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Volumn 11, Issue 9, 2015, Pages 1636-1651

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

Author keywords

AA; Antioxidants; Autophagy; DHA; HMOX1; LC3B; MAP1LC3B; NFE2L2; NRF2; OA; Omega 3; p62; PUFA; ROS; SQSTM1

Indexed keywords

ANTIOXIDANT; AUTOPHAGY PROTEIN 5; CELL PROTEIN; DOCOSAHEXAENOIC ACID; NFE2L2 PROTEIN; OMEGA 3 FATTY ACID; PROTEIN AGGREGATE; PROTEIN P62; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN 5; MICROTUBULE ASSOCIATED PROTEIN; SEQUESTOSOME 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN;

EID: 84953859301     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1061170     Document Type: Article
Times cited : (98)

References (100)
  • 1
    • 75949083202 scopus 로고    scopus 로고
    • Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates
    • PMID:19725834
    • Martinez A, Portero-Otin M, Pamplona R, Ferrer I. Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol 2010; 20:281-97;PMID:19725834; http://dx.doi.org/10.1111/j.1750-3639.2009.00326.x.
    • (2010) Brain Pathol , vol.20 , pp. 281-297
    • Martinez, A.1    Portero-Otin, M.2    Pamplona, R.3    Ferrer, I.4
  • 4
    • 0036284021 scopus 로고    scopus 로고
    • Early accumulation of p62 in neurofibrillary tangles in Alzheimer’s disease: Possible role in tangle formation
    • PMID:12060347
    • Kuusisto E, Salminen A, Alafuzoff I. Early accumulation of p62 in neurofibrillary tangles in Alzheimer’s disease: possible role in tangle formation. Neuropathol Appl Neurobiol 2002; 28:228-37;PMID:12060347; http://dx.doi.org/10.1046/j.1365-2990.2002.00394.x.
    • (2002) Neuropathol Appl Neurobiol , vol.28 , pp. 228-237
    • Kuusisto, E.1    Salminen, A.2    Alafuzoff, I.3
  • 6
    • 4744349602 scopus 로고    scopus 로고
    • Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions
    • PMID:15379887
    • Nagaoka U, Kim K, Jana NR, Doi H, Maruyama M, Mitsui K, Oyama F, Nukina N. Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions. J Neurochem 2004; 91:57-68; PMID:15379887; http://dx.doi.org/10.1111/j.1471-4159.2004.02692.x.
    • (2004) J Neurochem , vol.91 , pp. 57-68
    • Nagaoka, U.1    Kim, K.2    Jana, N.R.3    Doi, H.4    Maruyama, M.5    Mitsui, K.6    Oyama, F.7    Nukina, N.8
  • 7
    • 79959208615 scopus 로고    scopus 로고
    • Age-related macular degeneration (AMD): Alzheimer’s disease in the eye?
    • PMID:21297256
    • Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer’s disease in the eye? J Alzheimers Dis 2011; 24:615-31; PMID:21297256.
    • (2011) J Alzheimers Dis , vol.24 , pp. 615-631
    • Kaarniranta, K.1    Salminen, A.2    Haapasalo, A.3    Soininen, H.4    Hiltunen, M.5
  • 8
    • 84880797112 scopus 로고    scopus 로고
    • Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
    • PMID:23590900
    • Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 2013; 9:973-84; PMID:23590900; http://dx.doi.org/10.4161/auto.24546.
    • (2013) Autophagy , vol.9 , pp. 973-984
    • Kaarniranta, K.1    Sinha, D.2    Blasiak, J.3    Kauppinen, A.4    Vereb, Z.5    Salminen, A.6    Boulton, M.E.7    Petrovski, G.8
  • 9
    • 33751103471 scopus 로고    scopus 로고
    • Age-related macular degeneration–emerging pathogenetic and therapeutic concepts
    • PMID:17101537
    • Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Age-related macular degeneration–emerging pathogenetic and therapeutic concepts. Ann Med 2006; 38:450-71; PMID:17101537; http://dx.doi.org/10.1080/07853890600946724.
    • (2006) Ann Med , vol.38 , pp. 450-471
    • Gehrs, K.M.1    Erson, D.H.2    Johnson, L.V.3    Hageman, G.S.4
  • 10
    • 84863726788 scopus 로고    scopus 로고
    • Consequences of oxidative stress in age-related macular degeneration
    • PMID:22510306
    • Jarrett SG, Boulton ME. Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med 2012; 33:399-417; PMID:22510306; http://dx.doi.org/10.1016/j.mam.2012.03.009.
    • (2012) Mol Aspects Med , vol.33 , pp. 399-417
    • Jarrett, S.G.1    Boulton, M.E.2
  • 11
    • 0024378477 scopus 로고
    • Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration
    • PMID:2759786
    • Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 1989; 30:1691-9; PMID:2759786.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 1691-1699
    • Dorey, C.K.1    Wu, G.2    Ebenstein, D.3    Garsd, A.4    Weiter, J.J.5
  • 12
    • 0033026846 scopus 로고    scopus 로고
    • Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration
    • Holz FG, Bellmann C, Margaritidis M, Schutt F, Otto TP, Volcker HE. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 1999; 237:145-52; http://dx.doi.org/10.1007/s004170050209.
