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Volumn 66, Issue , 2016, Pages 7-16

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review

Author keywords

CD4 T cells; CD8 T cells; Inflammation; T cell receptor; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; IMMUNOLOGIC FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84953352655     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.08.012     Document Type: Review
Times cited : (51)

References (125)
  • 1
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin-dependent diabetes
    • Katz J.D., Benoist C., Mathis D. T helper cell subsets in insulin-dependent diabetes. Science 1995, 268:1185-1188.
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 2
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • Arif S., Tree T.I., Astill T.P., Tremble J.M., Bishop A.J., Dayan C.M., et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J. Clin. Invest. 2004, 113:451-463.
    • (2004) J. Clin. Invest. , vol.113 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3    Tremble, J.M.4    Bishop, A.J.5    Dayan, C.M.6
  • 4
    • 80052829943 scopus 로고    scopus 로고
    • Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated beta-cell death
    • Arif S., Moore F., Marks K., Bouckenooghe T., Dayan C.M., Planas R., et al. Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated beta-cell death. Diabetes 2011, 60:2112-2119.
    • (2011) Diabetes , vol.60 , pp. 2112-2119
    • Arif, S.1    Moore, F.2    Marks, K.3    Bouckenooghe, T.4    Dayan, C.M.5    Planas, R.6
  • 6
    • 77953223382 scopus 로고    scopus 로고
    • Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
    • Tree T.I., Lawson J., Edwards H., Skowera A., Arif S., Roep B.O., et al. Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes 2010, 59:1451-1460.
    • (2010) Diabetes , vol.59 , pp. 1451-1460
    • Tree, T.I.1    Lawson, J.2    Edwards, H.3    Skowera, A.4    Arif, S.5    Roep, B.O.6
  • 7
    • 77955662673 scopus 로고    scopus 로고
    • IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes
    • Petrich de Marquesini L.G., Fu J., Connor K.J., Bishop A.J., McLintock N.E., Pope C., et al. IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes. Diabetologia 2010, 53:1451-1460.
    • (2010) Diabetologia , vol.53 , pp. 1451-1460
    • Petrich de Marquesini, L.G.1    Fu, J.2    Connor, K.J.3    Bishop, A.J.4    McLintock, N.E.5    Pope, C.6
  • 8
    • 84908632192 scopus 로고    scopus 로고
    • Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes
    • Arif S., Leete P., Nguyen V., Marks K., Nor N.M., Estorninho M., et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes 2014, 63:3835-3845.
    • (2014) Diabetes , vol.63 , pp. 3835-3845
    • Arif, S.1    Leete, P.2    Nguyen, V.3    Marks, K.4    Nor, N.M.5    Estorninho, M.6
  • 9
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005, 435:220-223.
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3    Babaya, N.4    Liu, E.5    Miao, D.6
  • 11
    • 80053628904 scopus 로고    scopus 로고
    • Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
    • Crawford F., Stadinski B., Jin N., Michels A., Nakayama M., Pratt P., et al. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:16729-16734.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 16729-16734
    • Crawford, F.1    Stadinski, B.2    Jin, N.3    Michels, A.4    Nakayama, M.5    Pratt, P.6
  • 15
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N., Magnani C.F., Huber S., Gianolini M.E., Pala M., Licona-Limon P., et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 2013, 19:739-746.
    • (2013) Nat. Med. , vol.19 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3    Gianolini, M.E.4    Pala, M.5    Licona-Limon, P.6
  • 16
    • 17844364504 scopus 로고    scopus 로고
    • Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
    • Brusko T.M., Wasserfall C.H., Clare-Salzler M.J., Schatz D.A., Atkinson M.A. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 2005, 54:1407-1414.
    • (2005) Diabetes , vol.54 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Atkinson, M.A.5
  • 17
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005, 54:92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 18
    • 34447640430 scopus 로고    scopus 로고
    • At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction
    • Glisic-Milosavljevic S., Waukau J., Jailwala P., Jana S., Khoo H.J., Albertz H., et al. At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction. PLoS One 2007, 2:e146.
    • (2007) PLoS One , vol.2 , pp. e146
    • Glisic-Milosavljevic, S.1    Waukau, J.2    Jailwala, P.3    Jana, S.4    Khoo, H.J.5    Albertz, H.6
  • 19
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider A., Rieck M., Sanda S., Pihoker C., Greenbaum C., Buckner J.H. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J. Immunol. 2008, 181:7350-7355.
    • (2008) J. Immunol. , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5    Buckner, J.H.6
  • 20
    • 55449111318 scopus 로고    scopus 로고
    • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • Lawson J.M., Tremble J., Dayan C., Beyan H., Leslie R.D., Peakman M., et al. Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin. Exp. Immunol. 2008, 154:353-359.
    • (2008) Clin. Exp. Immunol. , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3    Beyan, H.4    Leslie, R.D.5    Peakman, M.6
  • 21
    • 80755148666 scopus 로고    scopus 로고
    • Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    • Ferraro A., Socci C., Stabilini A., Valle A., Monti P., Piemonti L., et al. Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes 2011, 60:2903-2913.
