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Volumn 288, Issue 16, 2013, Pages 11436-11447

Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED;

EID: 84876570034     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.437103     Document Type: Article
Times cited : (127)

References (59)
  • 1
    • 0019786296 scopus 로고
    • Lens differentiation in vertebrates. A review of cellular and molecular features
    • Piatigorsky, J. (1981) Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19, 134-153.
    • (1981) Differentiation , vol.19 , pp. 134-153
    • Piatigorsky, J.1
  • 3
    • 0016317403 scopus 로고
    • Denucleation process of the lens
    • Kuwabara, T., and Imaizumi, M. (1974) Denucleation process of the lens. Invest. Ophthalmol. 13, 973-981.
    • (1974) Invest. Ophthalmol. , vol.13 , pp. 973-981
    • Kuwabara, T.1    Imaizumi, M.2
  • 5
    • 79960625179 scopus 로고    scopus 로고
    • Lens fibre cell differentiation and organelle loss: Many paths lead to clarity
    • Wride, M. A. (2011) Lens fibre cell differentiation and organelle loss: many paths lead to clarity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 1219-1233.
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.366 , pp. 1219-1233
    • Wride, M.A.1
  • 6
    • 0001074829 scopus 로고
    • Cell production and migration in the epithelial layer of the lens
    • Hanna, C., and O'Brien, J. E. (1961) Cell production and migration in the epithelial layer of the lens. Arch. Ophthalmol. 66, 103-107.
    • (1961) Arch. Ophthalmol. , vol.66 , pp. 103-107
    • Hanna, C.1    O'Brien, J.E.2
  • 7
    • 0019517471 scopus 로고
    • Cell population kinetics of the mouse lens epithelium
    • Rafferty, N. S., and Rafferty, K. A., Jr. (1981) Cell population kinetics of the mouse lens epithelium. J. Cell. Physiol. 107, 309-315.
    • (1981) J. Cell. Physiol. , vol.107 , pp. 309-315
    • Rafferty, N.S.1    Rafferty Jr., K.A.2
  • 8
    • 84864030778 scopus 로고    scopus 로고
    • Parallels between neuron and lens fiber cell structure and molecular regulatory networks
    • Frederikse, P. H., Kasinathan, C., and Kleiman, N. J. (2012) Parallels between neuron and lens fiber cell structure and molecular regulatory networks. Dev. Biol. 368, 255-260.
    • (2012) Dev. Biol. , vol.368 , pp. 255-260
    • Frederikse, P.H.1    Kasinathan, C.2    Kleiman, N.J.3
  • 9
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima, N., and Komatsu, M. (2011) Autophagy: renovation of cells and tissues. Cell 147, 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 11
    • 0021209279 scopus 로고
    • Sequential structural response of lens epithelium to retina-conditioned medium
    • Walton, J., and McAvoy, J. (1984) Sequential structural response of lens epithelium to retina-conditioned medium. Exp. Eye Res. 39, 217-229.
    • (1984) Exp. Eye Res. , vol.39 , pp. 217-229
    • Walton, J.1    McAvoy, J.2
  • 12
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., and Ohsumi, Y. (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 13
    • 28444455308 scopus 로고    scopus 로고
    • Organelle degradation during the lens and erythroid differentiation is independent of autophagy
    • Matsui, M., Yamamoto, A., Kuma, A., Ohsumi, Y., and Mizushima, N. (2006) Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem. Biophys. Res. Commun. 339, 485-489.
    • (2006) Biochem. Biophys. Res. Commun. , vol.339 , pp. 485-489
    • Matsui, M.1    Yamamoto, A.2    Kuma, A.3    Ohsumi, Y.4    Mizushima, N.5
  • 16
    • 0035945343 scopus 로고    scopus 로고
    • Human VPS34 is required for internal vesicle formation within multivesicular endosomes
    • Futter, C. E., Collinson, L. M., Backer, J. M., and Hopkins, C. R. (2001) Human VPS34 is required for internal vesicle formation within multivesicular endosomes. J. Cell Biol. 155, 1251-1264.
