Melatonin: Reducing the toxicity and increasing the efficacy of drugs

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 10, 2002, Pages 1299-1321

  Reiter, Russel J ^a   Tan, Dun Xian ^a   Sainz, Rosa M ^a   Mayo, Juan C ^a   Lopez Burillo, Silvia ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOXIDANT; BLEOMYCIN; CAPOSIDE 50; CARBAMAZEPINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYSTEINE; CYTARABINE; DOXORUBICIN; EPIRUBICIN; ERYTHROPOIETIN; GENTAMICIN; GLUTATHIONE; HALOPERIDOL; INDOLE; INDOMETACIN; IRON; ISONIAZID; LIPID; MELATONIN; MORPHINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEPRAZOLE; PHENOBARBITAL; RANITIDINE; SCAVENGER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIOXIDANT ACTIVITY; AUTOIMMUNE DISEASE; BLOOD TOXICITY; BODY FLUID; CANCER; CARDIOTOXICITY; CELL COMPARTMENTALIZATION; CELL LEVEL; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG RETENTION; GASTROINTESTINAL SYMPTOM; HUMAN; INFECTION; LIPID PEROXIDATION; LIVER TOXICITY; MENTAL DISEASE; MOLECULAR PHYLOGENY; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PINEAL BODY; PROTEIN SYNTHESIS; REVIEW; SIDE EFFECT; TOXICITY TESTING;

ANIMALS; ANTIOXIDANTS; FREE RADICAL SCAVENGERS; HUMANS; MELATONIN; OXIDATIVE STRESS; PHARMACEUTICAL PREPARATIONS;

EID: 0036797512     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702760345374     Document Type: Review

References (216)

1. Adbel-Wahab, M. H., Aksoul, E. E. M. S., Abdel-Aziz, A. H. (2000) Modulatory effects of melatonin and vitamin E on doxorubicin-induced cardiotoxicity in Ehrlich ascites carcinoma-bearing mice. Tumori 86: 157-162
2. Absi, E., Ayala, A., Machado, A., Parrado, J. (2000) Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of Complex I of the mitochondrial respiratory chain. J. Pineal Res. 29: 40-47
3. Acuña-Castroviejo, D., Escames, G., Macias, M., Muñoz-Hoyos, A., Molina Carballo, A., Arouzo, M., Montes, R., Vives, F. (1995) Cell protective role of melatonin in the brain. J. Pineal Res. 19; 57-63
4. Acuña-Castroviejo, D., Martin, M., Marcias, M., Escames, G., Leon, J., Khaldy, H., Reiter, R. J. (2001) Melatonin, mitochondria, and cellular bioenergetics. J. Pineal Res. 30: 65-74
5. Ackworth, I. N., McCabe, D. R., Maher, T. J. (1997) The analysis of free radicals, their reaction products, and antioxidants. In: Bashin, S. I., Salem, H. (eds) Oxidants, antioxidants and free radicals. pp 23-78
6. Agapito, M. T., Antolin, Y., de Brio, M. T., Lopez-Burillo, S., Pablos, M. I., Recio, J. M. (2001) Protective effect of melatonin against adriamycin toxicity in the rat. J. Pineal Res. 31: 23-30
7. Alarcon de la Lastra, C., Motilva, V., Martin, M. J., Nieto, A., Barranco, M. D., Cabeza, J., Herrerias, J. M. (1999) Protective effect of melatonin on indomethacin-induced gastric injury in rats. J. Pineal Res. 26: 101-107
8. Albarran, M. T., Lopez-Burillo, S., Pablos, M. I., Reiter, R. J., Agapito, M. T. (2001) Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light. J. Pineal Res. 30: 227-233
9. Antolin, I., Rodriguez, C., Sainz, R. M., Mayo, J. C., Uria, H., Kolter, M. L., Rodriguez-Colunga, M. J., Tolivia, D., Menendez-Pelaez, A. (1996) Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J. 10: 882-890
10. Antunes, F., Barclay, L. R. C., Ingold, K. O., King, M., Norris, J. Q., Scaiano, J. C., Xi, F. (1999) On the antioxidant activity of melatonin. Free Radical Biol. Med. 26: 117-128
11. Anwar, M. M., Mahfouz, H. A., Sayed, A. S. (1998) Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs. Comp. Biochem. Physiol. 119A: 493-501
12. Arendt, J. (1988) Melatonin and the human circadian system. In: Miles, A., Philbrick, D. R. S., Thompson, C. (eds) Melatonin: clinical perspective. Oxford Press, Oxford, pp 43-61
13. Arendt, J. (1993a) Melatonin and the mammalian pineal gland. London, Chapman and Hall, p. 331
14. Arendt, J. (1993b) Some effects of light and melatonin on human rhythms. In: Wetterberg, L. (ed.) Light and biological rhythms in man. Oxford, Pergamon Press, pp 203-215
15. Arslan S. O., Zerin, M., Vural, H., Coskum, A. (2002) The effect of melatonin on bleomycin-induced pulmonary fibrosis. J. Pineal Res. 32: 21-25
16. Awara, W. M., El-Gohary, M., El-Nabi, S. H., Fadel, W. A. (1998) In vivo and in vitro evaluation of the mutagenic potential of carbamazepine: does melatonin have anti-mutagenic activity? Toxicology 125: 45-52
17. Balzer, I., Hardeland, R. (1996) Melatonin in algae and higher plants - possible roles as a phytohormone and antioxidant. Bot. Acuta 109: 180-183
18. Bandyopadhyay, D., Biswas, K., Bandyopadhyay, U., Reiter, R. J., Banerjee, R. K. (2000) Melatonin protects against stress-induced gastric lesions by scavenging hydroxyl radicals. J. Pineal Res. 29: 143-151
19. Bandyopadhyay, D., Biswas, K., Battacharyya, M., Reiter, R. J., Banerjee, R. K. (2001) Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr. Mol. Med. 1: 501-513
20. Bandyopadhyay, D., Bandyopadhyay, A., Das, P. K., Reiter, R. J., Biswas, K., Banerjee, R. K. (2002) Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J. Pineal Res. 33: 1-7
