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Volumn 12, Issue 7, 2013, Pages 1180-1189

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; IWR 2; PROTEIN INHIBITOR; SEN 461; SEN 973; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

EID: 84880070384     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-1176-T     Document Type: Article
Times cited : (48)

References (41)
  • 1
    • 0026772731 scopus 로고
    • Wnt genes
    • Nusse R, Varmus HE. Wnt genes. Cell 1992;69:1073-87.
    • (1992) Cell , vol.69 , pp. 1073-1087
    • Nusse, R.1    Varmus, H.E.2
  • 2
    • 19644373254 scopus 로고    scopus 로고
    • Wnt signaling in disease and in development
    • DOI 10.1038/sj.cr.7290260
    • Nusse R. Wnt signaling in disease and in development. Cell Res 2005;15:28-32. (Pubitemid 41653961)
    • (2005) Cell Research , vol.15 , Issue.1 , pp. 28-32
    • Nusse, R.1
  • 3
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 4
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 2006;5:997-1014. (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 5
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • DOI 10.1126/science.275.5307.1787
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin -Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-90. (Pubitemid 27136715)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 7
    • 33645750603 scopus 로고    scopus 로고
    • Redundant expression of canonical Wnt ligands in human breast cancer cell lines
    • Benhaj K, Akcali KC, Ozturk M. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncol Rep 2006;15:701-7.
    • (2006) Oncol Rep , vol.15 , pp. 701-707
    • Benhaj, K.1    Akcali, K.C.2    Ozturk, M.3
  • 8
    • 80055040407 scopus 로고    scopus 로고
    • Fzd7 has a critical role in cell proliferation in triple negative breast cancer
    • Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan YC, et al. Fzd7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 2011;30:4437-46.
    • (2011) Oncogene , vol.30 , pp. 4437-4446
    • Yang, L.1    Wu, X.2    Wang, Y.3    Zhang, K.4    Wu, J.5    Yuan, Y.C.6
  • 9
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • DOI 10.1038/sj.onc.1206817
    • Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003;22:7218-21. (Pubitemid 37378553)
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3    Xu, Z.4    McCormick, F.5    Jablons, D.M.6
  • 10
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • DOI 10.1016/j.ccr.2004.09.032, PII S1535610804003046
    • Bafico A, Liu G, Goldin L, Harris V, Aaronson SA. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 2004;6:497-506. (Pubitemid 39469985)
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 11
    • 79958214511 scopus 로고    scopus 로고
    • Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression
    • Rajan N, Burn J, Langtry J, Sieber-Blum M, Lord CJ, Ashworth A. Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. J Pathol 2011;224:309-21.
    • (2011) J Pathol , vol.224 , pp. 309-321
    • Rajan, N.1    Burn, J.2    Langtry, J.3    Sieber-Blum, M.4    Lord, C.J.5    Ashworth, A.6
  • 12
    • 77952107413 scopus 로고    scopus 로고
    • PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas
    • Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010;17:497-509.
    • (2010) Cancer Cell , vol.17 , pp. 497-509
    • Zheng, H.1    Ying, H.2    Wiedemeyer, R.3    Yan, H.4    Quayle, S.N.5    Ivanova, E.V.6
  • 13
    • 80054774352 scopus 로고    scopus 로고
    • FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
    • Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, et al. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011;20:427-42.
    • (2011) Cancer Cell , vol.20 , pp. 427-442
    • Zhang, N.1    Wei, P.2    Gong, A.3    Chiu, W.T.4    Lee, H.T.5    Colman, H.6
  • 15
    • 62549151288 scopus 로고    scopus 로고
    • Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth
    • Pu P, Zhang Z, Kang C, Jiang R, Jia Z, Wang G, et al. Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth. Cancer Gene Ther 2009;16:351-61.
    • (2009) Cancer Gene Ther , vol.16 , pp. 351-361
    • Pu, P.1    Zhang, Z.2    Kang, C.3    Jiang, R.4    Jia, Z.5    Wang, G.6
  • 17
    • 80052773858 scopus 로고    scopus 로고
    • The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence
    • Lambiv WL, Vassallo I, Delorenzi M, Shay T, Diserens AC, Misra A, et al. The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol 2011;13:736-47.
    • (2011) Neuro Oncol , vol.13 , pp. 736-747
    • Lambiv, W.L.1    Vassallo, I.2    Delorenzi, M.3    Shay, T.4    Diserens, A.C.5    Misra, A.6
  • 18
    • 79954575702 scopus 로고    scopus 로고
    • Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation
    • Jin X, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, et al. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res 2011;71:3066-75.
    • (2011) Cancer Res , vol.71 , pp. 3066-3075
    • Jin, X.1    Jeon, H.Y.2    Joo, K.M.3    Kim, J.K.4    Jin, J.5    Kim, S.H.6
  • 21
    • 33746808398 scopus 로고    scopus 로고
    • Wnt beta-catenin/signaling in development and disease
    • Clevers H. Wnt beta-catenin/signaling in development and disease. Cell 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 22
  • 24
    • 1642562179 scopus 로고    scopus 로고
    • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with b-catenin defects and promotes neoplastic transformation
