Hedgehog Signaling Pathway Is Active in GBM with GLI1 mRNA Expression Showing a Single Continuous Distribution Rather than Discrete High/Low Clusters

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Chandra, Vikas ^a   Das, Tapojyoti ^a,f   Gulati, Puneet ^b   Biswas, Nidhan K ^a   Rote, Sarang ^b   Chatterjee, Uttara ^c   Ghosh, Samarendra N ^b   Deb, Sumit ^b   Saha, Suniti K ^d   Chowdhury, Anup K ^b   Ghosh, Subhashish ^b   Rudin, Charles M ^e   Mukherjee, Ankur ^a   Basu, Analabha ^a   Dhara, Surajit ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL GENOMICS   (India)

^b BANGUR INSTITUTE OF NEUROLOGY   (India)

^c INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^d MEDICAL COLLEGE AND HOSPITAL   (India)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VISMODEGIB; ANILIDE; ONCOPROTEIN; PYRIDINE DERIVATIVE; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL DIVISION; CLUSTER ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA EXTRACTION; DOSE RESPONSE; DOWN REGULATION; GENE EXPRESSION; GENETIC DATABASE; GLIOBLASTOMA; HEMISPHERE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; TRANSCRIPTOMICS; UPREGULATION; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MEDULLOBLASTOMA; METABOLISM; PATHOLOGY;

ERINACEIDAE;

ANILIDES; APOPTOSIS; CELL CYCLE CHECKPOINTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HEDGEHOG PROTEINS; HUMANS; MEDULLOBLASTOMA; ONCOGENE PROTEINS; PYRIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UP-REGULATION; ZINC FINGER PROTEIN GLI1;

EID: 84925060886     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116390     Document Type: Article

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