-
1
-
-
55949121679
-
Wnt-mediated self-renewal of neural stem/progenitor cells
-
Kalani MY, Cheshier SH, Cord BJ et al. Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci USA 2008;105: 16970-16975.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 16970-16975
-
-
Kalani, M.Y.1
Cheshier, S.H.2
Cord, B.J.3
-
2
-
-
43049144313
-
Wnt signaling and stem cell control
-
Nusse R. Wnt signaling and stem cell control. Cell Res 2008;18: 523-527.
-
(2008)
Cell Res
, vol.18
, pp. 523-527
-
-
Nusse, R.1
-
3
-
-
0035256772
-
Gliomagenesis: Genetic alterations and mouse models
-
Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001;2:120-129.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 120-129
-
-
Holland, E.C.1
-
4
-
-
82655179978
-
Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas
-
Pulvirenti T, Van Der Heijden M, Droms LA et al. Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas. Cancer Res 2011;71:7280-7290.
-
(2011)
Cancer Res
, vol.71
, pp. 7280-7290
-
-
Pulvirenti, T.1
Van Der Heijden, M.2
Droms, L.A.3
-
5
-
-
0037135177
-
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
-
Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002;297:365-369.
-
(2002)
Science
, vol.297
, pp. 365-369
-
-
Chenn, A.1
Walsh, C.A.2
-
6
-
-
0038517899
-
Beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
-
Zechner D, Fujita Y, Hulsken J et al. Beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol 2003;258:406-418.
-
(2003)
Dev Biol
, vol.258
, pp. 406-418
-
-
Zechner, D.1
Fujita, Y.2
Hulsken, J.3
-
8
-
-
33645732219
-
Molecular pathology of malignant gliomas
-
Louis DN. Molecular pathology of malignant gliomas. Annu Rev Pathol 2006;1:97-117.
-
(2006)
Annu Rev Pathol
, vol.1
, pp. 97-117
-
-
Louis, D.N.1
-
9
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-996.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
-
10
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-1068.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
11
-
-
0034612289
-
Glioblastoma multiforme: The terminator
-
Holland EC. Glioblastoma multiforme: the terminator. Proc Natl Acad Sci USA 2000;97:6242-6244.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6242-6244
-
-
Holland, E.C.1
-
12
-
-
0036675901
-
The molecular and genetic basis of neurological tumours
-
Zhu Y, Parada LF. The molecular and genetic basis of neurological tumours. Nat Rev Cancer 2002;2:616-626.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 616-626
-
-
Zhu, Y.1
Parada, L.F.2
-
13
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in Pdgfra, Idh1, Egfr, and Nf1
-
Verhaak RG, Hoadley KA, Purdom E et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in Pdgfra, Idh1, Egfr, and Nf1. Cancer Cell 2010;17: 98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
14
-
-
84865302520
-
Activation of canonical Wnt/Beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of Zeb1 and other activators of epithelial-to-mesenchymal transition
-
Kahlert UD, Maciaczyk D, Doostkam S et al. Activation of canonical Wnt/Beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of Zeb1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett 2012;325:42-53.
-
(2012)
Cancer Lett
, vol.325
, pp. 42-53
-
-
Kahlert, U.D.1
Maciaczyk, D.2
Doostkam, S.3
-
15
-
-
84874512532
-
Unique genome-wide map of Tcf4 and Stat3 targets using Chip-Seq reveals their association with new molecular subtypes of glioblastoma
-
Zhang JX, Zhang J, Yan W et al. Unique genome-wide map of Tcf4 and Stat3 targets using Chip-Seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol 2013;15: 279-289.
-
(2013)
Neuro Oncol
, vol.15
, pp. 279-289
-
-
Zhang, J.X.1
Zhang, J.2
Yan, W.3
-
16
-
-
84940107521
-
Targeting aggressive cancer stem cells in glioblastoma
-
Seymour T, Nowak A, Kakulas F. Targeting aggressive cancer stem cells in glioblastoma. Front Oncol 2015;5:159.
-
(2015)
Front Oncol
, vol.5
, pp. 159
-
-
Seymour, T.1
Nowak, A.2
Kakulas, F.3
-
17
-
-
84899524502
-
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
-
Suva ML, Rheinbay E, Gillespie SM et al. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell 2014;157:580-594.
-
(2014)
Cell
, vol.157
, pp. 580-594
-
-
Suva, M.L.1
Rheinbay, E.2
Gillespie, S.M.3
-
18
-
-
84962634897
-
Cancer stem cells in glioma: Challenges and opportunities
-
Wang J, Ma Y, Cooper MK. Cancer stem cells in glioma: challenges and opportunities. Transl Cancer Res 2013;2:429-441.
-
(2013)
Transl Cancer Res
, vol.2
, pp. 429-441
-
-
Wang, J.1
Ma, Y.2
Cooper, M.K.3
-
19
-
-
84933517549
-
The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence
-
Auffinger B, Spencer D, Pytel P et al. The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence. Expert Rev Neurother 2015;15:741-752.
-
(2015)
Expert Rev Neurother
, vol.15
, pp. 741-752
-
-
Auffinger, B.1
Spencer, D.2
Pytel, P.3
-
20
-
-
70849122697
-
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
-
Brennan C, Momota H, Hambardzumyan D et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 2009; 4:e7752.
-
(2009)
PLoS One
, vol.4
, pp. e7752
-
-
Brennan, C.1
Momota, H.2
Hambardzumyan, D.3
-
21
-
-
84885781199
-
Lgr4 promotes glioma cell proliferation through activation of Wnt signaling
-
Yu CY, Liang GB, Du P et al. Lgr4 promotes glioma cell proliferation through activation of Wnt signaling. Asian Pac J Cancer Prev 2013;14: 4907-4911.
-
(2013)
Asian Pac J Cancer Prev
, vol.14
, pp. 4907-4911
-
-
Yu, C.Y.1
Liang, G.B.2
Du, P.3
-
22
-
-
84869210716
-
Foxm1 and Wnt/Beta-catenin signaling in glioma stem cells
-
Gong A, Huang S. Foxm1 and Wnt/Beta-catenin signaling in glioma stem cells. Cancer Res 2012;72:5658-5662.
-
(2012)
Cancer Res
, vol.72
, pp. 5658-5662
-
-
Gong, A.1
Huang, S.2
-
24
-
-
80855143649
-
Induction of canonical wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella Vectensis
-
Trevino M, Stefanik DJ, Rodriguez R et al. Induction of canonical wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella Vectensis. Dev Dyn 2011;240:2673-2679.
-
(2011)
Dev Dyn
, vol.240
, pp. 2673-2679
-
-
Trevino, M.1
Stefanik, D.J.2
Rodriguez, R.3
-
25
-
-
79959247656
-
The beta-catenin Hmp-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C
-
Sumiyoshi E, Takahashi S, Obata H et al. The beta-catenin Hmp-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. Elegans. Dev Biol 2011;355:302-312.