    • (2011) Diabetes , vol.60 , pp. 2903-2913
    • Ferraro, A.1    Socci, C.2    Stabilini, A.3    Valle, A.4    Monti, P.5    Piemonti, L.6
  • 22
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A., Cooper J.D., Lowe C.E., Walker N., Nutland S., Widmer B., et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am. J. Hum. Genet. 2005, 76:773-779.
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3    Walker, N.4    Nutland, S.5    Widmer, B.6
  • 23
    • 84904740187 scopus 로고    scopus 로고
    • Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes
    • Thompson W.S., Pekalski M.L., Simons H.Z., Smyth D.J., Castro-Dopico X., Guo H., et al. Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes. Clin. Exp. Immunol. 2014, 177:571-585.
    • (2014) Clin. Exp. Immunol. , vol.177 , pp. 571-585
    • Thompson, W.S.1    Pekalski, M.L.2    Simons, H.Z.3    Smyth, D.J.4    Castro-Dopico, X.5    Guo, H.6
  • 24
    • 58149302798 scopus 로고    scopus 로고
    • Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study
    • Thrower S.L., James L., Hall W., Green K.M., Arif S., Allen J.S., et al. Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study. Clin. Exp. Immunol. 2009, 155:156-165.
    • (2009) Clin. Exp. Immunol. , vol.155 , pp. 156-165
    • Thrower, S.L.1    James, L.2    Hall, W.3    Green, K.M.4    Arif, S.5    Allen, J.S.6
  • 25
    • 77956360380 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential
    • Peakman M., von Herrath M. Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential. Diabetes 2010, 59:2087-2093.
    • (2010) Diabetes , vol.59 , pp. 2087-2093
    • Peakman, M.1    von Herrath, M.2
  • 26
    • 84876089704 scopus 로고    scopus 로고
    • Progress in immune-based therapies for type 1 diabetes
    • von Herrath M., Peakman M., Roep B. Progress in immune-based therapies for type 1 diabetes. Clin. Exp. Immunol. 2013, 172:186-202.
    • (2013) Clin. Exp. Immunol. , vol.172 , pp. 186-202
    • von Herrath, M.1    Peakman, M.2    Roep, B.3
  • 27
    • 84946472495 scopus 로고    scopus 로고
    • Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanised model
    • Gibson V.B., Nikolic T., Pearce V.Q., Demengeot O., Roep B.O., Peakman M. Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanised model. Clin. Exp. Immunol. 2015.
    • (2015) Clin. Exp. Immunol.
    • Gibson, V.B.1    Nikolic, T.2    Pearce, V.Q.3    Demengeot, O.4    Roep, B.O.5    Peakman, M.6
  • 28
    • 70749093491 scopus 로고    scopus 로고
    • Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes
    • Planas R., Carrillo J., Sanchez A., de Villa M.C., Nunez F., Verdaguer J., et al. Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin. Exp. Immunol. 2010, 159:23-44.
    • (2010) Clin. Exp. Immunol. , vol.159 , pp. 23-44
    • Planas, R.1    Carrillo, J.2    Sanchez, A.3    de Villa, M.C.4    Nunez, F.5    Verdaguer, J.6
  • 30
    • 84921753054 scopus 로고    scopus 로고
    • T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
    • Becattini S., Latorre D., Mele F., Foglierini M., De Gregorio C., Cassotta A., et al. T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines. Science 2015, 347:400-406.
    • (2015) Science , vol.347 , pp. 400-406
    • Becattini, S.1    Latorre, D.2    Mele, F.3    Foglierini, M.4    De Gregorio, C.5    Cassotta, A.6
  • 31
    • 84940112129 scopus 로고    scopus 로고
    • Phenotypic complexity of the human regulatory T cell compartment revealed by mass cytometry
    • Mason G.M., Lowe K., Melchiotti R., Ellis R., de Rinaldis E., Peakman M., et al. Phenotypic complexity of the human regulatory T cell compartment revealed by mass cytometry. J. Immunol. 2015 Sep 1, 195(5):2030-2037.
    • (2015) J. Immunol. , vol.195 , Issue.5 , pp. 2030-2037
    • Mason, G.M.1    Lowe, K.2    Melchiotti, R.3    Ellis, R.4    de Rinaldis, E.5    Peakman, M.6
  • 32
    • 84922311090 scopus 로고    scopus 로고
    • Expression profiling. Combinatorial labeling of single cells for gene expression cytometry
    • Fan H.C., Fu G.K., Fodor S.P. Expression profiling. Combinatorial labeling of single cells for gene expression cytometry. Science 2015, 347:1258367.
    • (2015) Science , vol.347 , pp. 1258367
    • Fan, H.C.1    Fu, G.K.2    Fodor, S.P.3
  • 33
    • 84928395184 scopus 로고    scopus 로고
    • RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells
    • Chen K.H., Boettiger A.N., Moffitt J.R., Wang S., Zhuang X. RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 2015, 348:aaa6090.