    • (1999) Graefes Arch Clin Exp Ophthalmol , vol.237 , pp. 145-152
    • Holz, F.G.1    Bellmann, C.2    Margaritidis, M.3    Schutt, F.4    Otto, T.P.5    Volcker, H.E.6
  • 13
    • 0034800655 scopus 로고    scopus 로고
    • AREDS report no. 8
    • Age-Related Eye Disease Study Research G. A randomized, placebo-controlled, clinical trial of highdose supplementation with vitamins C and E, b carotene, and zinc for age-related macular degeneration and vision loss, PMID:11594942
    • Age-Related Eye Disease Study Research G. A randomized, placebo-controlled, clinical trial of highdose supplementation with vitamins C and E, b carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001; 119:1417-36; PMID:11594942; http://dx.doi.org/10.1001/archopht.119.10.1417.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1417-1436
  • 14
    • 78651369886 scopus 로고    scopus 로고
    • Compositional studies of human RPE lipofuscin: Mechanisms of molecular modifications
    • PMID:21182214
    • Murdaugh LS, Mandal S, Dill AE, Dillon J, Simon JD, Gaillard ER. Compositional studies of human RPE lipofuscin: mechanisms of molecular modifications. J Mass Spectrom 2011; 46:90-5;PMID:21182214; http://dx.doi.org/10.1002/jms.1865.
    • (2011) J Mass Spectrom , vol.46 , pp. 90-95
    • Murdaugh, L.S.1    Mandal, S.2    Dill, A.E.3    Dillon, J.4    Simon, J.D.5    Gaillard, E.R.6
  • 15
    • 0034012166 scopus 로고    scopus 로고
    • Rusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • PMID:10783137
    • Mullins RF, Russell SR, Anderson DH, Hageman GS. rusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 2000; 14:835-46; PMID:10783137.
    • (2000) FASEB J , vol.14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Erson, D.H.3    Hageman, G.S.4
  • 17
    • 84923829587 scopus 로고    scopus 로고
    • The proteomics of drusen
    • Crabb JW. The proteomics of drusen. Cold Spring Harb Perspect Med 2014; 4:a017194; PMID:24799364; http://dx.doi.org/10.1101/cshperspect.a017194
    • (2014) Cold Spring Harb Perspect Med , vol.4
    • Crabb, J.W.1
  • 18
    • 0033520640 scopus 로고    scopus 로고
    • Oxidative damage and age-related macular degeneration
    • PMID:10562656
    • Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis 1999; 5:32; PMID:10562656.
    • (1999) Mol Vis , vol.5 , pp. 32
    • Winkler, B.S.1    Boulton, M.E.2    Gottsch, J.D.3    Sternberg, P.4
  • 19
    • 60949098753 scopus 로고    scopus 로고
    • Heat shock proteins as gatekeepers of proteolytic pathways- Implications for age-related macular degeneration (AMD)
    • PMID:19274853
    • Kaarniranta K, Salminen A, Eskelinen EL, Kopitz J. Heat shock proteins as gatekeepers of proteolytic pathways- Implications for age-related macular degeneration (AMD). Ageing Res Rev 2009; 8:128-39;PMID:19274853; http://dx.doi.org/10.1016/j.arr.2009.01.001.
    • (2009) Ageing Res Rev , vol.8 , pp. 128-139
    • Kaarniranta, K.1    Salminen, A.2    Eskelinen, E.L.3    Kopitz, J.4
  • 20
    • 84863722159 scopus 로고    scopus 로고
    • How does the macula protect itself from oxidative stress?
    • PMID:22503691
    • Handa JT. How does the macula protect itself from oxidative stress? Mol Aspects Med 2012; 33:418-35;PMID:22503691; http://dx.doi.org/10.1016/j.mam.2012.03.006.
    • (2012) Mol Aspects Med , vol.33 , pp. 418-435
    • Handa, J.T.1
  • 21
    • 50649116818 scopus 로고    scopus 로고
    • Misfolded proteins partition between two distinct quality control compartments
    • PMID:18756251
    • Kaganovich D, Kopito R, Frydman J. Misfolded proteins partition between two distinct quality control compartments. Nature 2008; 454:1088-95;PMID:18756251; http://dx.doi.org/10.1038/nature07195.
    • (2008) Nature , vol.454 , pp. 1088-1095
    • Kaganovich, D.1    Kopito, R.2    Frydman, J.3
  • 22
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • PMID:15483602
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004; 431:805-10; PMID:15483602; http://dx.doi.org/10.1038/nature02998.
