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Volumn 6, Issue 4, 2011, Pages

Age-related retinopathy in NRF2-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; NFE2L2 PROTEIN, MOUSE;

EID: 79955765832     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019456     Document Type: Article
Times cited : (275)

References (62)
  • 1
    • 1842530296 scopus 로고    scopus 로고
    • Causes and prevalence of visual impairment among adults in the United States
    • Congdon N, O'Colmain B, Klaver CC, Klein R, Munoz B, et al. (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122: 477-485.
    • (2004) Arch Ophthalmol , vol.122 , pp. 477-485
    • Congdon, N.1    O'Colmain, B.2    Klaver, C.C.3    Klein, R.4    Munoz, B.5
  • 2
    • 33846472391 scopus 로고    scopus 로고
    • Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study
    • Klein R, Klein BE, Knudtson MD, Meuer SM, Swift M, et al. (2007) Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 114: 253-262.
    • (2007) Ophthalmology , vol.114 , pp. 253-262
    • Klein, R.1    Klein, B.E.2    Knudtson, M.D.3    Meuer, S.M.4    Swift, M.5
  • 3
    • 70349572812 scopus 로고    scopus 로고
    • Relationship between RPE and choriocapillaris in age-related macular degeneration
    • McLeod DS, Grebe R, Bhutto I, Merges C, Baba T, et al. (2009) Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest Ophthalmol Vis Sci 50: 4982-4991.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 4982-4991
    • McLeod, D.S.1    Grebe, R.2    Bhutto, I.3    Merges, C.4    Baba, T.5
  • 4
    • 0031050490 scopus 로고    scopus 로고
    • Characteristics of Drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration
    • Spraul CW, Grossniklaus HE, (1997) Characteristics of Drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration. Arch Ophthalmol 115: 267-273.
    • (1997) Arch Ophthalmol , vol.115 , pp. 267-273
    • Spraul, C.W.1    Grossniklaus, H.E.2
  • 5
    • 77249147331 scopus 로고    scopus 로고
    • The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    • Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, et al. (2010) The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 29: 95-112.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 95-112
    • Anderson, D.H.1    Radeke, M.J.2    Gallo, N.B.3    Chapin, E.A.4    Johnson, P.T.5
  • 6
    • 77952147434 scopus 로고    scopus 로고
    • Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    • Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, et al. (2010) Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A 107: 7401-7406.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7401-7406
    • Chen, W.1    Stambolian, D.2    Edwards, A.O.3    Branham, K.E.4    Othman, M.5
  • 10
    • 24344479164 scopus 로고    scopus 로고
    • Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes
    • Katsuoka F, Motohashi H, Ishii T, Aburatani H, Engel JD, et al. (2005) Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol Cell Biol 25: 8044-8051.
    • (2005) Mol Cell Biol , vol.25 , pp. 8044-8051
    • Katsuoka, F.1    Motohashi, H.2    Ishii, T.3    Aburatani, H.4    Engel, J.D.5
  • 11
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S, (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 12
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults
    • Osburn WO, Kensler TW, (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 659: 31-39.
    • (2008) Mutat Res , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 13
    • 77950023482 scopus 로고    scopus 로고
    • Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy
    • Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, et al. (2010) Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy. Exp Eye Res 90: 493-500.
    • (2010) Exp Eye Res , vol.90 , pp. 493-500
    • Uno, K.1    Prow, T.W.2    Bhutto, I.A.3    Yerrapureddy, A.4    McLeod, D.S.5
  • 14
    • 77955117592 scopus 로고    scopus 로고
    • Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells
    • Ni M, Li X, Yin Z, Jiang H, Sidoryk-Wegrzynowicz M, et al. (2010) Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci 116: 590-603.
    • (2010) Toxicol Sci , vol.116 , pp. 590-603
    • Ni, M.1    Li, X.2    Yin, Z.3    Jiang, H.4    Sidoryk-Wegrzynowicz, M.5
  • 16
    • 77749339881 scopus 로고    scopus 로고
    • Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
    • Rojo AI, Innamorato NG, Martin-Moreno AM, De Ceballos ML, Yamamoto M, et al. (2010) Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Glia 58: 588-598.