21. Barlow-Walden, L. R., Reiter, R. J., Abe, M. Pablos, M., Menendez-Pelaez A., Chen, L. D., Poeggeler, B. (1995) Melatonin stimulates brain glutathione peroxidase activity. Neurochem. Int. 26: 497-502
22. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., Freeman, B. A. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl Acad. Sci. USA 87: 1620-1624
23. Blanchard, B., Pompon, D., Ducroq, C. (2000) Nitrosation of melatonin by nitric oxide and peroxynitrite. J. Pineal Res. 29: 184-192
24. Blask, D. E. (2001) An overview of the neuroendocrine regulation of experimental tumor growth by melatonin and its analogues and the therapeutic use of melatonin in oncology. In: Bartsch, C., Bartsch, H., Blask, D. E., Cardinali, D. P., Hrushesky, W. J. M., Menke, D. (eds) The pineal gland and cancer. Berlin, Springer, pp 309-342
25. Blask, D. E., Cos, S., Hill, S. H., Burns, D. M., Lemus-Wilson, A., Grasso, D. S. (1991) Melatonin action on oncogenesis. In: Fraschini, F., Reiter, R. J. (eds) Role of melatonin and pineal peptides in neuroimmunomodulation. New York, Plenum Press, pp 233-240
26. Borg, D. (1999) Oxygen radicals and tissue injury. In: Tarr, M., Samson, F. (eds) Oxygen free radicals and tissue injury. Boston, Birkhaüser, pp 12-53
27. Borowicz, K. K., Kaminski, R., Gasior, M., Kleinrok, Z., Czuczwar, S. J. (1999) Influence of melatonin on the protective action of conventional anti-epileptic drugs against maximal electroshock in mice. Eur. Neuropsychopharmacol. 9: 185-190
28. Brömme, H. J., Mörke, W., Peschke, E., Ebelt, H., Peschke, D. (2000) Scavenging effect of melatonin on hydroxyl radicals generated by alloxan. J. Pineal Res. 29: 201-208
29. Brusco, L. I., Marquez, M., Cardinali, D. P. (1998) Monozygotic twins with Alzheimer's disease treated with melatonin. J. Pineal Res. 25: 260-263
30. Brusco, L. I., Marquez, M., Cardinali, D. P. (2000) Melatonin treatment stabilizes chronobiologic and cognitive systems in Alzheimer's disease. Neuroendocrinol. Lett. 21: 39-42
31. Brzezinki, A. (1997) Melatonin in humans. N. Engl. J. Med. 336: 186-195
32. Brzozowska, I., Konturek, P. C., Brzozowski, T., Konturek, S. J., Kwiecien, S., Pajdo, R., Drozdowicz, D., Pawlik, M., Ptak, A., Hahn, E. G. (2002) Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. J. Pineal Res. 32: 149-162
33. Brzozowski, T., Konturek, P. C., Konturek, S. J., Pajdo, R., Bielanski, W., Brzowska, I., Stachura, J., Hahn, E. G. (1997) The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin. J. Pineal Res. 23: 79-89
34. Bubenik, G. A. (2001) Localization, physiological significance and possible clinical implication of gastrointestinal melatonin. Biol. Signals Recept. 10: 350-356
35. Burkhardt, S., Poeggeler, B., Tan, D. X., Rosner, C., Gruetzner, T., Nitzki, F., Schoenke, M., Thuermann, S., Reiter, R. J., Hardeland, R. (2001) Oxidation products formed from melatonin in various radical-generating systems. In: Hardeland, R. (ed.) Actions and redox properties of melatonin and other aromatic amino acid metabolites. Göttingen, Cuvillier Verlag, pp 9-22
36. Cadenas, E., Packer, L. (eds) (2002) Handbook of antioxidants. 2nd Edition, New York, Marcel Dekker, p. 712
37. Cagnoli, C. M., Atabay, C., Kharlamova, E., Manev, H. (1995) Melatonin protects neurons from singlet oxygen-induced apoptosis. J. Pineal Res. 18: 222-226
38. Calabresi, P., Chabner, B. A. (1991) Section XII, chemotherapy of neoplastic diseases. In: Gilman, A. G., Rall, T. W., Niles, A. S., Taylor, P. (eds) The pharmacologic basis of therapeutics. Vol. 2, 8th edition, McGraw Hill, New York, pp 1202-1276
39. Chan, T. Y., Tang, P. L. (1996) Characterization of the antioxidant effects of melatonin and related indoleamines in vitro. J. Pineal Res. 20: 187-191
40. Cohen-Mansfield, J., Garfinkel, D., Lipson, S. (2000) Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study. Arch. Gerontol. Geriatr. 31: 65-76
41. Conti, A., Conconi, S., Hertens, E., Skwarlo-Sonta, K., Markowska, M., Maestroni, G. J. M. (2000) Evidence for melatonin synthesis in mouse and human bone marrow cells. J. Pineal Res. 28: 193-202
42. Costa, E. J. X., Shida, C. S., Biaggi, M. H., Ito, A. S. Lamy-Freund, M. P. (1997) How melatonin interacts with lipid bilayers: a study by fluorescence and ERS spectroscopies. FEBS Lett. 416: 103-106
43. Crespo, E., Macias, M., Pozo, D., Escames, G., Martin, M., Vives, F., Guerrero, J. M., Acuña-Castroviejo, D. (1999) Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J. 13: 1537-1546
44. Cuzzocrea, S., Reiter, R. J. (2001) Pharmacological actions of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur. J. Pharmacol. 426: 1-10
45. 2- and cyclophosphamide-induced DNA damage. Mutagenesis 14: 107-122
46. Das, D., Bandyopadhyay, D., Bhattacharjee, M., Banerjee, R. K. (1997) Hydroxyl radical is a major causative factor in stress-induced gastric ulceration. Free Radic. Biol. Med. 23: 8-18
47. de Lourdes, V. Seabra, M., Bignotto, M., Pinto, L. R., Tufik, S. (2000) Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J. Pineal Res. 29: 193-200
48. Dellegar, S. M., Murphy, S. A., Broune, A. E., DiCesare, J. C., Purser, G. H. (1999) Identification of factors affecting the rate of deactivation of hypochlorous acid by melatonin. Biochem. Biophys. Res. Commun. 257: 431-439