    • (2001) J. Cell Biol. , vol.155 , pp. 1251-1264
    • Futter, C.E.1    Collinson, L.M.2    Backer, J.M.3    Hopkins, C.R.4
  • 17
    • 33646789810 scopus 로고    scopus 로고
    • Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes
    • Johnson, E. E., Overmeyer, J. H., Gunning, W. T., and Maltese, W. A. (2006) Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes. J. Cell Sci. 119, 1219-1232.
    • (2006) J. Cell Sci. , vol.119 , pp. 1219-1232
    • Johnson, E.E.1    Overmeyer, J.H.2    Gunning, W.T.3    Maltese, W.A.4
  • 20
    • 3042570454 scopus 로고    scopus 로고
    • Insertion of a Pax6 consensus binding site into the αa-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice
    • Zhao, H., Yang, Y., Rizo, C. M., Overbeek, P. A., and Robinson, M. L. (2004) Insertion of a Pax6 consensus binding site into the αA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest. Ophthalmol. Vis. Sci. 45, 1930-1939.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 1930-1939
    • Zhao, H.1    Yang, Y.2    Rizo, C.M.3    Overbeek, P.A.4    Robinson, M.L.5
  • 22
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • Hosokawa, N., Hara, Y., and Mizushima, N. (2006) Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett. 580, 2623-2629.
    • (2006) FEBS Lett. , vol.580 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 23
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • Kihara, A., Kabeya, Y., Ohsumi, Y., and Yoshimori, T. (2001) Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2, 330-335.
    • (2001) EMBO Rep. , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 24
    • 0031283282 scopus 로고    scopus 로고
    • Disruption of α3 connexin gene leads to proteolysis and cataractogenesis in mice
    • Gong, X., Li, E., Klier, G., Huang, Q., Wu, Y., Lei, H., Kumar, N. M., Horwitz, J., and Gilula, N. B. (1997) Disruption of α3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 91, 833-843.
    • (1997) Cell , vol.91 , pp. 833-843
    • Gong, X.1    Li, E.2    Klier, G.3    Huang, Q.4    Wu, Y.5    Lei, H.6    Kumar, N.M.7    Horwitz, J.8    Gilula, N.B.9
  • 25
    • 0038607621 scopus 로고    scopus 로고
    • Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole animals, insects, and plants
    • Kawamoto, T. (2003) Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole animals, insects, and plants. Arch. Histol. Cytol. 66, 123-143.
    • (2003) Arch. Histol. Cytol. , vol.66 , pp. 123-143
    • Kawamoto, T.1
  • 26
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death
    • Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Overvatn, A., Stenmark, H., and Johansen, T. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death. J. Cell Biol. 171, 603-614.
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 28
    • 33846931622 scopus 로고    scopus 로고
    • Proteolytic mechanisms underlying mitochondrial degradation in the ocular lens
    • Zandy, A. J., and Bassnett, S. (2007) Proteolytic mechanisms underlying mitochondrial degradation in the ocular lens. Invest. Ophthalmol. Vis. Sci. 48, 293-302.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 293-302
    • Zandy, A.J.1    Bassnett, S.2
  • 30
    • 60549093730 scopus 로고    scopus 로고
    • Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
    • Korolchuk, V. I., Mansilla, A., Menzies, F. M., and Rubinsztein, D. C. (2009) Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol. Cell 33, 517-527.
    • (2009) Mol. Cell , vol.33 , pp. 517-527
    • Korolchuk, V.I.1    Mansilla, A.2    Menzies, F.M.3    Rubinsztein, D.C.4
  • 31
    • 79960636155 scopus 로고    scopus 로고
    • The ageing lens and cataract: A model of normal and pathological ageing
    • Michael, R., and Bron, A. J. (2011) The ageing lens and cataract: a model of normal and pathological ageing. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 1278-1292.
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.366 , pp. 1278-1292
    • Michael, R.1    Bron, A.J.2
  • 32
    • 33845425645 scopus 로고    scopus 로고
    • Crystallins in the eye: Function and pathology
    • Andley, U. P. (2007) Crystallins in the eye: Function and pathology. Prog. Retin. Eye Res. 26, 78-98.