    • (2015) Science , vol.348 , pp. aaa6090
    • Chen, K.H.1    Boettiger, A.N.2    Moffitt, J.R.3    Wang, S.4    Zhuang, X.5
  • 34
    • 84888339051 scopus 로고    scopus 로고
    • A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping
    • Estorninho M., Gibson V.B., Kronenberg-Versteeg D., Liu Y.F., Ni C., Cerosaletti K., et al. A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping. J. Immunol. 2013, 191:5430-5440.
    • (2013) J. Immunol. , vol.191 , pp. 5430-5440
    • Estorninho, M.1    Gibson, V.B.2    Kronenberg-Versteeg, D.3    Liu, Y.F.4    Ni, C.5    Cerosaletti, K.6
  • 35
    • 84929676377 scopus 로고    scopus 로고
    • Clonal deletion prunes but does not eliminate self-specific alphabeta CD8(+) T lymphocytes
    • Yu W., Jiang N., Ebert P.J., Kidd B.A., Muller S., Lund P.J., et al. Clonal deletion prunes but does not eliminate self-specific alphabeta CD8(+) T lymphocytes. Immunity 2015, 42:929-941.
    • (2015) Immunity , vol.42 , pp. 929-941
    • Yu, W.1    Jiang, N.2    Ebert, P.J.3    Kidd, B.A.4    Muller, S.5    Lund, P.J.6
  • 36
    • 84924610426 scopus 로고    scopus 로고
    • High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4(+) T cells
    • Eugster A., Lindner A., Catani M., Heninger A.-K., Dahl A., Klemroth S., et al. High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4(+) T cells. J. Immunol. 2015, 194:2531-2538.
    • (2015) J. Immunol. , vol.194 , pp. 2531-2538
    • Eugster, A.1    Lindner, A.2    Catani, M.3    Heninger, A.-K.4    Dahl, A.5    Klemroth, S.6
  • 37
    • 84888407214 scopus 로고    scopus 로고
    • Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells
    • Eugster A., Lindner A., Heninger A.K., Wilhelm C., Dietz S., Catani M., et al. Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells. J. Immunol. Methods 2013, 400-401:13-22.
    • (2013) J. Immunol. Methods , pp. 13-22
    • Eugster, A.1    Lindner, A.2    Heninger, A.K.3    Wilhelm, C.4    Dietz, S.5    Catani, M.6
  • 41
    • 36849012027 scopus 로고    scopus 로고
    • Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    • Nejentsev S., Howson J.M., Walker N.M., Szeszko J., Field S.F., Stevens H.E., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007, 450:887-892.
    • (2007) Nature , vol.450 , pp. 887-892
    • Nejentsev, S.1    Howson, J.M.2    Walker, N.M.3    Szeszko, J.4    Field, S.F.5    Stevens, H.E.6
  • 42
    • 84856825977 scopus 로고    scopus 로고
    • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    • Coppieters K.T., Dotta F., Amirian N., Campbell P.D., Kay T.W., Atkinson M.A., et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 2012, 209:51-60.
    • (2012) J. Exp. Med. , vol.209 , pp. 51-60
    • Coppieters, K.T.1    Dotta, F.2    Amirian, N.3    Campbell, P.D.4    Kay, T.W.5    Atkinson, M.A.6
  • 44
    • 55849116389 scopus 로고    scopus 로고
    • CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    • Skowera A., Ellis R.J., Varela-Calvino R., Arif S., Huang G.C., Van-Krinks C., et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J. Clin. Invest. 2008, 118:3390-3402.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3390-3402
    • Skowera, A.1    Ellis, R.J.2    Varela-Calvino, R.3    Arif, S.4    Huang, G.C.5    Van-Krinks, C.6
  • 45
    • 84863222103 scopus 로고    scopus 로고
    • Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells
    • Kronenberg D., Knight R.R., Estorninho M., Ellis R.J., Kester M.G., de Ru A., et al. Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells. Diabetes 2012, 61:1752-1759.
    • (2012) Diabetes , vol.61 , pp. 1752-1759
    • Kronenberg, D.1    Knight, R.R.2    Estorninho, M.3    Ellis, R.J.4    Kester, M.G.5    de Ru, A.6
  • 46
    • 84930398461 scopus 로고    scopus 로고
    • A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells
    • Knight R.R., Dolton G., Kronenberg-Versteeg D., Eichmann M., Zhao M., Huang G.C., et al. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clin. Exp. Immunol. 2015, 179:100-107.
    • (2015) Clin. Exp. Immunol. , vol.179 , pp. 100-107
    • Knight, R.R.1    Dolton, G.2    Kronenberg-Versteeg, D.3    Eichmann, M.4    Zhao, M.5    Huang, G.C.6
  • 47
    • 80052695684 scopus 로고    scopus 로고
    • T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives
    • Mallone R., Brezar V., Boitard C. T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives. Clin. Dev. Immunol. 2011, 2011:513210.
