ATP-Dependent effector-like functions of RIG-I-like receptors

Molecular Cell

Volumn 58, Issue 3, 2015, Pages 541-548

  Yao, Hui ^a,b   Dittmann, Meike ^c   Peisley, Alys ^a,d   Hoffmann, Hans Heinrich ^c   Gilmore, Rachel H ^c   Schmidt, Tobias ^e   Schmid Burgk, Jonathan L ^e   Hornung, Veit ^e   Rice, Charles M ^c   Hur, Sun ^a,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NANKAI UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; INITIATION FACTOR 2ALPHA; INTERFERON; MDA5 PROTEIN; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; STAT1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; ANTIVIRUS AGENT; BETA INTERFERON; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; DOUBLE STRANDED RNA; IFIH1 PROTEIN, HUMAN; PROTEIN KINASE R; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; DELETION MUTANT; DISSOCIATION; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; RNA BINDING; SIGNAL TRANSDUCTION; VIRUS INHIBITION; VIRUS REPLICATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE; VIRUS INFECTION; WESTERN BLOTTING;

VERTEBRATA;

ADENOSINE TRIPHOSPHATE; ANTIVIRAL AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; EIF-2 KINASE; HEK293 CELLS; HUMANS; INTERFERON-BETA; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PHOSPHORYLATION; RECEPTORS, PATTERN RECOGNITION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, VIRAL; VIRAL PROTEINS; VIRUS DISEASES;

EID: 84928928403     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.03.014     Document Type: Article

References (21)

1. Chang H.-W., Jacobs B.L. Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA. Virology 1993, 194:537-547.
2. Cui S., Eisenächer K., Kirchhofer A., Brzózka K., Lammens A., Lammens K., Fujita T., Conzelmann K.K., Krug A., Hopfner K.P. The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol. Cell 2008, 29:169-179.
3. Donelan N.R., Basler C.F., García-Sastre A. A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J.Virol. 2003, 77:13257-13266.
4. Gack M.U., Albrecht R.A., Urano T., Inn K.-S., Huang I.-C., Carnero E., Farzan M., Inoue S., Jung J.U., García-Sastre A. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 2009, 5:439-449.
5. García M.A., Meurs E.F., Esteban M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 2007, 89:799-811.
6. Goubau D., Deddouche S., Reis e Sousa C. Cytosolic sensing of viruses. Immunity 2013, 38:855-869.
7. Jankowsky E., Bowers H. Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases. Nucleic Acids Res. 2006, 34:4181-4188.
8. Jiang X., Kinch L.N., Brautigam C.A., Chen X., Du F., Grishin N.V., Chen Z.J. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity 2012, 36:959-973.
9. Kato H., Takahasi K., Fujita T. RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol. Rev. 2011, 243:91-98.
10. Li S., Min J.-Y., Krug R.M., Sen G.C. Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 2006, 349:13-21.
11. Linder P., Jankowsky E. From unwinding to clamping - the DEAD box RNA helicase family. Nat. Rev. Mol. Cell Biol. 2011, 12:505-516.
12. McKenna S.A., Lindhout D.A., Kim I., Liu C.W., Gelev V.M., Wagner G., Puglisi J.D. Molecular framework for the activation of RNA-dependent protein kinase. J.Biol. Chem. 2007, 282:11474-11486.
13. McKenna S.A., Lindhout D.A., Shimoike T., Puglisi J.D. Biophysical and biochemical investigations of dsRNA-activated kinase PKR. Methods Enzymol. 2007, 430:373-396.
14. Myong S., Cui S., Cornish P.V., Kirchhofer A., Gack M.U., Jung J.U., Hopfner K.-P., Ha T. Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science 2009, 323:1070-1074.
15. Patel J.R., Jain A., Chou Y.Y., Baum A., Ha T., García-Sastre A. ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon. EMBO Rep. 2013, 14:780-787.
16. Peisley A., Lin C., Wu B., Orme-Johnson M., Liu M., Walz T., Hur S. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc. Natl. Acad. Sci. USA 2011, 108:21010-21015.
17. Peisley A., Jo M.H., Lin C., Wu B., Orme-Johnson M., Walz T., Hohng S., Hur S. Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc. Natl. Acad. Sci. USA 2012, 109:E3340-E3349.
18. Peisley A., Wu B., Yao H., Walz T., Hur S. RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol. Cell 2013, 51:573-583.
19. Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T., Bieniasz P., Rice C.M. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011, 472:481-485.
20. Wu B., Peisley A., Tetrault D., Li Z., Egelman E.H., Magor K.E., Walz T., Penczek P.A., Hur S. Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I. Mol. Cell 2014, 55:511-523.
21. Yoneyama M., Fujita T. Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 2008, 29:178-181.