    • (2010) Glia , vol.58 , pp. 588-598
    • Rojo, A.I.1    Innamorato, N.G.2    Martin-Moreno, A.M.3    de Ceballos, M.L.4    Yamamoto, M.5
  • 17
    • 33746628449 scopus 로고    scopus 로고
    • Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration
    • Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A 103: 11282-11287.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11282-11287
    • Imamura, Y.1    Noda, S.2    Hashizume, K.3    Shinoda, K.4    Yamaguchi, M.5
  • 19
    • 38949185692 scopus 로고    scopus 로고
    • Oxidative damage-induced inflammation initiates age-related macular degeneration
    • Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, et al. (2008) Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med 14: 194-198.
    • (2008) Nat Med , vol.14 , pp. 194-198
    • Hollyfield, J.G.1    Bonilha, V.L.2    Rayborn, M.E.3    Yang, X.4    Shadrach, K.G.5
  • 20
    • 76349096488 scopus 로고    scopus 로고
    • Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration
    • Albert DM, Neekhra A, Wang S, Darjatmoko SR, Sorenson CM, et al. (2010) Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration. Arch Ophthalmol 128: 212-222.
    • (2010) Arch Ophthalmol , vol.128 , pp. 212-222
    • Albert, D.M.1    Neekhra, A.2    Wang, S.3    Darjatmoko, S.R.4    Sorenson, C.M.5
  • 22
    • 23844463473 scopus 로고    scopus 로고
    • Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration
    • Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, et al. (2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A 102: 11900-11905.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11900-11905
    • Malek, G.1    Johnson, L.V.2    Mace, B.E.3    Saloupis, P.4    Schmechel, D.E.5
  • 23
    • 0344791691 scopus 로고    scopus 로고
    • Basal linear deposit and large drusen are specific for early age-related maculopathy
    • Curcio CA, Millican CL, (1999) Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol 117: 329-339.
    • (1999) Arch Ophthalmol , vol.117 , pp. 329-339
    • Curcio, C.A.1    Millican, C.L.2
  • 24
    • 0027452475 scopus 로고
    • Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman Lecture
    • Green WR, Enger C, (1993) Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman Lecture. Ophthalmology 100: 1519-1535.
    • (1993) Ophthalmology , vol.100 , pp. 1519-1535
    • Green, W.R.1    Enger, C.2
  • 25
    • 33846414372 scopus 로고    scopus 로고
    • New molecular histopathologic insights into the pathogenesis of age-related macular degeneration
    • Handa JT, (2007) New molecular histopathologic insights into the pathogenesis of age-related macular degeneration. Int Ophthalmol Clin 47: 15-50.
    • (2007) Int Ophthalmol Clin , vol.47 , pp. 15-50
    • Handa, J.T.1
  • 26
    • 0021647467 scopus 로고
    • Choroidal neovascularization can digest Bruch's membrane. A prior break is not essential
    • Heriot WJ, Henkind P, Bellhorn RW, Burns MS, (1984) Choroidal neovascularization can digest Bruch's membrane. A prior break is not essential. Ophthalmology 91: 1603-1608.
    • (1984) Ophthalmology , vol.91 , pp. 1603-1608
    • Heriot, W.J.1    Henkind, P.2    Bellhorn, R.W.3    Burns, M.S.4
  • 27
    • 0344676389 scopus 로고    scopus 로고
    • An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
    • Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, et al. (2003) An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 9: 1390-1397.
    • (2003) Nat Med , vol.9 , pp. 1390-1397
    • Ambati, J.1    Anand, A.2    Fernandez, S.3    Sakurai, E.4    Lynn, B.C.5
  • 28
    • 0022494095 scopus 로고
    • Ultrastructure of Bruch's membrane after krypton laser photocoagulation. I. Breakdown of Bruch's membrane
    • Pollack A, Korte GE, Weitzner AL, Henkind P, (1986) Ultrastructure of Bruch's membrane after krypton laser photocoagulation. I. Breakdown of Bruch's membrane. Arch Ophthalmol 104: 1372-1376.
    • (1986) Arch Ophthalmol , vol.104 , pp. 1372-1376
    • Pollack, A.1    Korte, G.E.2    Weitzner, A.L.3    Henkind, P.4
  • 29
    • 0031424208 scopus 로고    scopus 로고
    • Imaging of retinal autofluorescence in patients with age-related macular degeneration
    • Solbach U, Keilhauer C, Knabben H, Wolf S, (1997) Imaging of retinal autofluorescence in patients with age-related macular degeneration. Retina 17: 385-389.