    • (2011) Clin. Dev. Immunol. , vol.2011 , pp. 513210
    • Mallone, R.1    Brezar, V.2    Boitard, C.3
  • 48
    • 84922789087 scopus 로고    scopus 로고
    • Generation of beta cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice
    • Babad J., Mukherjee G., Follenzi A., Ali R., Roep B.O., Shultz L.D., et al. Generation of beta cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin. Exp. Immunol. 2015, 179:398-413.
    • (2015) Clin. Exp. Immunol. , vol.179 , pp. 398-413
    • Babad, J.1    Mukherjee, G.2    Follenzi, A.3    Ali, R.4    Roep, B.O.5    Shultz, L.D.6
  • 49
    • 84920275601 scopus 로고    scopus 로고
    • Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
    • Skarstrand H., Krupinska E., Haataja T.J., Vaziri-Sani F., Lagerstedt J.O., Lernmark A. Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients. Clin. Exp. Immunol. 2015, 179:220-229.
    • (2015) Clin. Exp. Immunol. , vol.179 , pp. 220-229
    • Skarstrand, H.1    Krupinska, E.2    Haataja, T.J.3    Vaziri-Sani, F.4    Lagerstedt, J.O.5    Lernmark, A.6
  • 50
    • 84962018413 scopus 로고    scopus 로고
    • The streetlight effect in type 1 diabetes
    • Battaglia M., Atkinson M.A. The streetlight effect in type 1 diabetes. Diabetes 2015, 64:1081-1090.
    • (2015) Diabetes , vol.64 , pp. 1081-1090
    • Battaglia, M.1    Atkinson, M.A.2
  • 53
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 55
    • 84906661993 scopus 로고    scopus 로고
    • Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes
    • McGinty J.W., Chow I.T., Greenbaum C., Odegard J., Kwok W.W., James E.A. Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes 2014, 63:3033-3040.
    • (2014) Diabetes , vol.63 , pp. 3033-3040
    • McGinty, J.W.1    Chow, I.T.2    Greenbaum, C.3    Odegard, J.4    Kwok, W.W.5    James, E.A.6
  • 56
    • 0030615171 scopus 로고    scopus 로고
    • The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition
    • Meadows L., Wang W., den Haan J.M., Blokland E., Reinhardus C., Drijfhout J.W., et al. The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 1997, 6:273-281.
    • (1997) Immunity , vol.6 , pp. 273-281
    • Meadows, L.1    Wang, W.2    den Haan, J.M.3    Blokland, E.4    Reinhardus, C.5    Drijfhout, J.W.6
  • 57
    • 62449239575 scopus 로고    scopus 로고
    • Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
    • Petersen J., Wurzbacher S.J., Williamson N.A., Ramarathinam S.H., Reid H.H., Nair A.K., et al. Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2776-2781.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 2776-2781
    • Petersen, J.1    Wurzbacher, S.J.2    Williamson, N.A.3    Ramarathinam, S.H.4    Reid, H.H.5    Nair, A.K.6
  • 58
    • 84907931326 scopus 로고    scopus 로고
    • Identification and characterisation of peptide binding motifs of six autoimmune disease-associated human leukocyte antigen-class I molecules including HLA-B*39:06
    • Eichmann M., de Ru A., van Veelen P.A., Peakman M., Kronenberg-Versteeg D. Identification and characterisation of peptide binding motifs of six autoimmune disease-associated human leukocyte antigen-class I molecules including HLA-B*39:06. Tissue antigens 2014, 84:378-388.
    • (2014) Tissue antigens , vol.84 , pp. 378-388
    • Eichmann, M.1    de Ru, A.2    van Veelen, P.A.3    Peakman, M.4    Kronenberg-Versteeg, D.5
  • 59
    • 27544446623 scopus 로고    scopus 로고
    • T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
    • Tynan F.E., Burrows S.R., Buckle A.M., Clements C.S., Borg N.A., Miles J.J., et al. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 2005, 6:1114-1122.
    • (2005) Nat. Immunol. , vol.6 , pp. 1114-1122
    • Tynan, F.E.1    Burrows, S.R.2    Buckle, A.M.3    Clements, C.S.4    Borg, N.A.5    Miles, J.J.6
  • 60
    • 84857189975 scopus 로고    scopus 로고
    • Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
    • Bulek A.M., Cole D.K., Skowera A., Dolton G., Gras S., Madura F., et al. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat. Immunol. 2012, 13:283-289.
    • (2012) Nat. Immunol. , vol.13 , pp. 283-289
    • Bulek, A.M.1    Cole, D.K.2    Skowera, A.3    Dolton, G.4    Gras, S.5    Madura, F.6
  • 61
    • 84890333499 scopus 로고    scopus 로고
    • HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity
    • Paul S., Weiskopf D., Angelo M.A., Sidney J., Peters B., Sette A. HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity. J. Immunol. 2013, 191:5831-5839.
