 로고    scopus 로고
    • Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant-hepatitis
    • Chemin, I., Takahashi, S., Belloc, C., Lang, M.A., Ando, K., Guidotti, L.G., Chisari, F.V. and Wild, C.P. (1996) Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant-hepatitis. Hepatology, 24, 649-656.
    • (1996) Hepatology , vol.24 , pp. 649-656
    • Chemin, I.1    Takahashi, S.2    Belloc, C.3    Lang, M.A.4    Ando, K.5    Guidotti, L.G.6    Chisari, F.V.7    Wild, C.P.8
  • 17
    • 0033041076 scopus 로고    scopus 로고
    • Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen
    • Chemin, I., Ohgaki, H., Chisari, F.V. and Wild, C.P. (1999) Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen. Liver, 19, 81-87.
    • (1999) Liver , vol.19 , pp. 81-87
    • Chemin, I.1    Ohgaki, H.2    Chisari, F.V.3    Wild, C.P.4
  • 19
    • 0031418206 scopus 로고    scopus 로고
    • Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus
    • Chomarat, P., Sipowicz, M.A., Diwan, B.A., Fornwald, L.W., Awasthi, Y.C., Anver, M.R., Rice, J.M., Anderson, L.M. and Wild, C.P. (1997) Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus. Carcinogenesis, 18, 2179-2190.
    • (1997) Carcinogenesis , vol.18 , pp. 2179-2190
    • Chomarat, P.1    Sipowicz, M.A.2    Diwan, B.A.3    Fornwald, L.W.4    Awasthi, Y.C.5    Anver, M.R.6    Rice, J.M.7    Anderson, L.M.8    Wild, C.P.9
  • 20
    • 17444438044 scopus 로고    scopus 로고
    • Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: The role of the HBx protein
    • Chomarat, P., Rice, J.M., Slagle, B.L. and Wild, C.P. (1998) Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein. Toxicol. Lett., 102/103, 595-601.
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 595-601
    • Chomarat, P.1    Rice, J.M.2    Slagle, B.L.3    Wild, C.P.4
  • 21
    • 0027325389 scopus 로고
    • High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal
    • Coursaget, P., Depril, N., Chabaud, M., Nandi, R., Mayelo, V., LeCann, P. and Yvonnet, B. (1993) High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Br. J. Cancer, 67, 1395-1397.
    • (1993) Br. J. Cancer , vol.67 , pp. 1395-1397
    • Coursaget, P.1    Depril, N.2    Chabaud, M.3    Nandi, R.4    Mayelo, V.5    LeCann, P.6    Yvonnet, B.7
  • 22
    • 0032549474 scopus 로고    scopus 로고
    • Chemopreventive properties of chlorophylls towards aflatoxin B1: A review of the antimutagenicity and anticarcinogenicity data in rainbow trout
    • Dashwood, R., Negishi, T., Hayatsu, H., Breinholt, V., Hendricks, J. and Bailey, G. (1998) Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout. Mutat. Res., 399, 245-253.
    • (1998) Mutat. Res. , vol.399 , pp. 245-253
    • Dashwood, R.1    Negishi, T.2    Hayatsu, H.3    Breinholt, V.4    Hendricks, J.5    Bailey, G.6
  • 24
    • 0024336422 scopus 로고
    • Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus
    • De Flora, S., Hietanen, E., Bartsch, H., Camoirano, A., Izzotti, A., Bagnasco, M. and Millman, I. (1989) Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus. Carcinogenesis, 10, 1099-1106.
    • (1989) Carcinogenesis , vol.10 , pp. 1099-1106
    • De Flora, S.1    Hietanen, E.2    Bartsch, H.3    Camoirano, A.4    Izzotti, A.5    Bagnasco, M.6    Millman, I.7
  • 25
    • 0032506782 scopus 로고    scopus 로고
    • The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts
    • Denissenko, M.F, Koudriakova, T.B., Smith, L., O'Connor, T.R., Riggs, A.D. and Pfeifer, G.P. (1998) The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts. Oncogene, 17, 3007-3014.
    • (1998) Oncogene , vol.17 , pp. 3007-3014
    • Denissenko, M.F.1    Koudriakova, T.B.2    Smith, L.3    O'Connor, T.R.4    Riggs, A.D.5    Pfeifer, G.P.6
  • 26
    • 0032954049 scopus 로고    scopus 로고
    • Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems
    • Denissenko, M.F, Cahill, J., Koudriakova, T.B., Gerber, N. and Pfeifer, G.P. (1999) Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems. Mutat. Res., 425, 205-211.
    • (1999) Mutat. Res. , vol.425 , pp. 205-211
    • Denissenko, M.F.1    Cahill, J.2    Koudriakova, T.B.3    Gerber, N.4    Pfeifer, G.P.5
  • 28
    • 0028341249 scopus 로고
    • Absence of p53 mutation at codon 249 in duck hepatocellular carcinomas from the high incidence area of Qidong (China)
    • Duflot, A., Hollstein, M., Mehrotra, R., Trepo, C., Montesano, R. and Cova, L. (1994) Absence of p53 mutation at codon 249 in duck hepatocellular carcinomas from the high incidence area of Qidong (China). Carcinogenesis, 15, 1353-1357.
    • (1994) Carcinogenesis , vol.15 , pp. 1353-1357
    • Duflot, A.1    Hollstein, M.2    Mehrotra, R.3    Trepo, C.4    Montesano, R.5    Cova, L.6
  • 29
    • 0029112585 scopus 로고
    • Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation
    • Dumenco, L., Oguey, D., Wu, J., Messier, N. and Fausto, N. (1995) Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation. Hepatology, 22, 1279-1288.
    • (1995) Hepatology , vol.22 , pp. 1279-1288
    • Dumenco, L.1    Oguey, D.2    Wu, J.3    Messier, N.4    Fausto, N.5
  • 31
    • 0003778537 scopus 로고
    • The Toxicology of the Aflatoxins: Human Health, Veterinary, and Agricultural Signficance
    • Academic Press, London, UK
    • Eaton, D.L. and Groopman, J.D. (1994) The Toxicology of the Aflatoxins: Human Health, Veterinary, and Agricultural Signficance. Academic Press, London, UK.
    • (1994)
    • Eaton, D.L.1    Groopman, J.D.2
  • 32
    • 0035807837 scopus 로고    scopus 로고
    • Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
    • Egner, P.A., Wang, J.B., Zhu, Y.R. et al. (2001) Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc. Natl Acad. Sci. USA, 98, 14601-14606.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14601-14606
    • Egner, P.A.1    Wang, J.B.2    Zhu, Y.R.3
  • 33
    • 0029027667 scopus 로고
    • Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent
    • Forrester, K., Lupold, S.E., Ott, V.L., Chay, C.H., Band, V., Wang, X.W. and Harris, C.C. (1995) Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent. Oncogene, 10, 2103-2111.
