메뉴 건너뛰기




Volumn 188, Issue 2, 2010, Pages 301-308

Methylmercury-induced neurotoxicity and apoptosis

Author keywords

Apoptosis; Cell death; In vitro; Methylmercury; Neural stem cells; Neurotoxicity

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM; CALPAIN; CASPASE; CATHEPSIN; CYTOCHROME C; GLUTATHIONE; METHYLMERCURY; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SELENIUM; THIOL GROUP; METHYLMERCURY DERIVATIVE;

EID: 77956458798     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.04.007     Document Type: Review
Times cited : (266)

References (142)
  • 2
    • 0015268017 scopus 로고
    • The pharmacology of mercury compounds
    • Clarkson T.W. The pharmacology of mercury compounds. Annu. Rev. Pharmacol. 1972, 12:375-406.
    • (1972) Annu. Rev. Pharmacol. , vol.12 , pp. 375-406
    • Clarkson, T.W.1
  • 5
    • 78651053970 scopus 로고
    • Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds
    • Hunter D., Russell D.S. Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds. J. Neurol. Neurosurg. Psychiatry 1954, 17:235.
    • (1954) J. Neurol. Neurosurg. Psychiatry , vol.17 , pp. 235
    • Hunter, D.1    Russell, D.S.2
  • 6
    • 77956647438 scopus 로고
    • Pathology of Minamata disese, in: Minamata Disease, Study group of Minamata Disease, Kumamoto University, Japan
    • T. Takeuchi, Pathology of Minamata disese, in: Minamata Disease, Study group of Minamata Disease, Kumamoto University, Japan, 1968, pp. 141-228.
    • (1968) , pp. 141-228
    • Takeuchi, T.1
  • 7
    • 0000185397 scopus 로고
    • Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound
    • Matsumoto H., Koya G., Takeuchi T. Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound. J. Neuropathol. Exp. Neurol. 1965, 24:563-574.
    • (1965) J. Neuropathol. Exp. Neurol. , vol.24 , pp. 563-574
    • Matsumoto, H.1    Koya, G.2    Takeuchi, T.3
  • 8
    • 0342705385 scopus 로고
    • A pathological study on the fetal Minamata disease diagnosed clinically so-called infantile cerebral palsy (in Japanese)
    • Takeuchi T., Matsumoto H., Koya G.A. A pathological study on the fetal Minamata disease diagnosed clinically so-called infantile cerebral palsy (in Japanese). Adv. Neurol. Sci. 1964, 8:145-161.
    • (1964) Adv. Neurol. Sci. , vol.8 , pp. 145-161
    • Takeuchi, T.1    Matsumoto, H.2    Koya, G.A.3
  • 10
    • 0018256847 scopus 로고
    • Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero
    • Choi B.H., Lapham L.W., Amin-Zaki L., Saleem T. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J. Neuropathol. Exp. Neurol. 1978, 37:719-733.
    • (1978) J. Neuropathol. Exp. Neurol. , vol.37 , pp. 719-733
    • Choi, B.H.1    Lapham, L.W.2    Amin-Zaki, L.3    Saleem, T.4
  • 12
    • 0032076133 scopus 로고    scopus 로고
    • Mercury levels along the food chain and risk for exposed populations
    • Renzoni A., Zino F., Franchi E. Mercury levels along the food chain and risk for exposed populations. Environ. Res. 1998, 77:68-72.
    • (1998) Environ. Res. , vol.77 , pp. 68-72
    • Renzoni, A.1    Zino, F.2    Franchi, E.3
  • 15
    • 77956648196 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration and U.S.Environmental Protection Agency, What You Need to Know About Mercury in Fish and Shellfish
    • U.S. Food and Drug Administration and U.S.Environmental Protection Agency, What You Need to Know About Mercury in Fish and Shellfish, 2004, http://www.cfsan.fda.gov.seafood1.html/.
    • (2004)
  • 16
    • 0020555977 scopus 로고
    • Methyl mercury exposure in northern Quebec. II. Neurologic findings in children
    • McKeown-Eyssen G.E., Ruedy J., Neims A. Methyl mercury exposure in northern Quebec. II. Neurologic findings in children. Am. J. Epidemiol. 1983, 118:470-479.
    • (1983) Am. J. Epidemiol. , vol.118 , pp. 470-479
    • McKeown-Eyssen, G.E.1    Ruedy, J.2    Neims, A.3
  • 17
    • 77956647278 scopus 로고
    • Physical and Mental Development of Children with Prenatal Exposure to Methylmercury in Fish. Stage 2, Interviews and Psycologycal Test at Age 6, Solna, National Swedish Environmental Protection Board Report 3642
    • T. Kjellström, P. Kennedy, S. Wallis, A. Stewart, L. Friberg, B. Lind, P. Wutherspoon, C. Mantell, Physical and Mental Development of Children with Prenatal Exposure to Methylmercury in Fish. Stage 2, Interviews and Psycologycal Test at Age 6, Solna, National Swedish Environmental Protection Board Report 3642, 1989.
    • (1989)
    • Kjellström, T.1    Kennedy, P.2    Wallis, S.3    Stewart, A.4    Friberg, L.5    Lind, B.6    Wutherspoon, P.7    Mantell, C.8
  • 21
    • 0033806985 scopus 로고    scopus 로고
    • Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet
    • Davidson P.W., Palumbo D., Myers G.J., Cox C., Shamlaye C.F., Sloane-Reeves J., Cernichiari E., Wilding G.E., Clarkson T.W. Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet. Environ. Res. 2000, 84:1-11.