    • Kolligs FT, Nieman MT, Winer I, Hu G, Van Mater D, Feng Y, et al. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with b-catenin defects and promotes neoplastic transformation. Cancer Cell 2002;1:145-55.
    • (2002) Cancer Cell , vol.1 , pp. 145-155
    • Kolligs, F.T.1    Nieman, M.T.2    Winer, I.3    Hu, G.4    Van Mater, D.5    Feng, Y.6
  • 25
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009;5:100-7.
    • (2009) Nat Chem Biol , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3    Lu, J.4    Ma, Z.5    Fan, C.W.6
  • 27
    • 84861843671 scopus 로고    scopus 로고
    • A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
    • Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res 2012;72:2822-32.
    • (2012) Cancer Res , vol.72 , pp. 2822-2832
    • Waaler, J.1    Machon, O.2    Tumova, L.3    Dinh, H.4    Korinek, V.5    Wilson, S.R.6
  • 28
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semënov M, Tamai K, He X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 2005;29:26770-5.
    • (2005) J Biol Chem , vol.29 , pp. 26770-26775
    • Semënov, M.1    Tamai, K.2    He, X.3
  • 29
    • 33845702137 scopus 로고    scopus 로고
    • Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells
    • DOI 10.1038/sj.onc.1209752, PII 1209752
    • Oloumi A, Syam S, Dedhar S. Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 2006;25:7747-57. (Pubitemid 44967969)
    • (2006) Oncogene , vol.25 , Issue.59 , pp. 7747-7757
    • Oloumi, A.1    Syam, S.2    Dedhar, S.3
  • 30
    • 77955731525 scopus 로고    scopus 로고
    • Metastasis-associated protein 1 short form stimulates Wnt1 pathway in mammary epithelial and cancer cells
    • Kumar R, Balasenthil S, Pakala SB, Rayala SK, Sahin AA, Ohshiro K. Metastasis-associated protein 1 short form stimulates Wnt1 pathway in mammary epithelial and cancer cells. Cancer Res 2010;70:6598-608.
    • (2010) Cancer Res , vol.70 , pp. 6598-6608
    • Kumar, R.1    Balasenthil, S.2    Pakala, S.B.3    Rayala, S.K.4    Sahin, A.A.5    Ohshiro, K.6
  • 31
    • 77956555479 scopus 로고    scopus 로고
    • Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer
    • Nakashima N, Huang CL, Liu D, Ueno M, Yokomise H. Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer. Int J Oncol 2010;37:687-94.
    • (2010) Int J Oncol , vol.37 , pp. 687-694
    • Nakashima, N.1    Huang, C.L.2    Liu, D.3    Ueno, M.4    Yokomise, H.5
  • 32
    • 10844230334 scopus 로고    scopus 로고
    • Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-04-2370
    • Verras M, Brown J, Li X, Nusse R, Sun Z. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res 2004;64:8860-6. (Pubitemid 39665490)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 8860-8866
    • Verras, M.1    Brown, J.2    Li, X.3    Nusse, R.4    Sun, Z.5
  • 33
    • 0036484916 scopus 로고    scopus 로고
    • Regulation of Wnt3 and Wnt3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45
    • Katoh M. Regulation of Wnt3 and Wnt3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. Int J Oncol 2002;2:373-7.
    • (2002) Int J Oncol , vol.2 , pp. 373-377
    • Katoh, M.1
  • 34
    • 0031469373 scopus 로고    scopus 로고
    • Formation and function of Spermann's organizer
    • Harland R, Gerhart J. Formation and function of Spermann's organizer. Annu Rev Cell Dev Biol 1997;13:611-67.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 611-667
    • Harland, R.1    Gerhart, J.2
  • 35
    • 0036675901 scopus 로고    scopus 로고
    • The molecular and genetic basis of neurological tumours
    • DOI 10.1038/nrc866
    • Zhu Y, Parada LF. The molecular and genetic basis of neurological tumours. Nat Rev Cancer 2002;2:616-26. (Pubitemid 37328928)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 616-626
    • Zhu, Y.1    Parada, L.F.2
  • 37
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 38
    • 67649417871 scopus 로고    scopus 로고
    • Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway
    • Zhang LY, Ye J, Zhang F, Li FF, Li H, Gu Y, et al. Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. Int J Cancer 2009;35:25-32.
    • (2009) Int J Cancer , vol.35 , pp. 25-32
    • Zhang, L.Y.1    Ye, J.2    Zhang, F.3    Li, F.F.4    Li, H.5    Gu, Y.6
  • 39
    • 55549111212 scopus 로고    scopus 로고
    • SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
    • Kim MJ, Chia IV, Costantini F. SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J 2008;22:3785-94.
    • (2008) FASEB J , vol.22 , pp. 3785-3794
    • Kim, M.J.1    Chia, I.V.2    Costantini, F.3
  • 40
    • 79956128376 scopus 로고    scopus 로고
    • The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/β-catenin signaling
    • Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, et al. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/β-catenin signaling. Mol Cell Biol 2011;10:2053-65.
    • (2011) Mol Cell Biol , vol.10 , pp. 2053-2065
    • Lui, T.T.1    Lacroix, C.2    Ahmed, S.M.3    Goldenberg, S.J.4    Leach, C.A.5    Daulat, A.M.6
  • 41
    • 78449235156 scopus 로고    scopus 로고
    • The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)
    • Kim S, Jho EH. The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2). J Biol Chem 2010;285:36420-6.
    • (2010) J Biol Chem , vol.285 , pp. 36420-36426
    • Kim, S.1    Jho, E.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.