    • (2013) J. Immunol. , vol.191 , pp. 5831-5839
    • Paul, S.1    Weiskopf, D.2    Angelo, M.A.3    Sidney, J.4    Peters, B.5    Sette, A.6
  • 62
    • 80755153651 scopus 로고    scopus 로고
    • Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers
    • Unger W.W., Velthuis J., Abreu J.R., Laban S., Quinten E., Kester M.G., et al. Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers. J. Autoimmun. 2011, 37:151-159.
    • (2011) J. Autoimmun. , vol.37 , pp. 151-159
    • Unger, W.W.1    Velthuis, J.2    Abreu, J.R.3    Laban, S.4    Quinten, E.5    Kester, M.G.6
  • 63
    • 84904240682 scopus 로고    scopus 로고
    • Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
    • Dolton G., Lissina A., Skowera A., Ladell K., Tungatt K., Jones E., et al. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clin. Exp. Immunol. 2014, 177:47-63.
    • (2014) Clin. Exp. Immunol. , vol.177 , pp. 47-63
    • Dolton, G.1    Lissina, A.2    Skowera, A.3    Ladell, K.4    Tungatt, K.5    Jones, E.6
  • 65
    • 82455192402 scopus 로고    scopus 로고
    • DRiPs solidify: progress in understanding endogenous MHC class I antigen processing
    • Yewdell J.W. DRiPs solidify: progress in understanding endogenous MHC class I antigen processing. Trends Immunol. 2011, 32:548-558.
    • (2011) Trends Immunol. , vol.32 , pp. 548-558
    • Yewdell, J.W.1
  • 66
    • 82255164138 scopus 로고    scopus 로고
    • Towards a systems understanding of MHC class I and MHC class II antigen presentation
    • Neefjes J., Jongsma M.L., Paul P., Bakke O. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat. Rev. Immunol. 2011, 11:823-836.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 823-836
    • Neefjes, J.1    Jongsma, M.L.2    Paul, P.3    Bakke, O.4
  • 68
    • 82255183367 scopus 로고    scopus 로고
    • Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes
    • Luce S., Lemonnier F., Briand J.P., Coste J., Lahlou N., Muller S., et al. Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes. Diabetes 2011, 60:3289-3299.
    • (2011) Diabetes , vol.60 , pp. 3289-3299
    • Luce, S.1    Lemonnier, F.2    Briand, J.P.3    Coste, J.4    Lahlou, N.5    Muller, S.6
  • 69
    • 84897052535 scopus 로고    scopus 로고
    • Immune modulation in humans: implications for type 1 diabetes mellitus
    • Roep B.O., Tree T.I. Immune modulation in humans: implications for type 1 diabetes mellitus. Nat. Rev. Endocrinol. 2014, 10:229-242.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 229-242
    • Roep, B.O.1    Tree, T.I.2
  • 71
    • 57349118383 scopus 로고    scopus 로고
    • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
    • Varela-Rohena A., Molloy P.E., Dunn S.M., Li Y., Suhoski M.M., Carroll R.G., et al. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat. Med. 2008, 14:1390-1395.
    • (2008) Nat. Med. , vol.14 , pp. 1390-1395
    • Varela-Rohena, A.1    Molloy, P.E.2    Dunn, S.M.3    Li, Y.4    Suhoski, M.M.5    Carroll, R.G.6
  • 72
    • 84866419166 scopus 로고    scopus 로고
    • Why must T cells be cross-reactive?
    • Sewell A.K. Why must T cells be cross-reactive?. Nat. Rev. Immunol. 2012, 12:669-677.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 669-677
    • Sewell, A.K.1
  • 73
    • 84908635248 scopus 로고    scopus 로고
    • Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes
    • Rodriguez-Calvo T., Ekwall O., Amirian N., Zapardiel-Gonzalo J., von Herrath M.G. Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes. Diabetes 2014, 63:3880-3890.
    • (2014) Diabetes , vol.63 , pp. 3880-3890
    • Rodriguez-Calvo, T.1    Ekwall, O.2    Amirian, N.3    Zapardiel-Gonzalo, J.4    von Herrath, M.G.5
  • 74
    • 77951983004 scopus 로고    scopus 로고
    • Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    • Velthuis J.H., Unger W.W., Abreu J.R., Duinkerken G., Franken K., Peakman M., et al. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010, 59:1721-1730.
    • (2010) Diabetes , vol.59 , pp. 1721-1730
    • Velthuis, J.H.1    Unger, W.W.2    Abreu, J.R.3    Duinkerken, G.4    Franken, K.5    Peakman, M.6
  • 75
    • 84962052827 scopus 로고    scopus 로고
    • Beta-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure
    • Skowera A., Ladell K., McLaren J.E., Dolton G., Matthews K.K., Gostick E., et al. beta-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes 2015, 64:916-925.