    • (2000) Environ. Res. , vol.84 , pp. 1-11
    • Davidson, P.W.1    Palumbo, D.2    Myers, G.J.3    Cox, C.4    Shamlaye, C.F.5    Sloane-Reeves, J.6    Cernichiari, E.7    Wilding, G.E.8    Clarkson, T.W.9
  • 25
    • 0032707981 scopus 로고    scopus 로고
    • Methylmercury: a new look at the risks
    • Mahaffey K.R. Methylmercury: a new look at the risks. Public Health Rep. 1999, 114:396-399.
    • (1999) Public Health Rep. , vol.114 , pp. 396-399
    • Mahaffey, K.R.1
  • 26
    • 33845513945 scopus 로고    scopus 로고
    • Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure
    • Budtz-Jorgensen E., Keiding N., Grandjean P., Weihe P. Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure. Ann. Epidemiol. 2007, 17:27-35.
    • (2007) Ann. Epidemiol. , vol.17 , pp. 27-35
    • Budtz-Jorgensen, E.1    Keiding, N.2    Grandjean, P.3    Weihe, P.4
  • 27
    • 73849140882 scopus 로고    scopus 로고
    • Defining a lowest observable adverse effect hair concentrations of mercury for neurodevelopmental effects of prenatal methylmercury exposure through maternal fish consumption: a systematic review
    • Schoeman K., Bend J.R., Hill J., Nash K., Koren G. Defining a lowest observable adverse effect hair concentrations of mercury for neurodevelopmental effects of prenatal methylmercury exposure through maternal fish consumption: a systematic review. Ther. Drug Monit. 2009, 31:670-682.
    • (2009) Ther. Drug Monit. , vol.31 , pp. 670-682
    • Schoeman, K.1    Bend, J.R.2    Hill, J.3    Nash, K.4    Koren, G.5
  • 30
    • 0036803999 scopus 로고    scopus 로고
    • Silent latency periods in methylmercury poisoning and in neurodegenerative disease
    • Weiss B., Clarkson T.W., Simon W. Silent latency periods in methylmercury poisoning and in neurodegenerative disease. Environ. Health Perspect. 2002, 110(Suppl. 5):851-854.
    • (2002) Environ. Health Perspect. , vol.110 , Issue.SUPPL. 5 , pp. 851-854
    • Weiss, B.1    Clarkson, T.W.2    Simon, W.3
  • 32
    • 64149130360 scopus 로고    scopus 로고
    • The endocrine effects of mercury in humans and wildlife
    • Tan S.W., Meiller J.C., Mahaffey K.R. The endocrine effects of mercury in humans and wildlife. Crit. Rev. Toxicol. 2009, 39:228-269.
    • (2009) Crit. Rev. Toxicol. , vol.39 , pp. 228-269
    • Tan, S.W.1    Meiller, J.C.2    Mahaffey, K.R.3
  • 34
    • 70349838928 scopus 로고    scopus 로고
    • Environmental toxins, a potential risk factor for diabetes among Canadian Aboriginals
    • Sharp D. Environmental toxins, a potential risk factor for diabetes among Canadian Aboriginals. Int. J. Circumpolar Health 2009, 68:316-326.
    • (2009) Int. J. Circumpolar Health , vol.68 , pp. 316-326
    • Sharp, D.1
  • 35
    • 0014233398 scopus 로고
    • Distribution and excretion of various mercury compounds after single injections in poultry
    • Swensson A., Ulfvarson U. Distribution and excretion of various mercury compounds after single injections in poultry. Acta Pharmacol. Toxicol. (Copenh) 1968, 26:259-272.
    • (1968) Acta Pharmacol. Toxicol. (Copenh) , vol.26 , pp. 259-272
    • Swensson, A.1    Ulfvarson, U.2
  • 36
    • 0014330798 scopus 로고
    • Mercury compounds in the blood of rats treated with ethylmercuric chloride
    • Takeda Y., Kunugi T., Terao T., Ukita T. Mercury compounds in the blood of rats treated with ethylmercuric chloride. Toxicol. Appl. Pharmacol. 1968, 13:165-173.
    • (1968) Toxicol. Appl. Pharmacol. , vol.13 , pp. 165-173
    • Takeda, Y.1    Kunugi, T.2    Terao, T.3    Ukita, T.4
  • 37
    • 0025307642 scopus 로고
    • Mercury neurotoxicity: mechanisms of blood-brain barrier transport
    • Aschner M., Aschner J.L. Mercury neurotoxicity: mechanisms of blood-brain barrier transport. Neurosci. Biobehav. Rev. 1990, 14:169-176.
    • (1990) Neurosci. Biobehav. Rev. , vol.14 , pp. 169-176
    • Aschner, M.1    Aschner, J.L.2
  • 39
    • 0033783247 scopus 로고    scopus 로고
    • Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood
    • Vahter M., Akesson A., Lind B., Bjors U., Schutz A., Berglund M. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ. Res. 2000, 84:186-194.
    • (2000) Environ. Res. , vol.84 , pp. 186-194
    • Vahter, M.1    Akesson, A.2    Lind, B.3    Bjors, U.4    Schutz, A.5    Berglund, M.6
  • 41
  • 42
    • 77956649888 scopus 로고
    • WHO, Environmental Health Criteria 101: Methylmercury, World Health Organization, Geneva
    • WHO, Environmental Health Criteria 101: Methylmercury, World Health Organization, Geneva, 1990.
