β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

Developmental Biology

Volumn 258, Issue 2, 2003, Pages 406-418

  Zechner, Dietmar ^a   Fujita, Yasuyuki ^a   Hülsken, Jörg ^a   Müller, Thomas ^a   Walther, Ingrid ^a   Taketo, Makoto M ^b   Crenshaw III, E Bryan ^c   Birchmeier, Walter ^a   Birchmeier, Carmen ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b KYOTO UNIVERSITY   (Japan)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Neural stem cells; Neuronal progenitors; Progenitor pool; Proliferation versus differentiation; Wnt signaling; Catenin

Indexed keywords

BETA CATENIN;

ALLELE; ANIMAL TISSUE; ARTICLE; BRAIN; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; EMBRYO; MOUSE; MUTANT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD; STEM CELL;

EID: 0038517899     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0012-1606(03)00123-4     Document Type: Article

References (54)

1. Aberle H., Bauer A., Stappert J., Kispert A., Kemler R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16:1997;3797-3804.
2. Ahn K., Mishina Y., Hanks M.C., Behringer R.R., Crenshaw E.B. 3rd. BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 128:2001;4449-4461.
3. Akagi K., Sandig V., Vooijs M., Van der Valk M., Giovannini M., Strauss M., Berns A. Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res. 25:1997;1766-1773.
4. Amit S., Hatzubai A., Birman Y., Andersen J.S., Ben-Shushan E., Mann M., Ben-Neriah Y., Alkalay I. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45 a molecular switch for the Wnt pathway . Genes Dev. 16:2002;1066-1076.
5. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 382:1996;638-642.
6. Bienz M., Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 103:2000;311-320.
7. Boutros M., Mihaly J., Bouwmeester T., Mlodzik M. Signaling specificity by Frizzled receptors in Drosophila. Science. 288:2000;1825-1828.
8. Brault V., Moore R., Kutsch S., Ishibashi M., Rowitch D.H., McMahon A.P., Sommer L., Boussadia O., Kemler R. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 128:2001;1253-1264.
9. Cameron H.A., Hazel T.G., McKay R.D. Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 36:1998;287-306.
10. Campos-Ortega J.A. Genetic mechanisms of early neureogenesis in Drosophila melanogaster. Mol. Neurobiol. 10:1995;75-89.
11. Chenn A., Walsh C.A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science. 297:2002;365-369.
12. Damalas A., Ben-Ze'ev A., Simcha I., Shtutman M., Leal J.F., Zhurinsky J., Geiger B., Oren M. Excess beta-catenin promotes accumulation of transcriptionally active p53. EMBO J. 18:1999;3054-3063.
13. de la Pompa J.L., Wakeham A., Correia K.M., Samper E., Brown S., Aguilera R.J., Nakano T., Honjo T., Mak T.W., Rossant J., Conlon R.A. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. 124:1997;1139-1148.
14. Dickinson M.E., Krumlauf R., McMahon A.P. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 120:1994;1453-1471.
15. Galceran J., Miyashita-Lin E.M., Devaney E., Rubenstein J.L., Grosschedl R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 127:2000;469-482.
16. Gridely T. Notch in vertebrate development and disease. Mol. Cell. Neurosci. 9:1997;103-108.
17. Harada N., Tamai Y., Ishikawa T., Sauer B., Takaku K., Oshima M., Taketo M.M. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18:1999;5931-5942.
18. Hasegawa S., Sato T., Akazawa H., Okada H., Maeno A., Ito M., Sugitani Y., Shibata H., Miyazaki Ji J., Katsuki M., Yamauchi Y., Yamamura Ki K., Katamine S., Noda T. Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc. Natl. Acad. Sci. USA. 99:2002;297-302.
19. Hsu W., Shakya R., Costantini F. Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J. Cell Biol. 155:2001;1055-1064.
20. Huelsken J., Birchmeier W. New aspects of Wnt signaling pathways in higher vertebrates. Curr. Opin. Genet. Dev. 11:2001;547-553.
21. Huelsken J., Vogel R., Erdmann B., Cotsarelis G., Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 105:2001;533-545.
22. Hulsken J., Birchmeier W., Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127:1994;2061-2069.
23. Ikeya M., Lee S.M., Johnson J.E., McMahon A.P., Takada S. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature. 389:1997;966-970.