    • (2015) Diabetes , vol.64 , pp. 916-925
    • Skowera, A.1    Ladell, K.2    McLaren, J.E.3    Dolton, G.4    Matthews, K.K.5    Gostick, E.6
  • 76
    • 84866425219 scopus 로고    scopus 로고
    • Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
    • Scotto M., Afonso G., Larger E., Raverdy C., Lemonnier F.A., Carel J.C., et al. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia 2012, 55:2026-2031.
    • (2012) Diabetologia , vol.55 , pp. 2026-2031
    • Scotto, M.1    Afonso, G.2    Larger, E.3    Raverdy, C.4    Lemonnier, F.A.5    Carel, J.C.6
  • 77
    • 84938397867 scopus 로고    scopus 로고
    • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
    • McKinney E.F., Lee J.C., Jayne D.R., Lyons P.A., Smith K.G. T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection. Nature 2015, 523:612-616.
    • (2015) Nature , vol.523 , pp. 612-616
    • McKinney, E.F.1    Lee, J.C.2    Jayne, D.R.3    Lyons, P.A.4    Smith, K.G.5
  • 80
    • 84955352134 scopus 로고    scopus 로고
    • Factors impeding the discovery of an intervention-based treatment for type 1 diabetes
    • von Herrath M.G., Korsgren O., Atkinson M.A. Factors impeding the discovery of an intervention-based treatment for type 1 diabetes. Clin. Exp. Immunol. 2015.
    • (2015) Clin. Exp. Immunol.
    • von Herrath, M.G.1    Korsgren, O.2    Atkinson, M.A.3
  • 81
    • 0036085788 scopus 로고    scopus 로고
    • Type 1A diabetes mellitus-associated autoimmunity
    • Liu E.E.G. Type 1A diabetes mellitus-associated autoimmunity. Endocrinol. Metab. Clin. North Am. 2002, 31:391-410.
    • (2002) Endocrinol. Metab. Clin. North Am. , vol.31 , pp. 391-410
    • Liu, E.E.G.1
  • 86
    • 84864381301 scopus 로고    scopus 로고
    • Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data
    • Greenbaum C.J., Beam C.A., Boulware D., Gitelman S.E., Gottlieb P.A., Herold K.C., et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data. Diabetes 2012, 61:2066-2073.
    • (2012) Diabetes , vol.61 , pp. 2066-2073
    • Greenbaum, C.J.1    Beam, C.A.2    Boulware, D.3    Gitelman, S.E.4    Gottlieb, P.A.5    Herold, K.C.6
  • 87
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • Hummel M.B.E., Schmid S., Walter M., Knopff A., Ziegler A.G. Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann. Intern Med. 2004, 140:882-886.
    • (2004) Ann. Intern Med. , vol.140 , pp. 882-886
    • Hummel, M.B.E.1    Schmid, S.2    Walter, M.3    Knopff, A.4    Ziegler, A.G.5
  • 88
    • 84939961476 scopus 로고    scopus 로고
    • The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
    • Krischer J.P., Lynch K.F., Schatz D.A., Ilonen J., Lernmark A., Hagopian W.A., et al. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia 2015, 58:980-987.
    • (2015) Diabetologia , vol.58 , pp. 980-987
    • Krischer, J.P.1    Lynch, K.F.2    Schatz, D.A.3    Ilonen, J.4    Lernmark, A.5    Hagopian, W.A.6
  • 89
    • 84878847275 scopus 로고    scopus 로고
    • Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children
    • Achenbach P.H.M., Thümer L., Boerschmann H., Höfelmann D., Ziegler A.G. Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children. Diebetologia 2013, 56:1615-1622.
    • (2013) Diebetologia , vol.56 , pp. 1615-1622
    • Achenbach, P.H.M.1    Thümer, L.2    Boerschmann, H.3    Höfelmann, D.4    Ziegler, A.G.5
  • 91
    • 84920827660 scopus 로고    scopus 로고
    • Islet inflammation in human type 1 diabetes mellitus
    • Morgan N.G.L.P., Foulis A.K., Richardson S.J. Islet inflammation in human type 1 diabetes mellitus. IUBMB Life 2014, 66:723-734.
    • (2014) IUBMB Life , vol.66 , pp. 723-734
    • Morgan, N.G.L.P.1    Foulis, A.K.2    Richardson, S.J.3
  • 94
    • 84929514280 scopus 로고    scopus 로고
    • Novel therapies for memory cells in autoimmune diseases
    • Bhargava P., Calabresi P.A. Novel therapies for memory cells in autoimmune diseases. Clin. Exp. Immunol. 2015, 180:353-360.
    • (2015) Clin. Exp. Immunol. , vol.180 , pp. 353-360
    • Bhargava, P.1    Calabresi, P.A.2
  • 96
    • 84922805709 scopus 로고    scopus 로고
    • Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
    • Peterson C.T., Sharma V., Elmen L., Peterson S.N. Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clin. Exp. Immunol. 2015, 179:363-377.