    • (1990)
  • 43
    • 0028840790 scopus 로고
    • Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure
    • Vahter M.E., Mottet N.K., Friberg L.T., Lind S.B., Charleston J.S., Burbacher T.M. Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol. Appl. Pharmacol. 1995, 134:273-284.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 273-284
    • Vahter, M.E.1    Mottet, N.K.2    Friberg, L.T.3    Lind, S.B.4    Charleston, J.S.5    Burbacher, T.M.6
  • 44
    • 0035872463 scopus 로고    scopus 로고
    • Roles of the metallothionein family of proteins in the central nervous system
    • Hidalgo J., Aschner M., Zatta P., Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res. Bull. 2001, 55:133-145.
    • (2001) Brain Res. Bull. , vol.55 , pp. 133-145
    • Hidalgo, J.1    Aschner, M.2    Zatta, P.3    Vasak, M.4
  • 46
    • 0028206137 scopus 로고
    • Mechanisms of methylmercury-induced neurotoxicity
    • Atchison W.D., Hare M.F. Mechanisms of methylmercury-induced neurotoxicity. FASEB J. 1994, 8:622-629.
    • (1994) FASEB J. , vol.8 , pp. 622-629
    • Atchison, W.D.1    Hare, M.F.2
  • 47
    • 0031172258 scopus 로고    scopus 로고
    • Altered sensitivity of posttranslationally modified microtubules to methylmercury in differentiating embryonal carcinoma-derived neurons
    • Graff R.D., Falconer M.M., Brown D.L., Reuhl K.R. Altered sensitivity of posttranslationally modified microtubules to methylmercury in differentiating embryonal carcinoma-derived neurons. Toxicol. Appl. Pharmacol. 1997, 144:215-224.
    • (1997) Toxicol. Appl. Pharmacol. , vol.144 , pp. 215-224
    • Graff, R.D.1    Falconer, M.M.2    Brown, D.L.3    Reuhl, K.R.4
  • 48
    • 0025313038 scopus 로고
    • Organometal-induced increases in oxygen reactive species: the potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage
    • LeBel C.P., Ali S.F., McKee M., Bondy S.C. Organometal-induced increases in oxygen reactive species: the potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol. Appl. Pharmacol. 1990, 104:17-24.
    • (1990) Toxicol. Appl. Pharmacol. , vol.104 , pp. 17-24
    • LeBel, C.P.1    Ali, S.F.2    McKee, M.3    Bondy, S.C.4
  • 49
    • 0026102123 scopus 로고
    • Oxidative mechanisms underlying methyl mercury neurotoxicity
    • Sarafian T.A., Verity M.A. Oxidative mechanisms underlying methyl mercury neurotoxicity. Int. J. Dev. Neurosci. 1991, 9:147-153.
    • (1991) Int. J. Dev. Neurosci. , vol.9 , pp. 147-153
    • Sarafian, T.A.1    Verity, M.A.2
  • 50
    • 0028020707 scopus 로고
    • Methylmercury poisoning induces oxidative stress in the mouse brain
    • Yee S., Choi B.H. Methylmercury poisoning induces oxidative stress in the mouse brain. Exp. Mol. Pathol. 1994, 60:188-196.
    • (1994) Exp. Mol. Pathol. , vol.60 , pp. 188-196
    • Yee, S.1    Choi, B.H.2
  • 51
    • 0031309785 scopus 로고    scopus 로고
    • 2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury
    • 2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury. Toxicol. Appl. Pharmacol. 1997, 147:319-330.
    • (1997) Toxicol. Appl. Pharmacol. , vol.147 , pp. 319-330
    • Marty, M.S.1    Atchison, W.D.2
  • 52
    • 0031595962 scopus 로고    scopus 로고
    • 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury
    • 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury. Toxicol. Appl. Pharmacol. 1998, 150:98-105.
    • (1998) Toxicol. Appl. Pharmacol. , vol.150 , pp. 98-105
    • Marty, M.S.1    Atchison, W.D.2
  • 53
    • 0027194712 scopus 로고
    • 2+ and inositol phosphate levels in cultured cerebellar granule neurons
    • 2+ and inositol phosphate levels in cultured cerebellar granule neurons. J. Neurochem. 1993, 61:648-657.
    • (1993) J. Neurochem. , vol.61 , pp. 648-657
    • Sarafian, T.A.1
  • 56
    • 0034663064 scopus 로고    scopus 로고
    • Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells
    • Sirois J.E., Atchison W.D. Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 2000, 167:1-11.
    • (2000) Toxicol. Appl. Pharmacol. , vol.167 , pp. 1-11
    • Sirois, J.E.1    Atchison, W.D.2
  • 57
    • 0027366931 scopus 로고
    • Effects of methylmercury on protein kinase A and protein kinase C in the mouse brain
    • Saijoh K., Fukunaga T., Katsuyama H., Lee M.J., Sumino K. Effects of methylmercury on protein kinase A and protein kinase C in the mouse brain. Environ. Res. 1993, 63:264-273.
    • (1993) Environ. Res. , vol.63 , pp. 264-273
    • Saijoh, K.1    Fukunaga, T.2    Katsuyama, H.3    Lee, M.J.4    Sumino, K.5
  • 58
    • 0034518449 scopus 로고    scopus 로고
    • (2+) in cell physiology and pathophysiology
    • (2+) in cell physiology and pathophysiology. Cell Calcium 2000, 28:339-348.
    • (2000) Cell Calcium , vol.28 , pp. 339-348
    • Duchen, M.R.1
  • 59
    • 0034474266 scopus 로고    scopus 로고
    • Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium
    • Mundy W.R., Freudenrich T.M. Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium. Neurotoxicology 2000, 21:1135-1144.