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 23
    • 84886952788 scopus 로고    scopus 로고
    • Protein oxidation in aging and the removal of oxidized proteins
    • PMID:23333925
    • Heohn A, Keonig J, Grune T. Protein oxidation in aging and the removal of oxidized proteins. J Proteomics 2013; 92:132-59; PMID:23333925; http://dx.doi.org/10.1016/j.jprot.2013.01.004.
    • (2013) J Proteomics , vol.92 , pp. 132-159
    • Heohn, A.1    Keonig, J.2    Grune, T.3
  • 24
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • PMID:17909521
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9:1102-9; PMID:17909521; http://dx.doi.org/10.1038/ncb1007-1102.
    • (2007) Nat Cell Biol , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 26
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • PMID:17347651
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007; 26:1749-60; PMID:17347651; http://dx.doi.org/10.1038/sj.emboj.7601623.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 27
    • 79959415069 scopus 로고    scopus 로고
    • Biogenesis and cargo selectivity of autophagosomes
    • PMID:21548784
    • Weidberg H, Shvets E, Elazar Z. Biogenesis and cargo selectivity of autophagosomes. Ann Rev Biochem 2011; 80:125-56; PMID:21548784; http://dx.doi.org/10.1146/annurev-biochem-052709-094552.
    • (2011) Ann Rev Biochem , vol.80 , pp. 125-156
    • Weidberg, H.1    Shvets, E.2    Elazar, Z.3
  • 28
    • 34548259958 scopus 로고    scopus 로고
    • P62/ SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • PMID:17580304
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. p62/ SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45;PMID:17580304; http://dx.doi.org/10.1074/jbc.M702824200.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6    Overvatn, A.7    Bjorkoy, G.8    Johansen, T.9
  • 29
    • 27944504351 scopus 로고    scopus 로고
    • Johansen T. P62/ SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death
    • PMID:16286508
    • Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/ SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death. J Cell Biol 2005; 171:603-14;PMID:16286508; http://dx.doi.org/10.1083/jcb.200507002.
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7
  • 33
    • 77956420489 scopus 로고    scopus 로고
    • Can autophagy promote longevity?
    • PMID:20811357
    • Madeo F, Tavernarakis N, Kroemer G. Can autophagy promote longevity? Nat Cell Biol 2010; 12:842-6;PMID:20811357; http://dx.doi.org/10.1038/ncb0910-842.
    • (2010) Nat Cell Biol , vol.12 , pp. 842-846
    • Madeo, F.1    Tavernarakis, N.2    Kroemer, G.3
  • 34
    • 84896903811 scopus 로고    scopus 로고
    • Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/ betaA3/A1-crystallin via V-ATPase-MTORC1 signaling
    • PMID:24468901
    • Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/ betaA3/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy 2014; 10:480-96; PMID:24468901; http://dx.doi.org/10.4161/auto.27292.
    • (2014) Autophagy , vol.10 , pp. 480-496
    • Valapala, M.1    Wilson, C.2    Hose, S.3    Bhutto, I.A.4    Grebe, R.5    Dong, A.6    Greenbaum, S.7    Gu, L.8    Sengupta, S.9    Cano, M.10
  • 35
    • 0030466371 scopus 로고    scopus 로고
    • The retardation of aging by caloric restriction: Studies in rodents and primates
    • PMID:8994305
    • Weindruch R. The retardation of aging by caloric restriction: studies in rodents and primates. Toxicol Pathol 1996; 24:742-5; PMID:8994305; http://dx.doi.org/10.1177/019262339602400618.
    • (1996) Toxicol Pathol , vol.24 , pp. 742-745
    • Weindruch, R.1
  • 36
    • 84868101259 scopus 로고    scopus 로고
    • The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction
    • PMID:22868943
    • Rascon B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging 2012; 4:499-508; PMID:22868943.
    • (2012) Aging , vol.4 , pp. 499-508
    • Rascon, B.1    Hubbard, B.P.2    Sinclair, D.A.3    Amdam, G.V.4
  • 37
    • 51649088498 scopus 로고    scopus 로고
    • The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23
    • PMID:18779490
    • SanGiovanni JP, Chew EY, Agron E, Clemons TE, Ferris FL, 3rd, Gensler G, Lindblad AS, Milton RC, Seddon JM, Klein R, et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch Ophthalmol 2008; 126:1274-9; PMID:18779490; http://dx.doi.org/10.1001/archopht.126.9.1274.
    • (2008) Arch Ophthalmol , vol.126 , pp. 1274-1279
    • Sangiovanni, J.P.1    Chew, E.Y.2    Agron, E.3    Clemons, T.E.4    Ferris, F.L.5    Gensler, G.6    Lindblad, A.S.7    Milton, R.C.8    Seddon, J.M.9    Klein, R.10
  • 38
    • 0344305692 scopus 로고    scopus 로고
    • Progression of agerelated macular degeneration: Association with dietary fat, transunsaturated fat, nuts, and fish intake
    • PMID:14662593
    • Seddon JM, Cote J, Rosner B. Progression of agerelated macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol 2003; 121:1728-37; PMID:14662593; http://dx.doi.org/10.1001/archopht.121.12.1728.