    • (1995) Oncogene , vol.10 , pp. 2103-2111
    • Forrester, K.1    Lupold, S.E.2    Ott, V.L.3    Chay, C.H.4    Band, V.5    Wang, X.W.6    Harris, C.C.7
  • 34
    • 0020519324 scopus 로고
    • Base substitution mutations induced by metabolically activated aflatoxin B1
    • Foster, P.L., Eisenstadt, E. and Miller, J.H. (1983) Base substitution mutations induced by metabolically activated aflatoxin B1. Proc. Natl Acad. Sci. USA, 80, 2695-2698.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 2695-2698
    • Foster, P.L.1    Eisenstadt, E.2    Miller, J.H.3
  • 35
    • 0026532048 scopus 로고
    • Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates
    • Fujimoto, Y., Hampton, L.L., Luo, L.D., Wirth, P.J. and Thorgeirsson, S.S. (1992) Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates. Cancer Res., 52, 1044-1046.
    • (1992) Cancer Res. , vol.52 , pp. 1044-1046
    • Fujimoto, Y.1    Hampton, L.L.2    Luo, L.D.3    Wirth, P.J.4    Thorgeirsson, S.S.5
  • 36
    • 0028084735 scopus 로고
    • Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China
    • Fujimoto, Y., Hampton, L.L., Wirth, P.J., Wang, N.J., Xie, J.P. and Thorgeirsson, S.S. (1994) Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res., 54, 281-285.
    • (1994) Cancer Res. , vol.54 , pp. 281-285
    • Fujimoto, Y.1    Hampton, L.L.2    Wirth, P.J.3    Wang, N.J.4    Xie, J.P.5    Thorgeirsson, S.S.6
  • 37
    • 0030339769 scopus 로고    scopus 로고
    • The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4
    • Gallagher, E.P., Kunze, K.L., Stapleton, P.L. and Eaton, D.L. (1996) The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol. Appl. Pharmacol., 141, 595-606.
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 595-606
    • Gallagher, E.P.1    Kunze, K.L.2    Stapleton, P.L.3    Eaton, D.L.4
  • 39
    • 0025198508 scopus 로고
    • Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: Comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2
    • Gopalakrishnan, S., Harris, T.M. and Stone, M.P. (1990) Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2. Biochemistry, 29, 10438-10448.
    • (1990) Biochemistry , vol.29 , pp. 10438-10448
    • Gopalakrishnan, S.1    Harris, T.M.2    Stone, M.P.3
  • 40
    • 0032919238 scopus 로고    scopus 로고
    • The light at the end of the tunnel for chemical-specific biomarkers: Daylight or headlight?
    • Groopman, J.D. and Kensler, T.W. (1999) The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis, 20, 1-11.
    • (1999) Carcinogenesis , vol.20 , pp. 1-11
    • Groopman, J.D.1    Kensler, T.W.2
  • 41
    • 0022136725 scopus 로고
    • Aflatoxin metabolism in humans: Detection of metabolites and nucleic acid adducts in urine by affinity chromatography
    • Groopman, J.D., Donahue, P.R., Zhu, J.Q., Chen, J.S. and Wogan, G.N. (1985) Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proc. Natl Acad. Sci. USA, 82, 6492-6496.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 6492-6496
    • Groopman, J.D.1    Donahue, P.R.2    Zhu, J.Q.3    Chen, J.S.4    Wogan, G.N.5
  • 42
    • 0026501157 scopus 로고
    • Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats
    • Groopman, J.D., DeMatos, P., Egner, P.A., Love-Hunt, A. and Kensler, T.W. (1992) Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis, 13, 101-106.
    • (1992) Carcinogenesis , vol.13 , pp. 101-106
    • Groopman, J.D.1    DeMatos, P.2    Egner, P.A.3    Love-Hunt, A.4    Kensler, T.W.5
  • 44
    • 0027436854 scopus 로고
    • The mutation of codon-249 in the p53 gene is not specific in Japanese hepatocellular-carcinoma
    • Hayashi, H., Sugio, K., Matsumata, T., Adachi, E., Urata, K., Tanaka, S. and Sugimachi, K. (1993) The mutation of codon-249 in the p53 gene is not specific in Japanese hepatocellular-carcinoma. Liver, 13, 279-281.
    • (1993) Liver , vol.13 , pp. 279-281
    • Hayashi, H.1    Sugio, K.2    Matsumata, T.3    Adachi, E.4    Urata, K.5    Tanaka, S.6    Sugimachi, K.7
  • 45
    • 0026050193 scopus 로고
    • Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide
    • Hayes, J.D., Judah, D.J., McLellan, L.I., Kerr, L.A., Peacock, S.D. and Neal, G.E. (1991) Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J., 279, 385-398.
    • (1991) Biochem. J. , vol.279 , pp. 385-398
    • Hayes, J.D.1    Judah, D.J.2    McLellan, L.I.3    Kerr, L.A.4    Peacock, S.D.5    Neal, G.E.6
  • 46
    • 0026639135 scopus 로고
    • Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide
    • Hayes, J.D., Judah, D.J., Neal, G.E. and Nguyen, T. (1992) Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J., 285, 173-180.
    • (1992) Biochem. J. , vol.285 , pp. 173-180
    • Hayes, J.D.1    Judah, D.J.2    Neal, G.E.3    Nguyen, T.4
  • 47
    • 0027337582 scopus 로고
    • Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
    • Hayes, J.D., Judah, D.J. and Neal, G.E. (1993) Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. Cancer Res., 53, 3887-3894.
    • (1993) Cancer Res. , vol.53 , pp. 3887-3894
    • Hayes, J.D.1    Judah, D.J.2    Neal, G.E.3
  • 48
    • 0029664692 scopus 로고    scopus 로고
    • Determination of aflatoxin B1 biotransformation and binding to hepatic macromolecules in human precision liver slices
    • Heinonen, J.T., Fisher, R., Brendel, K. and Eaton, D.L. (1996) Determination of aflatoxin B1 biotransformation and binding to hepatic macromolecules in human precision liver slices. Toxicol. Appl. Pharmacol., 136, 1-7.
    • (1996) Toxicol. Appl. Pharmacol. , vol.136 , pp. 1-7
    • Heinonen, J.T.1    Fisher, R.2    Brendel, K.3    Eaton, D.L.4
  • 50
    • 0027510125 scopus 로고
    • Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas
    • Hosono, S., Chou, M.J., Lee, C.S. and Shih, C. (1993) Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas. Oncogene, 8, 491-496.