    • (2000) Neurotoxicology , vol.21 , pp. 1135-1144
    • Mundy, W.R.1    Freudenrich, T.M.2
  • 60
    • 0031593221 scopus 로고    scopus 로고
    • Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve
    • InSug O., Datar S., Koch C.J., Shapiro I.M., Shenker B.J. Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 1997, 124:211-224.
    • (1997) Toxicology , vol.124 , pp. 211-224
    • InSug, O.1    Datar, S.2    Koch, C.J.3    Shapiro, I.M.4    Shenker, B.J.5
  • 61
    • 0033562940 scopus 로고    scopus 로고
    • Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve, Toxicol. Appl. Pharmacol
    • B.J. Shenker, T.L. Guo, I.O, I.M. Shapiro, Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve, Toxicol. Appl. Pharmacol. 157 (1999) 23-35.
    • (1999) , vol.157 , pp. 23-35
    • Shenker, B.J.1    Guo, T.L.2    Shapiro I.O, I.M.3
  • 62
    • 0034530010 scopus 로고    scopus 로고
    • Toxicity of methylmercury conjugated with l-cysteine on rat thymocytes and human leukemia K562 cells in comparison with that of methylmercury chloride
    • Oyama Y., Yamazaki Y., Okada Y., Takahama K., Satoh M., Hayashi H. Toxicity of methylmercury conjugated with l-cysteine on rat thymocytes and human leukemia K562 cells in comparison with that of methylmercury chloride. Environ. Toxicol. Pharmacol. 2000, 9:49-55.
    • (2000) Environ. Toxicol. Pharmacol. , vol.9 , pp. 49-55
    • Oyama, Y.1    Yamazaki, Y.2    Okada, Y.3    Takahama, K.4    Satoh, M.5    Hayashi, H.6
  • 64
    • 0020535002 scopus 로고
    • Stimulation of lipid peroxidation by methyl mercury in rats
    • Yonaha M., Saito M., Sagai M. Stimulation of lipid peroxidation by methyl mercury in rats. Life Sci. 1983, 32:1507-1514.
    • (1983) Life Sci. , vol.32 , pp. 1507-1514
    • Yonaha, M.1    Saito, M.2    Sagai, M.3
  • 65
    • 0035906526 scopus 로고    scopus 로고
    • Involvement of enhanced sensitivity of N-methyl-d-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity
    • Miyamoto K., Nakanishi H., Moriguchi S., Fukuyama N., Eto K., Wakamiya J., Murao K., Arimura K., Osame M. Involvement of enhanced sensitivity of N-methyl-d-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity. Brain Res. 2001, 901:252-258.
    • (2001) Brain Res. , vol.901 , pp. 252-258
    • Miyamoto, K.1    Nakanishi, H.2    Moriguchi, S.3    Fukuyama, N.4    Eto, K.5    Wakamiya, J.6    Murao, K.7    Arimura, K.8    Osame, M.9
  • 66
    • 20444403753 scopus 로고    scopus 로고
    • Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes
    • Shanker G., Syversen T., Aschner J.L., Aschner M. Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Brain Res. Mol. Brain Res. 2005, 137:11-22.
    • (2005) Brain Res. Mol. Brain Res. , vol.137 , pp. 11-22
    • Shanker, G.1    Syversen, T.2    Aschner, J.L.3    Aschner, M.4
  • 67
    • 0033032410 scopus 로고    scopus 로고
    • Protective role of dl-alpha-lipoic acid against mercury-induced neural lipid peroxidation
    • Anuradha B., Varalakshmi P. Protective role of dl-alpha-lipoic acid against mercury-induced neural lipid peroxidation. Pharmacol. Res. 1999, 39:67-80.
    • (1999) Pharmacol. Res. , vol.39 , pp. 67-80
    • Anuradha, B.1    Varalakshmi, P.2
  • 68
    • 0018195969 scopus 로고
    • Modification of methylmercury toxicity and metabolism by selenium and vitamin E: possible mechanisms
    • Ganther H.E. Modification of methylmercury toxicity and metabolism by selenium and vitamin E: possible mechanisms. Environ. Health Perspect. 1978, 25:71-76.
    • (1978) Environ. Health Perspect. , vol.25 , pp. 71-76
    • Ganther, H.E.1
  • 69
    • 0030010607 scopus 로고    scopus 로고
    • Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists
    • Park S.T., Lim K.T., Chung Y.T., Kim S.U. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists. Neurotoxicology 1996, 17:37-45.
    • (1996) Neurotoxicology , vol.17 , pp. 37-45
    • Park, S.T.1    Lim, K.T.2    Chung, Y.T.3    Kim, S.U.4
  • 70
    • 0034951105 scopus 로고    scopus 로고
    • Methylmercury neurotoxicity in cultures of human neurons, astrocytes, neuroblastoma cells
    • Sanfeliu C., Sebastia J., Ki S.U. Methylmercury neurotoxicity in cultures of human neurons, astrocytes, neuroblastoma cells. Neurotoxicology 2001, 22:317-327.
    • (2001) Neurotoxicology , vol.22 , pp. 317-327
    • Sanfeliu, C.1    Sebastia, J.2    Ki, S.U.3
  • 71
    • 34447250976 scopus 로고    scopus 로고
    • In vitro toxicity induced by methylmercury on sympathetic neurons is reverted by l-cysteine or glutathione
    • Melo Reis R.A., Herculano A.M., da Silva M.C., dos Santos R.M., do Nascimento J.L. In vitro toxicity induced by methylmercury on sympathetic neurons is reverted by l-cysteine or glutathione. Neurosci. Res. 2007, 58:278-284.
