Melatonin protects against oxidative organ injury in a rat model of sepsis

Surgery Today

Volumn 35, Issue 1, 2005, Pages 52-59

  Şener, Göksel ^a   Toklu, Hale ^a   Kapucu, Caner ^a   Ercan, Feriha ^b   Erkanli, Gözde ^b   Kaçmaz, Ayhan ^c   Tilki, Metin ^c   Yeǧen, Berrak Ç ^b  

^a MARMARA UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c HAYDARPASA NUMUNE EDUCATION AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Glutathione; Lipid peroxidation; Melatonin; Myeloperoxidase activity; Sepsis

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; MELATONIN; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN TISSUE; CECUM LIGATION; CONTROLLED STUDY; DIAPHRAGM; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; HEART; INFECTION PREVENTION; KIDNEY; LIGATION; LIVER; LUNG; MALE; NONHUMAN; ORGAN INJURY; OXIDATIVE STRESS; RAT; SEPSIS; SHAM FEEDING; SPECIES COMPARISON; TISSUE SECTION; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; LIVER FUNCTION TEST; MORTALITY; MULTIPLE ORGAN FAILURE; OXIDATION REDUCTION REACTION; PROBABILITY; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUTATHIONE; LIVER FUNCTION TESTS; MALE; MALONDIALDEHYDE; MELATONIN; MULTIPLE ORGAN FAILURE; OXIDATION-REDUCTION; PROBABILITY; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; SEPSIS; SURVIVAL RATE;

EID: 16644381348     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00595-004-2879-1     Document Type: Article

References (45)