    • (1993) Oncogene , vol.8 , pp. 491-496
    • Hosono, S.1    Chou, M.J.2    Lee, C.S.3    Shih, C.4
  • 51
    • 0028997943 scopus 로고
    • Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: Lack of association
    • Hsieh, D.P.H. and Atkinson, D.N. (1995) Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. Food Addit. Contam., 12, 421-424.
    • (1995) Food Addit. Contam. , vol.12 , pp. 421-424
    • Hsieh, D.P.H.1    Atkinson, D.N.2
  • 52
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu, I.C., Metcalf, R.A, Sun, T., Welsh, J.A., Wang, N.J. and Harris, C.C. (1991) Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature, 350, 427-428.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 53
    • 0027344549 scopus 로고
    • Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene
    • Hulla, J.E., Chen, Z.Y. and Eaton, D.L. (1993) Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene. Cancer Res., 53, 9-11.
    • (1993) Cancer Res. , vol.53 , pp. 9-11
    • Hulla, J.E.1    Chen, Z.Y.2    Eaton, D.L.3
  • 54
    • 0035217180 scopus 로고    scopus 로고
    • The genetic determinants of the CYP3A5 polymorphism
    • Hustert, E., Haberl, M., Burk, O. et al. (2001) The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics, 11, 773-779.
    • (2001) Pharmacogenetics , vol.11 , pp. 773-779
    • Hustert, E.1    Haberl, M.2    Burk, O.3
  • 55
    • 0011840567 scopus 로고
    • IARC IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Naturally Occurring Substances: Food Items and Constitutents, Heterocyclic Armonatic Amines and Mycotoxins, IARC Scientific Publications no. 56. IARC, Lyon
    • IARC (1993) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Naturally Occurring Substances: Food Items and Constitutents, Heterocyclic Armonatic Amines and Mycotoxins, IARC Scientific Publications no. 56. IARC, Lyon.
    • (1993)
  • 56
    • 2642565982 scopus 로고    scopus 로고
    • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Traditional Herbal Medicines, Some Mycotoxins, Napthalene and Styrene
    • IARC 2002, in press. IARC, Lyon
    • IARC (2002) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Traditional Herbal Medicines, Some Mycotoxins, Napthalene and Styrene. Vol 82, 2002, in press. IARC, Lyon.
    • (2002) , vol.82
  • 57
    • 0032524187 scopus 로고    scopus 로고
    • Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: Evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase
    • Ireland, L.S., Harrison, D.J., Neal, G.E. and Hayes, J.D. (1998) Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. Biochem. J., 332, 21-34.
    • (1998) Biochem. J. , vol.332 , pp. 21-34
    • Ireland, L.S.1    Harrison, D.J.2    Neal, G.E.3    Hayes, J.D.4
  • 58
  • 59
    • 0035137702 scopus 로고    scopus 로고
    • Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
    • Jackson, P.E., Qian, G.S., Friesen, M.D., Zhu, Y.R., Lu, P., Wang, J.B., Wu, Y., Kensler, T.W., Vogelstein, B. and Groopman, J.D. (2001) Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Cancer Res., 61, 33-35.
    • (2001) Cancer Res. , vol.61 , pp. 33-35
    • Jackson, P.E.1    Qian, G.S.2    Friesen, M.D.3    Zhu, Y.R.4    Lu, P.5    Wang, J.B.6    Wu, Y.7    Kensler, T.W.8    Vogelstein, B.9    Groopman, J.D.10
  • 60
    • 16944362010 scopus 로고    scopus 로고
    • Oltipraz chemoprevention trial in Qidong, People's Republic of China: Study design and clinical outcomes
    • Jacobson, L.P, Zhang, B.C., Zhu, Y.R. et al. (1997) Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes. Cancer Epidemiol. Biomarkers Prev., 6, 257-265.
    • (1997) Cancer Epidemiol. Biomarkers Prev. , vol.6 , pp. 257-265
    • Jacobson, L.P.1    Zhang, B.C.2    Zhu, Y.R.3
  • 63
    • 0030894660 scopus 로고    scopus 로고
    • Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: Estimation of kinetic parameters
    • Johnson, W.W., Ueng, Y.F., Widersten, M., Mannervik, B., Hayes, J.D., Sherratt, P.J., Ketterer, B. and Guengerich, F.P. (1997a) Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. Biochemistry, 36, 3056-3060.
    • (1997) Biochemistry , vol.36 , pp. 3056-3060
    • Johnson, W.W.1    Ueng, Y.F.2    Widersten, M.3    Mannervik, B.4    Hayes, J.D.5    Sherratt, P.J.6    Ketterer, B.7    Guengerich, F.P.8
  • 64
    • 0030612534 scopus 로고    scopus 로고
    • Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase
    • Johnson, W.W., Yamazaki, H., Shimada, T., Ueng, Y.F. and Guengerich, F.P. (1997b) Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. Chem. Res. Toxicol., 10, 672-676.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 672-676
    • Johnson, W.W.1    Yamazaki, H.2    Shimada, T.3    Ueng, Y.F.4    Guengerich, F.P.5
  • 65
    • 0027245948 scopus 로고
    • A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
    • Judah, D.J., Hayes, J.D., Yang, J.C., Lian, L.Y, Roberts, G.C., Farmer, P.B., Lamb, J.H. and Neal, G.E. (1993) A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant. Biochem. J., 292, 13-18.
    • (1993) Biochem. J. , vol.292 , pp. 13-18
    • Judah, D.J.1    Hayes, J.D.2    Yang, J.C.3    Lian, L.Y.4    Roberts, G.C.5    Farmer, P.B.6    Lamb, J.H.7    Neal, G.E.8
  • 66
    • 0029609048 scopus 로고
    • Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice
    • Kamataki, T., Hashimoto, H., Shimoji, M., Itoh, S., Nakayama, K., Hattori, K., Yokoi, T., Katsuki, M. and Aizawa, S. (1995) Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice. Toxicol. Lett., 82/83, 879-882.
    • (1995) Toxicol. Lett. , vol.82-83 , pp. 879-882
    • Kamataki, T.1    Hashimoto, H.2    Shimoji, M.3    Itoh, S.4    Nakayama, K.5    Hattori, K.6    Yokoi, T.7    Katsuki, M.8    Aizawa, S.9
  • 67
    • 0031416757 scopus 로고    scopus 로고
    • Minisatellite rearrangements are increased in liver tumours induced by transplacental aflatoxin B1 treatment of hepatitis B virus transgenic mice, but not in spontaneously arising tumours
    • Kaplanski, C., Chisari, F.V. and Wild, C.P. (1997) Minisatellite rearrangements are increased in liver tumours induced by transplacental aflatoxin B1 treatment of hepatitis B virus transgenic mice, but not in spontaneously arising tumours. Carcinogenesis, 18, 633-639.