49. Dijk, K. D. J., Cajochen, C. (1997) Melatonin and circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J. Biol. Rhythms 12: 627-639
50. Dubocovich, M. L., Mansana, M. I., Benloucif, S. (1999) Molecular pharmacology and function of melatonin receptors. Adv. Exp. Med. Biol. 460: 181-190
51. Dugo, L., Serraino, I., Fulia, F., De Sarro, A., Caputi, A. P., Cuzzocrea, S. (2001) Effect of melatonin on energy depletion mediated by peroxynitrite and poly(ADP-ribose)synthase activation in an acute model of inflammation. J. Pineal Res. 31: 76-84
52. Fauteck, J., Schmidt, A., Lerchl, A., Kurlmann, G., Wittowski, W. (1999) Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol. Signals Recept. 8: 105-110
53. Flejter, W. L., Ostemborski, J. A., Hassel, T. M., Cohen, M. M. (1989) Cytogenetic effects of phenytoin and/or carbamazepine on human peripheral leukocytes. Epilepsia 30; 374-379
54. Fulia, F., Gitto, E., Cuzzocrea, S., Reiter, R. J, Dugo, L., Gitto, P., Barberi, S., Cordaro, S., Barberi, I. (2001) Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J. Pineal Res. 31: 343-349
55. Futugami, M., Sato, S., Sakamoto, T., Yokoyaya, Y., Saito, Y. (2001) Effects of melatonin on the proliferation and cis-diamminedichloro-platinum (CDDP) sensitivity of cultured human ovarian cancer cells. Gynecol. Oncol. 82: 544-549
56. Garcia, J. J, Reiter, R. J., Guerrero, J. M., Escames, G., Yu, B. P., Oh, C. S., Muñoz-Hoyos, A. (1997) Melatonin prevents changes in microsomal membrane fluidity during lipid peroxidation. FEBS Lett. 408: 297-300
57. Garcia, J. J., Reiter, R. J., Ortiz, G. G., Oh, C. S., Tang, L., Yu, B. P., Escames, G. (1998) Melatonin enhances tamoxifen's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation. J. Membr. Biol. 162: 59-65
58. Garcia-Mauriño, S., Gonzalez-Haba, M. G., Calvo, J. R., Goberna, R., Guerrero, J. M. (1998) Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells. J. Neuroimmunol. 92: 76-84
59. Garcia-Mauriño, S., Pozo, D., Calvo, J. R., Guerrero, J. M. (2000) Correlation between nuclear receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines. J. Pineal Res. 29: 129-137
60. Garfinkel, D., Laudon, M., Nof, D., Zisapel, N. (1995) Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 346: 541-544
61. Gilad, E., Cuczzocrea, S., Zingarelli, B., Salzman, A. L., Szabo, C. (1997) Melatonin is a scavenger of peroxynitrite. Life Sci. 60: 169-174
62. Gille, L., Nohl, H. (1997) Analyses of the molecular mechanism of adriamycin-induced toxicity. Free Radic. Biol. Med. 23: 775-782
63. Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimacrchi, G., Barberi, I. (2001a) Effects of melatonin treatment in septic newborns. Pediatr. Res. 50: 756-760
64. Gitto, E., Tan, D. X., Reiter, R. J., Karbownik, M., Manchester, L. C., Cuzzocrea, S., Fulia, F., Barberi, I. (2001b) Individual and synergistic actions of melatonin: studies with vitamin E, and vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. J. Pharm. Pharmacol. 53: 1393-1401
65. Granzotto, M., Rapozzi, V., Decorti, G., Giraldi, T. (2001) Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleotropically resistant tumor cells. J. Pineal Res. 31: 206-213
66. Grisham, M. B. (1992) Reactive metabolites of oxygen and nitrogen in biology and medicine. R. G. Landis Company, Austin, p. 104
67. Guerrero, J. M., Reiter, R. J. (1992) A brief survey of pineal gland-immune system interactions. Endocrine Res. 18: 91-113
68. Guerrero, J. M., Reiter, R. J. (2000) Melatonin-immune system relationships. Curr. Topics Med. Chem. 2: 167-180
69. Guerrero, J. M., Pozo, D., Garcia-Maurino, S., Carrillo-Vico, S., Osuna, C., Calvo, R. J. (2000) Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells. Biol. Signals Recept. 9: 197-202
70. Halliwell, B., Gutteridge, J. M. C. (1999) Free radicals in biology and medicine. 3rd Edition, Clarendon Press, Oxford, p. 724
71. Hara, M., Yoshida, M., Nishijima, H., Yokosuka, M., Iigo, M., Ohtani-Kaneko, R., Shimada, A., Hasegawa, T., Akama, Y., Hirata, K. (2001) Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats. J. Pineal Res. 30: 129-138
72. Hardeland, R., Fuhrberg, B. (1996) Ubiquitous melatonin - presence and effects in unicells, plants and animals. Trends Comp. Biochem. Physiol. 2: 25-45
73. Hardeland, R., Reiter, R. J., Poeggeler, B., Tan, D. X. (1993) The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances. Neurosci. Biobehav. Rev. 17: 347-357
74. Hardeland, R., Balzer, I., Poeggeler, B., Fuhrberg, B., Uria, H., Behrmann, G., Wolfm R., Meyer, T. J., Reiter, R. J. (1995) On the primary functions of melatonin in evolution: mediation of photoperiodic signals in unicells, photo-oxidation and scavenging of free radicals. J. Pineal Res. 18: 104-111
75. Hassan, M. I., Ahmed, M. I., Kassim, S. K., Rashad, A., Khalifa, A. (1999) Cis-platinum-induced immunosuppression: relationship to melatonin in human peripheral blood mononuclear cells. Clin. Chem. 32: 621-626
76. Hauptmann, N., Cadenas, E. (1997) The oxygen paradox: biochemistry of active oxygen. In: Scandalios, J. G. (ed.) Oxidative stress and the molecular biology of antioxidant defenses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 1-20