-
(2011)
Elegans. Dev Biol
, vol.355
, pp. 302-312
-
-
Sumiyoshi, E.1
Takahashi, S.2
Obata, H.3
-
26
-
-
17244375063
-
Role of the Wnt signaling network in embryogenesis and tumorigenesis
-
Nakamura T, Akiyama T. Role of the Wnt signaling network in embryogenesis and tumorigenesis. Seikagaku 2005;77:5-19.
-
(2005)
Seikagaku
, vol.77
, pp. 5-19
-
-
Nakamura, T.1
Akiyama, T.2
-
27
-
-
42549164807
-
Wnt signalling and its impact on development and cancer
-
Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008;8:387-398.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 387-398
-
-
Klaus, A.1
Birchmeier, W.2
-
29
-
-
0033392360
-
Wnt signalling in mammalian development and cancer
-
Smalley MJ, Dale TC. Wnt signalling in mammalian development and cancer. Cancer Metastasis Rev 1999;18:215-230.
-
(1999)
Cancer Metastasis Rev
, vol.18
, pp. 215-230
-
-
Smalley, M.J.1
Dale, T.C.2
-
30
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982;31:99-109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
31
-
-
67649365847
-
Activation of Wnt/Beta-Catenin/Tcf signaling pathway in human astrocytomas
-
Sareddy GR, Panigrahi M, Challa S et al. Activation of Wnt/Beta-Catenin/Tcf signaling pathway in human astrocytomas. Neurochem Int 2009;55:307-317.
-
(2009)
Neurochem Int
, vol.55
, pp. 307-317
-
-
Sareddy, G.R.1
Panigrahi, M.2
Challa, S.3
-
32
-
-
79958171015
-
Wnt/Beta-catenin pathway in human glioma: Expression pattern and clinical/prognostic correlations
-
Liu C, Tu Y, Sun X et al. Wnt/Beta-catenin pathway in human glioma: expression pattern and clinical/prognostic correlations. Clin Exp Med 2011;11:105-112.
-
(2011)
Clin Exp Med
, vol.11
, pp. 105-112
-
-
Liu, C.1
Tu, Y.2
Sun, X.3
-
33
-
-
80054774352
-
Foxm1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
-
Zhang N, Wei P, Gong A et al. Foxm1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011;20:427-442.
-
(2011)
Cancer Cell
, vol.20
, pp. 427-442
-
-
Zhang, N.1
Wei, P.2
Gong, A.3
-
34
-
-
37349025355
-
Snapshot: Noncanonical Wnt signaling pathways
-
Semenov MV, Habas R, Macdonald BT et al. Snapshot: noncanonical Wnt signaling pathways. Cell 2007;131:1378.
-
(2007)
Cell
, vol.131
, pp. 1378
-
-
Semenov, M.V.1
Habas, R.2
Macdonald, B.T.3
-
35
-
-
42149159492
-
Wnt signaling: An essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal
-
Cohen ED, Tian Y, Morrisey EE. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 2008;135:789-798.
-
(2008)
Development
, vol.135
, pp. 789-798
-
-
Cohen, E.D.1
Tian, Y.2
Morrisey, E.E.3
-
36
-
-
77954210220
-
An updated overview on Wnt signaling pathways: A prelude for more
-
Rao TP, Kuhl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 2010;106:1798-1806.
-
(2010)
Circ Res
, vol.106
, pp. 1798-1806
-
-
Rao, T.P.1
Kuhl, M.2
-
37
-
-
58149185543
-
Planar cell polarity signaling: From fly development to human disease
-
Simons M, Mlodzik M. Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet 2008;42:517-540.
-
(2008)
Annu Rev Genet
, vol.42
, pp. 517-540
-
-
Simons, M.1
Mlodzik, M.2
-
38
-
-
61449249121
-
Selective activation mechanisms of Wnt signaling pathways
-
Kikuchi A, Yamamoto H, Sato A. Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol 2009;19:119-129.
-
(2009)
Trends Cell Biol
, vol.19
, pp. 119-129
-
-
Kikuchi, A.1
Yamamoto, H.2
Sato, A.3
-
39
-
-
40549104452
-
The Calcineurin/Nfat signaling pathway: A novel therapeutic target in leukemia and solid tumors
-
Medyouf H, Ghysdael J. The Calcineurin/Nfat signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle 2008;7:297-303.
-
(2008)
Cell Cycle
, vol.7
, pp. 297-303
-
-
Medyouf, H.1
Ghysdael, J.2
-
40
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin, and Nfat
-
Hogan PG, Chen L, Nardone J et al. Transcriptional regulation by calcium, calcineurin, and Nfat. Genes Dev 2003;17:2205-2232.
-
(2003)
Genes Dev
, vol.17
, pp. 2205-2232
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
-
41
-
-
84871846692
-
Wnt signalling pathways as therapeutic targets in cancer
-
Anastas JN, Moon RT. Wnt signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013;13:11-26.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 11-26
-
-
Anastas, J.N.1
Moon, R.T.2
-
42
-
-
0038636318
-
Tumor formation by genetic mutations in the components of the Wnt signaling pathway
-
Kikuchi A. Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci 2003;94:225-229.
-
(2003)
Cancer Sci
, vol.94
, pp. 225-229
-
-
Kikuchi, A.1
-
43
-
-
65849356587
-
Beta-catenin status in paediatric medulloblastomas: Correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
-
Fattet S, Haberler C, Legoix P et al. Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics. J Pathol 2009;218:86-94.
-
(2009)
J Pathol
, vol.218
, pp. 86-94
-
-
Fattet, S.1
Haberler, C.2
Legoix, P.3
-
44
-
-
42049087606
-
Correlation between beta-catenin mutations and expression of wnt-signaling target genes in hepatocellular carcinoma
-
Austinat M, Dunsch R, Wittekind C et al. Correlation between beta-catenin mutations and expression of wnt-signaling target genes in hepatocellular carcinoma. Mol Cancer 2008;7:21.
-
(2008)
Mol Cancer
, vol.7
, pp. 21
-
-
Austinat, M.1
Dunsch, R.2
Wittekind, C.3
-
45
-
-
37249092516
-
Genetic alterations of wnt signaling pathway-associated genes in hepatocellular carcinoma
-
Kim YD, Park CH, Kim HS et al. Genetic alterations of wnt signaling pathway-associated genes in hepatocellular carcinoma. J Gastro-enterol Hepatol 2008;23:110-118.
-
(2008)
J Gastro-enterol Hepatol
, vol.23
, pp. 110-118
-
-
Kim, Y.D.1
Park, C.H.2
Kim, H.S.3
-
46
-
-
0032521433
-
Mutational analysis of the Apc/Beta-Catenin/Tcf pathway in colorectal cancer
-
Sparks AB, Morin PJ, Vogelstein B et al. Mutational analysis of the Apc/Beta-Catenin/Tcf pathway in colorectal cancer. Cancer Res 1998;58: 1130-1134.