    • (1997) Carcinogenesis , vol.18 , pp. 633-639
    • Kaplanski, C.1    Chisari, F.V.2    Wild, C.P.3
  • 68
    • 0034177905 scopus 로고    scopus 로고
    • P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India
    • Katiyar, S., Dash, B.C., Thakur, V., Guptan, R.C., Sarin, S.K. and Das, B.C. (2000) P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India. Cancer, 88, 1565-1573.
    • (2000) Cancer , vol.88 , pp. 1565-1573
    • Katiyar, S.1    Dash, B.C.2    Thakur, V.3    Guptan, R.C.4    Sarin, S.K.5    Das, B.C.6
  • 69
    • 0029829190 scopus 로고    scopus 로고
    • p53 abnormalities in hepatocellular carcinoma from United States patients: Analysis of all 11 exons
    • Kazachkov, Y., Khaoustov, V., Yoffe, B., Solomon, H., Klintmalm, G.B.G. and Tabor, E. (1996) p53 abnormalities in hepatocellular carcinoma from United States patients: analysis of all 11 exons. Carcinogenesis, 17, 2207-2212.
    • (1996) Carcinogenesis , vol.17 , pp. 2207-2212
    • Kazachkov, Y.1    Khaoustov, V.2    Yoffe, B.3    Solomon, H.4    Klintmalm, G.B.G.5    Tabor, E.6
  • 70
    • 0022497046 scopus 로고
    • Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: Role of induction of glutathione S-transferases
    • Kensler, T.W., Egner, P.A., Davidson, N.E., Roebuck, B.D., Pikul, A. and Groopman, J.D. (1986) Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res., 46, 3924-3931.
    • (1986) Cancer Res. , vol.46 , pp. 3924-3931
    • Kensler, T.W.1    Egner, P.A.2    Davidson, N.E.3    Roebuck, B.D.4    Pikul, A.5    Groopman, J.D.6
  • 72
    • 0343545529 scopus 로고    scopus 로고
    • Oltipraz chemoprevention trial in Qidong, People's Republic of China: Modulation of serum aflatoxin albumin adduct biomarkers
    • Kensler, T.W., He, X., Otieno, M. et al. (1998) Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers. Cancer Epidemiol. Biomarkers Prev., 7, 127-134.
    • (1998) Cancer Epidemiol. Biomarkers Prev. , vol.7 , pp. 127-134
    • Kensler, T.W.1    He, X.2    Otieno, M.3
  • 74
    • 0028114747 scopus 로고
    • Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice
    • Kirby, G.M., Chemin, I., Montesano, R., Chisari, F.V., Lang, M.A. and Wild, C.P. (1994a) Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice. Mol. Carcinog., 11, 74-80.
    • (1994) Mol. Carcinog. , vol.11 , pp. 74-80
    • Kirby, G.M.1    Chemin, I.2    Montesano, R.3    Chisari, F.V.4    Lang, M.A.5    Wild, C.P.6
  • 75
    • 0028004322 scopus 로고
    • Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver
    • Kirby, G.M., Pelkonen, P., Vatanasapt, V., Camus, A.M., Wild, C.P. and Lang, M.A. (1994b) Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Mol. Carcinog., 11, 81-89.
    • (1994) Mol. Carcinog. , vol.11 , pp. 81-89
    • Kirby, G.M.1    Pelkonen, P.2    Vatanasapt, V.3    Camus, A.M.4    Wild, C.P.5    Lang, M.A.6
  • 78
    • 0032814943 scopus 로고    scopus 로고
    • cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3
    • Knight, L.P., Primiano, T., Groopman, J.D., Kensler, T.W. and Sutter, T.R. (1999) cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Carcinogenesis, 20, 1215-1223.
    • (1999) Carcinogenesis , vol.20 , pp. 1215-1223
    • Knight, L.P.1    Primiano, T.2    Groopman, J.D.3    Kensler, T.W.4    Sutter, T.R.5
  • 79
    • 0030886974 scopus 로고    scopus 로고
    • An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot
    • Kobertz, W.R., Wang, D., Wogan, G.N. and Essigmann, J.M. (1997) An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot. Proc. Natl Acad. Sci. USA, 94, 9579-9584.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9579-9584
    • Kobertz, W.R.1    Wang, D.2    Wogan, G.N.3    Essigmann, J.M.4
  • 81
    • 0027186579 scopus 로고
    • Genetic changes and histopathological grades in human hepatocellular carcinomas
    • Konishi, M., Kikuchiyanoshita, R., Tanaka, K. et al. (1993) Genetic changes and histopathological grades in human hepatocellular carcinomas. Jpn. J. Cancer Res., 84, 893-899.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 893-899
    • Konishi, M.1    Kikuchiyanoshita, R.2    Tanaka, K.3
  • 82
    • 0028069350 scopus 로고
    • Aflatoxin B1-adduct formation in rat and human small bowel enterocytes
    • Kolars, J.C., Benedict, P., Schmiedlin Ren, P. and Watkins, P.B. (1994) Aflatoxin B1-adduct formation in rat and human small bowel enterocytes. Gastroenterology, 106, 433-439.
    • (1994) Gastroenterology , vol.106 , pp. 433-439
    • Kolars, J.C.1    Benedict, P.2    Schmiedlin Ren, P.3    Watkins, P.B.4
  • 83
    • 0026740713 scopus 로고
    • p53 mutations in human hepatocellular carcinomas from Germany
    • Kress, S., Jahn, U.R., Buchmann, A., Bannasch, P. and Schwarz, M. (1992) p53 mutations in human hepatocellular carcinomas from Germany. Cancer Res., 52, 3220-3223.
    • (1992) Cancer Res. , vol.52 , pp. 3220-3223
    • Kress, S.1    Jahn, U.R.2    Buchmann, A.3    Bannasch, P.4    Schwarz, M.5
  • 84
    • 0029027985 scopus 로고
    • Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event
    • Kubicka, S., Trautwein, C., Schrem, H., Tillmann, H. and Manns, M. (1995) Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event. J. Hepatol., 23, 412-419.
