The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

Diabetologia

Volumn 58, Issue 5, 2015, Pages 980-987

  Krischer, Jeffrey P ^a   Lynch, Kristian F ^a   Schatz, Desmond A ^b   Ilonen, Jorma ^c,d   Lernmark, Åke ^e   Hagopian, William A ^f   Rewers, Marian J ^g   She, Jin Xiong ^h   Simell, Olli G ⁱ   Toppari, Jorma ^d,i   Ziegler, Anette G ^j,k   Akolkar, Beena ^l   Bonifacio, Ezio ^m  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF COLORADO DENVER   (United States)

^h MEDICAL COLLEGE OF GEORGIA   (United States)

ⁱ TURKU UNIVERSITY HOSPITAL   (Finland)

^j INSTITUTE OF EPIDEMIOLOGY   (Germany)

^k TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^l NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^m CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

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Author keywords

Autoimmunity; Diabetes in young children; HLA DR DQ genotypes; Incidence; Islet autoantibodies; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; HLA DQ ANTIGEN; INSULIN;

BLOOD; CHILD; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET; PRESCHOOL CHILD;

AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE;

EID: 84939961476     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3514-y     Document Type: Article

References (18)

1. (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183-1197
2. Orban T, Sosenko JM, Cuthbertson D et al (2009) Pancreatic islet autoantibodies as predictors of type 1 diabetes in the diabetes prevention trial-type 1. Diabetes Care 32:2269–2274
3. Ziegler AG, Rewers M, Simell O et al (2013) Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309:2473–2479
4. Ziegler AG, Bonifacio E (2012) Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 55:1937–1943
5. Ilonen J, Hammais A, Laine AP et al (2013) Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life. Diabetes 62:3636–3640
6. TEDDY Study Group (2007) The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 8:286–298
7. TEDDY Study Group (2008) The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Ann N Y Acad Sci 1150:1–13
8. Hagopian WA, Erlich H, Lernmark A et al (2011) The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes 12:733–743
9. Bonifacio E, Yu L, Williams AK et al (2010) Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 95:3360–3367
10. Koczwara K, Bonifacio E, Ziegler AG (2004) Transmission of maternal islet antibodies and risk of autoimmune diabetes in offspring of mothers with type 1 diabetes. Diabetes 53:1–4
11. Lynch KF, Lernmark B, Merlo J, Cilio CM, Ivarsson SA, Lernmark A (2008) Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. J Perinatol 28:211–217
12. Ulm K (1990) A simple method to calculate the confidence interval of a standardized mortality ratio (SMR). Am J Epidemiol 131:373–375
13. O’Leary LA, Dorman JS, LaPorte RE et al (1991) Familial and sporadic insulin-dependent diabetes: evidence for heterogeneous etiologies? Diabetes Res Clin Pract 14:183–190
14. Dahlquist G, Blom L, Holmgren G et al (1985) The epidemiology of diabetes in Swedish children 0–14 years—a six-year prospective study. Diabetologia 28:802–808
15. Graham J, Hagopian WA, Kockum I et al (2002) Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51:1346–1355
16. Mäkinen A, Härkönen T, Ilonen J, Knip M (2008) Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes. Eur J Endocrinol 159:19–26
17. Vermeulen I, Weets I, Asanghanwa M et al (2011) Contribution of antibodies against IA-2beta and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care 34:1760–1765
18. Torn C, Hadley D, Lee HS et al (2014) Role of type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study. Diabetes. doi:10.2337/db14-1497