    • (1997) Retina , vol.17 , pp. 385-389
    • Solbach, U.1    Keilhauer, C.2    Knabben, H.3    Wolf, S.4
  • 30
    • 0037893667 scopus 로고    scopus 로고
    • Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time
    • von Ruckmann A, Fitzke FW, Bird AC, (1999) Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time. Graefes Arch Clin Exp Ophthalmol 237: 1-9.
    • (1999) Graefes Arch Clin Exp Ophthalmol , vol.237 , pp. 1-9
    • von Ruckmann, A.1    Fitzke, F.W.2    Bird, A.C.3
  • 31
    • 0035069027 scopus 로고    scopus 로고
    • Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    • Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE, (2001) Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 1051-1056.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1051-1056
    • Holz, F.G.1    Bellman, C.2    Staudt, S.3    Schutt, F.4    Volcker, H.E.5
  • 32
    • 33745646365 scopus 로고    scopus 로고
    • Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration
    • Hwang JC, Chan JW, Chang S, Smith RT, (2006) Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 47: 2655-2661.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 2655-2661
    • Hwang, J.C.1    Chan, J.W.2    Chang, S.3    Smith, R.T.4
  • 33
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins RF, Russell SR, Anderson DH, Hageman GS, (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. Faseb J 14: 835-846.
    • (2000) Faseb J , vol.14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 34
    • 11144258543 scopus 로고    scopus 로고
    • Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
    • Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, et al. (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A 99: 14682-14687.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14682-14687
    • Crabb, J.W.1    Miyagi, M.2    Gu, X.3    Shadrach, K.4    West, K.A.5
  • 35
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: from phenomenology to molecular understanding in less than a decade
    • Klionsky DJ, (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 36
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • Rubinsztein DC, (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443: 780-786.
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 37
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters JJ, (2005) Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 8: 3-5.
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 39
    • 0035082072 scopus 로고    scopus 로고
    • Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration
    • Li J, Tso MO, Lam TT, (2001) Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration. Br J Ophthalmol 85: 287-290.
    • (2001) Br J Ophthalmol , vol.85 , pp. 287-290
    • Li, J.1    Tso, M.O.2    Lam, T.T.3
  • 40
    • 0032967793 scopus 로고    scopus 로고
    • Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells
    • Hageman GS, Mullins RF, Russell SR, Johnson LV, Anderson DH, (1999) Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J 13: 477-484.
    • (1999) FASEB J , vol.13 , pp. 477-484
    • Hageman, G.S.1    Mullins, R.F.2    Russell, S.R.3    Johnson, L.V.4    Anderson, D.H.5
  • 41
    • 0034954060 scopus 로고    scopus 로고
    • Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis
    • Mullins RF, Aptsiauri N, Hageman GS, (2001) Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (Lond) 15: 390-395.
    • (2001) Eye (Lond) , vol.15 , pp. 390-395
    • Mullins, R.F.1    Aptsiauri, N.2    Hageman, G.S.3
  • 43
    • 40649108843 scopus 로고    scopus 로고
    • Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    • Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, et al. (2008) Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 105: 2325-2330.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2325-2330
    • Pearson, K.J.1    Lewis, K.N.2    Price, N.L.3    Chang, J.W.4    Perez, E.5
  • 44
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM, (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13: 805-811.
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 45
    • 44849094781 scopus 로고    scopus 로고
    • Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    • Morimoto RI, (2008) Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22: 1427-1438.
    • (2008) Genes Dev , vol.22 , pp. 1427-1438
    • Morimoto, R.I.1
  • 46
    • 18044366931 scopus 로고    scopus 로고
    • RPE lipofuscin and its role in retinal pathobiology
    • Sparrow JR, Boulton M, (2005) RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80: 595-606.
    • (2005) Exp Eye Res , vol.80 , pp. 595-606
    • Sparrow, J.R.1    Boulton, M.2
  • 47
    • 77953913051 scopus 로고    scopus 로고
    • Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
    • Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141: 1146-1158.