    • (1995) J. Hepatol. , vol.23 , pp. 412-419
    • Kubicka, S.1    Trautwein, C.2    Schrem, H.3    Tillmann, H.4    Manns, M.5
  • 85
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl, P., Zhang, J., Lin, Y. et al. (2001) Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genet., 27, 383-391.
    • (2001) Nature Genet. , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 86
    • 0028865229 scopus 로고
    • Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture
    • Langouet, S., Coles, B., Morel, F., Becquemont, L., Beaune, P., Guengerich, F.P., Ketterer, B. and Guillouzo, A. (1995) Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. Cancer Res., 55, 5574-5579.
    • (1995) Cancer Res. , vol.55 , pp. 5574-5579
    • Langouet, S.1    Coles, B.2    Morel, F.3    Becquemont, L.4    Beaune, P.5    Guengerich, F.P.6    Ketterer, B.7    Guillouzo, A.8
  • 87
    • 0030926083 scopus 로고    scopus 로고
    • Hepatocellular carcinoma p53 G→T transversions at codon 249: The fingerprint of aflatoxin exposure?
    • Lasky, T. and Magder, L. (1997) Hepatocellular carcinoma p53 G→T transversions at codon 249: the fingerprint of aflatoxin exposure? Environ. Health Perspect., 105, 392-397.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 392-397
    • Lasky, T.1    Magder, L.2
  • 89
    • 0032513173 scopus 로고    scopus 로고
    • p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions
    • Lee, C.C., Liu, J.Y., Lin, J.K., Chu, J.S. and Shew, J.Y. (1998) p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions. Cancer Lett., 125, 1-7.
    • (1998) Cancer Lett. , vol.125 , pp. 1-7
    • Lee, C.C.1    Liu, J.Y.2    Lin, J.K.3    Chu, J.S.4    Shew, J.Y.5
  • 90
    • 0026698102 scopus 로고
    • Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma, pigmentosum and DNA repair proficient human cells
    • Levy, D.D., Groopman, J.D., Lim, S.E., Seidman, M.M. and Kraemer, K.H. (1992) Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma, pigmentosum and DNA repair proficient human cells. Cancer Res., 52, 5668-5673.
    • (1992) Cancer Res. , vol.52 , pp. 5668-5673
    • Levy, D.D.1    Groopman, J.D.2    Lim, S.E.3    Seidman, M.M.4    Kraemer, K.H.5
  • 91
    • 0027210367 scopus 로고
    • Aberrations of p53 gene in human hepatocellular carcinoma from China
    • Li, D., Cao, Y., He, L., Wang, N.J. and Gu, J.R. (1993) Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis, 14, 169-173.
    • (1993) Carcinogenesis , vol.14 , pp. 169-173
    • Li, D.1    Cao, Y.2    He, L.3    Wang, N.J.4    Gu, J.R.5
  • 92
    • 0034213737 scopus 로고    scopus 로고
    • Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis)
    • Li, Y., Su, J., Qin, L., Egner, P.A., Wang, J., Groopman, J.D., Kensler, T.W. and Roebuck, B.D. (2000) Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis). Cancer Lett., 154, 79-83.
    • (2000) Cancer Lett. , vol.154 , pp. 79-83
    • Li, Y.1    Su, J.2    Qin, L.3    Egner, P.A.4    Wang, J.5    Groopman, J.D.6    Kensler, T.W.7    Roebuck, B.D.8
  • 93
    • 0030791718 scopus 로고    scopus 로고
    • p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan
    • Lunn, R.M., Zhang, Y.J., Wang, L.Y., Chen, C.J., Lee, P.H., Lee, C.S., Tsai, W.Y. and Santella, R.M. (1997) p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res., 57, 3471-3477.
    • (1997) Cancer Res. , vol.57 , pp. 3471-3477
    • Lunn, R.M.1    Zhang, Y.J.2    Wang, L.Y.3    Chen, C.J.4    Lee, P.H.5    Lee, C.S.6    Tsai, W.Y.7    Santella, R.M.8
  • 94
    • 0033152748 scopus 로고    scopus 로고
    • XRCC1 polymorphisms: Effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency
    • Lunn, R.M., Langlois, R.G., Hsieh, L.L., Thompson, C.L. and Bell, D.A. (1999) XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res., 59, 2557-2561.
    • (1999) Cancer Res. , vol.59 , pp. 2557-2561
    • Lunn, R.M.1    Langlois, R.G.2    Hsieh, L.L.3    Thompson, C.L.4    Bell, D.A.5
  • 95
    • 0028965135 scopus 로고
    • Cellular interactions and metabolism of aflatoxin: An update
    • McLean, M. and Dutton, M.F. (1995) Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther., 65, 163-192.
    • (1995) Pharmacol. Ther. , vol.65 , pp. 163-192
    • McLean, M.1    Dutton, M.F.2
  • 96
    • 0031442701 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: From gene to public health
    • Montesano, R., Hainaut, P. and Wild, C.P. (1997) Hepatocellular carcinoma: from gene to public health. J. Natl Cancer Inst., 89, 1844-1851.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1844-1851
    • Montesano, R.1    Hainaut, P.2    Wild, C.P.3
  • 97
    • 0027497708 scopus 로고
    • Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones
    • Morel, F., Fardel, O., Meyer, D.J., Langouet, S., Gilmore, K.S., Meunier, B., Tu, C.P., Kensler, T.W., Ketterer, B. and Guillouzo, A. (1993) Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones. Cancer Res., 53, 231-234.
    • (1993) Cancer Res. , vol.53 , pp. 231-234
    • Morel, F.1    Fardel, O.2    Meyer, D.J.3    Langouet, S.4    Gilmore, K.S.5    Meunier, B.6    Tu, C.P.7    Kensler, T.W.8    Ketterer, B.9    Guillouzo, A.10
  • 98
    • 0022270571 scopus 로고
    • The metabolism of aflatoxin B1 by human liver
    • Moss, E.J. and Neal, G.E. (1985) The metabolism of aflatoxin B1 by human liver. Biochem. Pharmacol., 34, 3193-3197.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3193-3197
    • Moss, E.J.1    Neal, G.E.2
  • 99
    • 0026041836 scopus 로고
    • Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
    • Murakami, Y., Hayashi, K., Hirohashi, S. and Sekiya, T. (1991) Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res., 51, 5520-5525.
    • (1991) Cancer Res. , vol.51 , pp. 5520-5525
    • Murakami, Y.1    Hayashi, K.2    Hirohashi, S.3    Sekiya, T.4
  • 101
    • 0028123801 scopus 로고
    • p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese
    • Ng, I.O., Chung, L.P., Tsang, S.W., Lam, C.L., Lai, E.C., Fan, S.T. and Ng, M. (1994a) p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene, 9, 985-990.