77. Hengstler, J. G., Hengst, A., Fuchs, J., Tanner, B., Pohl, J., Oesch, F. (1997) Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after inactivation of cytochrome P-450 2B1. Mutat. Res. 373: 215-233
78. Henley, C. M., Rybak, L. P. (1993) Developmental ototoxicity. Otolaryngol. Clin. North. Am. 26: 857-871
79. Herrera, J., Nava, M., Romero, F., Rodriquez-Iturbe, B. (2001) Melatonin prevents oxidative stress resulting from iron and erythropoietin administration. Am. J. Kidney Dis. 37: 750-757
80. Humes, H. D., Weinberg, J. M. (1986) Toxic nephropathies. In: Brenner, B. W., Rector, F. C. (eds) The kidney. Saunders, Philadelphia, pp 1491-1493
81. Ianas, O., Olinescu, R., Balescu, I. (1991) Melatonin involvement in oxidative processes. Rom. Endocrinol. 29: 147-153
82. Inauen, W., Wyss, P. A., Kayser, S., Baumgartner, A, Schurer-Maly, C. C., Koelz, H. R., Halter, F. (1998) Influence of prostaglandins, omeprazole and indomethacin on healing experimental gastric ulcers in the rat. Gastroenterology 95: 636-641
83. Jahnke, G., Marr, M., Myers, C., Wilson, R., Travlos, G., Price, C. (1999) Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol. Res. 50: 271-279
84. Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., Laudon, M. (2000) Clinical trials of controlled-release melatonin in children with slee-wake cycle disorders. J. Pineal Res. 29: 34-39
85. Jenkinson, S. G., Jordan, J. M., Duncan, C. A. (1989) Effects of selenium on glutathione-induced protection from hyperbaric hyperoxia in rat. Am. J. Physiol. 257: L393-398
86. Kane, M. A., Johnson, A., Robinson, W. A. (1994) Serum melatonin levels in melanoma patients after repeated oral administration. Melanoma Res. 4: 59-65
87. Kanematsu, N., Mori, Y., Hayashi, S., Hoshino, K. (1989) Presence of a distinct 24-hour melatonin rhythm in the ventricular cerebrospinal fluid of the goat. J. Pineal Res. 7: 143-152
88. Karbownik, M., Reiter, R. J. (2000) Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc. Soc. Exp. Biol. Med. 225: 9-22
89. Kaul, N., Sivelski-Iliskovic, N., Hill, M., Slezak, J., Singal, P. K. (1993) Free radicals and the heart. J. Pharmacol. Toxicol. Meth. 30: 55-67
90. Kociba, R. J., Sleight, S. D. (1971) Acute toxicologic and pathologic effects of cis-diamminedichloroplatinum (NSL 119875) in the male rat. Cancer Chemother. Rev. 55: 1-8
91. Kotler, M., Rodriquez, C., Sainz, R. M., Antolin, I., Menendez-Pelaez, A. (1998) Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J. Pineal Res. 24: 83-89
92. Kwok, C. S., Mun, K. C. (2000) The beneficial effect of melatonin for cyclosporine hepatotoxicity in rats. Transplant. Proc. 32: 2009-2010
93. Lissoni, P. (2002) Is there a role for melatonin in supportive care? Support Care Cancer 10: 110-116
94. Lissoni, P., Paolorossi, F., Ardizzoia, A., Barni, S., Chilelli, M., Mancuso, M., Tancini, G., Conti, A., Maestroni, G. J. M. (1997) A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in poor clinical state. J. Pineal Res. 23: 15-19
95. Lissoni, P., Barni, S., Mandala, M., Ardizzoia, A., Paolorossi, F., Vaghi, M., Longarini, R., Malugani, F., Tancini, G. (1999a) Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumor patients with poor clinical status. Eur. J. Cancer 35: 1688-1692
96. Lissoni, P., Tancini, G., Paolorossi, F., Mandala, M., Ardizzoia, A., Malugani, F., Giani, L., Borni, S. (1999b) Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. J. Pineal Res. 26: 169-173
97. Lissoni, P., Bucovec, R., Bonfanti, A., Giani, L., Mandelli, A., Roselli, M. G., Rovelli, F., Fumagolli, L. (2001) Thrombopoietic properties of 5-methyoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer-related thrombocytopenia. J. Pineal Res. 30: 123-126
98. Livrea, M. A., Tesoriere, L., D'Arpa, D., Morreale, M. (1997) Reaction of melatonin with lipoperoxyl radicals in phospholipid bilayers. Free Radic. Biol. Med. 23: 706-711
99. Livrea, M. A., Tesoriere, L., Tan, D. X., Reiter, R. J. (2002) Radical and reactive intermediate-scavenging properties of melatonin in pure chemical systems. In: Cadenas, E., Packer, L. (eds) Handbook of antioxidants. 2nd edition, Marcel Dekker, New York, pp 615-631
100. Lopez-Gonzalez, M. A., Guerrero, J. M., Delgado, F. (1997) Presence of the pineal hormone melatonin in rat cochlea: its variations with lighting conditions. Neurosci. Lett. 238: 81-83
101. Lopez-Gonzalez, M. A., Guerrero, J. M., Rojas, R., Osuna, C., Delgado, F. (1999) Melatonin and other antioxidants prolong the postmortem activity of the outer hair cells of the organ of Corti: its relation to the type of death. J. Pineal Res. 27: 73-77
102. Lopez-Gonzalez, M. A., Guerrero, J. M., Torronteras, R., Osuna, C., Delgado, F. (2000a) Ototoxicity caused by aminoglycosides is ameliorated by melatonin without interfering with the antibiotic capacity of the drugs. J. Pineal Res. 28: 26-33
103. Lopez-Gonzalez, M. A., Guerrero, J. M., Guerrero, J. M., Rojas, F., Delgado, F. (2000b) Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants. J. Pineal Res. 28: 73-80