    • (2015) Clin. Exp. Immunol. , vol.179 , pp. 363-377
    • Peterson, C.T.1    Sharma, V.2    Elmen, L.3    Peterson, S.N.4
  • 97
    • 84887624109 scopus 로고    scopus 로고
    • Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
    • Gitelman S.E., Gottlieb P.A., Rigby M.R., Felner E.I., Willi S.M., Fisher L.K., et al. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2013, 1:306-316.
    • (2013) Lancet Diabetes Endocrinol. , vol.1 , pp. 306-316
    • Gitelman, S.E.1    Gottlieb, P.A.2    Rigby, M.R.3    Felner, E.I.4    Willi, S.M.5    Fisher, L.K.6
  • 99
    • 84887052291 scopus 로고    scopus 로고
    • Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders
    • Herold K.C., Gitelman S.E., Ehlers M.R., Gottlieb P.A., Greenbaum C.J., Hagopian W., et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes 2013, 62:3766-3774.
    • (2013) Diabetes , vol.62 , pp. 3766-3774
    • Herold, K.C.1    Gitelman, S.E.2    Ehlers, M.R.3    Gottlieb, P.A.4    Greenbaum, C.J.5    Hagopian, W.6
  • 100
    • 84887055430 scopus 로고    scopus 로고
    • Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial
    • Hagopian W., Ferry R.J., Sherry N., Carlin D., Bonvini E., Johnson S., et al. Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial. Diabetes 2013, 62:3901-3908.
    • (2013) Diabetes , vol.62 , pp. 3901-3908
    • Hagopian, W.1    Ferry, R.J.2    Sherry, N.3    Carlin, D.4    Bonvini, E.5    Johnson, S.6
  • 101
    • 84876095279 scopus 로고    scopus 로고
    • Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial
    • Herold K.C., Gitelman S.E., Willi S.M., Gottlieb P.A., Waldron-Lynch F., Devine L., et al. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia 2013, 56:391-400.
    • (2013) Diabetologia , vol.56 , pp. 391-400
    • Herold, K.C.1    Gitelman, S.E.2    Willi, S.M.3    Gottlieb, P.A.4    Waldron-Lynch, F.5    Devine, L.6
  • 102
    • 80051471700 scopus 로고    scopus 로고
    • Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial
    • Sherry N., Hagopian W., Ludvigsson J., Jain S.M., Wahlen J., Ferry R.J., et al. Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial. Lancet 2011, 378:487-497.
    • (2011) Lancet , vol.378 , pp. 487-497
    • Sherry, N.1    Hagopian, W.2    Ludvigsson, J.3    Jain, S.M.4    Wahlen, J.5    Ferry, R.J.6
  • 103
    • 67649933375 scopus 로고    scopus 로고
    • Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years
    • Herold K.C., Gitelman S., Greenbaum C., Puck J., Hagopian W., Gottlieb P., et al. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin. Immunol. 2009, 132:166-173.
    • (2009) Clin. Immunol. , vol.132 , pp. 166-173
    • Herold, K.C.1    Gitelman, S.2    Greenbaum, C.3    Puck, J.4    Hagopian, W.5    Gottlieb, P.6
  • 104
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • Herold K.C., Gitelman S.E., Masharani U., Hagopian W., Bisikirska B., Donaldson D., et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005, 54:1763-1769.
    • (2005) Diabetes , vol.54 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6
  • 105
    • 77949513969 scopus 로고    scopus 로고
    • Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
    • Keymeulen B., Candon S., Fafi-Kremer S., Ziegler A., Leruez-Ville M., Mathieu C., et al. Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood 2010, 115:1145-1155.
    • (2010) Blood , vol.115 , pp. 1145-1155
    • Keymeulen, B.1    Candon, S.2    Fafi-Kremer, S.3    Ziegler, A.4    Leruez-Ville, M.5    Mathieu, C.6
  • 106
    • 84908218494 scopus 로고    scopus 로고
    • Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes
    • Aronson R., Gottlieb P.A., Christiansen J.S., Donner T.W., Bosi E., Bode B.W., et al. Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes. Diabetes Care 2014, 37:2746-2754.
    • (2014) Diabetes Care , vol.37 , pp. 2746-2754
    • Aronson, R.1    Gottlieb, P.A.2    Christiansen, J.S.3    Donner, T.W.4    Bosi, E.5    Bode, B.W.6
  • 107
    • 84896116224 scopus 로고    scopus 로고
    • Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study
    • Ambery P., Donner T.W., Biswas N., Donaldson J., Parkin J., Dayan C.M. Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study. Diabet. Med. 2014, 31:399-402.
    • (2014) Diabet. Med. , vol.31 , pp. 399-402
    • Ambery, P.1    Donner, T.W.2    Biswas, N.3    Donaldson, J.4    Parkin, J.5    Dayan, C.M.6
  • 110
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    • Orban T., Bundy B., Becker D.J., DiMeglio L.A., Gitelman S.E., Goland R., et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011, 378:412-419.