    • (1994) Oncogene , vol.9 , pp. 985-990
    • Ng, I.O.1    Chung, L.P.2    Tsang, S.W.3    Lam, C.L.4    Lai, E.C.5    Fan, S.T.6    Ng, M.7
  • 102
    • 0028226101 scopus 로고
    • Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people
    • Ng, I.O., Srivastava, G., Chung, L.P., Tsang, S.W. and Ng, M.M. (1994b) Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people. Cancer, 74, 30-37.
    • (1994) Cancer , vol.74 , pp. 30-37
    • Ng, I.O.1    Srivastava, G.2    Chung, L.P.3    Tsang, S.W.4    Ng, M.M.5
  • 103
    • 0027243142 scopus 로고
    • p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan
    • Nose, H., Imazeki, F., Ohto, M. and Omata, M. (1993) p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan. Cancer, 72, 355-360.
    • (1993) Cancer , vol.72 , pp. 355-360
    • Nose, H.1    Imazeki, F.2    Ohto, M.3    Omata, M.4
  • 104
    • 0026459290 scopus 로고
    • p53 gene mutation spectrum in hepatocellular carcinoma
    • Oda, T., Tsuda, H., Scarpa, A., Sakamoto, M. and Hirohashi, S. (1992) p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res., 52, 6358-6364.
    • (1992) Cancer Res. , vol.52 , pp. 6358-6364
    • Oda, T.1    Tsuda, H.2    Scarpa, A.3    Sakamoto, M.4    Hirohashi, S.5
  • 105
    • 0025748539 scopus 로고
    • p53 mutation in hepatocellular carcinoma after aflatoxin exposure
    • Ozturk, M. (1991) p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet, 338, 1356-1359.
    • (1991) Lancet , vol.338 , pp. 1356-1359
    • Ozturk, M.1
  • 106
    • 0034643920 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1
    • Park, U.S., Su, J.J., Ban, K.C., Qin, L., Lee, E.H. and Lee, Y.I. (2000) Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1. Gene, 251, 73-80.
    • (2000) Gene , vol.251 , pp. 73-80
    • Park, U.S.1    Su, J.J.2    Ban, K.C.3    Qin, L.4    Lee, E.H.5    Lee, Y.I.6
  • 107
    • 0030453076 scopus 로고    scopus 로고
    • Mutation of tumor suppressor gene p53 in hepatocelluclar carcinomas from Korea
    • Park, Y.M., Yoo, Y.D., Paik, S.Y., Kim, B.S. and Tabor, E. (1996) Mutation of tumor suppressor gene p53 in hepatocelluclar carcinomas from Korea. Exp. Mol. Med., 28, 173-179.
    • (1996) Exp. Mol. Med. , vol.28 , pp. 173-179
    • Park, Y.M.1    Yoo, Y.D.2    Paik, S.Y.3    Kim, B.S.4    Tabor, E.5
  • 108
  • 109
    • 0026356298 scopus 로고
    • Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens
    • Puisieux, A., Lim, S., Groopman, J. and Ozturk, M. (1991) Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res., 51, 6185-6189.
    • (1991) Cancer Res. , vol.51 , pp. 6185-6189
    • Puisieux, A.1    Lim, S.2    Groopman, J.3    Ozturk, M.4
  • 111
    • 0025135056 scopus 로고
    • Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides
    • Raney, K.D., Gopalakrishnan, S., Byrd, S., Stone, M.P. and Harris, T.M. (1990) Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides. Chem. Res. Toxicol., 3, 254-261.
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 254-261
    • Raney, K.D.1    Gopalakrishnan, S.2    Byrd, S.3    Stone, M.P.4    Harris, T.M.5
  • 112
    • 0026730960 scopus 로고
    • Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases
    • Raney, K.D., Meyer, D.J., Ketterer, B., Harris, T.M. and Guengerich, F.P. (1992) Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. Chem. Res. Toxicol., 5, 470-478.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 470-478
    • Raney, K.D.1    Meyer, D.J.2    Ketterer, B.3    Harris, T.M.4    Guengerich, F.P.5
  • 113
    • 0027533120 scopus 로고
    • DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin-B1 8,9-exo-epoxide
    • Raney, V.M., Harris, T.M. and Stone, M.P. (1993) DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin-B1 8,9-exo-epoxide. Chem. Res. Toxicol., 6, 64-68.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 64-68
    • Raney, V.M.1    Harris, T.M.2    Stone, M.P.3
  • 114
    • 0027986684 scopus 로고
    • State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses
    • Rivkina, M., Cullen, J.M., Robinson, W.S. and Marion, P.L. (1994) State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses. Cancer Res., 54, 5430-5437.
    • (1994) Cancer Res. , vol.54 , pp. 5430-5437
    • Rivkina, M.1    Cullen, J.M.2    Robinson, W.S.3    Marion, P.L.4
  • 115
    • 0030449113 scopus 로고    scopus 로고
    • Absence of mutations in the p53 tumour suppressor gene in woodchuck hepatocellular carcinomas associated with hapadnavirus infection and intake of aflatoxin B1
    • Rivkina, M., Cote, P.J., Robinson, W.S., Tennant, B.C. and Marion, P.L. (1996) Absence of mutations in the p53 tumour suppressor gene in woodchuck hepatocellular carcinomas associated with hapadnavirus infection and intake of aflatoxin B1. Carcinogenesis, 17, 2689-2694.
    • (1996) Carcinogenesis , vol.17 , pp. 2689-2694
    • Rivkina, M.1    Cote, P.J.2    Robinson, W.S.3    Tennant, B.C.4    Marion, P.L.5
  • 116
    • 0025925257 scopus 로고
    • Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry
    • Roebuck, B.D., Liu, Y.L., Rogers, A.E., Groopman, J.D. and Kensler, T.W. (1991) Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res., 51, 5501-5506.
    • (1991) Cancer Res. , vol.51 , pp. 5501-5506
    • Roebuck, B.D.1    Liu, Y.L.2    Rogers, A.E.3    Groopman, J.D.4    Kensler, T.W.5
  • 118
    • 0025924798 scopus 로고
    • Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins
    • Sabbioni, G. and Wild, CP (1991) Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins. Carcinogenesis, 12, 97-103.
    • (1991) Carcinogenesis , vol.12 , pp. 97-103
    • Sabbioni, G.1    Wild, C.P.2
  • 119
    • 0023197905 scopus 로고
    • Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats
    • Sabbioni, G., Skipper, P.L., Buchi, G. and Tannenbaum, S.R. (1987) Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats. Carcinogenesis, 8, 819-824.