104. MacDougall, I. C., Hutton, P. D., Covill, I., Coles, G. A., Williams, J. D. (1989) Poor response to treatment of renal anemia with erythropoietin corrected by iron given intravenously. Br. Med. J. 299: 157-158
105. Maestroni, G. J. M. (2001) The immunotherapeutic potential of melatonin. Exp. Opin. Invest. Drugs 10: 467-476
106. Mahal, H. S., Sharma, H. S., Mukherjee, T. (1999) Antioxidant properties of melatonin: a pulse radiolysis study. Free Radic. Biol. Med. 26: 557-565
107. Mahmud, T., Scott, D. C., Bjarnason, I. (1996) A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity. Ann. Rheum. Dis. 55: 211-213
108. Manchester, L. C., Poeggeler, B., Alvarez, F. L., Ogden, G. B., Reiter, R. J. (1995) Melatonin immunoreactivity in the prokaryote Rhodospirillum rubrum: implications for an ancient antioxidant system. Cell. Mol. Biol. Res 41: 391-395
109. Marshall, K. A., Reiter, R. J., Poeggeler, B., Aroma, O. I., Halliwell, B. (1996) Evaluation of the antioxidant activity of melatonin in vitro. Free Radic. Biol. Med. 21: 307-315
110. Martin, M., Macias, M., Escames, G., Reiter, R. J., Agapito, M. T., Ortiz, G. G., Acuña-Castroviejo, D. (2000a). Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo. J. Pineal Res. 28: 242-248
111. Martin, M., Macias, M., Escames, G., Leon, J., Acuña-Castroviejo, D. (2000b) Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl-hydroperoxide-induced mitochondrial oxidative damage. FASEB J. 14: 1677-1679
112. Martin, M., Macias, M., Leon, J., Escames, G., Khaldy, H., Acuña-Castroviejo, D. (2002) Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria. Int. J. Biochem. Cell Biol. 34: 348-357
113. Matuszak, K., Reszka, K. F., Chignell, C. F. (1997) Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigation. Free Radic. Biol. Med. 23: 367-372
114. McMillen, I. C., Nowak, R. (1989) Maternal pinealectomy abolishes the diurnal rhythm in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation. J. Endocrinol. 120: 459-464
115. Menendez-Pelaez, A., Reiter, R. J. (1993) Distribution of melatonin in mammalian tissues: relative importance of nuclear versus cytosolic localization. J. Pineal Res. 15: 59-69
116. Menendez-Pelaez, A., Poeggeler, B., Reiter, R. J., Barlow-Walden, L. R., Pablos, M. I., Tan, D. X. (1993) Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence. J. Cell. Biochem. 53: 373-382
117. Molina-Carballo, A., Muñoz-Hoyos, A., Reiter, R. J., Sanchez-Forte, M., Moreno-Madrid, F., Rufo-Campos, M., Molina-Font, J. A., Acuña-Castroviejo, D. (1997) Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. J. Pineal Res. 23: 97-105
118. Montilla, P., Tunez, I., Muñoz, M. C., Lopez, A., Soria, J. V. (1997a) Hyperlipidemic nephropathy induced by adriamycin: effect of melatonin administration. Nephron 76: 345-350
119. Montilla, P., Tunez, I., Muñoz, M. C., Soria, J. V., Lopez, A. (1997b) Antioxidative effect of melatonin in rat brain oxidative stress induced by adriamycin. J. Physiol. Biochem. 53: 301-306
120. Montilla, P., Tunez, T., Muñoz, M. C., Gascon, F. L., Lopez Soria, J. V. (1998) Protective role of melatonin and retinal palmitate in oxidative stress and hyperlipidemic nephropathy induced by adriamycin in rats. J. Pineal Res. 25: 86-93
121. Montilla, P., Tunez, I., Muñoz de Agreeda, M. C., Cabrera, E., Montilla, M. C., Plascencia, J., de la Torre, E. J. (2000) Protective effect of melatonin against oxidative stress induced by ligature of extra-hepatic biliary duct in rats: comparison with the effect of 5-adenosyl-L-methionine. J. Pineal Res. 28: 143-149
122. Morishima, I., Matsui, H., Mukawa, A., Hayashi, K., Toki, Y., Okumura, K., Ito, T., Hayakawa, T. (1998) Melatonin, a pineal hormone with antioxidant property, protects against adriamycin-cardiopathy in rats. Life Sci. 68: 511-521
123. Morishima, I., Okumura, K., Matsui, H., Kaneko, S., Numaguchi, Y., Kawakami, K., Mokuno, S., Hayakawa, M., Toki, Y., Ito, T., Hayakawa, T. (1999) Zinc accumulation in adriamycin-induced cardiomyopathy in rats: effects of melatonin, a cardioprotective antioxidant. J. Pineal Res. 26: 204-210
124. Muñoz-Hoyos, A., Sanchez-Forte, M., Molina-Carballo, A., Escames, G., Martin-Medina, E., Reiter, R. J., Molina-Font, J. A., Acuña-Castroviejo, D. (1998) Melatonin's role as an antioxidant and neuronal protector: experimental and clinical evidence. J. Child Neurol. 13: 501-509
125. Noda, Y., Mori, A., Liburty, R., Packer, L. (1999) Melatonin and its precursors scavenge nitric oxide. J. Pineal Res. 27: 159-163
126. Nordlund, J. J., Lerner, A. B. (1976) The effects of oral melatonin on skin color and on the release of pituitary hormones. J. Clin. Endocrinol. Metab. 45: 758-764
127. Okatani, Y., Okamoto, K., Hayashi, K., Wakatsuki, A., Sagara, Y. (1998) Maternal-fetal transfer of melatonin in human pregnancy near term. J. Pineal Res. 25: 129-134
128. Okatani, Y., Wakatsuki, A., Shinohara, K., Kaneda, C., Fukaya, T. (2001) Melatonin stimulates glutathione peroxidase activity in human chorion. J. Pineal Res. 30: 199-205
129. Othman, A. I., El-Missiry, M. A., Amer, M. A. (2001) The protective action of melatonin on indomethacin-induced gastric and testicular oxidative stress in rats. Redox Rept. 6: 173-177