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
-
47
-
-
0036500176
-
The Apc/Beta-Catenin pathway in ulcerative colitis-related colorectal carcinomas: A muta-tional analysis
-
Aust DE, Terdiman JP, Willenbucher RF et al. The Apc/Beta-Catenin pathway in ulcerative colitis-related colorectal carcinomas: a muta-tional analysis. Cancer 2002;94:1421-1427.
-
(2002)
Cancer
, vol.94
, pp. 1421-1427
-
-
Aust, D.E.1
Terdiman, J.P.2
Willenbucher, R.F.3
-
48
-
-
0037168610
-
Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at Apc
-
Sieber OM, Heinimann K, Gorman P et al. Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at Apc. Proc Natl Acad Sci USA 2002;99:16910-16915.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16910-16915
-
-
Sieber, O.M.1
Heinimann, K.2
Gorman, P.3
-
49
-
-
0032030894
-
Sporadic medulloblastomas contain oncogenic beta-catenin mutations
-
Zurawel RH, Chiappa SA, Allen C et al. Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res 1998;58:896-899.
-
(1998)
Cancer Res
, vol.58
, pp. 896-899
-
-
Zurawel, R.H.1
Chiappa, S.A.2
Allen, C.3
-
50
-
-
0034033921
-
Nuclear localization and mutation of beta-catenin in medulloblastomas
-
Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of beta-catenin in medulloblastomas. J Neuropathol Exp Neurol 2000;59: 333-337.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 333-337
-
-
Eberhart, C.G.1
Tihan, T.2
Burger, P.C.3
-
51
-
-
0037056236
-
Role of Wnt pathway in medulloblastoma oncogenesis
-
Yokota N, Nishizawa S, Ohta S et al. Role of Wnt pathway in medulloblastoma oncogenesis. Int J Cancer 2002;101:198-201.
-
(2002)
Int J Cancer
, vol.101
, pp. 198-201
-
-
Yokota, N.1
Nishizawa, S.2
Ohta, S.3
-
52
-
-
0037473082
-
Axin1 mutations but not deletions in cerebellar medulloblastomas
-
Baeza N, Masuoka J, Kleihues P et al. Axin1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003;22:632-636.
-
(2003)
Oncogene
, vol.22
, pp. 632-636
-
-
Baeza, N.1
Masuoka, J.2
Kleihues, P.3
-
53
-
-
84875652172
-
Ctnnb1 Axin1 and Apc expression analysis of different medulloblastoma variants
-
Silva R, Marie SK, Uno M et al. Ctnnb1, Axin1 and Apc expression analysis of different medulloblastoma variants. Clinics (Sao Paulo) 2013;68:167-172.
-
(2013)
Clinics (Sao Paulo)
, vol.68
, pp. 167-172
-
-
Silva, R.1
Marie, S.K.2
Uno, M.3
-
54
-
-
33846193290
-
The many ways of Wnt in cancer
-
Polakis P. The many ways of Wnt in cancer. Curr Opin Genet Dev 2007;17:45-51.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 45-51
-
-
Polakis, P.1
-
55
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
56
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-850.
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
57
-
-
85047699343
-
Human Dkk-1, a gene encoding a wnt antagonist, responds to dna damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
-
Shou J, Ali-Osman F, Multani AS et al. Human Dkk-1, a gene encoding a wnt antagonist, responds to dna damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 2002;21:878-889.
-
(2002)
Oncogene
, vol.21
, pp. 878-889
-
-
Shou, J.1
Ali-Osman, F.2
Multani, A.S.3
-
58
-
-
0034738968
-
Secreted frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
-
Roth W, Wild-Bode C, Platten M et al. Secreted frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 2000;19:4210-4220.
-
(2000)
Oncogene
, vol.19
, pp. 4210-4220
-
-
Roth, W.1
Wild-Bode, C.2
Platten, M.3
-
59
-
-
84904724121
-
Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme
-
Schiefer L, Visweswaran M, Perumal V et al. Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme. Cancer Gene Ther 2014;21:297-303.
-
(2014)
Cancer Gene Ther
, vol.21
, pp. 297-303
-
-
Schiefer, L.1
Visweswaran, M.2
Perumal, V.3
-
60
-
-
79952823258
-
Epigenetic regulation of wnt pathway antagonists in human glioblastoma Multiforme
-
Foltz G, Yoon JG, Lee H et al. Epigenetic regulation of wnt pathway antagonists in human glioblastoma Multiforme. Genes Cancer 2010;1: 81-90.
-
(2010)
Genes Cancer
, vol.1
, pp. 81-90
-
-
Foltz, G.1
Yoon, J.G.2
Lee, H.3
-
61
-
-
0031848068
-
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
-
Korinek V, Barker N, Moerer P et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-383.
-
(1998)
Nat Genet
, vol.19
, pp. 379-383
-
-
Korinek, V.1
Barker, N.2
Moerer, P.3
-
62
-
-
0036113510
-
Wnt signals are required for the initiation of hair follicle development
-
Andl T, Reddy ST, Gaddapara T et al. Wnt signals are required for the initiation of hair follicle development. Dev Cell 2002;2: 643-653.
-
(2002)
Dev Cell
, vol.2
, pp. 643-653
-
-
Andl, T.1
Reddy, S.T.2
Gaddapara, T.3
-
63
-
-
0032567078
-
De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
-
Gat U, DasGupta R, Degenstein L et al. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 1998;95:605-614.
-
(1998)
Cell
, vol.95
, pp. 605-614
-
-
Gat, U.1
Dasgupta, R.2
Degenstein, L.3
-
64
-
-
79959703149
-
Brain cancer stem cells: Current status on glioblastoma multiforme
-
Facchino S, Abdouh M, Bernier G. Brain cancer stem cells: current status on glioblastoma multiforme. Cancers (Basel) 2011;3:1777-1797.
-
(2011)
Cancers (Basel)
, vol.3
, pp. 1777-1797
-
-
Facchino, S.1
Abdouh, M.2
Bernier, G.3
-
65
-
-
79959738249
-
Glioblastoma stem-like cells-biology and therapeutic implications
-
Gursel DB, Shin BJ, Burkhardt JK et al. Glioblastoma stem-like cells-biology and therapeutic implications. Cancers (Basel) 2011;3: 2655-2666.
-
(2011)
Cancers (Basel)
, vol.3
, pp. 2655-2666
-
-
Gursel, D.B.1
Shin, B.J.2
Burkhardt, J.K.3
-
66
-
-
77955222623
-
The Wnt/Beta-catenin pathway regulates growth and maintenance of colonospheres
-
Kanwar SS, Yu Y, Nautiyal J et al. The Wnt/Beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer 2010;9:212.