    • (1987) Carcinogenesis , vol.8 , pp. 819-824
    • Sabbioni, G.1    Skipper, P.L.2    Buchi, G.3    Tannenbaum, S.R.4
  • 120
    • 0032978584 scopus 로고    scopus 로고
    • The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells
    • Schleger, C., Becker, R., Oesch, F. and Steinberg, P. (1999) The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells. Hepatology, 29, 834-838.
    • (1999) Hepatology , vol.29 , pp. 834-838
    • Schleger, C.1    Becker, R.2    Oesch, F.3    Steinberg, P.4
  • 121
    • 0026518760 scopus 로고
    • p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China
    • Scorsone, K.A., Zhou, Y.Z., Butel, J.S. and Slagle, B.L. (1992) p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res., 52, 1635-1638.
    • (1992) Cancer Res. , vol.52 , pp. 1635-1638
    • Scorsone, K.A.1    Zhou, Y.Z.2    Butel, J.S.3    Slagle, B.L.4
  • 122
    • 0025857503 scopus 로고
    • Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice
    • Sell, S., Hunt, J.M., Dunsford, H.A. and Chisari, F.V. (1991) Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. Cancer Res., 51, 1278-1285.
    • (1991) Cancer Res. , vol.51 , pp. 1278-1285
    • Sell, S.1    Hunt, J.M.2    Dunsford, H.A.3    Chisari, F.V.4
  • 123
    • 0029005157 scopus 로고
    • Codon-249 mutation on the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore
    • Shi, C.Y., Phang, T.W., Lin, Y., Wae, A., Li, B., Lee, H.P., Ong, C.N. (1995) Codon-249 mutation on the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore. Brit. J. Cancer, 72(1), 146-149.
    • (1995) Brit. J. Cancer , vol.72 , Issue.1 , pp. 146-149
    • Shi, C.Y.1    Phang, T.W.2    Lin, Y.3    Wae, A.4    Li, B.5    Lee, H.P.6    Ong, C.N.7
  • 124
    • 0032975123 scopus 로고    scopus 로고
    • Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China
    • Shimizu, Y., Zhu, J.J., Han, F., Ishikawa, T. and Oda, H. (1999) Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China. Int. J. Cancer, 82, 187-190.
    • (1999) Int. J. Cancer , vol.82 , pp. 187-190
    • Shimizu, Y.1    Zhu, J.J.2    Han, F.3    Ishikawa, T.4    Oda, H.5
  • 125
    • 0035067203 scopus 로고    scopus 로고
    • The chemistry and biology of aflatoxin B1: From mutational spectrometry to carcinogenesis
    • Smela, M.E., Currier, S.S., Bailey, E.A. and Essigmann, J.M. (2001) The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis. Carcinogenesis, 22, 535-545.
    • (2001) Carcinogenesis , vol.22 , pp. 535-545
    • Smela, M.E.1    Currier, S.S.2    Bailey, E.A.3    Essigmann, J.M.4
  • 126
    • 0034734038 scopus 로고    scopus 로고
    • Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis
    • Sohn, S., Jaitovitch-Groisman, I., Benlimame, N., Galipeau, J., Batist, G. and Alaoui-Jamali, M.A. (2000) Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis. Mutat. Res., 460, 17-28.
    • (2000) Mutat. Res. , vol.460 , pp. 17-28
    • Sohn, S.1    Jaitovitch-Groisman, I.2    Benlimame, N.3    Galipeau, J.4    Batist, G.5    Alaoui-Jamali, M.A.6
  • 127
    • 15844415447 scopus 로고    scopus 로고
    • An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico
    • Soini, Y., Chia, S.C., Bennett, W.P. et al. (1996) An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis, 17, 1007-1012,
    • (1996) Carcinogenesis , vol.17 , pp. 1007-1012
    • Soini, Y.1    Chia, S.C.2    Bennett, W.P.3
  • 128
    • 0034905993 scopus 로고    scopus 로고
    • Hepatitis B, aflatoxin B, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies
    • Stern, M.C., Umbach, D.M., Yu, M.C., London, S.J., Zhang, Z.Q. and Taylor, J.A. (2001) Hepatitis B, aflatoxin B, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies. Cancer Epidemiol. Biomarkers Prev., 10, 617-625.
    • (2001) Cancer Epidemiol. Biomarkers Prev. , vol.10 , pp. 617-625
    • Stern, M.C.1    Umbach, D.M.2    Yu, M.C.3    London, S.J.4    Zhang, Z.Q.5    Taylor, J.A.6
  • 129
    • 0034884668 scopus 로고    scopus 로고
    • Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line
    • Stettler, P.M. and Sengstag, C. (2001) Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line. Mol. Carcinog., 31, 125-138.
    • (2001) Mol. Carcinog. , vol.31 , pp. 125-138
    • Stettler, P.M.1    Sengstag, C.2
  • 130
    • 0032795048 scopus 로고    scopus 로고
    • Interactions between hepatitis B virus infection and exposure to aflatoxins in the development of hepatocellular carcinoma; a molecular epidemiological approach
    • Sylla, A., Diallo, M.S., Castegnaro, J. and Wild, C.P. (1999) Interactions between hepatitis B virus infection and exposure to aflatoxins in the development of hepatocellular carcinoma; a molecular epidemiological approach. Mutat. Res., Fund Mol. M. 428(1-2): 187-196.
    • (1999) Mutat. Res., Fund Mol. M. , vol.428 , Issue.1-2 , pp. 187-196
    • Sylla, A.1    Diallo, M.S.2    Castegnaro, J.3    Wild, C.P.4
  • 131
    • 0034909066 scopus 로고    scopus 로고
    • Persistent hyperendemicity of hepatitis C virus infection in Taiwan: The important role of iatrogenic risk factors
    • Sun, C.A., Chen, H.C., Lu, S.N., Chen, C.J., Lu, C.F., You, S.L. and Lin, S.H. (2001) Persistent hyperendemicity of hepatitis C virus infection in Taiwan: the important role of iatrogenic risk factors. J. Med. Virol., 65, 30-34.
    • (2001) J. Med. Virol. , vol.65 , pp. 30-34
    • Sun, C.A.1    Chen, H.C.2    Lu, S.N.3    Chen, C.J.4    Lu, C.F.5    You, S.L.6    Lin, S.H.7
  • 132
    • 0027241524 scopus 로고
    • Tumor progression in hepatocellular-carcinoma may be mediated by p53 mutation
    • Tanaka, S., Toh, Y., Adachi, E., Matsumata, T., Mori, R. and Sugimachi, K. (1993) Tumor progression in hepatocellular-carcinoma may be mediated by p53 mutation. Cancer Res., 53, 2884-2887.