130. Özbek, E., Turkoz, Y., Shna, E., Ozugulu, F., Mizrak, B., Ozbek, M. (2000) Melatonin administration prevents the nephrotoxicity induced by gentamicin. BJU Int. 85: 742-746
131. Ozols, R. G., Deiseroth, N., Javadpour, A. B., Messerschmidt, G., Young, R. C. (1983) Treatment of poor prognosis non-seminomatous tubular cancer with a high-dose platinum combination chemotherapy regimen. Cancer 51: 1803-1807
132. Pablos, M. I., Agapito, M. T., Gutierrez, R., Recio, J. M., Reiter, R. J., Barlow-Walden, L. R., Acuña-Castroviejo, D. (1995) Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J. Pineal Res. 19: 111-115
133. Pablos, M. T., Guerrero, J. M., Ortiz, G. G., Agapito, M. T., Reiter, R. J. (1997a) Both melatonin and putative nuclear melatonin receptor agonist CGP 52608 stimulate glutathione peroxidase and glutathione reductase activity in mouse brain in vitro. Neuroendocrinol. Lett. 18: 49-58
134. Pablos, M. I., Reiter, R. J., Chuang, J. I., Ortiz, G. G., Guerrero, J. M., Sewerynek, E., Agapito, M. T., Melchiorri, D., Lawrence, R., Deneke, S. M. (1997b) Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. Am. J. Physiol. 83: 354-358
135. Pang, C. S., Tsang, S. F., Yang, J. C. (2001) Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice. Life Sci. 68: 943-951
136. Phelps, D. T., Ferro, T. J., Higgins, P. J., Sankar, R., Parker, D. M., Johnson, M. (1995) TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase. Am. J. Physiol. 269: L551-L559
137. Pieri, C., Marra, M., Moroni, F., Recchioni, R., Marcheselli, F. (1994) Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci. 55: 271-276
138. Pieri, C., Moroni, M., Marcheselli, F., Marra, M., Recchioni, R. (1995) Melatonin is an efficient antioxidant. Arch. Gerontol. Geriatr. 20: 159-165
139. Pierrefiche, G., Topall, G., Courbain, G. (1993) Antioxidant activity of melatonin in mice. Res. Commun. Chem. Pathol. Pharmacol. 80: 211-223
140. Pippenger, C. E., Browne, R. W., Armstrong, D. (1998) Regulatory antioxidative enzymes. In: Armstrong, D. (ed.) Free radical and antioxidant protocols. Human Press, Totowa pp 299-313
141. Poeggeler, B., Reiter, R. J., Tan, D. X., Chen, L. D., Manchester, L. C. (1993) Melatonin, hydroxyl radical-mediated oxidative damage and aging: a hypothesis. J. Pineal Res. 14: 151-169
142. Poeggeler, B., Saarela, S., Reiter, R. J., Tan, D. X., Chen, L. D., Manchester, L. C., Barlow-Walden, L. (1994) Melatonin - a highly potent radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole assessed in vitro. Ann. NY Acad. Sci. 738: 419-420
143. Poeggeler, B., Reiter, R. J., Hardeland, R., Tan, D. X., Barlow-Walden, L. R. (1996) Melatonin and structurally related endogenous indoles act as electron donors and radical scavengers in vitro. Redox Rept. 2: 179-184
144. Poeggeler, B., Thuermann, S., Dore, A., Schoenke, M., Burkhardt, S., Hardeland, R. (2002) Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs. J. Pineal Res. 33: 20-30
145. Post, A., Holsboer, F., Behl, C. (1998) Induction of NF-κB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-κB and neuroprotection by antioxidants. J. Neurosci. 18: 727-736
146. Pozo, D., Reiter, R. J., Calvo, J. R., Guerrero, J. M. (1997) Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J. Cell. Biochem. 65: 430-442
147. Rapozzi, V., Zorzet, S., Comelli, M., Mavelli, I., Perissin, L., Giraldi, T. (1998) Melatonin decreases bone marrow and lymphocyte toxicity of adriamycin in mice bearing TLX5 lymphoma. Life Sci. 63: 1701-1713
148. Rapozzi, V., Comelli, M., Mavelli, I., Sentjurc, M., Sahara, M., Perissin, L., Giraldi, T. (1999) Melatonin and oxidative damage in mice liver induced by the prooxidant drug, adriamycin. In Vivo 13: 45-50
149. Ravi, R., Somani, S. M., Rybak, L. P. (1995) Mechanisms of cisplatin ototoxicity: antioxidant system. Pharmacol. Toxicol. 76: 386-394
150. Reiter, R. J. (1980) The pineal and its hormones in the control of reproduction in mammals. Endocr. Rev. 1: 109-131
151. Reiter, R. J. (1991) Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr. Rev. 12: 151-180
152. Reiter, R. J. (1992) The aging pineal gland and its physiological consequences. Bio Essays 14: 169-175
153. Reiter, R. J. (1997) Aging and oxygen toxicity. Age 20: 201-213
154. Reiter, R. J. (1999) Oxidative damage to nuclear DNA: amelioration by melatonin. Neuroendocrinol. Lett. 20: 145-150
155. Reiter, R. J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L. R., Chuang, S. H., Ortiz, G. G., Acuña-Castroviejo, D. (1995) A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18: 1-11
156. Reiter, R. J., Tan, D. X., Acuña-Castroviejo, D., Burkhardt, S., Karbownik, M. (2000a) Melatonin: mechanisms and actions as an antioxidant. Curr. Topics Biophys. 24: 171-183
157. Reiter, R. J., Tan, D. X., Osuna, C., Gitto, E. (2000b) Actions of melatonin in the reduction of oxidative stress. J. Biomed. Sci. 7: 444-458
158. Reiter, R. J., Tan, D. X., Karbownik, M. (2001a) Cholethiasis, oxidative stress and melatonin. J. Pineal Res. 30: 127-128
159. Reiter, R. J., Tan, D. X., Burkhardt, S., Manchester, L. C. (2001b) Melatonin in plants. Nutr. Rev. 59: 286-290