24. Ioannidis V., Beermann F., Clevers H., Held W. The beta-catenin-TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nat. Immunol. 2:2001;691-697.
25. Jessell T.M. Neuronal specification in the spinal cord inductive signals and transcriptional codes . Nat. Rev. Genet. 1:2000;20-29.
26. Johe K.K., Hazel T.G., Muller T., Dugich-Djordjevic M.M., McKay R.D. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10:1996;3129-3140.
27. Kageyama R., Ohtsuka T. The Notch-Hes pathway in mammalian neural development. Cell Res. 9:1999;179-188.
28. Krebs L.T., Deftos M.L., Bevan M.J., Gridley T. The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev. Biol. 238:2001;110-119.
29. Kuhl, M., Sheldahl, L.C., Park, M., Miller, J.R., Moon, R.T. 2000. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16, 279-283.
30. Lamar E., Deblandre G., Wettstein D., Gawantka V., Pollet N., Niehrs C., Kintner C. Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev. 15:2001;1885-1899.
31. Lee S.M., Tole S., Grove E., McMahon A.P. A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. 127:2000;457-467.
32. Liu C., Li Y., Semenov M., Han C., Baeg G.H., Tan Y., Zhang Z., Lin X., He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 108:2002;837-847.
33. Lustig B., Jerchow B., Sachs M., Weiler S., Pietsch T., Karsten U., van de Wetering M., Clevers H., Schlag P.M., Birchmeier W., Behrens J. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22:2002;1184-1193.
34. Lutolf S., Radtke F., Aguet M., Suter U., Taylor V. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development. 129:2002;373-385.
35. McMahon A.P., Bradley A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell. 62:1990;1073-1085.
36. McMahon A.P., Joyner A.L., Bradley A., McMahon J.A. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell. 69:1992;581-595.
37. Megason S.G., McMahon A.P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 129:2002;2087-2098.
38. Moon R.T., Bowerman B., Boutros M., Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science. 296:2002;1644-1646.
39. Muroyama Y., Fujihara M., Ikeya M., Kondoh H., Takada S. Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16:2002;548-553.
40. Nakamura Y., Sakakibara S., Miyata T., Ogawa M., Shimazaki T., Weiss S., Kageyama R., Okano H. The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells. J. Neurosci. 20:2000;283-293.
41. Niehrs C. Developmental biology. Solving a sticky problem. Nature. 413:2001;787-788.
42. Ohtsuka T., Ishibashi M., Gradwohl G., Nakanishi S., Guillemot F., Kageyama R. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 18:1999;2196-2207.
43. Parr B.A., Shea M.J., Vassileva G., McMahon A.P. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 119:1993;247-261.
44. Pinson K.I., Brennan J., Monkley S., Avery B.J., Skarnes W.C. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407:2000;535-538.
45. Polakis P. Wnt signaling and cancer. Genes Dev. 14:2000;1837-1851.
46. Schwarz-Romond T., Asbrand C., Bakkers J., Kuhl M., Schaeffer H.J., Huelsken J., Behrens J., Hammerschmidt M., Birchmeier W. The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16:2002;2073-2084.
47. Simeone A. Towards the comprehension of genetic mechanisms controlling brain morphogenesis. Trends Neurosci. 25:2002;119-121.
48. Tada M., Concha M.L., Heisenberg C.P. Non-canonical Wnt signalling and regulation of gastrulation movements. Semin. Cell. Dev. Biol. 13:2002;251-260.
49. Temple S. The development of neural stem cells. Nature. 414:2001;112-117.
50. Thomas K.R., Capecchi M.R. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 346:1990;847-850.
51. Van de Wetering M., Sancho E., Verweij C., de Lau W., Oving I., Hurlstone A., van der Horn K., Batlle E., Cordreuse D., Haramis A.P., Tjong-Pon-Fong M., Moerer P., van den Born M., Soete G., Pals S., Eilers M., Medema R., Clevers H. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111:2002;241-250.
52. Willert J., Epping M., Pollack J., Brown P., Nusse R. A Transcriptional Response to Wnt protein in human embryonic carcinoma cells. BMC Dev. Biol. 2:2002;8.
53. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell. Dev. Biol. 14:1998;59-88.
54. Wong M.H., Rubinfeld B., Gordon J.I. Effects of forced expression of an NH2-terminal truncated beta-catenin on mouse intestinal epithelial homeostasis. J. Cell Biol. 141:1998;765-777.