-
(2010)
Mol Cancer
, vol.9
, pp. 212
-
-
Kanwar, S.S.1
Yu, Y.2
Nautiyal, J.3
-
67
-
-
84908043107
-
Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence
-
Ramachandran I, Ganapathy V, Gillies E et al. Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis 2014;5:e1246.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1246
-
-
Ramachandran, I.1
Ganapathy, V.2
Gillies, E.3
-
68
-
-
79954575702
-
Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
-
Jin X, Jeon HY, Joo KM et al. Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation. Cancer Res 2011;71:3066-3075.
-
(2011)
Cancer Res
, vol.71
, pp. 3066-3075
-
-
Jin, X.1
Jeon, H.Y.2
Joo, K.M.3
-
69
-
-
77951975325
-
Wnt activity defines colon cancer stem cells and is regulated by the micro-environment
-
Vermeulen L, De Sousa EMF, van der Heijden M et al. Wnt activity defines colon cancer stem cells and is regulated by the micro-environment. Nat Cell Biol 2010;12:468-476.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 468-476
-
-
Vermeulen, L.1
De Sousa Emf2
Van Der Heijden, M.3
-
70
-
-
33847740988
-
Wnt/Beta-catenin signaling in cancer stemness and malignant behavior
-
Fodde R, Brabletz T. Wnt/Beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007;19:150-158.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 150-158
-
-
Fodde, R.1
Brabletz, T.2
-
71
-
-
84907487414
-
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
-
Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 2014;346:1248012.
-
(2014)
Science
, vol.346
, pp. 1248012
-
-
Clevers, H.1
Loh, K.M.2
Nusse, R.3
-
73
-
-
84874591445
-
Cancer stem cell contribution to glioblastoma invasiveness
-
Ortensi B, Setti M, Osti D et al. Cancer stem cell contribution to glioblastoma invasiveness. Stem Cell Res Ther 2013;4:18.
-
(2013)
Stem Cell Res Ther
, vol.4
, pp. 18
-
-
Ortensi, B.1
Setti, M.2
Osti, D.3
-
75
-
-
77952107413
-
Plagl2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas
-
Zheng H, Ying H, Wiedemeyer R et al. Plagl2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010;17:497-509.
-
(2010)
Cancer Cell
, vol.17
, pp. 497-509
-
-
Zheng, H.1
Ying, H.2
Wiedemeyer, R.3
-
76
-
-
84906830118
-
Plagl2 regulates actin cyto-skeletal architecture and cell migration
-
Sekiya R, Maeda M, Yuan H et al. Plagl2 regulates actin cyto-skeletal architecture and cell migration. Carcinogenesis 2014;35: 1993-2001.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1993-2001
-
-
Sekiya, R.1
Maeda, M.2
Yuan, H.3
-
77
-
-
84878000228
-
Melk-dependent foxm1 phosphorylation is essential for proliferation of glioma stem cells
-
Joshi K, Banasavadi-Siddegowda Y, Mo X et al. Melk-dependent foxm1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 2013;31:1051-1063.
-
(2013)
Stem Cells
, vol.31
, pp. 1051-1063
-
-
Joshi, K.1
Banasavadi-Siddegowda, Y.2
Mo, X.3
-
78
-
-
84948665221
-
Foxm1 promotes stemness and radio-resistance of glioblastoma by regulating the master stem cell regulator Sox2
-
Lee Y, Kim KH, Kim DG et al. Foxm1 promotes stemness and radio-resistance of glioblastoma by regulating the master stem cell regulator Sox2. PLoS One 2015;10:e0137703.
-
(2015)
PLoS One
, vol.10
, pp. e0137703
-
-
Lee, Y.1
Kim, K.H.2
Kim, D.G.3
-
79
-
-
84878543522
-
An aberrant transcription factor network essential for wnt signaling and stem cell maintenance in glioblastoma
-
Rheinbay E, Suva ML, Gillespie SM et al. An aberrant transcription factor network essential for wnt signaling and stem cell maintenance in glioblastoma. Cell Rep 2013;3:1567-1579.
-
(2013)
Cell Rep
, vol.3
, pp. 1567-1579
-
-
Rheinbay, E.1
Suva, M.L.2
Gillespie, S.M.3
-
80
-
-
33846138014
-
Sprinter: A novel transmembrane protein required for Wg secretion and signaling
-
Goodman RM, Thombre S, Firtina Z et al. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development 2006;133:4901-4911.
-
(2006)
Development
, vol.133
, pp. 4901-4911
-
-
Goodman, R.M.1
Thombre, S.2
Firtina, Z.3
-
81
-
-
84855225395
-
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis
-
Augustin I, Goidts V, Bongers A et al. The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. EMBO Mol Med 2012;4: 38-51.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 38-51
-
-
Augustin, I.1
Goidts, V.2
Bongers, A.3
-
82
-
-
33646123992
-
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
-
Bartscherer K, Pelte N, Ingelfinger D et al. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006;125: 523-533.
-
(2006)
Cell
, vol.125
, pp. 523-533
-
-
Bartscherer, K.1
Pelte, N.2
Ingelfinger, D.3
-
83
-
-
84927796473
-
Lef1 regulates glioblastoma cell proliferation, migration, invasion, and cancer stem-like cell self-renewal
-
Gao X, Mi Y, Ma Y et al. Lef1 regulates glioblastoma cell proliferation, migration, invasion, and cancer stem-like cell self-renewal. Tumour Biol 2014;35:11505-11511.
-
(2014)
Tumour Biol
, vol.35
, pp. 11505-11511
-
-
Gao, X.1
Mi, Y.2
Ma, Y.3
-
84
-
-
81055125819
-
Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with Htert-dysfunction
-
Xue Y, Li L, Zhang D et al. Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with Htert-dysfunction. PLoS One 2011;6:e27748.
-
(2011)
PLoS One
, vol.6
, pp. e27748
-
-
Xue, Y.1
Li, L.2
Zhang, D.3
-
85
-
-
84856082583
-
Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties
-
Sarrio D, Franklin CK, Mackay A et al. Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells 2012;30:292-303.
-
(2012)
Stem Cells
, vol.30
, pp. 292-303
-
-
Sarrio, D.1
Franklin, C.K.2
Mackay, A.3
-
86
-
-
84855391207
-
Gli1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells
-
Joost S, Almada LL, Rohnalter V et al. Gli1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res 2012;72:88-99.
-
(2012)
Cancer Res
, vol.72
, pp. 88-99
-
-
Joost, S.1
Almada, L.L.2
Rohnalter, V.3
-
87
-
-
80052285316
-
Zeb1 is required for trkb-induced epithelial-mesenchymal transition, anoikis resistance and metastasis
-
Smit MA, Peeper DS. Zeb1 is required for trkb-induced epithelial-mesenchymal transition, anoikis resistance and metastasis. Oncogene 2011;30:3735-3744.
-
(2011)
Oncogene
, vol.30
, pp. 3735-3744
-
-
Smit, M.A.1
Peeper, D.S.2
-
88
-
-
79955559699
-
Snai1 is involved in the proliferation and migration of glioblastoma cells
-
Han SP, Kim JH, Han ME et al. Snai1 is involved in the proliferation and migration of glioblastoma cells. Cell Mol Neurobiol 2011;31: 489-496.