160. Reiter, R. J., Tan, D. X., Manchester, L. C., Qi, W. (2001c) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem. Biophys. 34: 347-256
161. Reiter, R. J., Tan, D. X., Manchester, L. C., Calvo, J. R. (2002a) Antioxidant capacity of melatonin. In: Cadenas, E., Packer, L. (eds) Handbook of antioxidants. 2nd edition, Marcel Dekker, New York, pp 565-614
162. Reiter, R. J., Tan, D. X., Sainz, R. M., Mayo, J. C. (2002b) Melatonin
163. Reppert, S. M. (1997) Melatonin receptors: molecular biology of a new family of G-protein-coupled receptors. J. Biol Rhythms 12: 528-531
164. Rybak, L. P., Rani, R., Somani, S. M. (1995) Mechanism of protection by diethyldithiocarbonate against cisplatin ototoxicity: antioxidant system. Fund. Appl. Toxicol. 26: 293-300
165. Sauer, L. A., Dauchy, R. T., Blask, D. E. (2001) Polyunsaturated fatty acids, melatonin, and cancer prevention. Biochem. Pharmacol. 61: 1455-1462
166. Scandalios, J. G. (ed.) (1997) Oxidative stress and the molecular biology of antioxidant defenses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, p. 890
167. Sener, G., Özer, Sehirli, A., Altunbas, H. Z., Ersoy, Y., Paskaloglu, K., Arbak, S., Ayanoglu-Dulger, G. (2002) Melatonin protects against gentamicin-induced nephrotoxicity in rats. J. Pineal Res. 32: 231-236
168. Sener-Muratoglu, G., Paskologlu, K., Arbak, S., Hurdag, C., Ayanoglu-Dulger, G. (2001) Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig. Dis. Sci. 46: 318-330
169. Shamir, E., Barak, Y., Shalman, I., Laudon, M., Zisapel, N., Tarrasch, R., Elizur, A., Weizman, R. (2001) Melatonin treatment in tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch. Gen. Psychiatr. 58: 1049-1052
170. Shida, C. S., Castrucci, A. M. L., Lamy-Freund, M. T. (1994) High melatonin solubility in aqueous media. J. Pineal Res. 16: 198-201
171. Shifow, A. A., Kumar, K. V., Naidu, M. U. R., Ratnakar, K. S. (2000) Melatonin, a pineal hormone with antioxidant properties, protects against gentamicin-induced nephrotoxicity in rats. Nephron 85: 167-174
172. Sies, H. (1986) Biochemistry of oxidative stress. Angew Chem. Int. Ed. Engl. 25: 1058-1071
173. Sies, H. (ed.) (1997) Antioxidants in disease mechanisms and therapy. Academic Press, San Diego, p. 707
174. Simmons, C. F., Bogusky, R. T., Humes, H. D. (1980) Inhibitory effects of gentamicin on renal mitochondrial oxidative phosphorylation. J. Pharmacol. Exp. Ther. 214: 709-715
175. Singal, P. K., Iliskovic, N. (1998) Doxorubicin-induced cardiomyopathy. N. Engl. J. Med. 339: 900-905
176. Sivelski-Iliskovic, N., Thomas, T. P., Kaul, N., Slezak, J., Singal, P. K. (1994) Doxorubicin-induced cardiomyopathy: a model of congestive heart failure. In: Nagano, M., Takeda, N., Dhalla, N. S. (eds) The cardiomyopathic heart. Raven Press, New York, pp 277-283
177. Skinner, D. C., Malpaux, B. (2000) High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus. Endocrinology 140: 4399-4405
178. Stadnicki, S. W., Gleischmann, R. W., Schaeppi, U. (1975) Ototoxicity of cisdichlororodiammine (II) (NSC-119875): hearing loss and other toxic effects in Rhesus monkeys. Cancer Chemother. Rev. 59: 467-480
179. Stefulj, J., Hörtner, M., Ghosh, M., Schauenstein, K., Rinner, I., Wölfer, A., Semmler, J., Liebmann, P. M. (2001) Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. J. Pineal Res. 30: 243-247
180. Susa, N., Ueno, S., Furukawa, Y., Ueda, I., Sugiyama, M. (1997) Potent protective effect of melatonin on chromium (VI)-induced DNA single strand breaks, cytotoxicity and lipid peroxidation in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol. 144: 22-27
181. Tan, D. X., Chen, L. D., Poeggeler, B., Manchester, L. C., Reiter, R. J. (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr. J. 1: 57-60
182. Tan, D. X., Manchester, L. C., Reiter, R. J., Plummer, B. F., Hardies, L. J., Weintraub, S., Vijayalaxmi, Shepherd, A. M. M. (1998) A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of melatonin interaction with hydroxyl radicals. Biochem. Biophys. Res. Commun. 253: 614-620
183. Tan, D. X., Manchester, L. C., Reiter, R. J., Qi, W., Hanes, M. A., Farley, N. J. (1999a) High physiological levels of melatonin in the bile of mammals. Life Sci. 65: 2523-2529
184. Tan, D. X., Manchester, L. C., Reiter, R. J., Qi, W. B., Zhang, M., Weintraub, S. T., Cabrera, J., Sainz, R. M., Mayo, J. C. (1999b) Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim. Biophys. Acta 1472: 206-214
185. Tan, D. X., Manchester, L. C., Reiter, R. J., Plummer, B. F., Limson, J., Weintraub, S. T., Qi, W. (2000a) Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Radic. Biol. Med. 29: 1177-1185
186. Tan, D. X., Manchester, L. C., Reiter, R. J., Qi, W., Karbownik, M., Calvo, J. R. (2000b) Significance of melatonin in antioxidative defense system: reactions and products. Biol. Signals Recept. 9: 137-159
187. 2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J. 15: 2294-2296
188. Tan, D. X., Reiter, R. J., Manchester, L. C., Yan, M. T., El-Sawi, M., Sainz, R. M., Mayo, J. C., Kohen, R., Allegra, M., Hardeland, R. (2002) Chemical and physical properties and potential mechanisms: melatonin as a free radical scavenger. Curr. Topics Med. Chem. 2: 181-197