    • (2007) Neurosci. Res. , vol.58 , pp. 278-284
    • Melo Reis, R.A.1    Herculano, A.M.2    da Silva, M.C.3    dos Santos, R.M.4    do Nascimento, J.L.5
  • 72
    • 36048987358 scopus 로고    scopus 로고
    • Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity
    • Shichiri M., Takanezawa Y., Uchida K., Tamai H., Arai H. Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Brain Res. 2007, 1182:106-115.
    • (2007) Brain Res. , vol.1182 , pp. 106-115
    • Shichiri, M.1    Takanezawa, Y.2    Uchida, K.3    Tamai, H.4    Arai, H.5
  • 74
    • 0026565594 scopus 로고
    • Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain
    • LeBel C.P., Ali S.F., Bondy S.C. Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain. Toxicol. Appl. Pharmacol. 1992, 112:161-165.
    • (1992) Toxicol. Appl. Pharmacol. , vol.112 , pp. 161-165
    • LeBel, C.P.1    Ali, S.F.2    Bondy, S.C.3
  • 75
    • 0013973564 scopus 로고
    • Biochemical changes in the brain in rats poisoned with an alkymercury compound, with special reference to the inhibition of protein synthesis in brain cortex slices
    • Yoshino Y., Mozai T., Nakao K. Biochemical changes in the brain in rats poisoned with an alkymercury compound, with special reference to the inhibition of protein synthesis in brain cortex slices. J. Neurochem. 1966, 13:1223-1230.
    • (1966) J. Neurochem. , vol.13 , pp. 1223-1230
    • Yoshino, Y.1    Mozai, T.2    Nakao, K.3
  • 76
    • 0017660016 scopus 로고
    • Effect of methyl mercury on phosphorylation, transport, and oxidation in mammalian mitochondria
    • Sone N., Larsstuvold M.K., Kagawa Y. Effect of methyl mercury on phosphorylation, transport, and oxidation in mammalian mitochondria. J. Biochem. (Tokyo) 1977, 82:859-868.
    • (1977) J. Biochem. (Tokyo) , vol.82 , pp. 859-868
    • Sone, N.1    Larsstuvold, M.K.2    Kagawa, Y.3
  • 77
    • 0029953552 scopus 로고    scopus 로고
    • Oxidative stress in neurotoxic effects of methylmercury poisoning
    • Yee S., Choi B.H. Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology 1996, 17:17-26.
    • (1996) Neurotoxicology , vol.17 , pp. 17-26
    • Yee, S.1    Choi, B.H.2
  • 78
    • 0025818058 scopus 로고
    • Disruption of the potential across the synaptosomal plasma membrane and mitochondria by neurotoxic agents
    • Bondy S.C., McKee M. Disruption of the potential across the synaptosomal plasma membrane and mitochondria by neurotoxic agents. Toxicol. Lett. 1991, 58:13-21.
    • (1991) Toxicol. Lett. , vol.58 , pp. 13-21
    • Bondy, S.C.1    McKee, M.2
  • 79
    • 0034653128 scopus 로고    scopus 로고
    • Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury
    • Castoldi A.F., Barni S., Turin I., Gandini C., Manzo L. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J. Neurosci. Res. 2000, 59:775-787.
    • (2000) J. Neurosci. Res. , vol.59 , pp. 775-787
    • Castoldi, A.F.1    Barni, S.2    Turin, I.3    Gandini, C.4    Manzo, L.5
  • 81
    • 78650545101 scopus 로고    scopus 로고
    • Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases
    • [Epub ahead of print]
    • Tofighi R., Johansson C., Goldoni M., Ibrahim W.N., Gogvadze V., Mutti A., Ceccatelli S. Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases. Neurotox. Res. 2010, [Epub ahead of print].
    • (2010) Neurotox. Res.
    • Tofighi, R.1    Johansson, C.2    Goldoni, M.3    Ibrahim, W.N.4    Gogvadze, V.5    Mutti, A.6    Ceccatelli, S.7
  • 82
    • 37349063741 scopus 로고    scopus 로고
    • Methylmercury at low doses modulates the toxicity of PCB153 on PC12 neuronal cell line in asynchronous combination experiments
    • Goldoni M., Caglieri A., Poli D., Vettori M.V., Ceccatelli S., Mutti A. Methylmercury at low doses modulates the toxicity of PCB153 on PC12 neuronal cell line in asynchronous combination experiments. Food Chem. Toxicol. 2008, 46:808-811.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 808-811
    • Goldoni, M.1    Caglieri, A.2    Poli, D.3    Vettori, M.V.4    Ceccatelli, S.5    Mutti, A.6
  • 83
  • 84
    • 33751188543 scopus 로고    scopus 로고
    • Cell death mechanisms in AtT20 pituitary cells exposed to polychlorinated biphenyls (PCB 126 and PCB 153) and methylmercury
    • Johansson C., Tofighi R., Tamm C., Goldoni M., Mutti A., Ceccatelli S. Cell death mechanisms in AtT20 pituitary cells exposed to polychlorinated biphenyls (PCB 126 and PCB 153) and methylmercury. Toxicol. Lett. 2006, 167:183-190.
    • (2006) Toxicol. Lett. , vol.167 , pp. 183-190
    • Johansson, C.1    Tofighi, R.2    Tamm, C.3    Goldoni, M.4    Mutti, A.5    Ceccatelli, S.6
  • 86
    • 0035577791 scopus 로고    scopus 로고
    • Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport
    • Shanker G., Aschner M. Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport. J. Neurosci. Res. 2001, 66:998-1002.