1. Neviere RR, Ceepinskas G, Madorin WS, Hoque N, Karmazyn M, Sibbald WJ, et al. LPS pretreatment ameliorates peritonitis-induced myocardial inflammation and dysfunction: role of myocytes. Am J Physiol (Heart Circ Physiol 46) 1999;277:H885-92.
2. Bian K, Murad F. Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs. Free Radic Biol Med 2001;31:421-9.
3. Bohles H. Antioxidative vitamins in prematurely and maturely born infants. Int J Vit Nutr Res 1997;67:321-8.
4. Heller AR, Groth G, Heller SC, Breitkreutz R, Nebe T, Quintel M, et al. N-Acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients. Crit Care Med 2001;29:272-6.
5. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocr J 1993;1:57-60.
6. Pierrefiche G, Topall G, Courboin G, Henriet I, Laborit H. Antioxidant activity of melatonin in mice. Res Commun Chem Pathol Pharmacol 1993;80:211-23.
7. Poeggeler B, Saarela S, Reiter RJ, Tan DX, Chen LD, Manchester LC, et al. Melatonin - a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole assessed in vitro. Ann NY Acad Sci 1994;738:419-20.
8. Carcia JJ, Reiter RJ, Guerrero JM, Escames G, Yu BP, Oh CS, et al. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett 1997;408:297-300.
9. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 2001;34:237-56.
10. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutat Res 1998;397:203-8.
11. Fujimura N, Sumita S, Narimatsu E, Nakayama Y, Shitinohe Y. Effects of isoproterenol on diapragmatic contractility in septic peritonitis. Am J Respir Crit Care Med 2000;161:440-6.
12. Bauer JD, Ackermann PG, Toro G. Bray's clinical methods. St. Louis: Mosby; 1968. p. 308-15.
13. Beuge JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;53:302.
14. Beutler E. Glutathione in red blood cell metabolism. A manual of biochemical methods. New York: Grune and Stratton; 1975. p. 112.
15. Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods 1990;24:285-95.
16. Ozveri ES, Bozkurt A, Haklar G, Cetinel S, Arbak S, Yegen C, et al. Estrogens ameliorate remote organ inflammation induced by burn injury in rats. Inflamm Res 2001;50:585-91.
17. Sener G, Satiroǧlu H, Kabasakal L, Arbak S, Oner S, Ercan F, et al. The protective effect of melatonin on cisplatin nephrotoxicity. Fundam Clin Pharmacol 2000;14;553-60.
18. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Rep 1997;3:3-15.
19. Feihl F, Waeber B, Liaudet L. Is nitric oxide overproduction the target of choice for the management of septic shock? Pharmacol Ther 2001;91:179-213.
20. Wickel DJ, Cheadle WG, Mercer-Jones MA, Garrison RN. Poor outcome from peritonitis is caused by disease acuity and organ failure, not recurrent peritoneal infection. Ann Surg 1997;225:744-53.
21. Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50:756-60.
22. Wu CC, Chiao CW, Hsiao G, Chen A, Yen MH. Melatonin prevents endotoxin-induced circulatory failure in rats. J Pineal Res 2001;30:147-56.
23. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
24. Reiter RJ, Acuna-Castroviejo D, Tan DX, Burkhart S. Free radical-mediated molecular damage. Ann N Y Acad Sci 2001;939:200-15.
25. Reiter RJ, Maestroni GJM. Melatonin in relation to the antioxidative defense and immune systems: possible implications for cell and organ transplantation. J Mol Med 1999;77:36-9.
26. Lin AT, Chen MT, Yang CH, Chang LS. Oxygen free radical-induced lipid peroxidation in overdistention of the rabbit urinary bladders. Neurourol Urodyn 1995;14:553-4.
27. Saito M, Wada K, Kamisaki Y, Miyagawa I. Effect of ischemia-reperfusion on contractile function of rat urinary bladder: possible role of nitric oxide. Life Sci 1998;62:149-56.
28. Lefer AM. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol Toxicol 1993;33:71-90.
29. Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress. J Biomed Sci 2000;7:444-58.
30. Supinski G, Stofan D, Callahan LA, Nethery D, Nosek TM, DiMarco A. Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm. J Appl Physiol 1999;87:783-91.
31. Sener G, Sehirli AO, Keyer-Uysal M, Arbak S, Ersoy Y, Yegen BC. The protective effect of melatonin on renal ischemia-reperfusion in rat. J Pineal Res 2002;32:120-6.
32. Şener G, Şehirli AO, Şatiroǧlu H, Keyer-Uysal M, Yegen BC. Melatonin prevents oxidative kidney damage in a rat model of thermal injury. Life Sci 2002;70:2977-85.
33. Sewerynek E, Abe M, Reiter RJ, Barlow-Walden LR, Chen L, McCabe TJ, et al. Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated rats. J Cell Biochem 1995;58:436-44.
34. Cuzzocrea S, Tan DX, Costantino G, Mazzon E, Caputi AP, Reiter RJ. The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J 1999;13:1930-8.
35. Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leukocyte Biol 2000;67:591-602.
36. Cuzzocrea S, Reiter RJ. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur J Pharmacol 2001;426:1-10.
37. Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia-reperfusion induced granulocyte infiltration. Am J Physiol 1990;258:G185-90.
38. Donnahoo KK, Meng X, Ayala A, Cain MP, Harken AH, Meldrum DR. Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol 1999;277:R922-9.
39. Cuzzocrea S, Costantino G, Mazzon E, Micali A, De Sarro A, Caputi AP. Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion. J Pineal Res 2000;28:52-63.
40. Shaw S, Herbert V, Colman N, Jayatilleke E. Effect of ethanol-generated free radicals on gastric intrinsic factor and glutathione. Alcohol 1990;7:153-7.
41. Ross D. Glutathione, free radicals and chemotherapeutic agents. Pharmacol Ther 1988;37:231-49.
42. Szabo S, Nagy L, Plebani M. Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin Chim Acta 1992;206:95-105.
43. Villa P, Saccani A, Sica A. Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. J Infect Dis 2002;185:1115-20.
44. Tanjoh K, Shima A, Aida M, Tomita R, Kurosu Y. Nitric oxide and active oxygen species in severe sepsis and surgically stressed patients. Surg Today 1995;25:774-7.
45. Jan JE, Hamilton D, Seward N, Fast DK, Freman RD, Laudon M. Clinical trials of controlled-release melatonin in children with sleep-wake disorders. J Pineal Res 2000;29:34-9.