    • (2003) Arch Ophthalmol , vol.121 , pp. 1728-1737
    • Seddon, J.M.1    Cote, J.2    Rosner, B.3
  • 39
    • 33745839872 scopus 로고    scopus 로고
    • Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: The US Twin Study of Age-Related Macular Degeneration
    • PMID:16832023
    • Seddon JM, George S, Rosner B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch Ophthalmol 2006; 124:995-1001;PMID:16832023; http://dx.doi.org/10.1001/archopht.124.7.995.
    • (2006) Arch Ophthalmol , vol.124 , pp. 995-1001
    • Seddon, J.M.1    George, S.2    Rosner, B.3
  • 40
    • 45149132510 scopus 로고    scopus 로고
    • Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: A systematic review and meta-analysis
    • PMID:18541848
    • Chong EW, Kreis AJ, Wong TY, Simpson JA, Guymer RH. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. Archives of ophthalmology 2008; 126:826-33;PMID:18541848; http://dx.doi.org/10.1001/archopht.126.6.826.
    • (2008) Archives of Ophthalmology , vol.126 , pp. 826-833
    • Chong, E.W.1    Kreis, A.J.2    Wong, T.Y.3    Simpson, J.A.4    Guymer, R.H.5
  • 41
    • 84875770625 scopus 로고    scopus 로고
    • High concentrations of plasma n3 fatty acids are associated with decreased risk for late age-related macular degeneration
    • PMID:23406618
    • Merle BM, Delyfer MN, Korobelnik JF, Rougier MB, Malet F, Feart C, Le Goff M, Peuchant E, Letenneur L, Dartigues JF, et al. High concentrations of plasma n3 fatty acids are associated with decreased risk for late age-related macular degeneration. J Nutr 2013; 143:505-11; PMID:23406618; http://dx.doi.org/10.3945/jn.112.171033.
    • (2013) J Nutr , vol.143 , pp. 505-511
    • Merle, B.M.1    Delyfer, M.N.2    Korobelnik, J.F.3    Rougier, M.B.4    Malet, F.5    Feart, C.6    Le Goff, M.7    Peuchant, E.8    Letenneur, L.9    Dartigues, J.F.10
  • 42
    • 84897140274 scopus 로고    scopus 로고
    • Nutritional AMDTSG. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration
    • PMID:24557349
    • Merle BM, Benlian P, Puche N, Bassols A, Delcourt C, Souied EH, Nutritional AMDTSG. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Invest Ophthalmol Visual Sci 2014; 55:2010-9; PMID:24557349; http://dx.doi.org/10.1167/iovs.14-13916.
    • (2014) Invest Ophthalmol Visual Sci , vol.55 , pp. 2010-2019
    • Merle, B.M.1    Benlian, P.2    Puche, N.3    Bassols, A.4    Delcourt, C.5    Souied, E.H.6
  • 43
    • 80052235755 scopus 로고    scopus 로고
    • Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved
    • PMID:21824086
    • Serini S, Fasano E, Piccioni E, Cittadini AR, Calviello G. Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved. Curr Med Chem 2011; 18:4065-75; PMID:21824086; http://dx.doi.org/10.2174/092986711796957310.
    • (2011) Curr Med Chem , vol.18 , pp. 4065-4075
    • Serini, S.1    Fasano, E.2    Piccioni, E.3    Cittadini, A.R.4    Calviello, G.5
  • 44
    • 69449087035 scopus 로고    scopus 로고
    • Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection
    • PMID:19520558
    • Bazan NG. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids 2009; 81:205-11; PMID:19520558; http://dx.doi.org/10.1016/j.plefa.2009.05.024.
    • (2009) Prostaglandins Leukot Essent Fatty Acids , vol.81 , pp. 205-211
    • Bazan, N.G.1
  • 45
    • 0024652027 scopus 로고
    • Coronary heart disease in Greenland Inuit: A paradox. Implications for western diet patterns
    • PMID:2736000
    • Dyerberg J. Coronary heart disease in Greenland Inuit: a paradox. Implications for western diet patterns. Arctic Med Res 1989; 48:47-54;PMID:2736000.
    • (1989) Arctic Med Res , vol.48 , pp. 47-54
    • Dyerberg, J.1
  • 46
    • 0037700424 scopus 로고    scopus 로고
    • Fish consumption and the risk of Alzheimer disease: Is it time to make dietary recommendations?
    • PMID:12873846
    • Friedland RP. Fish consumption and the risk of Alzheimer disease: is it time to make dietary recommendations? Arch Neurol 2003; 60:923-4;PMID:12873846; http://dx.doi.org/10.1001/archneur.60.7.923.