    • (2011) Lancet , vol.378 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    DiMeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 111
    • 84897851090 scopus 로고    scopus 로고
    • Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment
    • Orban T., Bundy B., Becker D.J., Dimeglio L.A., Gitelman S.E., Goland R., et al. Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care 2014, 37:1069-1075.
    • (2014) Diabetes Care , vol.37 , pp. 1069-1075
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    Dimeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 112
    • 84907487451 scopus 로고    scopus 로고
    • Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline
    • Orban T., Beam C.A., Xu P., Moore K., Jiang Q., Deng J., et al. Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline. Diabetes 2014, 63:3449-3457.
    • (2014) Diabetes , vol.63 , pp. 3449-3457
    • Orban, T.1    Beam, C.A.2    Xu, P.3    Moore, K.4    Jiang, Q.5    Deng, J.6
  • 113
    • 84899144218 scopus 로고    scopus 로고
    • Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up
    • Marek-Trzonkowska N., Mysliwiec M., Dobyszuk A., Grabowska M., Derkowska I., Juscinska J., et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. Clin. Immunol. 2014, 153:23-30.
    • (2014) Clin. Immunol. , vol.153 , pp. 23-30
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Derkowska, I.5    Juscinska, J.6
  • 114
    • 84865483192 scopus 로고    scopus 로고
    • Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children
    • Marek-Trzonkowska N., Mysliwiec M., Dobyszuk A., Grabowska M., Techmanska I., Juscinska J., et al. Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children. Diabetes Care 2012, 35:1817-1820.
    • (2012) Diabetes Care , vol.35 , pp. 1817-1820
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Techmanska, I.5    Juscinska, J.6
  • 115
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q., Henriksen K.J., Bi M., Finger E.B., Szot G., Ye J., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 2004, 199:1455-1465.
    • (2004) J. Exp. Med. , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6
  • 117
    • 14944371830 scopus 로고    scopus 로고
    • Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
    • Mekala D.J., Geiger T.L. Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Blood 2005, 105:2090-2092.
    • (2005) Blood , vol.105 , pp. 2090-2092
    • Mekala, D.J.1    Geiger, T.L.2
  • 118
    • 77955380678 scopus 로고    scopus 로고
    • Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
    • Brusko T.M., Koya R.C., Zhu S., Lee M.R., Putnam A.L., McClymont S.A., et al. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One 2010, 5:e11726.
    • (2010) PLoS One , vol.5 , pp. e11726
    • Brusko, T.M.1    Koya, R.C.2    Zhu, S.3    Lee, M.R.4    Putnam, A.L.5    McClymont, S.A.6
  • 119
    • 65249120858 scopus 로고    scopus 로고
    • Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor
    • Elinav E., Adam N., Waks T., Eshhar Z. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. Gastroenterology 2009, 136:1721-1731.
    • (2009) Gastroenterology , vol.136 , pp. 1721-1731
    • Elinav, E.1    Adam, N.2    Waks, T.3    Eshhar, Z.4
  • 120
    • 70249108787 scopus 로고    scopus 로고
    • Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity
    • Hombach A.A., Kofler D., Rappl G., Abken H. Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity. Gene Ther. 2009, 16:1088-1096.
    • (2009) Gene Ther. , vol.16 , pp. 1088-1096
    • Hombach, A.A.1    Kofler, D.2    Rappl, G.3    Abken, H.4
  • 121
    • 84868108174 scopus 로고    scopus 로고
    • Can we vaccinate against Type 1 diabetes?
    • Peakman M. Can we vaccinate against Type 1 diabetes?. F1000 Biol. Rep. 2012, 4:19.
    • (2012) F1000 Biol. Rep. , vol.4 , pp. 19
    • Peakman, M.1
  • 122
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M., Wraith D.C. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat. Med. 2005, 11:S69-S76.
    • (2005) Nat. Med. , vol.11 , pp. S69-S76
    • Larche, M.1    Wraith, D.C.2
  • 123
    • 78049232715 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy of autoimmune and allergic diseases
    • Sabatos-Peyton C.A., Verhagen J., Wraith D.C. Antigen-specific immunotherapy of autoimmune and allergic diseases. Curr. Opin. Immunol. 2010, 22:609-615.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 609-615
    • Sabatos-Peyton, C.A.1    Verhagen, J.2    Wraith, D.C.3
  • 124
    • 84908375090 scopus 로고    scopus 로고
    • From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela
    • Steinman L., Shoenfeld Y. From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela. J. Autoimmun. 2014, 54:1-7.
    • (2014) J. Autoimmun. , vol.54 , pp. 1-7
    • Steinman, L.1    Shoenfeld, Y.2
  • 125
    • 84953370139 scopus 로고    scopus 로고
    • Abul Abbas: ane pitope of scholarship
    • Gershwin M.E., Shoenfeld Y. Abul Abbas: ane pitope of scholarship. J. Autoimmun. 2013, 45:1-6.
    • (2013) J. Autoimmun. , vol.45 , pp. 1-6
    • Gershwin, M.E.1    Shoenfeld, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.