    • (2001) J. Neurosci. Res. , vol.66 , pp. 998-1002
    • Shanker, G.1    Aschner, M.2
  • 87
    • 0036905468 scopus 로고    scopus 로고
    • The consequences of methylmercury exposure on interactive functions between astrocytes and neurons
    • Allen J.W., Shanker G., Tan K.H., Aschner M. The consequences of methylmercury exposure on interactive functions between astrocytes and neurons. Neurotoxicology 2002, 23:755-759.
    • (2002) Neurotoxicology , vol.23 , pp. 755-759
    • Allen, J.W.1    Shanker, G.2    Tan, K.H.3    Aschner, M.4
  • 88
    • 68049114474 scopus 로고    scopus 로고
    • Uptake and efflux of methylmercury in vitro: comparison of transport mechanisms in C6, B35 and RBE4 cells
    • Heggland I., Kaur P., Syversen T. Uptake and efflux of methylmercury in vitro: comparison of transport mechanisms in C6, B35 and RBE4 cells. Toxicol. In Vitro 2009, 23:1020-1027.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 1020-1027
    • Heggland, I.1    Kaur, P.2    Syversen, T.3
  • 89
    • 0028229736 scopus 로고
    • Mechanism of methylmercury efflux from cultured astrocytes
    • Fujiyama J., Hirayama K., Yasutake A. Mechanism of methylmercury efflux from cultured astrocytes. Biochem. Pharmacol. 1994, 47:1525-1530.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1525-1530
    • Fujiyama, J.1    Hirayama, K.2    Yasutake, A.3
  • 90
    • 0025879014 scopus 로고
    • Interactions of methylmercury with rat primary astrocyte cultures: methylmercury efflux
    • Aschner M., Eberle N.B., Kimelberg H.K. Interactions of methylmercury with rat primary astrocyte cultures: methylmercury efflux. Brain Res. 1991, 554:10-14.
    • (1991) Brain Res. , vol.554 , pp. 10-14
    • Aschner, M.1    Eberle, N.B.2    Kimelberg, H.K.3
  • 91
    • 0027512435 scopus 로고
    • Reduced methylmercury accumulation in a methylmercury-resistant rat pheochromocytoma PC12 cell line
    • Miura K., Clarkson T.W. Reduced methylmercury accumulation in a methylmercury-resistant rat pheochromocytoma PC12 cell line. Toxicol. Appl. Pharmacol. 1993, 118:39-45.
    • (1993) Toxicol. Appl. Pharmacol. , vol.118 , pp. 39-45
    • Miura, K.1    Clarkson, T.W.2
  • 93
    • 0024418897 scopus 로고
    • Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption
    • Miura K., Imura N. Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption. Biol. Trace Element Res. 1989, 21:313-316.
    • (1989) Biol. Trace Element Res. , vol.21 , pp. 313-316
    • Miura, K.1    Imura, N.2
  • 94
    • 67349190556 scopus 로고    scopus 로고
    • Mercury toxicity and the mitigating role of selenium
    • Berry M.J., Ralston N.V. Mercury toxicity and the mitigating role of selenium. Ecohealth 2008, 5:456-459.
    • (2008) Ecohealth , vol.5 , pp. 456-459
    • Berry, M.J.1    Ralston, N.V.2
  • 96
    • 75249106472 scopus 로고    scopus 로고
    • MRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach
    • Hogberg H.T., Kinsner-Ovaskainen A., Coecke S., Hartung T., Bal-Price A.K. mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach. Toxicol. Sci. 2010, 113:95-115.
    • (2010) Toxicol. Sci. , vol.113 , pp. 95-115
    • Hogberg, H.T.1    Kinsner-Ovaskainen, A.2    Coecke, S.3    Hartung, T.4    Bal-Price, A.K.5
  • 97
    • 58049198418 scopus 로고    scopus 로고
    • Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes
    • Wang L., Jiang H., Yin Z., Aschner M., Cai J. Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol. Sci. 2009, 107:135-143.
    • (2009) Toxicol. Sci. , vol.107 , pp. 135-143
    • Wang, L.1    Jiang, H.2    Yin, Z.3    Aschner, M.4    Cai, J.5
  • 98
    • 33845967486 scopus 로고    scopus 로고
    • DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury
    • Hwang G.W., Naganuma A. DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury. J. Toxicol. Sci. 2006, 31:537-538.
    • (2006) J. Toxicol. Sci. , vol.31 , pp. 537-538
    • Hwang, G.W.1    Naganuma, A.2
  • 99
    • 67650760534 scopus 로고    scopus 로고
    • Methylmercury speciation influences brain gene expression and behavior in gestationally-exposed mice pups
    • Glover C.N., Zheng D., Jayashankar S., Sales G.D., Hogstrand C., Lundebye A.K. Methylmercury speciation influences brain gene expression and behavior in gestationally-exposed mice pups. Toxicol. Sci. 2009, 110:389-400.
    • (2009) Toxicol. Sci. , vol.110 , pp. 389-400
    • Glover, C.N.1    Zheng, D.2    Jayashankar, S.3    Sales, G.D.4    Hogstrand, C.5    Lundebye, A.K.6
  • 101
    • 37549056621 scopus 로고    scopus 로고
    • Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
    • Padhi B.K., Pelletier G., Williams A., Berndt-Weis L., Yauk C., Bowers W.J., Chu I. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicol. Lett. 2008, 176:93-103.
    • (2008) Toxicol. Lett. , vol.176 , pp. 93-103
    • Padhi, B.K.1    Pelletier, G.2    Williams, A.3    Berndt-Weis, L.4    Yauk, C.5    Bowers, W.J.6    Chu, I.7
  • 103
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26:239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 104
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: enemies within
    • Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science 1998, 281:1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 107
    • 6844241966 scopus 로고    scopus 로고
    • A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis
    • Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol. Pathol. 1997, 25:624-631.