    • (2003) Arch Neurol , vol.60 , pp. 923-924
    • Friedland, R.P.1
  • 47
    • 0029068579 scopus 로고
    • Fish, n-3 fatty acids and human colorectal and breast cancer mortality
    • PMID:7549825
    • Caygill CP, Hill MJ. Fish, n-3 fatty acids and human colorectal and breast cancer mortality. Eur J Cancer Prev 1995; 4:329-32; PMID:7549825; http://dx.doi.org/10.1097/00008469-199508000-00008.
    • (1995) Eur J Cancer Prev , vol.4 , pp. 329-332
    • Caygill, C.P.1    Hill, M.J.2
  • 48
    • 80655134737 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
    • PMID:21811093
    • Jing K, Song KS, Shin S, Kim N, Jeong S, Oh HR, Park JH, Seo KS, Heo JY, Han J, et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy 2011; 7:1348-58; PMID:21811093; http://dx.doi. org/10.4161/auto.7.11.16658.
    • (2011) Autophagy , vol.7 , pp. 1348-1358
    • Jing, K.1    Song, K.S.2    Shin, S.3    Kim, N.4    Jeong, S.5    Oh, H.R.6    Park, J.H.7    Seo, K.S.8    Heo, J.Y.9    Han, J.10
  • 49
    • 84874218519 scopus 로고    scopus 로고
    • Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARgamma activation in MCF-7 breast cancer cells
    • PMID:23168911
    • Rovito D, Giordano C, Vizza D, Plastina P, Barone I, Casaburi I, Lanzino M, De Amicis F, Sisci D, Mauro L, et al. Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARgamma activation in MCF-7 breast cancer cells. J Cell Physiol 2013; 228:1314-22; PMID:23168911; http://dx.doi.org/10.1002/jcp.24288.
    • (2013) J Cell Physiol , vol.228 , pp. 1314-1322
    • Rovito, D.1    Giordano, C.2    Vizza, D.3    Plastina, P.4    Barone, I.5    Casaburi, I.6    Lanzino, M.7    De Amicis, F.8    Sisci, D.9    Mauro, L.10
  • 50
    • 84880124645 scopus 로고    scopus 로고
    • The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROSmediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53
    • PMID:23841076
    • Shin S, Jing K, Jeong S, Kim N, Song KS, Heo JY, Park JH, Seo KS, Han J, Park JI, et al. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROSmediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. Biomed Res Int 2013; 2013:568671; PMID:23841076; http://dx.doi.org/10.1155/2013/568671.
    • (2013) Biomed Res Int , vol.2013 , pp. 568671
    • Shin, S.1    Jing, K.2    Jeong, S.3    Kim, N.4    Song, K.S.5    Heo, J.Y.6    Park, J.H.7    Seo, K.S.8    Han, J.9    Park, J.I.10
  • 51
    • 84902673006 scopus 로고    scopus 로고
    • Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-kappaB activation and enhancing autophagy
    • PMID:24911523
    • Williams-Bey Y, Boularan C, Vural A, Huang NN, Hwang IY, Shan-Shi C, Kehrl JH. Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-kappaB activation and enhancing autophagy. PloS One 2014; 9:e97957;PMID:24911523; http://dx.doi.org/10.1371/journal.pone.0097957.
    • (2014) Plos One , vol.9
    • Williams-Bey, Y.1    Boularan, C.2    Vural, A.3    Huang, N.N.4    Hwang, I.Y.5    Shan-Shi, C.6    Kehrl, J.H.7
  • 52
    • 84896715810 scopus 로고    scopus 로고
    • Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy
    • PMID:23887854
    • Hsu HC, Chen CY, Chiang CH, Chen MF. Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy. Eur J Nutr 2014; 53:541-7;PMID:23887854; http://dx.doi.org/10.1007/s00394-013-0562-2.
    • (2014) Eur J Nutr , vol.53 , pp. 541-547
    • Hsu, H.C.1    Chen, C.Y.2    Chiang, C.H.3    Chen, M.F.4
  • 53
    • 84869392417 scopus 로고    scopus 로고
    • EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase-8 activation, and autophagy induction
    • PMID:22903547
    • Fukui M, Kang KS, Okada K, Zhu BT. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. J Cell Biochem 2013; 114:192-203; PMID:22903547; http://dx.doi.org/10.1002/jcb.24354.
    • (2013) J Cell Biochem , vol.114 , pp. 192-203
    • Fukui, M.1    Kang, K.S.2    Okada, K.3    Zhu, B.T.4
  • 54
    • 33846257298 scopus 로고    scopus 로고
    • Enhanced incorporation of n-3 fatty acids from fish compared with fish oils
    • PMID:17269556
    • Elvevoll EO, Barstad H, Breimo ES, Brox J, Eilertsen KE, Lund T, Olsen JO, Osterud B. Enhanced incorporation of n-3 fatty acids from fish compared with fish oils. Lipids 2006; 41:1109-14; PMID:17269556; http://dx.doi.org/10.1007/s11745-006-5060-3.