-
(2011)
Cell Mol Neurobiol
, vol.31
, pp. 489-496
-
-
Han, S.P.1
Kim, J.H.2
Han, M.E.3
-
89
-
-
73049110243
-
The Emt-activator Zeb1 promotes tumorigenicity by repressing stemness-inhibiting micro-RNAs
-
Wellner U, Schubert J, Burk UC et al. The Emt-activator Zeb1 promotes tumorigenicity by repressing stemness-inhibiting micro-RNAs. Nat Cell Biol 2009;11:1487-1495.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1487-1495
-
-
Wellner, U.1
Schubert, J.2
Burk, U.C.3
-
90
-
-
77954674187
-
Twist1 promotes invasion through mesenchymal change in human glioblastoma
-
Mikheeva SA, Mikheev AM, Petit A et al. Twist1 promotes invasion through mesenchymal change in human glioblastoma. Mol Cancer 2010;9:194.
-
(2010)
Mol Cancer
, vol.9
, pp. 194
-
-
Mikheeva, S.A.1
Mikheev, A.M.2
Petit, A.3
-
91
-
-
77953546997
-
Snai2/Slug promotes growth and invasion in human gliomas
-
Yang HW, Menon LG, Black PM et al. Snai2/Slug promotes growth and invasion in human gliomas. BMC Cancer 2010;10:301.
-
(2010)
BMC Cancer
, vol.10
, pp. 301
-
-
Yang, H.W.1
Menon, L.G.2
Black, P.M.3
-
92
-
-
0345700653
-
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation
-
Howe LR, Watanabe O, Leonard J et al. Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res 2003;63:1906-1913.
-
(2003)
Cancer Res
, vol.63
, pp. 1906-1913
-
-
Howe, L.R.1
Watanabe, O.2
Leonard, J.3
-
93
-
-
12344308348
-
Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast
-
Kemler R, Hierholzer A, Kanzler B et al. Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 2004;131:5817-5824.
-
(2004)
Development
, vol.131
, pp. 5817-5824
-
-
Kemler, R.1
Hierholzer, A.2
Kanzler, B.3
-
94
-
-
79958265710
-
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
-
Scheel C, Eaton EN, Li SH et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011;145:926-940.
-
(2011)
Cell
, vol.145
, pp. 926-940
-
-
Scheel, C.1
Eaton, E.N.2
Li, S.H.3
-
95
-
-
79251611366
-
Interruption of beta-catenin suppresses the Egfr pathway by blocking multiple oncogenic targets in human glioma cells
-
Yue X, Lan F, Yang W et al. Interruption of beta-catenin suppresses the Egfr pathway by blocking multiple oncogenic targets in human glioma cells. Brain Res 2010;1366:27-37.
-
(2010)
Brain Res
, vol.1366
, pp. 27-37
-
-
Yue, X.1
Lan, F.2
Yang, W.3
-
96
-
-
79951696863
-
Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and Mmp-2
-
Kamino M, Kishida M, Kibe T et al. Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and Mmp-2. Cancer Sci 2011;102:540-548.
-
(2011)
Cancer Sci
, vol.102
, pp. 540-548
-
-
Kamino, M.1
Kishida, M.2
Kibe, T.3
-
97
-
-
62549151288
-
Downregulation of Wnt2 and Beta-catenin by Sirna suppresses malignant glioma cell growth
-
Pu P, Zhang Z, Kang C et al. Downregulation of Wnt2 and Beta-catenin by Sirna suppresses malignant glioma cell growth. Cancer Gene Ther 2009;16:351-361.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 351-361
-
-
Pu, P.1
Zhang, Z.2
Kang, C.3
-
98
-
-
33644827996
-
Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10
-
Varma RR, Hector SM, Clark K et al. Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10. Oncol Rep 2005;14:925-932.
-
(2005)
Oncol Rep
, vol.14
, pp. 925-932
-
-
Varma, R.R.1
Hector, S.M.2
Clark, K.3
-
99
-
-
84903754178
-
Wnt5a enhances resistance of melanoma cells to targeted Braf inhibitors
-
Anastas JN, Kulikauskas RM, Tamir T et al. Wnt5a enhances resistance of melanoma cells to targeted Braf inhibitors. J Clin Invest 2014;124: 2877-2890.
-
(2014)
J Clin Invest
, vol.124
, pp. 2877-2890
-
-
Anastas, J.N.1
Kulikauskas, R.M.2
Tamir, T.3
-
100
-
-
79956116022
-
Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer
-
Peng C, Zhang X, Yu H et al. Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer. Int J Gynecol Cancer 2011;21:280-288.
-
(2011)
Int J Gynecol Cancer
, vol.21
, pp. 280-288
-
-
Peng, C.1
Zhang, X.2
Yu, H.3
-
101
-
-
80555146643
-
A switch from canonical to noncanonical wnt signaling mediates drug resistance in colon cancer cells
-
Bordonaro M, Tewari S, Cicco CE et al. A switch from canonical to noncanonical wnt signaling mediates drug resistance in colon cancer cells. PLoS One 2011;6:e27308.
-
(2011)
PLoS One
, vol.6
, pp. e27308
-
-
Bordonaro, M.1
Tewari, S.2
Cicco, C.E.3
-
102
-
-
84873042539
-
Wnt5a-Nfat signaling mediates resistance to apoptosis in pancreatic cancer
-
Griesmann H, Ripka S, Pralle M et al. Wnt5a-Nfat signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia 2013;15: 11-22.
-
(2013)
Neoplasia
, vol.15
, pp. 11-22
-
-
Griesmann, H.1
Ripka, S.2
Pralle, M.3
-
103
-
-
33749576589
-
Genetic alterations associated with acquired temozolomide resistance in Snb-19, a human glioma cell line
-
Auger N, Thillet J, Wanherdrick K et al. Genetic alterations associated with acquired temozolomide resistance in Snb-19, a human glioma cell line. Mol Cancer Ther 2006;5:2182-2192.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2182-2192
-
-
Auger, N.1
Thillet, J.2
Wanherdrick, K.3
-
104
-
-
33847369455
-
Wnt/Beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
-
Chen MS, Woodward WA, Behbod F et al. Wnt/Beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 2007;120:468-477.