    • (1997) Toxicol. Pathol. , vol.25 , pp. 624-631
    • Nagashima, K.1
  • 108
    • 71049144033 scopus 로고    scopus 로고
    • Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain
    • Fujimura M., Usuki F., Sawada M., Takashima A. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology 2009, 30:1000-1007.
    • (2009) Neurotoxicology , vol.30 , pp. 1000-1007
    • Fujimura, M.1    Usuki, F.2    Sawada, M.3    Takashima, A.4
  • 109
    • 0029943154 scopus 로고    scopus 로고
    • Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure
    • Charleston J.S., Body R.L., Bolender R.P., Mottet N.K., Vahter M.E., Burbacher T.M. Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure. Neurotoxicology 1996, 17:127-138.
    • (1996) Neurotoxicology , vol.17 , pp. 127-138
    • Charleston, J.S.1    Body, R.L.2    Bolender, R.P.3    Mottet, N.K.4    Vahter, M.E.5    Burbacher, T.M.6
  • 110
    • 0034703356 scopus 로고    scopus 로고
    • Intrauterine methylmercury intoxication. Consequence of the inherent brain lesions and cognitive dysfunction in maturity
    • Kakita A., Wakabayashi K., Su M., Yoneoka Y., Sakamoto M., Ikuta F., Takahashi H. Intrauterine methylmercury intoxication. Consequence of the inherent brain lesions and cognitive dysfunction in maturity. Brain Res. 2000, 877:322-330.
    • (2000) Brain Res. , vol.877 , pp. 322-330
    • Kakita, A.1    Wakabayashi, K.2    Su, M.3    Yoneoka, Y.4    Sakamoto, M.5    Ikuta, F.6    Takahashi, H.7
  • 111
    • 0032442625 scopus 로고    scopus 로고
    • Methylmercury antagonizes the survival-promoting activity of insulin-like growth factor on developing cerebellar granule neurons
    • Bulleit R.F., Cui H. Methylmercury antagonizes the survival-promoting activity of insulin-like growth factor on developing cerebellar granule neurons. Toxicol. Appl. Pharmacol. 1998, 153:161-168.
    • (1998) Toxicol. Appl. Pharmacol. , vol.153 , pp. 161-168
    • Bulleit, R.F.1    Cui, H.2
  • 112
    • 0028090316 scopus 로고
    • Methylmercury induces apoptosis of rat cerebellar neurons in primary culture
    • Kunimoto M. Methylmercury induces apoptosis of rat cerebellar neurons in primary culture. Biochem. Biophys. Res. Commun. 1994, 204:310-317.
    • (1994) Biochem. Biophys. Res. Commun. , vol.204 , pp. 310-317
    • Kunimoto, M.1
  • 113
    • 0034668745 scopus 로고    scopus 로고
    • Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death
    • Dare E., Gotz M.E., Zhivotovsky B., Manzo L., Ceccatelli S. Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death. J. Neurosci. Res. 2000, 62:557-565.
    • (2000) J. Neurosci. Res. , vol.62 , pp. 557-565
    • Dare, E.1    Gotz, M.E.2    Zhivotovsky, B.3    Manzo, L.4    Ceccatelli, S.5
  • 114
    • 0035164923 scopus 로고    scopus 로고
    • Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons
    • Dare E., Gorman A.M., Ahlbom E., Gotz M., Momoi T., Ceccatelli S. Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons. Neurotox. Res. 2001, 3:501-514.
    • (2001) Neurotox. Res. , vol.3 , pp. 501-514
    • Dare, E.1    Gorman, A.M.2    Ahlbom, E.3    Gotz, M.4    Momoi, T.5    Ceccatelli, S.6
  • 116
    • 0034648117 scopus 로고    scopus 로고
    • Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia
    • Nishioku T., Takai N., Miyamoto K., Murao K., Hara C., Yamamoto K., Nakanishi H. Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia. Brain Res. 2000, 871:160-164.
    • (2000) Brain Res. , vol.871 , pp. 160-164
    • Nishioku, T.1    Takai, N.2    Miyamoto, K.3    Murao, K.4    Hara, C.5    Yamamoto, K.6    Nakanishi, H.7
  • 117
    • 0033229881 scopus 로고    scopus 로고
    • The involvement of microtubular disruption in methylmercury-induced apoptosis in neuronal and nonneuronal cell lines
    • Miura K., Koide N., Himeno S., Nakagawa I., Imura N. The involvement of microtubular disruption in methylmercury-induced apoptosis in neuronal and nonneuronal cell lines. Toxicol. Appl. Pharmacol. 1999, 160:279-288.
    • (1999) Toxicol. Appl. Pharmacol. , vol.160 , pp. 279-288
    • Miura, K.1    Koide, N.2    Himeno, S.3    Nakagawa, I.4    Imura, N.5
  • 118
    • 0038377454 scopus 로고    scopus 로고
    • Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons
    • Wilke R.A., Kolbert C.P., Rahimi R.A., Windebank A.J. Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons. Neurotoxicology 2003, 24:369-378.
    • (2003) Neurotoxicology , vol.24 , pp. 369-378
    • Wilke, R.A.1    Kolbert, C.P.2    Rahimi, R.A.3    Windebank, A.J.4
  • 119
    • 9744243587 scopus 로고    scopus 로고
    • Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin
    • Toimela T., Tahti H. Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin. Arch. Toxicol. 2004, 78:565-574.