    • (2006) Lipids , vol.41 , pp. 1109-1114
    • Elvevoll, E.O.1    Barstad, H.2    Breimo, E.S.3    Brox, J.4    Eilertsen, K.E.5    Lund, T.6    Olsen, J.O.7    Osterud, B.8
  • 55
    • 0029872876 scopus 로고    scopus 로고
    • ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    • PMID:8698076
    • Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 1996; 62:155-69; PMID:8698076; http://dx.doi.org/10.1006/exer.1996.0020.
    • (1996) Exp Eye Res , vol.62 , pp. 155-169
    • Dunn, K.C.1    Aotaki-Keen, A.E.2    Putkey, F.R.3    Hjelmeland, L.M.4
  • 56
    • 84877263161 scopus 로고    scopus 로고
    • Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro
    • PMID:23663688
    • Dai J, Shen J, Pan W, Shen S, Das UN. Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. Lipids Health Dis 2013; 12:71;PMID:23663688; http://dx.doi.org/10.1186/1476-511X-12-71.
    • (2013) Lipids Health Dis , vol.12 , pp. 71
    • Dai, J.1    Shen, J.2    Pan, W.3    Shen, S.4    Das, U.N.5
  • 57
    • 58849102749 scopus 로고    scopus 로고
    • DHA induces ER stress and growth arrest in human colon cancer cells: Associations with cholesterol and calcium homeostasis
    • PMID:18566476
    • Jakobsen CH, Storvold GL, Bremseth H, Follestad T, Sand K, Mack M, Olsen KS, Lundemo AG, Iversen JG, Krokan HE, et al. DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis. J Lipid Res 2008; 49:2089-100; PMID:18566476; http://dx.doi.org/10.1194/jlr.M700389-JLR200.
    • (2008) J Lipid Res , vol.49 , pp. 2089-2100
    • Jakobsen, C.H.1    Storvold, G.L.2    Bremseth, H.3    Follestad, T.4    Sand, K.5    Mack, M.6    Olsen, K.S.7    Lundemo, A.G.8    Iversen, J.G.9    Krokan, H.E.10
  • 58
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • PMID:24647116
    • Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 2014; 39:199-218; PMID:24647116; http://dx.doi.org/10.1016/j.tibs.2014.02.002.
    • (2014) Trends Biochem Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 59
    • 20444456655 scopus 로고    scopus 로고
    • Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: Role of mitogen-activated protein kinases and Nrf2
    • PMID:15964514
    • Anwar AA, Li FY, Leake DS, Ishii T, Mann GE, Siow RC. Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radic Biol Med 2005; 39:227-36; PMID:15964514; http://dx.doi.org/10.1016/j.freeradbiomed.2005.03.012.
    • (2005) Free Radic Biol Med , vol.39 , pp. 227-236
    • Anwar, A.A.1    Li, F.Y.2    Leake, D.S.3    Ishii, T.4    Mann, G.E.5    Siow, R.C.6
  • 61
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3- based E3 ligase to regulate proteasomal degradation of Nrf2
    • PMID:15282312
    • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3- based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24:7130-9;PMID:15282312; http://dx.doi.org/10.1128/MCB.24.16.7130-7139.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 62
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • PMID:9887101
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999; 13:76-86;PMID:9887101; http://dx.doi.org/10.1101/gad.13.1.76.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 63
    • 77953366801 scopus 로고    scopus 로고
    • A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
    • PMID:20421418
    • Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 2010; 30:3275-85; PMID:20421418; http://dx.doi.org/10.1128/MCB.00248-10.
    • (2010) Mol Cell Biol , vol.30 , pp. 3275-3285
    • Lau, A.1    Wang, X.J.2    Zhao, F.3    Villeneuve, N.F.4    Wu, T.5    Jiang, T.6    Sun, Z.7    White, E.8    Zhang, D.D.9
  • 64
    • 77954599053 scopus 로고    scopus 로고
    • P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • PMID:20452972
    • Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A, McMahon M, Hayes JD, Johansen T. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 2010; 285:22576-91; PMID:20452972; http://dx.doi.org/10.1074/jbc.M110.118976
    • (2010) J Biol Chem , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjottem, E.3    Larsen, K.B.4    Awuh, J.A.5    Overvatn, A.6    McMahon, M.7    Hayes, J.D.8    Johansen, T.9
  • 67
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • PMID:16647067
    • Hosokawa N, Hara Y, Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2006; 580:2623-9; PMID:16647067; http://dx.doi.org/10.1016/j.febslet.2006.04.008
    • (2006) FEBS Lett , vol.580 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 68
    • 84892859905 scopus 로고    scopus 로고
    • Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
    • PMID:24462201
    • Rogov V, Dotsch V, Johansen T, Kirkin V. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol Cell 2014; 53:167-78; PMID:24462201; http://dx.doi.org/10.1016/j.molcel.2013.12.014
    • (2014) Mol Cell , vol.53 , pp. 167-178
    • Rogov, V.1    Dotsch, V.2    Johansen, T.3    Kirkin, V.4
  • 69
    • 33745824614 scopus 로고    scopus 로고
    • ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy
    • PMID:16874109
    • Szeto J, Kaniuk NA, Canadien V, Nisman R, Mizushima N, Yoshimori T, Bazett-Jones DP, Brumell JH. ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy 2006; 2:189-99; PMID:16874109; http://dx.doi.org/10.4161/auto.2731.
