Glioblastoma stem-like cells-biology and therapeutic implications

Cancers

Volumn 3, Issue 2, 2011, Pages 2655-2666

  Gürsel, Demirkan B ^a   Shin, Benjamin J ^a   Burkhardt, Jan Karl ^a   Kesavabhotla, Kartik ^a   Schlaff, Cody D ^a   Boockvar, John A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Brain tumor stem cells; Culturing; Differentiation; Glioblastoma multiforme; Stem cell hypothesis; Stem like cells

Indexed keywords

CANCER RESEARCH; CANCER STEM CELL; CARCINOGENICITY; CELL CLONE; CELL GROWTH; CELL ISOLATION; CELL RENEWAL; CULTURE OPTIMIZATION; CULTURE TECHNIQUE; GLIOBLASTOMA; GLIOBLASTOMA STEM LIKE CELL; HUMAN; NERVE CELL DIFFERENTIATION; NONHUMAN; REVIEW; TUMOR XENOGRAFT;

EID: 79959738249     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3022655     Document Type: Review

References (39)

1. Bleau, A.M.; Howard, B.M.; Taylor, L.A.; Gursel, D.; Greenfield, J.P.; Lim Tung, H.Y.; Holland, E.C.; Boockvar, J.A. New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres in mice and humans. Neurosurg. Focus 2008, 24, E28.
2. Pollard, S.M.; Yoshikawa, K.; Clarke, I.D.; Danovi, D.; Stricker, S.; Russell, R.; Bayani, J.; Head, R.; Lee, M.; Bernstein, M., et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009, 4, 568-580.
3. Sanai, N.; Alvarez-Buylla, A.; Berger, M.S. Neural stem cells and the origin of gliomas. N. Engl. J. Med. 2005, 353, 811-822.
4. Wang, J.C. Evaluating Therapeutic efficacy against cancer stem cells: New challenges posed by a new paradigm. Cell Stem Cell 2007, 1, 497-501.
5. Lee, J.; Kotliarova, S.; Kotliarov, Y.; Li, A.; Su, Q.; Donin, N.M.; Pastorino, S.; Purow, B.W.; Christopher, N.; Zhang, W., et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006, 9, 391-403.
6. Kelly, J.J.; Stechishin, O.; Chojnacki, A.; Lun, X.; Sun, B.; Senger, D.L.; Forsyth, P.; Auer, R.N.; Dunn, J.F.; Cairncross, J.G., et al. Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens. Stem Cells 2009, 27, 1722-1733.
7. Wang, J.; Wang, X.; Jiang, S.; Lin, P.; Zhang, J.; Wu, Y.; Xiong, Z.; Ren, J.J.; Yang, H. Partial biological characterization of cancer stem-like cell line (WJ(2)) of human glioblastoma multiforme. Cell. Mol. Neurobiol. 2008, 28, 991-1003.
8. Gursel, D.B.; Beyene, R.; Hofstetter, C.; Greenfield, J.P.; Souweidane, M.M.; Arango, M.; Kaplitt, M.; Howard, B.; Boockvar, J.A. Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction. J. Neurooncol. 2011, in press.
9. Windrem, M.S.; Roy, N.S.; Wang, J.; Nunes, M.; Benraiss, A.; Goodman, R.; McKhann, G.M., 2nd; Goldman, S.A. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J. Neurosci. Res. 2002, 69, 966-975.
10. Ahmed, S. The culture of neural stem cells. J. Cell. Biochem. 2009, 106, 1-6.
11. Silber, J.; Lim, D.A.; Petritsch, C.; Persson, A.I.; Maunakea, A.K.; Yu, M.; Vandenberg, S.R.; Ginzinger, D.G.; James, C.D.; Costello, J.F., et al. MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008, 6, 14.
12. Chong, Y.K.; Toh, T.B.; Zaiden, N.; Poonepalli, A.; Leong, S.H.; Ong, C.E.; Yu, Y.; Tan, P.B.; See, S.J.; Ng, W.H., et al. Cryopreservation of neurospheres derived from human glioblastoma multiforme. Stem Cells 2009, 27, 29-39.
13. Denysenko, T.; Gennero, L.; Roos, M.A.; Melcarne, A.; Juenemann, C.; Faccani, G.; Morra, I.; Cavallo, G.; Reguzzi, S.; Pescarmona, G.; Ponzetto, A. Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies. Cell Biochem. Funct. 2010, 28, 343-351.
14. Fan, X.; Salford, L.G.; Widegren, B. Glioma stem cells: evidence and limitation. Semin. Cancer Biol. 2007, 17, 214-218.
15. Panchalingam, K.M.; Paramchuk, W.J.; Chiang, C.Y.; Shah, N.; Madan, A.; Hood, L.; Foltz, G.; Behie, L.A. Bioprocessing of human glioblastoma brain cancer tissue. Tissue Eng. Part A 2010, 16, 1169-1177.
16. Suslov, O.N.; Kukekov, V.G.; Ignatova, T.N.; Steindler, D.A. Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc. Natl. Acad. Sci. USA 2002, 99, 14506-14511.
17. Galli, R.; Binda, E.; Orfanelli, U.; Cipelletti, B.; Gritti, A.; De Vitis, S.; Fiocco, R.; Foroni, C.; Dimeco, F.; Vescovi, A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004, 64, 7011-7021.
