Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts

Journal of Experimental Medicine

Volumn 190, Issue 4, 1999, Pages 451-459

  Zhang, Xinping ^a   Morham, Scott G ^b   Langenbach, Robert ^c   Young, Donald A ^a,d  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cyclooxygenase; Neoplastic transformation; Nonsteroidal antiinflammatory drugs; ras; Transgenic knockout cells

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IBUPROFEN; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN SYNTHASE; SULINDAC; THYMIDINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; FIBROBLAST; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN VIRUS 40;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; ARACHIDONIC ACID; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; EMBRYO; FIBROBLASTS; IBUPROFEN; INDOMETHACIN; ISOENZYMES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NITROBENZENES; ONCOGENE PROTEINS, VIRAL; PIROXICAM; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS P21(RAS); RNA, MESSENGER; SIMIAN VIRUS 40; SULFONAMIDES; SULINDAC;

EID: 0033575760     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.4.451     Document Type: Article

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