    • (2010) Cell , vol.141 , pp. 1146-1158
    • Lee, J.H.1    Yu, W.H.2    Kumar, A.3    Lee, S.4    Mohan, P.S.5
  • 48
    • 77951665859 scopus 로고    scopus 로고
    • Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    • Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, et al. (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci 13: 567-576.
    • (2010) Nat Neurosci , vol.13 , pp. 567-576
    • Martinez-Vicente, M.1    Talloczy, Z.2    Wong, E.3    Tang, G.4    Koga, H.5
  • 49
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D, (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 50
    • 58349109733 scopus 로고    scopus 로고
    • Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration
    • Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, et al. (2009) Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 4: e4160.
    • (2009) PLoS One , vol.4
    • Wang, A.L.1    Lukas, T.J.2    Yuan, M.3    Du, N.4    Tso, M.O.5
  • 51
    • 77954599053 scopus 로고    scopus 로고
    • p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, et al. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285: 22576-22591.
    • (2010) J Biol Chem , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjottem, E.3    Larsen, K.B.4    Awuh, J.A.5
  • 52
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213-223.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5
  • 53
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, et al. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131: 1149-1163.
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5
  • 54
    • 35448975681 scopus 로고    scopus 로고
    • Progress in defining the molecular biology of age related macular degeneration
    • Lotery A, Trump D, (2007) Progress in defining the molecular biology of age related macular degeneration. Hum Genet 122: 219-236.
    • (2007) Hum Genet , vol.122 , pp. 219-236
    • Lotery, A.1    Trump, D.2
  • 55
    • 77956202732 scopus 로고    scopus 로고
    • Neuroprotection through stimulation of mitochondrial antioxidant protein expression
    • Greco T, Fiskum G, (2010) Neuroprotection through stimulation of mitochondrial antioxidant protein expression. J Alzheimers Dis 20 (Suppl 2): S427-437.
    • (2010) J Alzheimers Dis , vol.20 , Issue.SUPPL. 2
    • Greco, T.1    Fiskum, G.2
  • 56
    • 55449130008 scopus 로고    scopus 로고
    • Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress
    • Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, et al. (2008) Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol 8: 115-125.
    • (2008) Cardiovasc Toxicol , vol.8 , pp. 115-125
    • Zhu, H.1    Jia, Z.2    Strobl, J.S.3    Ehrich, M.4    Misra, H.P.5
  • 57
    • 75149117017 scopus 로고    scopus 로고
    • Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
    • Leiser SF, Miller RA, (2010) Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol 30: 871-884.
    • (2010) Mol Cell Biol , vol.30 , pp. 871-884
    • Leiser, S.F.1    Miller, R.A.2
  • 58
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, Kan YW, (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A 93: 13943-13948.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 59
    • 41149159019 scopus 로고    scopus 로고
    • Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not
    • Burk RF, Hill KE, Nakayama A, Mostert V, Levander XA, et al. (2008) Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Free Radic Biol Med 44: 1617-1623.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1617-1623
    • Burk, R.F.1    Hill, K.E.2    Nakayama, A.3    Mostert, V.4    Levander, X.A.5
  • 60
    • 0028282161 scopus 로고
    • A new procedure for fundus photography and fluorescein angiography in small laboratory animal eyes
    • DiLoreto D Jr, Grover DA, del Cerro C, del Cerro M, (1994) A new procedure for fundus photography and fluorescein angiography in small laboratory animal eyes. Curr Eye Res 13: 157-161.
    • (1994) Curr Eye Res , vol.13 , pp. 157-161
    • DiLoreto Jr., D.1    Grover, D.A.2    del Cerro, C.3    del Cerro, M.4
  • 61
    • 52049094091 scopus 로고    scopus 로고
    • A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images
    • Xu H, Koch P, Chen M, Lau A, Reid DM, et al. (2008) A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res 87: 319-326.
    • (2008) Exp Eye Res , vol.87 , pp. 319-326
    • Xu, H.1    Koch, P.2    Chen, M.3    Lau, A.4    Reid, D.M.5
  • 62
    • 62649101836 scopus 로고    scopus 로고
    • Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli
    • Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, et al. (2009) Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci 50: 1440-1447.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1440-1447
    • Lukinova, N.1    Iacovelli, J.2    Dentchev, T.3    Wolkow, N.4    Hunter, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.