    • (2007) Prog. Retin. Eye Res. , vol.26 , pp. 78-98
    • Andley, U.P.1
  • 34
    • 70449526292 scopus 로고    scopus 로고
    • Acell polarity protein aPKCλ is required for eye lens formation and growth
    • Sugiyama, Y., Akimoto, K., Robinson, M. L., Ohno, S., and Quinlan, R. A. (2009)Acell polarity protein aPKCλ is required for eye lens formation and growth. Dev. Biol. 336, 246-256.
    • (2009) Dev. Biol. , vol.336 , pp. 246-256
    • Sugiyama, Y.1    Akimoto, K.2    Robinson, M.L.3    Ohno, S.4    Quinlan, R.A.5
  • 35
    • 34249879299 scopus 로고    scopus 로고
    • Conditional deletion of 1-integrin from the developing lens leads to loss of the lens epithelial phenotype
    • Simirskii, V. N., Wang, Y., and Duncan, M. K. (2007) Conditional deletion of 1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev. Biol. 306, 658-668.
    • (2007) Dev. Biol. , vol.306 , pp. 658-668
    • Simirskii, V.N.1    Wang, Y.2    Duncan, M.K.3
  • 37
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura, E., Kishi, C., Inoue, K., and Mizushima, N. (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 19, 5360-5372.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 38
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
    • Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N., and Yue, Z. (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 11, 468-476.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6    Heintz, N.7    Yue, Z.8
  • 40
    • 0025876317 scopus 로고
    • Nuclear breakdown during terminal differentiation of primary lens fibres in mice: A transmission electron microscopic study
    • Vrensen, G. F., Graw, J., and De Wolf, A. (1991) Nuclear breakdown during terminal differentiation of primary lens fibres in mice: a transmission electron microscopic study. Exp. Eye Res. 52, 647-659.
    • (1991) Exp. Eye Res. , vol.52 , pp. 647-659
    • Vrensen, G.F.1    Graw, J.2    De Wolf, A.3
  • 41
    • 77956594634 scopus 로고    scopus 로고
    • The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish
    • Imai, F., Yoshizawa, A., Fujimori-Tonou, N., Kawakami, K., and Masai, I. (2010) The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish. Development 137, 3257-3268.
    • (2010) Development , vol.137 , pp. 3257-3268
    • Imai, F.1    Yoshizawa, A.2    Fujimori-Tonou, N.3    Kawakami, K.4    Masai, I.5
  • 43
    • 0032563812 scopus 로고    scopus 로고
    • A function for lipoxygenase in programmed organelle degradation
    • van Leyen, K., Duvoisin, R. M., Engelhardt, H., and Wiedmann, M. (1998) A function for lipoxygenase in programmed organelle degradation. Nature 395, 392-395.
    • (1998) Nature , vol.395 , pp. 392-395
    • Van Leyen, K.1    Duvoisin, R.M.2    Engelhardt, H.3    Wiedmann, M.4
  • 45
    • 34249806740 scopus 로고    scopus 로고
    • Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens
    • Nakahara, M., Nagasaka, A., Koike, M., Uchida, K., Kawane, K., Uchiyama, Y., and Nagata, S. (2007) Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens. FEBS J. 274, 3055-3064.
    • (2007) FEBS J. , vol.274 , pp. 3055-3064
    • Nakahara, M.1    Nagasaka, A.2    Koike, M.3    Uchida, K.4    Kawane, K.5    Uchiyama, Y.6    Nagata, S.7
  • 46
    • 38549121318 scopus 로고    scopus 로고
    • DNase IIβ distribution and activity in the mouse lens
    • De Maria, A., and Bassnett, S. (2007) DNase IIβ distribution and activity in the mouse lens. Invest. Ophthalmol. Vis. Sci. 48, 5638-5646.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 5638-5646
    • De Maria, A.1    Bassnett, S.2
  • 49
    • 76149086512 scopus 로고    scopus 로고
    • FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
    • Pankiv, S., Alemu, E. A., Brech, A., Bruun, J. A., Lamark, T., Overvatn, A., Bjørkøy, G., and Johansen, T. (2010) FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J. Cell Biol. 188, 253-269.