    • (2006) Autophagy , vol.2 , pp. 189-199
    • Szeto, J.1    Kaniuk, N.A.2    Canadien, V.3    Nisman, R.4    Mizushima, N.5    Yoshimori, T.6    Bazett-Jones, D.P.7    Brumell, J.H.8
  • 70
    • 84921533914 scopus 로고    scopus 로고
    • Dual labeling with 5-bromo-20-deoxyuridine and 5-ethynyl-20-deoxyuridine for estimation of cell migration rate in the small intestinal epithelium
    • Asano M, Yamamoto T, Tsuruta T, Nishimura N, Sonoyama K. Dual labeling with 5-bromo-20-deoxyuridine and 5-ethynyl-20-deoxyuridine for estimation of cell migration rate in the small intestinal epithelium. Dev Growth Differ 2014; 57(1):68-73.
    • (2014) Dev Growth Differ , vol.57 , Issue.1 , pp. 68-73
    • Asano, M.1    Yamamoto, T.2    Tsuruta, T.3    Nishimura, N.4    Sonoyama, K.5
  • 71
    • 65949121134 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options
    • PMID:19721819
    • Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009; 7:65-74; PMID:19721819; http://dx.doi.org/10.2174/157015909787602823.
    • (2009) Curr Neuropharmacol , vol.7 , pp. 65-74
    • Uttara, B.1    Singh, A.V.2    Zamboni, P.3    Mahajan, R.T.4
  • 72
    • 84864348569 scopus 로고    scopus 로고
    • NRF2 and cancer: The good, the bad and the importance of context
    • PMID:22810811
    • Sporn MB, Liby KT. NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 2012; 12:564-71; PMID:22810811; http://dx.doi.org/10.1038/nrc3278.
    • (2012) Nat Rev Cancer , vol.12 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 74
    • 34047273206 scopus 로고    scopus 로고
    • Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3
    • PMID:17127771
    • Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, et al. Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem 2007; 282:2529-37; PMID:17127771; http://dx.doi.org/10.1074/jbc.M607622200.
    • (2007) J Biol Chem , vol.282 , pp. 2529-2537
    • Gao, L.1    Wang, J.2    Sekhar, K.R.3    Yin, H.4    Yared, N.F.5    Schneider, S.N.6    Sasi, S.7    Dalton, T.P.8    Erson, M.E.9    Chan, J.Y.10
  • 75
    • 84899725321 scopus 로고    scopus 로고
    • Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives
    • PMID:24736647
    • Cipollina C, Salvatore SR, Muldoon MF, Freeman BA, Schopfer FJ. Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives. PloS One 2014; 9:e94836; PMID:24736647; http://dx.doi.org/10.1371/journal.pone.0094836.
    • (2014) Plos One , vol.9
    • Cipollina, C.1    Salvatore, S.R.2    Muldoon, M.F.3    Freeman, B.A.4    Schopfer, F.J.5
  • 76
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID:18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 77
    • 57649203344 scopus 로고    scopus 로고
    • Autophagy in aging, disease and death: The true identity of a cell death impostor
    • PMID:19079285
    • Levine B, Kroemer G. Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ 2009; 16:1-2; PMID:19079285; http://dx.doi.org/10.1038/cdd.2008.139.
    • (2009) Cell Death Differ , vol.16 , pp. 1-2
    • Levine, B.1    Kroemer, G.2
  • 78
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular proteindegradation pathways in neurodegeneration
    • PMID:17051204
    • Rubinsztein DC. The roles of intracellular proteindegradation pathways in neurodegeneration. Nature 2006; 443:780-6; PMID:17051204; http://dx.doi.org/10.1038/nature05291.
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 79
    • 84876570034 scopus 로고    scopus 로고
    • Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
    • PMID:23479732
    • Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T, Mizushima N. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem 2013; 288:11436-47; PMID:23479732; http://dx.doi.org/10.1074/jbc.M112.437103.
    • (2013) J Biol Chem , vol.288 , pp. 11436-11447
    • Morishita, H.1    Eguchi, S.2    Kimura, H.3    Sasaki, J.4    Sakamaki, Y.5    Robinson, M.L.6    Sasaki, T.7    Mizushima, N.8
  • 81
    • 85005842121 scopus 로고    scopus 로고
    • Retinal damage in chloroquine maculopathy, revealed by high resolution imaging: A case report utilizing adaptive optics scanning laser ophthalmoscopy
    • PMID:24505207
    • Bae EJ, Kim KR, Tsang SH, Park SP, Chang S. Retinal damage in chloroquine maculopathy, revealed by high resolution imaging: a case report utilizing adaptive optics scanning laser ophthalmoscopy. Korean J Ophthalmol 2014; 28:100-7; PMID:24505207; http://dx.doi.org/10.3341/kjo.2014.28.1.100.