-
(2007)
J Cell Sci
, vol.120
, pp. 468-477
-
-
Chen, M.S.1
Woodward, W.A.2
Behbod, F.3
-
105
-
-
33846287519
-
Wnt/Beta-catenin mediates radiation resistance of mouse mammary progenitor cells
-
Woodward WA, Chen MS, Behbod F et al. Wnt/Beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA 2007;104:618-623.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 618-623
-
-
Woodward, W.A.1
Chen, M.S.2
Behbod, F.3
-
106
-
-
77649257221
-
Selective targeting of radiation-resistant tumor-initiating cells
-
Zhang M, Atkinson RL, Rosen JM. Selective targeting of radiation-resistant tumor-initiating cells. Proc Natl Acad Sci USA 2010;107:3522-3527.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3522-3527
-
-
Zhang, M.1
Atkinson, R.L.2
Rosen, J.M.3
-
107
-
-
81855217368
-
Silencing of the Wnt transcription factor Tcf4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
-
Kendziorra E, Ahlborn K, Spitzner M et al. Silencing of the Wnt transcription factor Tcf4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis 2011;32:1824-1831.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1824-1831
-
-
Kendziorra, E.1
Ahlborn, K.2
Spitzner, M.3
-
108
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-760.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
-
109
-
-
84868539590
-
Foxm1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51
-
Zhang N, Wu X, Yang L et al. Foxm1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51. Clin Cancer Res 2012;18: 5961-5971.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5961-5971
-
-
Zhang, N.1
Wu, X.2
Yang, L.3
-
110
-
-
84863230599
-
Wnt activation is implicated in glioblastoma radioresistance
-
Kim Y, Kim KH, Lee J et al. Wnt activation is implicated in glioblastoma radioresistance. Lab Invest 2012;92:466-473.
-
(2012)
Lab Invest
, vol.92
, pp. 466-473
-
-
Kim, Y.1
Kim, K.H.2
Lee, J.3
-
111
-
-
77952108366
-
Identification of a Cpg island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K et al. Identification of a Cpg island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010;17:510-522.
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
112
-
-
0030017885
-
Overexpression of the Egf receptor and P53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
-
Watanabe K, Tachibana O, Sata K et al. Overexpression of the Egf receptor and P53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996;6: 217-223.
-
(1996)
Brain Pathol
, vol.6
, pp. 217-223
-
-
Watanabe, K.1
Tachibana, O.2
Sata, K.3
-
113
-
-
0026521394
-
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails
-
Ekstrand AJ, Sugawa N, James CD et al. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails. Proc Natl Acad Sci USA 1992;89:4309-4313.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4309-4313
-
-
Ekstrand, A.J.1
Sugawa, N.2
James, C.D.3
-
114
-
-
4944255253
-
Genetic pathways to glioblastoma: A population-based study
-
Ohgaki H, Dessen P, Jourde B et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res 2004;64:6892-6899.
-
(2004)
Cancer Res
, vol.64
, pp. 6892-6899
-
-
Ohgaki, H.1
Dessen, P.2
Jourde, B.3
-
116
-
-
67651154339
-
Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: Where do we stand?
-
Karpel-Massler G, Schmidt U, Unterberg A et al. Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: where do we stand? Mol Cancer Res 2009;7:1000-1012.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1000-1012
-
-
Karpel-Massler, G.1
Schmidt, U.2
Unterberg, A.3
-
117
-
-
79960861074
-
Beta-Catenin/Tcf-4 complex transcrip-tionally regulates Akt1 in glioma
-
Chen L, Huang K, Han L et al. Beta-Catenin/Tcf-4 complex transcrip-tionally regulates Akt1 in glioma. Int J Oncol 2011;39:883-890.
-
(2011)
Int J Oncol
, vol.39
, pp. 883-890
-
-
Chen, L.1
Huang, K.2
Han, L.3
-
118
-
-
70449657727
-
Egf-induced Erk activation promotes Ck2-mediated disassociation of alpha-catenin from beta-catenin and transactivation of beta-catenin
-
Ji H, Wang J, Nika H et al. Egf-induced Erk activation promotes Ck2-mediated disassociation of alpha-catenin from beta-catenin and transactivation of beta-catenin. Mol Cell 2009;36:547-559.
-
(2009)
Mol Cell
, vol.36
, pp. 547-559
-
-
Ji, H.1
Wang, J.2
Nika, H.3
-
119
-
-
0345736990
-
Downregulation of caveolin-1 function by Egf leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
-
Lu Z, Ghosh S, Wang Z et al. Downregulation of caveolin-1 function by Egf leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell 2003;4:499-515.
-
(2003)
Cancer Cell
, vol.4
, pp. 499-515
-
-
Lu, Z.1
Ghosh, S.2
Wang, Z.3
-
120
-
-
58949099258
-
Prognostic significance of C-Met expression in glioblastomas
-
Kong DS, Song SY, Kim DH et al. Prognostic significance of C-Met expression in glioblastomas. Cancer 2009;115:140-148.
-
(2009)
Cancer
, vol.115
, pp. 140-148
-
-
Kong, D.S.1
Song, S.Y.2
Kim, D.H.3
-
121
-
-
84864863728
-
Met signaling regulates glioblastoma stem cells
-
Joo KM, Jin J, Kim E et al. Met signaling regulates glioblastoma stem cells. Cancer Res 2012;72:3828-3838.
-
(2012)
Cancer Res
, vol.72
, pp. 3828-3838
-
-
Joo, K.M.1
Jin, J.2
Kim, E.3
-
122
-
-
0030656205
-
Expression of C-Met correlates with grade of malignancy in human astrocytic tumours: An immunohistochemical study
-
Nabeshima K, Shimao Y, Sato S et al. Expression of C-Met correlates with grade of malignancy in human astrocytic tumours: an immunohistochemical study. Histopathology 1997;31:436-443.
-
(1997)
Histopathology
, vol.31
, pp. 436-443
-
-
Nabeshima, K.1
Shimao, Y.2
Sato, S.3
-
123
-
-
84875723571
-
Wnt/Beta-catenin signaling is a key downstream mediator of met signaling in glioblastoma stem cells
-
Kim KH, Seol HJ, Kim EH et al. Wnt/Beta-catenin signaling is a key downstream mediator of met signaling in glioblastoma stem cells. Neuro Oncol 2013;15:161-171.
-
(2013)
Neuro Oncol
, vol.15
, pp. 161-171
-
-
Kim, K.H.1
Seol, H.J.2
Kim, E.H.3
-
124
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003;3:903-911.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 903-911
-
-
Pasca Di Magliano, M.1
Hebrok, M.2
-
125
-
-
0035691884
-
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
-
Dahmane N, Sanchez P, Gitton Y et al. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 2001;128:5201-5212.
-
(2001)
Development
, vol.128
, pp. 5201-5212
-
-
Dahmane, N.1
Sanchez, P.2
Gitton, Y.3
-
126
-
-
79959251945
-
Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
-
Takezaki T, Hide T, Takanaga H et al. Essential role of the Hedgehog signaling pathway in human glioma-initiating cells. Cancer Sci 2011;102:1306-1312.