    • (2010) J. Cell Biol. , vol.188 , pp. 253-269
    • Pankiv, S.1    Alemu, E.A.2    Brech, A.3    Bruun, J.A.4    Lamark, T.5    Overvatn, A.6    Bjørkøy, G.7    Johansen, T.8
  • 53
    • 84955200036 scopus 로고    scopus 로고
    • Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages
    • Mrakovic, A., Kay, J. G., Furuya, W., Brumell, J. H., and Botelho, R. J. (2012) Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages. Traffic 13, 1667-1679.
    • (2012) Traffic , vol.13 , pp. 1667-1679
    • Mrakovic, A.1    Kay, J.G.2    Furuya, W.3    Brumell, J.H.4    Botelho, R.J.5
  • 54
    • 84860311580 scopus 로고    scopus 로고
    • Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell
    • Li, W., Zou, W., Yang, Y., Chai, Y., Chen, B., Cheng, S., Tian, D., Wang, X., Vale, R. D., and Ou, G. (2012) Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J. Cell Biol. 197, 27-35.
    • (2012) J. Cell Biol. , vol.197 , pp. 27-35
    • Li, W.1    Zou, W.2    Yang, Y.3    Chai, Y.4    Chen, B.5    Cheng, S.6    Tian, D.7    Wang, X.8    Vale, R.D.9    Ou, G.10
  • 55
    • 58649124705 scopus 로고    scopus 로고
    • Co-operative roles for E-cadherin and Ncadherin during lens vesicle separation and lens epithelial cell survival
    • Pontoriero, G. F., Smith, A. N., Miller, L. A., Radice, G. L., West-Mays, J. A., and Lang, R. A. (2009) Co-operative roles for E-cadherin and Ncadherin during lens vesicle separation and lens epithelial cell survival. Dev. Biol. 326, 403-417.
    • (2009) Dev. Biol. , vol.326 , pp. 403-417
    • Pontoriero, G.F.1    Smith, A.N.2    Miller, L.A.3    Radice, G.L.4    West-Mays, J.A.5    Lang, R.A.6
  • 56
    • 77952722628 scopus 로고    scopus 로고
    • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
    • Zhou, X., Wang, L., Hasegawa, H., Amin, P., Han, B. X., Kaneko, S., He, Y., and Wang, F. (2010) Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc. Natl. Acad. Sci. U.S.A. 107, 9424-9429.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 9424-9429
    • Zhou, X.1    Wang, L.2    Hasegawa, H.3    Amin, P.4    Han, B.X.5    Kaneko, S.6    He, Y.7    Wang, F.8
  • 57
    • 79551528853 scopus 로고    scopus 로고
    • The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation
    • Zhou, X., Takatoh, J., and Wang, F. (2011) The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. PLoS One 6, e16358.
    • (2011) PLoS One , vol.6
    • Zhou, X.1    Takatoh, J.2    Wang, F.3
  • 58
    • 80055054434 scopus 로고    scopus 로고
    • Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye
    • Murphy, T. R., Vihtelic, T. S., Ile, K. E., Watson, C. T., Willer, G. B., Gregg, R. G., Bankaitis, V. A., and Hyde, D. R. (2011) Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye. Exp. Eye Res. 93, 460-474.
    • (2011) Exp. Eye Res. , vol.93 , pp. 460-474
    • Murphy, T.R.1    Vihtelic, T.S.2    Ile, K.E.3    Watson, C.T.4    Willer, G.B.5    Gregg, R.G.6    Bankaitis, V.A.7    Hyde, D.R.8
  • 59
    • 23844552808 scopus 로고    scopus 로고
    • Structure and function of the Lowe syndrome protein OCRL1
    • Lowe, M. (2005) Structure and function of the Lowe syndrome protein OCRL1. Traffic 6, 711-719.
    • (2005) Traffic , vol.6 , pp. 711-719
    • Lowe, M.1


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