    • (2004) Arch. Toxicol. , vol.78 , pp. 565-574
    • Toimela, T.1    Tahti, H.2
  • 120
    • 33644956003 scopus 로고    scopus 로고
    • High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation
    • Tamm C., Duckworth J., Hermanson O., Ceccatelli S. High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J. Neurochem. 2006, 97:69-78.
    • (2006) J. Neurochem. , vol.97 , pp. 69-78
    • Tamm, C.1    Duckworth, J.2    Hermanson, O.3    Ceccatelli, S.4
  • 121
    • 40049084803 scopus 로고    scopus 로고
    • Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling
    • Tamm C., Duckworth J.K., Hermanson O., Ceccatelli S. Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling. Neuroreport 2008, 19:339-343.
    • (2008) Neuroreport , vol.19 , pp. 339-343
    • Tamm, C.1    Duckworth, J.K.2    Hermanson, O.3    Ceccatelli, S.4
  • 123
    • 0036836070 scopus 로고    scopus 로고
    • Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress
    • Fonfria E., Dare E., Benelli M., Sunol C., Ceccatelli S. Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress. Eur. J. Neurosci. 2002, 16:2013-2016.
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 2013-2016
    • Fonfria, E.1    Dare, E.2    Benelli, M.3    Sunol, C.4    Ceccatelli, S.5
  • 124
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
    • Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996, 86:147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 125
    • 0034630330 scopus 로고    scopus 로고
    • Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
    • Bratton S.B., MacFarlane M., Cain K., Cohen G.M. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp. Cell. Res. 2000, 256:27-33.
    • (2000) Exp. Cell. Res. , vol.256 , pp. 27-33
    • Bratton, S.B.1    MacFarlane, M.2    Cain, K.3    Cohen, G.M.4
  • 126
    • 0033213973 scopus 로고    scopus 로고
    • Caspase and calpain substrates: roles in synaptic plasticity and cell death
    • Chan S.L., Mattson M.P. Caspase and calpain substrates: roles in synaptic plasticity and cell death. J. Neurosci. Res. 1999, 58:167-190.
    • (1999) J. Neurosci. Res. , vol.58 , pp. 167-190
    • Chan, S.L.1    Mattson, M.P.2
  • 127
    • 0031452173 scopus 로고    scopus 로고
    • Structure and physiological function of calpains
    • Sorimachi H., Ishiura S., Suzuki K. Structure and physiological function of calpains. Biochem. J. 1997, 328(Pt 3):721-732.
    • (1997) Biochem. J. , vol.328 , Issue.PART 3 , pp. 721-732
    • Sorimachi, H.1    Ishiura, S.2    Suzuki, K.3
  • 128
    • 23944441220 scopus 로고    scopus 로고
    • Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation
    • Sakaue M., Okazaki M., Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology 2005, 213:97-106.
    • (2005) Toxicology , vol.213 , pp. 97-106
    • Sakaue, M.1    Okazaki, M.2    Hara, S.3
  • 130
    • 0027989510 scopus 로고
    • Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase
    • Oberhammer F.A., Hochegger K., Froschl G., Tiefenbacher R., Pavelka M. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell. Biol. 1994, 126:827-837.
    • (1994) J. Cell. Biol. , vol.126 , pp. 827-837
    • Oberhammer, F.A.1    Hochegger, K.2    Froschl, G.3    Tiefenbacher, R.4    Pavelka, M.5
  • 131
    • 0029133790 scopus 로고
    • Cellular injury induced by oxidative stress is mediated through lysosomal damage
    • Ollinger K., Brunk U.T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic. Biol. Med. 1995, 19:565-574.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 565-574
    • Ollinger, K.1    Brunk, U.T.2
  • 132
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29:323-333.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 133
    • 0034983544 scopus 로고    scopus 로고
    • Lysosomal involvement in apoptosis
    • Brunk U.T., Neuzil J., Eaton J.W. Lysosomal involvement in apoptosis. Redox Rep. 2001, 6:91-97.
    • (2001) Redox Rep. , vol.6 , pp. 91-97
    • Brunk, U.T.1    Neuzil, J.2    Eaton, J.W.3
  • 135
    • 0035408169 scopus 로고    scopus 로고
    • The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress
    • Kagedal K., Johansson U., Ollinger K. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J. 2001, 15:1592-1594.
    • (2001) FASEB J. , vol.15 , pp. 1592-1594
    • Kagedal, K.1    Johansson, U.2    Ollinger, K.3
  • 137
    • 70450222302 scopus 로고    scopus 로고
    • The role of lysosomal rupture in neuronal death
    • Yamashima T., Oikawa S. The role of lysosomal rupture in neuronal death. Prog. Neurobiol. 2009, 89:343-358.
    • (2009) Prog. Neurobiol. , vol.89 , pp. 343-358
    • Yamashima, T.1    Oikawa, S.2
  • 138
  • 139
    • 18244392443 scopus 로고    scopus 로고
    • Cell death independent of caspases: a review
    • Broker L.E., Kruyt F.A., Giaccone G. Cell death independent of caspases: a review. Clin. Cancer Res. 2005, 11:3155-3162.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3155-3162
    • Broker, L.E.1    Kruyt, F.A.2    Giaccone, G.3
  • 142
    • 13244298893 scopus 로고    scopus 로고
    • Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells
    • Fonfria E., Vilaro M.T., Babot Z., Rodriguez-Farre E., Sunol C. Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells. J. Neurosci. Res. 2005, 79:545-553.
    • (2005) J. Neurosci. Res. , vol.79 , pp. 545-553
    • Fonfria, E.1    Vilaro, M.T.2    Babot, Z.3    Rodriguez-Farre, E.4    Sunol, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.