    • (1993) Cancer Res. , vol.53 , pp. 2884-2887
    • Tanaka, S.1    Toh, Y.2    Adachi, E.3    Matsumata, T.4    Mori, R.5    Sugimachi, K.6
  • 133
    • 0028180458 scopus 로고
    • p53 gene abnormalities are closely-related to hepatoviral infections and occur at a late-stage of hepatocarcinogenesis
    • Teramoto, T., Satonaka, K., Kitazawa, S., Fujimori, T., Hayashi, K. and Maeda, S. (1994) p53 gene abnormalities are closely-related to hepatoviral infections and occur at a late-stage of hepatocarcinogenesis. Cancer Res., 54, 231-235.
    • (1994) Cancer Res. , vol.54 , pp. 231-235
    • Teramoto, T.1    Satonaka, K.2    Kitazawa, S.3    Fujimori, T.4    Hayashi, K.5    Maeda, S.6
  • 134
    • 0026657434 scopus 로고
    • Kinds of mutations induced by aflatoxin B1 in a shuttle vector replicating in human cells transiently expressing cytochrome P4501A2 cDNA
    • Trottier, Y., Waithe, W.I. and Anderson, A. (1992) Kinds of mutations induced by aflatoxin B1 in a shuttle vector replicating in human cells transiently expressing cytochrome P4501A2 cDNA. Mol. Carcinog., 6, 140-147.
    • (1992) Mol. Carcinog. , vol.6 , pp. 140-147
    • Trottier, Y.1    Waithe, W.I.2    Anderson, A.3
  • 136
    • 0028986147 scopus 로고
    • Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
    • Ueng, Y.F., Shimada, T., Yamazaki, H. and Guengerich, F.P. (1995) Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol., 8, 218-225.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 218-225
    • Ueng, Y.F.1    Shimada, T.2    Yamazaki, H.3    Guengerich, F.P.4
  • 137
    • 0032990244 scopus 로고    scopus 로고
    • p53 mutations in British patients with hepatocellular carcinoma: Clustering in genetic hemochromatosis
    • Vautier, G., Bomford, A.B., Portmann, B.C., Metivier, E., Williams, R. and Ryder, S.D. (1999) p53 mutations in British patients with hepatocellular carcinoma: clustering in genetic hemochromatosis. Gastroenterology, 117, 154-160.
    • (1999) Gastroenterology , vol.117 , pp. 154-160
    • Vautier, G.1    Bomford, A.B.2    Portmann, B.C.3    Metivier, E.4    Williams, R.5    Ryder, S.D.6
  • 139
    • 33646234399 scopus 로고    scopus 로고
    • Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China
    • Wang, J.S., Qian, G.S., Zarba, A. et al. (1996) Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China. Cancer Epidemiol. Biomarkers Prev., 5, 253-261.
    • (1996) Cancer Epidemiol. Biomarkers Prev. , vol.5 , pp. 253-261
    • Wang, J.S.1    Qian, G.S.2    Zarba, A.3
  • 140
    • 0033577057 scopus 로고    scopus 로고
    • Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China
    • Wang, J.S., Shen, X., He, X. et al. (1999) Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. J. Natl Cancer Inst., 91, 347-354.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 347-354
    • Wang, J.S.1    Shen, X.2    He, X.3
  • 141
    • 9544236289 scopus 로고    scopus 로고
    • Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan
    • Wang, L.Y., Hatch, M., Chen, C.J. et al. (1996) Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int. J. Cancer, 67, 620-625.
    • (1996) Int. J. Cancer , vol.67 , pp. 620-625
    • Wang, L.Y.1    Hatch, M.2    Chen, C.J.3
  • 142
    • 0032446266 scopus 로고    scopus 로고
    • Hepatitis B virus and liver cancer: Unanswered questions
    • Wild, C.P. and Hall, A.J. (1999) Hepatitis B virus and liver cancer: unanswered questions. Cancer Surv., 33, 35-54.
    • (1999) Cancer Surv. , vol.33 , pp. 35-54
    • Wild, C.P.1    Hall, A.J.2
  • 143
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • Wild, C.P. and Hall, A.J. (2000) Primary prevention of hepatocellular carcinoma in developing countries. Mutat. Res., 462, 381-393.
    • (2000) Mutat. Res. , vol.462 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 144
    • 0029872668 scopus 로고    scopus 로고
    • Etiology of cancer in humans and animals
    • Wild, C.P. and Kleihues, P. (1996) Etiology of cancer in humans and animals. Exp. Toxicol. Pathol., 48, 95-100.
    • (1996) Exp. Toxicol. Pathol. , vol.48 , pp. 95-100
    • Wild, C.P.1    Kleihues, P.2
  • 145
    • 0035234125 scopus 로고    scopus 로고
    • Exposure biomarkers in chemoprevention studies of liver cancer
    • Miller, A.B., Bartsch, H., Bofetta, P., Dragsted, L. and Vanio, H. (eds), IARC Scientific Publications no. 154. IARC, Lyon
    • Wild, C.P. and Turner, P.C. (2001) Exposure biomarkers in chemoprevention studies of liver cancer. In Miller, A.B., Bartsch, H., Bofetta, P., Dragsted, L. and Vanio, H. (eds), Biomarkers in Cancer Chemoprevention, IARC Scientific Publications no. 154. IARC, Lyon, pp. 215-222.
    • (2001) Biomarkers in Cancer Chemoprevention , pp. 215-222
    • Wild, C.P.1    Turner, P.C.2
  • 150
    • 0033755177 scopus 로고    scopus 로고
    • Genomic aberrations in human hepatocellular carcinomas of differing etiologies
    • Wong, N., Lai, P., Pang, E. et al. (2000) Genomic aberrations in human hepatocellular carcinomas of differing etiologies. Clin. Cancer Res., 6, 4000-4009.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4000-4009
    • Wong, N.1    Lai, P.2    Pang, E.3
  • 153
    • 0030744380 scopus 로고    scopus 로고
    • Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis
    • Zhou, T., Evans, A.A., London, W.T., Xia, X., Zou, H., Shen, F. and Clapper, M.L. (1997) Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis. Cancer Res., 57, 2749-2753.
    • (1997) Cancer Res. , vol.57 , pp. 2749-2753
    • Zhou, T.1    Evans, A.A.2    London, W.T.3    Xia, X.4    Zou, H.5    Shen, F.6    Clapper, M.L.7


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