18. Reynolds, B.A.; Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992, 255, 1707-1710.
19. Beier, D.; Hau, P.; Proescholdt, M.; Lohmeier, A.; Wischhusen, J.; Oefner, P.J.; Aigner, L.; Brawanski, A.; Bogdahn, U.; Beier, C.P. CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res. 2007, 67, 4010-4015.
20. Qiang, L.; Yang, Y.; Ma, Y.J.; Chen, F.H.; Zhang, L.B.; Liu, W.; Qi, Q.; Lu, N.; Tao, L.; Wang, X.T.; You, Q.D.; Guo, Q.L. Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. Cancer Lett. 2009, 279, 13-21.
21. Bez, A.; Corsini, E.; Curti, D.; Biggiogera, M.; Colombo, A.; Nicosia, R.F.; Pagano, S.F.; Parati, E.A. Neurosphere and neurosphere-forming cells: Morphological and ultrastructural characterization. Brain Res. 2003, 993, 18-29.
22. Singh, S.K.; Hawkins, C.; Clarke, I.D.; Squire, J.A.; Bayani, J.; Hide, T.; Henkelman, R.M.; Cusimano, M.D.; Dirks, P.B. Identification of human brain tumour initiating cells. Nature 2004, 432, 396-401.
23. Rich, J.N.; Eyler, C.E. Cancer stem cells in brain tumor biology. Cold Spring Harb. Symp. Quant. Biol. 2008, 73, 411-420.
24. Clarke, M.F.; Dick, J.E.; Dirks, P.B.; Eaves, C.J.; Jamieson, C.H.; Jones, D.L.; Visvader, J.; Weissman, I.L.; Wahl, G.M. Cancer stem cells-Perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006, 66, 9339-9344.
25. Varghese, M.; Olstorn, H.; Sandberg, C.; Vik-Mo, E.O.; Noordhuis, P.; Nister, M.; Berg-Johnsen, J.; Moe, M.C.; Langmoen, I.A. A comparison between stem cells from the adult human brain and from brain tumors. Neurosurgery 2008, 63, 1022-1033; discussion 1033-1024.
26. Hemmati, H.D.; Nakano, I.; Lazareff, J.A.; Masterman-Smith, M.; Geschwind, D.H.; Bronner-Fraser, M.; Kornblum, H.I. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA 2003, 100, 15178-15183.
27. Doetsch, F. The glial identity of neural stem cells. Nat. Neurosci. 2003, 6, 1127-1134.
28. Messam, C.A.; Hou, J.; Major, E.O. Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody. Exp. Neurol. 2000, 161, 585-596.
29. Gunther, H.S.; Schmidt, N.O.; Phillips, H.S.; Kemming, D.; Kharbanda, S.; Soriano, R.; Modrusan, Z.; Meissner, H.; Westphal, M.; Lamszus, K. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene 2008, 27, 2897-2909.
30. Prestegarden, L.; Svendsen, A.; Wang, J.; Sleire, L.; Skaftnesmo, K.O.; Bjerkvig, R.; Yan, T.; Askland, L.; Persson, A.; Sakariassen, P.O.; Enger, P.O. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res. 2010, 70, 4274-4279.
31. Ogden, A.T.; Waziri, A.E.; Lochhead, R.A.; Fusco, D.; Lopez, K.; Ellis, J.A.; Kang, J.; Assanah, M.; McKhann, G.M.; Sisti, M.B., et al. Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery 2008, 62, 505-514; discussion 514-505.
32. Liu, G.; Yuan, X.; Zeng, Z.; Tunici, P.; Ng, H.; Abdulkadir, I.R.; Lu, L.; Irvin, D.; Black, K.L.; Yu, J.S. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol. Cancer 2006, 5, 67.
33. Salmaggi, A.; Boiardi, A.; Gelati, M.; Russo, A.; Calatozzolo, C.; Ciusani, E.; Sciacca, F.L.; Ottolina, A.; Parati, E.A.; La Porta, C., et al. Glioblastoma-derived tumorospheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia 2006, 54, 850-860.
34. Wakimoto, H.; Kesari, S.; Farrell, C.J.; Curry, W.T., Jr.; Zaupa, C.; Aghi, M.; Kuroda, T.; Stemmer-Rachamimov, A.; Shah, K.; Liu, T.C., et al. Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors. Cancer Res. 2009, 69, 3472-3481.
35. Heppner, G.H. Tumor heterogeneity. Cancer Res. 1984, 44, 2259-2265.
36. Fidler, I.J.; Kripke, M.L. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977, 197, 893-895.
37. Fidler, I.J.; Hart, I.R. Biological diversity in metastatic neoplasms: Origins and implications. Science 1982, 217, 998-1003.
38. Holland, E.C. Progenitor cells and glioma formation. Curr. Opin. Neurol. 2001, 14, 683-688.
39. Li, Z.; Wang, H.; Eyler, C.E.; Hjelmeland, A.B.; Rich, J.N. Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways. J. Biol. Chem. 2009, 284, 16705-16709.