IFN-γ and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes

Diabetologia

Volumn 53, Issue 7, 2010, Pages 1451-1460

  De Marquesini, L G Petrich ^a   Fu, J ^a,b   Connor, K J ^a   Bishop, A J ^a   McLintock, N E ^a   Pope, C ^a   Wong, F S ^a   Dayan, C M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Elispot; First degree relatives; Interferon gamma; Interleukin 10; Proinsulin; Regulatory T cells; T cells; Type 1 diabetes

Indexed keywords

EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; PANCREAS ISLET CELL ANTIBODY; PROINSULIN; TYROSINE PHOSPHATASE LIKE INSOLINOMA ANTIGEN 2; TYROSINE PHOSPHATASE LIKE INSOLINOMA ANTIGEN 2 ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET BETA CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RELATIVE; T LYMPHOCYTE;

ADOLESCENT; ADULT; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; MALE; MIDDLE AGED; T-LYMPHOCYTES; YOUNG ADULT;

EID: 77955662673     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1739-3     Document Type: Article

References (39)

1. Achenbach P, Bonifacio E, Koczwara K, Ziegler AG (2005) Natural history of type 1 diabetes. Diabetes 54(Suppl 2):S25-S31.
2. Pozzilli P (2007) Immuno-intervention and preservation of beta-cell function in type 1 diabetes. Diabetes Metab Res Rev 23:255-256.
3. Achenbach P, Bonifacio E, Ziegler AG (2005) Predicting type 1 diabetes. Curr Diab Rep 5:98-103.
4. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA (1997) Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 46:1701-1710.
5. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS (2001) Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 24:398.
6. Gardner SG, Gale EA, Williams AJ et al (1999) Progression to diabetes in relatives with islet autoantibodies. Is it inevitable? Diabetes Care 22:2049-2054.
7. Verge CF, Gianani R, Kawasaki E et al (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933.
8. Mahon JL, Sosenko JM, Rafkin-Mervis L et al (2008) The TrialNet natural history study of the development of type 1 diabetes: objectives, design, and initial results. Pediatr Diabetes 10:97-104.
9. Redondo MJ, Rewers M, Yu L et al (1999) Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study. BMJ 318:698-702.
10. Roep BO (2003) The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia 46:305-321.
11. Wong FS, Dayan CM (2008) Regulatory T cells in autoimmune endocrine diseases. Trends Endocrinol Metab 19:292-299.
12. Pop SM, Wong CP, Culton DA, Clarke SH, Tisch R (2005) Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 201:1333-1346.
13. Tritt M, Sgouroudis E, d'Hennezel E, Albanese A, Piccirillo CA (2008) Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57:113-123.
14. Wildin RS, Smyk-Pearson S, Filipovich AH (2002) Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39:537-545.
15. Kukreja A, Cost G, Marker J et al (2002) Multiple immunoregulatory defects in type-1 diabetes. J Clin Invest 109:131-140.
16. Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA (2005) Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 54:1407-1414.
17. Tree TI, Roep BO, Peakman M (2006) A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann N Y Acad Sci 1079:9-18.
18. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54:92-99.
19. Jonson CO, Hedman M, Karlsson Faresjo M et al (2006) The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children. Clin Exp Immunol 145:48-55.
20. Shoda LK, Young DL, Ramanujan S et al (2005) A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 23:115-126.
21. Wraith DC (2003) Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells. J Autoimmun 20:273-275.
22. Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR (2001) Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358:1749-1753.
23. Herold KC, Burton JB, Francois F, Poumian-Ruiz E, Glandt M, Bluestone JA (2003) Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). J Clin Invest 111:409-418.
24. Di Lorenzo TP, Peakman M, Roep BO (2007) Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 148:1-16.
25. Arif S, Tree TI, Astill TP et al (2004) Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113:451-463.
26. Tree TI, Lawson J, Edwards H et al (2010). Naturally arising human CD4 T cells that recognize islet autoantigens and secrete IL-10 regulate pro-inflammatory T cell responses via linked suppression. Diabetes. doi:10.2337/d609-0503.
27. Durinovic-Bello I, Schlosser M, Riedl M et al (2004) Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 type 1 diabetes. Diabetologia 47:439-450.
28. Sanda S, Roep BO, von Herrath M (2008) Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. Clin Immunol 127:138-143.
29. American Diabetes Association (2008) Standards of medical care in diabetes-2008. Diabetes Care 31(Suppl 1):S12-S54.
30. Herold KC, Brooks-Worrell B, Palmer J et al (2009) Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes 58:2588-2595.
31. Gillespie KM, Valovin SJ, Saunby J et al (2000) HLA class II typing of whole genome amplified mouth swab DNA. Tissue Antigens 56:530-538.
32. Peakman M, Stevens EJ, Lohmann T et al (1999) Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest 104:1449-1457.
33. Panina-Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A (1989) Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 19:2237-2242.
34. Ostman J, Lonnberg G, Arnqvist HJ et al (2008) Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. J Intern Med 263:386-394.
35. Rapoport MJ, Bistritzer T, Aharoni D et al (2005) TH1/TH2 cytokine secretion of first degree relatives of T1DM patients. Cytokine 30:219-227.
36. Peakman M, Dayan CM (2001) Antigen-specific immunotherapy for autoimmune disease: fighting fire with fire? Immunology 104:361-366.
37. Higashide T, Kawamura T, Nagata M et al (2006) T cell epitope mapping study with insulin overlapping peptides using ELISPOT assay in Japanese children and adolescents with type 1 diabetes. Pediatr Res 59:445-450.
38. Herzog BA, Ott PA, Dittrich MT et al (2004) Increased in vivo frequency of IA-2 peptide-reactive IFNgamma+/IL-4- T cells in type 1 diabetic subjects. J Autoimmun 23:45-54.
39. Ott PA, Dittrich MT, Herzog BA et al (2004) T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol 24:327-339.