-
(2011)
Cancer Sci
, vol.102
, pp. 1306-1312
-
-
Takezaki, T.1
Hide, T.2
Takanaga, H.3
-
127
-
-
79955034739
-
Medulloblastoma comprises four distinct molecular variants
-
Northcott PA, Korshunov A, Witt H et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011;29: 1408-1414.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1408-1414
-
-
Northcott, P.A.1
Korshunov, A.2
Witt, H.3
-
128
-
-
84860821444
-
Molecular subgroups of medulloblastoma: The current consensus
-
Taylor MD, Northcott PA, Korshunov A et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012;123: 465-472.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 465-472
-
-
Taylor, M.D.1
Northcott, P.A.2
Korshunov, A.3
-
129
-
-
84924250617
-
Beta-Catenin-Gli1 Interaction regulates proliferation and tumor growth in medulloblastoma
-
Zinke J, Schneider FT, Harter PN et al. Beta-Catenin-Gli1 Interaction regulates proliferation and tumor growth in medulloblastoma. Mol Cancer 2015;14:17.
-
(2015)
Mol Cancer
, vol.14
, pp. 17
-
-
Zinke, J.1
Schneider, F.T.2
Harter, P.N.3
-
130
-
-
0036648241
-
Mutations in Sufu predispose to medulloblastoma
-
Taylor MD, Liu L, Raffel C et al. Mutations in Sufu predispose to medulloblastoma. Nat Genet 2002;31:306-310.
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
-
131
-
-
0027978368
-
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of Cdk4, Sas, and Mdm2
-
Reifenberger G, Reifenberger J, Ichimura K et al. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of Cdk4, Sas, and Mdm2. Cancer Res 1994;54:4299-4303.
-
(1994)
Cancer Res
, vol.54
, pp. 4299-4303
-
-
Reifenberger, G.1
Reifenberger, J.2
Ichimura, K.3
-
132
-
-
0029398189
-
Gene amplification in human gliomas
-
Collins VP. Gene amplification in human gliomas. Glia 1995;15: 289-296.
-
(1995)
Glia
, vol.15
, pp. 289-296
-
-
Collins, V.P.1
-
133
-
-
0029800810
-
Refined mapping of 12q13-Q15 amplicons in human malignant gliomas suggests cdk4/sas and mdm2 as independent amplification targets
-
Reifenberger G, Ichimura K, Reifenberger J et al. Refined mapping of 12q13-Q15 amplicons in human malignant gliomas suggests cdk4/sas and mdm2 as independent amplification targets. Cancer Res 1996;56:5141-5145.
-
(1996)
Cancer Res
, vol.56
, pp. 5141-5145
-
-
Reifenberger, G.1
Ichimura, K.2
Reifenberger, J.3
-
134
-
-
1842412437
-
High-level DNA amplifications are common genetic aberrations in B-cell neoplasms
-
Werner CA, Dohner H, Joos S et al. High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. Am J Pathol 1997;151:335-342.
-
(1997)
Am J Pathol
, vol.151
, pp. 335-342
-
-
Werner, C.A.1
Dohner, H.2
Joos, S.3
-
135
-
-
18744421982
-
Chromosomal and gene amplification in diffuse large B-cell lymphoma
-
Rao PH, Houldsworth J, Dyomina K et al. Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood 1998;92: 234-240.
-
(1998)
Blood
, vol.92
, pp. 234-240
-
-
Rao, P.H.1
Houldsworth, J.2
Dyomina, K.3
-
136
-
-
84925060886
-
Hedgehog signaling pathway is active in Gbm with Gli1 Mrna expression showing a single continuous distribution rather than discrete high/low clusters
-
Chandra V, Das T, Gulati P et al. Hedgehog signaling pathway is active in Gbm with Gli1 Mrna expression showing a single continuous distribution rather than discrete high/low clusters. PLoS One 2015;10: e0116390.
-
(2015)
PLoS One
, vol.10
, pp. e0116390
-
-
Chandra, V.1
Das, T.2
Gulati, P.3
-
137
-
-
79954626807
-
Beta-cCatenin and Gli1 are prognostic markers in glioblastoma
-
Rossi M, Magnoni L, Miracco C et al. Beta-cCatenin and Gli1 are prognostic markers in glioblastoma. Cancer Biol Ther 2011;11: 753-761.
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 753-761
-
-
Rossi, M.1
Magnoni, L.2
Miracco, C.3
-
138
-
-
33845967146
-
Suppressing Wnt signaling by the Hedgehog pathway through Sfrp-1
-
He J, Sheng T, Stelter AA et al. Suppressing Wnt signaling by the Hedgehog pathway through Sfrp-1. J Biol Chem 2006;281: 35598-35602.
-
(2006)
J Biol Chem
, vol.281
, pp. 35598-35602
-
-
He, J.1
Sheng, T.2
Stelter, A.A.3
-
139
-
-
84874598318
-
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
-
Sottoriva A, Spiteri I, Piccirillo SG et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci USA 2013;110:4009-4014.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 4009-4014
-
-
Sottoriva, A.1
Spiteri, I.2
Piccirillo, S.G.3
-
140
-
-
18344377028
-
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
-
He B, Reguart N, You L et al. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 2005;24:3054-3058.
-
(2005)
Oncogene
, vol.24
, pp. 3054-3058
-
-
He, B.1
Reguart, N.2
You, L.3
-
141
-
-
3442894128
-
An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
-
You L, He B, Xu Z et al. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res 2004;64:5385-5389.
-
(2004)
Cancer Res
, vol.64
, pp. 5385-5389
-
-
You, L.1
He, B.2
Xu, Z.3
-
142
-
-
28844448329
-
Therapeutic potential of antibodies against Fzd 10, a cell-surface protein, for synovial sarcomas
-
Nagayama S, Fukukawa C, Katagiri T et al. Therapeutic potential of antibodies against Fzd 10, a cell-surface protein, for synovial sarcomas. Oncogene 2005;24:6201-6212.
-
(2005)
Oncogene
, vol.24
, pp. 6201-6212
-
-
Nagayama, S.1
Fukukawa, C.2
Katagiri, T.3
-
143
-
-
33846673934
-
An antagonist of Dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth
-
Fujii N, You L, Xu Z et al. An antagonist of Dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res 2007;67:573-579.
-
(2007)
Cancer Res
, vol.67
, pp. 573-579
-
-
Fujii, N.1
You, L.2
Xu, Z.3
-
144
-
-
16644393169
-
Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of Ht-29 human colon cancer cells through differentiation-promoting effects
-
Yoshizumi T, Ohta T, Ninomiya I et al. Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of Ht-29 human colon cancer cells through differentiation-promoting effects. Int J Oncol 2004;25:631-639.