189. Taskiran, D., Tanyalcin, T., Sozmen, E. Y., Peker, G. O., Gulmen, V., Cagli, S., Kanit, L., Tekeli, G., Barcin, E., Zileli, M., Kutay, F. Z. (2000) The effects of melatonin on the antioxidant systems in experimental spinal injury. Int. J. Neurosci. 104: 63-73
190. Terzolo, M., Piovesan, A., Angeli, A. (1990) Effects of long-term, low-dose, time-specified melatonin administration on endocrine and cardiovascular variables in adult men. J. Pineal Res. 9: 113-124
191. Tesoriere, L., D'Arpa, D., Conti, S., Giaccone, V., Pintaudi, A. M., Livrea, M. A. (1999) Melatonin protects human's red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity. J. Pineal Res. 27: 95-105
192. Tricoice, H., Locatelli, A., Chemineau, P., Malpaux, B. (2001) Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 143: 84-90
193. Turjanski, A. G., Leonik, F., Rosenstein, R. E., Estrin, D. A., Doctorovich, F. (2000a) Scavenging of NO by melatonin. J. Am. Chem. Soc. 122: 10468-10469
194. Turjanski, A. G., Saenz, D. A., Doctorovich, F., Estrin, D. A., Rosenstein, R. E. (2000b) Nitrosation of melatonin by nitric oxide: a computational study. J. Pineal Res. 31: 97-101
195. Urata, Y., Honma, S., Goto, S., Todoroki, S., Ueda, T., Cho, S., Honma, K., Kondo, T. (1999) Melatonin induces γ-glutamyl-cysteine synthase mediated by activator protein-1 in human vascular endothelial cells. Free Radic. Biol. Med. 27: 838-847
196. Van Tassel, D., Roberts, N., Lewy, A., O'Neill, S.D. (2001) Melatonin in plant organs. J. Pineal Res. 31: 8-15
197. Villa, L. M., Salas, E., Darley-Usmar, M., Radomski, M. V., Moncada, S. (1994) Peroxynitrite induces both vasodilation and impaired vascular relaxation in the isolated perfused rat heart. Proc. Natl Acad. Sci. USA 91: 12383-12387
198. Vijay Kumar, K., Naidu, M. U. R., Shifow, A. A., Prayag, A., Ratnokar, K. S. (1999) Melatonin: an antioxidant protects against cyclosporine-induced nephrotoxicity. Transplantation 67: 1065-1068
199. Wakatsuki, A., Okatani, Y., Izumiya, C., Ikenoue, N. (1999) Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain. J. Pineal Res. 26, 147-152
200. Wakatsuki, A., Okatani, Y., Shinohara, K., Ikenoue, N., Kaneda, C., Fukaya, T. (2001) Melatonin protects fetal rat brain against oxidative mitochondrial damage. J. Pineal Res. 30: 22-28
201. Walker, P. D., Shah, S. V. (1988) Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure. J. Clin. Invest. 81: 334-341
202. Wallace, S. S. (1997) Oxidative damage to DNA and its repair. In: Scandolios, J. (ed.) Oxidative stress and molecular biology of antioxidative defenses. Cold Spring Laboratory Press, Cold Spring Harbor, pp 49-90
203. Wiid, I., Hoal van Helden, E., Hon, D., Lombard, C., van Helden, P. (1999) Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin. Anbiomicrob. Agents Chemother. 43: 975-977
204. Wolf, A., Trendelenburg, C. F., Diez-Fernandez, C., Prieto, P., Houy, S., Trommer, W. E., Cordier, A. (1997) Cyclosporine A-induced oxidative stress in rat hepatocytes. J. Pharmacol. Exp. Ther. 280: 1328-1334
205. Wright, J., Aldhous, M., Arendt, J. (1986) The effect of exogenous melatonin on endocrine function in man. Clin. Endocrinol. 24: 375-382
206. Xu, M. F., Tang, P. L., Qian, Z. M., Ashraf, M. (2001a) Effects of doxorubicin on the myocardium are mediated by oxygen free radicals. Life Sci. 68: 889-901
207. Xu, M. F., Ho, S., Qian, Z. M., Tang, P. L. (2001b) Melatonin protects against cardiac toxicity of doxorubicin in rat. J. Pineal Res. 31: 301-307
208. Yamamoto, H. A., Tang, H. W. (1996a) Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. Neurosci. Lett. 207: 89-92
209. Yamamoto, H. A., Tang, H. W. (1996b) Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. J. Pineal Res. 21: 108-113
210. Yamamoto, H. A., Tang, H. W. (1996c) Effect of melatonin, piperonyl butoxide, or cobalt chloride on L-cysteine-induced lipid peroxidation in homogenate from whole brain of mice. Toxicol. Lett. 89: 51-56
211. Yellon, S. M., Longo, L. D. (1987) Melatonin rhythms in fetal and maternal circulation during pregnancy in sheep. Am. J. Physiol. 252: E799-E802
212. Zachee, P., Farrant, A., Daelmans, R., Coalen, L., Goassens, W., Lins, R. L., Couthenye, M., DeBroe, M. E., Boogoerts, M. A. (1993) Oxidative injury to erythrocytes, cell rigidity and splenic hemolysis in hemodialized patients before and during erythropoietin treatment. Nephon 65: 288-293
213. Zang, L. Y., Cosma, G., Gardner, H., Vallynathan, V. (1998) Scavenging of reactive oxygen species by melatonin. Biochim. Biophys. Acta 1425: 467-477
214. Zaslavskaia, R. M., Biiasilov, N. S., Akhmetov, K. Z., Teiblium, M. M. (2000) Capozide-50 alone and in combination with melatonin in therapy of hypertension. Klin. Med. 78: 39-41 (in Russian)
215. Zhang, H., Squadrito, G. L., Pryor, W. A. (1998) The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated products. Biochem. Biophys. Res. Commun. 251: 83-87
216. Zhang, H., Squadrito, G. L., Uppu, R., Pryor, W. A. (1999) Reaction of peroxynitrite with melatonin: a mechanistic study. Chem. Res. Toxicol. 12: 526-534