    • (2014) Korean J Ophthalmol , vol.28 , pp. 100-107
    • Bae, E.J.1    Kim, K.R.2    Tsang, S.H.3    Park, S.P.4    Chang, S.5
  • 84
    • 0036566266 scopus 로고    scopus 로고
    • Aggregateprone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • PMID:11978769
    • Ravikumar B, Duden R, Rubinsztein DC. Aggregateprone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002; 11:1107-17; PMID:11978769; http://dx.doi.org/10.1093/hmg/11.9.1107.
    • (2002) Hum Mol Genet , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 87
    • 79955929541 scopus 로고    scopus 로고
    • Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE- 19/HPV-16 cells
    • PMID:21087962
    • Miyamoto N, Izumi H, Miyamoto R, Bin H, Kondo H, Tawara A, Sasaguri Y, Kohno K. Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE- 19/HPV-16 cells. Invest Ophthalmol Vis Sci 2011; PMID:21087962; http://dx.doi.org/10.1167/iovs.10-5775.
    • (2011) Invest Ophthalmol Vis Sci
    • Miyamoto, N.1    Izumi, H.2    Miyamoto, R.3    Bin, H.4    Kondo, H.5    Tawara, A.6    Sasaguri, Y.7    Kohno, K.8
  • 93
    • 84861600073 scopus 로고    scopus 로고
    • Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
    • PMID:22112056
    • Kinnunen K, Petrovski G, Moe MC, Berta A, Kaarniranta K. Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol 2012; 90:299-309; PMID:22112056; http://dx.doi.org/10.1111/j.1755-3768.2011.02179.x.
    • (2012) Acta Ophthalmol , vol.90 , pp. 299-309
    • Kinnunen, K.1    Petrovski, G.2    Moe, M.C.3    Berta, A.4    Kaarniranta, K.5
  • 94
    • 84863727273 scopus 로고    scopus 로고
    • Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
    • PMID:22542780
    • Bhutto I, Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex. Mol Aspects Med 2012; 33:295-317; PMID:22542780; http://dx.doi.org/10.1016/j.mam.2012.04.005.
    • (2012) Mol Aspects Med , vol.33 , pp. 295-317
    • Bhutto, I.1    Lutty, G.2
  • 96
    • 79960178230 scopus 로고    scopus 로고
    • Dietary omega-3 fatty acid and fish intake and incident age-related macular degeneration in women
    • PMID:21402976
    • Christen WG, Schaumberg DA, Glynn RJ, Buring JE. Dietary omega-3 fatty acid and fish intake and incident age-related macular degeneration in women. Arch Ophthalmol 2011; 129:921-9; PMID:21402976; http://dx.doi.org/10.1001/archophthalmol.2011.34.
    • (2011) Arch Ophthalmol , vol.129 , pp. 921-929
    • Christen, W.G.1    Schaumberg, D.A.2    Glynn, R.J.3    Buring, J.E.4
  • 97
    • 65649127117 scopus 로고    scopus 로고
    • Dietary fatty acids and the 10-year incidence of age-related macular degeneration: The Blue Mountains Eye Study
    • PMID:19433717
    • Tan JS, Wang JJ, Flood V, Mitchell P. Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. Arch Ophthalmol 2009; 27:656-65; PMID:19433717; http://dx.doi.org/10.1001/archophthalmol.2009.76.
    • (2009) Arch Ophthalmol , vol.27 , pp. 656-665
    • Tan, J.S.1    Wang, J.J.2    Flood, V.3    Mitchell, P.4
  • 98
    • 84881144615 scopus 로고    scopus 로고
    • Nutritional AMDTSG. Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: The Nutritional AMD Treatment 2 study
    • PMID:23395546
    • Souied EH, Delcourt C, Querques G, Bassols A, Merle B, Zourdani A, Smith T, Benlian P, Nutritional AMDTSG. Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. Ophthalmology 2013; 120:1619-31; PMID:23395546; http://dx.doi.org/10.1016/j.ophtha.2013.01.005.
    • (2013) Ophthalmology , vol.120 , pp. 1619-1631
    • Souied, E.H.1    Delcourt, C.2    Querques, G.3    Bassols, A.4    Merle, B.5    Zourdani, A.6    Smith, T.7    Benlian, P.8
  • 99
    • 84877734641 scopus 로고    scopus 로고
    • Lutein C zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
    • Age-Related Eye Disease Study 2 Research G, PMID:23644932
    • Age-Related Eye Disease Study 2 Research G. Lutein C zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Jama 2013; 309:2005-15; PMID:23644932; http://dx.doi.org/10.1001/jama.2013.4997.
    • (2013) Jama , vol.309 , pp. 2005-2015


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