-
(2004)
Int J Oncol
, vol.25
, pp. 631-639
-
-
Yoshizumi, T.1
Ohta, T.2
Ninomiya, I.3
-
145
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/creb-binding protein transcription
-
Emami KH, Nguyen C, Ma H et al. A small molecule inhibitor of beta-catenin/creb-binding protein transcription. Proc Natl Acad Sci USA 2004;101:12682-12687.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
-
146
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen B, Dodge ME, Tang W et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009;5:100-107.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
-
147
-
-
0346098155
-
Targeted degradation of beta-catenin by chimeric F-Box fusion proteins
-
Liu J, Stevens J, Matsunami N et al. Targeted degradation of beta-catenin by chimeric F-Box fusion proteins. Biochem Biophys Res Commun 2004;313:1023-1029.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 1023-1029
-
-
Liu, J.1
Stevens, J.2
Matsunami, N.3
-
148
-
-
84882935561
-
Cbp activity mediates effects of the histone deacetylase inhibitor butyrate on Wnt activity and apoptosis in colon cancer cells
-
Lazarova DL, Chiaro C, Wong T et al. Cbp activity mediates effects of the histone deacetylase inhibitor butyrate on Wnt activity and apoptosis in colon cancer cells. J Cancer 2013;4: 481-490.
-
(2013)
J Cancer
, vol.4
, pp. 481-490
-
-
Lazarova, D.L.1
Chiaro, C.2
Wong, T.3
-
149
-
-
0242331652
-
Eradication of pathogenic beta-catenin by Skp1/Cullin/F Box ubiquitination machinery
-
Su Y, Ishikawa S, Kojima M et al. Eradication of pathogenic beta-catenin by Skp1/Cullin/F Box ubiquitination machinery. Proc Natl Acad Sci USA 2003;100:12729-12734.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12729-12734
-
-
Su, Y.1
Ishikawa, S.2
Kojima, M.3
-
150
-
-
33646891527
-
Brain uptake of nonsteroidal anti-inflammatory drugs: Ibuprofen, flurbiprofen, and indomethacin
-
Parepally JM, Mandula H, Smith QR. Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. Pharm Res 2006;23:873-881.
-
(2006)
Pharm Res
, vol.23
, pp. 873-881
-
-
Parepally, J.M.1
Mandula, H.2
Smith, Q.R.3
-
151
-
-
0035838943
-
Acetaminophen distribution in the rat central nervous system
-
Courad JP, Besse D, Delchambre C et al. Acetaminophen distribution in the rat central nervous system. Life Sci 2001;69:1455-1464.
-
(2001)
Life Sci
, vol.69
, pp. 1455-1464
-
-
Courad, J.P.1
Besse, D.2
Delchambre, C.3
-
152
-
-
0033575760
-
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts
-
Zhang X, Morham SG, Langenbach R et al. Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J Exp Med 1999;190:451-459.
-
(1999)
J Exp Med
, vol.190
, pp. 451-459
-
-
Zhang, X.1
Morham, S.G.2
Langenbach, R.3
-
153
-
-
0035252741
-
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate Beta-Catenin/Tcf-4 signaling
-
Dihlmann S, Siermann A, von Knebel Doeberitz M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate Beta-Catenin/Tcf-4 signaling. Oncogene 2001;20:645-653.
-
(2001)
Oncogene
, vol.20
, pp. 645-653
-
-
Dihlmann, S.1
Siermann, A.2
Von Knebel Doeberitz, M.3
-
154
-
-
0025998557
-
Aspirin use and reduced risk of fatal colon cancer
-
Thun MJ, Namboodiri MM, Heath Jr CW. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991;325:1593-1596.
-
(1991)
N Engl J Med
, vol.325
, pp. 1593-1596
-
-
Thun, M.J.1
Namboodiri, M.M.2
Heath, C.W.3
-
155
-
-
0037421984
-
A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
-
Sandler RS, Halabi S, Baron JA et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 2003;348:883-890.
-
(2003)
N Engl J Med
, vol.348
, pp. 883-890
-
-
Sandler, R.S.1
Halabi, S.2
Baron, J.A.3
-
156
-
-
0037421985
-
A randomized trial of aspirin to prevent colorectal adenomas
-
Baron JA, Cole BF, Sandler RS et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med 2003;348:891-899.
-
(2003)
N Engl J Med
, vol.348
, pp. 891-899
-
-
Baron, J.A.1
Cole, B.F.2
Sandler, R.S.3
-
157
-
-
80053389973
-
Antitumor effect of aspirin in glioblastoma cells by modulation of beta-catenin/T-cell factor-mediated transcrip-tional activity
-
Lan F, Yue X, Han L et al. Antitumor effect of aspirin in glioblastoma cells by modulation of beta-catenin/T-cell factor-mediated transcrip-tional activity. J Neurosurg 2011;115:780-788.
-
(2011)
J Neurosurg
, vol.115
, pp. 780-788
-
-
Lan, F.1
Yue, X.2
Han, L.3
-
158
-
-
84885957673
-
Nonsteroidal anti-inflammatory drugs diclofenac and celecoxib attenuates Wnt/Beta-Catenin/Tcf signaling pathway in human glioblastoma cells
-
Sareddy GR, Kesanakurti D, Kirti PB et al. Nonsteroidal anti-inflammatory drugs diclofenac and celecoxib attenuates Wnt/Beta-Catenin/Tcf signaling pathway in human glioblastoma cells. Neuro-chem Res 2013;38:2313-2322.
-
(2013)
Neuro-chem Res
, vol.38
, pp. 2313-2322
-
-
Sareddy, G.R.1
Kesanakurti, D.2
Kirti, P.B.3
-
159
-
-
84880070384
-
Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells
-
De Robertis A, Valensin S, Rossi M et al. Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells. Mol Cancer Ther 2013;12:1180-1189.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 1180-1189
-
-
De Robertis, A.1
Valensin, S.2
Rossi, M.3
-
160
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes wnt signalling
-
Huang SM, Mishina YM, Liu S et al. Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 2009;461:614-620.
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
-
161
-
-
1642341682
-
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
-
He B, You L, Uematsu K et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004;6:7-14.
-
(2004)
Neoplasia
, vol.6
, pp. 7-14
-
-
He, B.1
You, L.2
Uematsu, K.3
-
162
-
-
84856862398
-
An Anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis
-
Hanaki H, Yamamoto H, Sakane H et al. An Anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther 2012;11:298-307.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 298-307
-
-
Hanaki, H.1
Yamamoto, H.2
Sakane, H.3
-
163
-
-
84877679493
-
A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth
-
Fontenot E, Rossi E, Mumper R et al. A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth. Mol Cancer Ther 2013;12:685-695.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 685-695
-
-
Fontenot, E.1
Rossi, E.2
Mumper, R.3
-
164
-
-
58149190789
-
The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
-
Safholm A, Tuomela J, Rosenkvist J et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res 2008;14:6556-6563.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6556-6563
-
-
Safholm, A.1
Tuomela, J.2
Rosenkvist, J.3
-
165
-
-
38949218365
-
Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against Fzd10
-
Fukukawa C, Hanaoka H, Nagayama S et al. Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against Fzd10. Cancer Sci 2008;99:432-440.
-
(2008)
Cancer Sci
, vol.99
, pp. 432-440
-
-
Fukukawa, C.1
Hanaoka, H.2
Nagayama, S.3
-
167
-
-
70449529637
-
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
-
Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol Dis 2010;37: 48-57.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 48-57
-
-
Gabathuler, R.1
|