Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy

European Journal of Nutrition

Volumn 53, Issue 2, 2014, Pages 541-547

  Hsu, Hsiu Ching ^a   Chen, Ching Yi ^b   Chiang, Chun Hsien ^b   Chen, Ming Fong ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Autophagy; Eicosapentaenoic acid; H9C2 myocardioblasts

Indexed keywords

3 METHYLADENINE; BECLIN 1; CATHEPSIN D; HYDROGEN PEROXIDE; ICOSAPENTAENOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CELL VIABILITY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; LYSOSOME; MYOBLAST; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ADENINE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE; EICOSAPENTAENOIC ACID; HYDROGEN PEROXIDE; MYOBLASTS; MYOCARDIUM; MYOCYTES, CARDIAC; ORGANELLES; OXIDATIVE STRESS; PHOSPHORYLATION; RATS;

EID: 84896715810     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0562-2     Document Type: Article

References (26)

1. Takemura G, Maruyama R, Goto K, Kanamori H, Tsujimoto A, Minatoguchi S, Fujiwara H (2009) Fate of isolated adult cardiomyocytes undergoing starvation-induced autophagic degeneration. Autophagy 5(1):90-92
2. Givvimani S, Munjal C, Tyagi N, Sen U, Metreveli N, Tyagi SC (2012) Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure. PLoS One 7(3):e32388. doi: 10.1371/journal.pone.0032388
3. Takagi H, Matsui Y, Sadoshima J (2007) The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal 9(9):1373-1381
4. Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T, Sadoshima J (2007) AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy 3(4):405-407
5. Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, Gillette TG, Hill JA (2011) Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci USA 108(10):4123-4128. doi: 10.1073/pnas.1015081108
6. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13(5):619-624. doi: 10.1038/nm1574
7. Cetrullo S, Tantini B, Flamigni F, Pazzini C, Facchini A, Stefanelli C, Caldarera CM, Pignatti C (2012) Antiapoptotic and antiautophagic effects of eicosapentaenoic acid in cardiac myoblasts exposed to palmitic acid. Nutrients 4(2):78-90. doi: 10.3390/nu4020078
8. Duda MK, O'Shea KM, Tintinu A, Xu W, Khairallah RJ, Barrows BR, Chess DJ, Azimzadeh AM, Harris WS, Sharov VG, Sabbah HN, Stanley WC (2009) Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. Cardiovasc Res 81(2):319-327
9. Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ (2008) n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects. Am J Clin Nutr 87(6):2003S-2009S
10. Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M, Kitakaze M (2003) Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts. J Cardiovasc Pharmacol 41(6):964-969
11. Engelbrecht AM, Engelbrecht P, Genade S, Niesler C, Page C, Smuts M, Lochner A (2005) Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J Mol Cell Cardiol 39(6):940-954. doi: 10.1016/j.yjmcc.2005.08.004
12. Pignier C, Revenaz C, Rauly-Lestienne I, Cussac D, Delhon A, Gardette J, Le Grand B (2007) Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity. Basic Res Cardiol 102(6):553-564. doi: 10.1007/s00395-007-0676-x
13. Raimondi L, Lodovici M, Visioli F, Sartiani L, Cioni L, Alfarano C, Banchelli G, Pirisino R, Cecchi E, Cerbai E, Mugelli A (2005) n-3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive rats. Eur J Nutr 44(6):327-333. doi: 10.1007/s00394-004-0528-5
14. Leroy C, Tricot S, Lacour B, Grynberg A (2008) Protective effect of eicosapentaenoic acid on palmitate-induced apoptosis in neonatal cardiomyocytes. Biochim Biophys Acta 1781(11-12):685-693. doi: 10.1016/j.bbalip.2008.07.009
15. Chen CY, Hsu HC, Lee AS, Tang D, Chow LP, Yang CY, Chen H, Lee YT, Chen CH (2012) The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells. J Vasc Res 49(4):329-341. doi: 10.1159/000337463
16. Zhang XQ, Dunner K Jr, Benedict WF (2010) Autophagy is induced by adenoviral-mediated interferon alpha treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced. Cancer Gene Ther 17(8):579-584. doi: 10.1038/cgt.2010.14
17. Nemchenko A, Chiong M, Turer A, Lavandero S, Hill JA (2011) Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol 51(4):584-593. doi: 10.1016/j.yjmcc.2011.06.010
18. Xie M, Morales CR, Lavandero S, Hill JA (2011) Tuning flux: autophagy as a target of heart disease therapy. Curr Opin Cardiol 26(3):216-222. doi: 10.1097/HCO.0b013e328345980a
19. Ma X, Godar RJ, Liu H, Diwan A (2012) Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy 8(3):297-309
20. Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A (2012) Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia-reperfusion injury. Circulation 125(25):3170-3181. doi: 10.1161/CIRCULATIONAHA.111.041814
21. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285(14):10850-10861. doi: 10.1074/jbc.M109.080796
22. Alers S, Loffler AS, Wesselborg S, Stork B (2012) Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 32(1):2-11. doi: 10.1128/MCB.06159-11
23. Mihaylova MM, Shaw RJ (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13(9):1016-1023. doi: 10.1038/ncb2329
24. Miyamoto S, Murphy AN, Brown JH (2009) Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr 41(2):169-180. doi: 10.1007/s10863-009-9205-y
25. Chaanine AH, Hajjar RJ (2011) AKT signalling in the failing heart. Eur J Heart Fail 13(8):825-829. doi: 10.1093/eurjhf/hfr080
26. Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T, Hasegawa K (2008) Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell Physiol 215(3):733-742. doi: 10.1002/jcp.21353