Prediction of type 1 diabetes in the general population

Diabetes Care

Volumn 33, Issue 6, 2010, Pages 1206-1212

  Knip, Mikael ^a,b   Korhonen, Sari ^c   Kulmala, Petri ^c   Veijola, Riitta ^c   Reunanen, Antti ^d   Raitakari, Olli T ^e   Viikari, Jorma ^f   Åkerblom, Hans K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

^f UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; PANCREAS ISLET CELL ANTIBODY; GLUTAMATE DECARBOXYLASE;

ADULT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CHILD; DISEASE COURSE; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALIDITY; PRESCHOOL CHILD; SCHOOL CHILD; SEROCONVERSION; ADOLESCENT; BLOOD; IMMUNOLOGY;

ADOLESCENT; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; MALE;

EID: 77956089036     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc09-1040     Document Type: Article

References (25)

1. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229 (Pubitemid 32718550)
2. Knip M. Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus. Ann Med 1997;29:447-451 (Pubitemid 27520573)
3. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo GF, Gale EAM, Bosi E. Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 1995;38:816-822
4. Verge C, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. Prediction of type 1 diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996;45: 926-933
5. Kulmala P, Savola K, Petersen JS, Vähäsalo P, Karjalainen J, Löppönen T, Dyrberg T, Åkerblom HK, Knip M, the Childhood Diabetes in Finland Study Group. Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes: a population-based study. J Clin Invest 1998;101:327-336
6. Ziegler A-G, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999;48:460-468
7. Yu Y, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A 2000;97:1701-1706
8. Kimpimäki T, Kupila A, Hämäläinen A-M, Kukko M, Kulmala P, Savola K, Simell T, Muona P, Ilonen J, Simell O, Knip M. The first signs of β-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001;86:4782-4788
9. Siljander H, Veijola R, Reunanen A, Virtanen SM, Åkerblom HK, Knip M. Prediction of type 1 diabetes among siblings of affected children and in the general population. Diabetologia 2007;50:2272-2275 (Pubitemid 47512404)
10. Åkerblom HK, Viikari J, Kouvalainen K. Cardiovascular risk factors in Finnish children and adolescents. Acta Paediatr Scand 1985;318(Suppl.):5-6
11. Kulmala P, Rahko J, Savola K, Vähäsalo P, Veijola R, Sjöroos M, Reunanen A, Ilonen J, Knip M. Stability of autoantibodies and their relation to genetic and metabolic markers of type I diabetes in initially unaffected schoolchildren. Diabetologia 2000;43:457-464
12. Veijola R, Reijonen H, Vähäsalo P, Sabbah E, Kulmala P, Ilonen J, Åkerblom HK, Knip M, the Childhood Diabetes in Finland Study Group. HLA DQB1 defined genetic susceptibility, beta-cell autoimmunity and metabolic characteristics in familial and non-familial insulin-dependent diabetes mellitus. J Clin Invest 1996;98:2489-2495
13. Bruining GJ, Molenaar JL, Grobbee DE, Hofman A, Sxheffer GJ, Bruining HA, deBruyn AM, Valkenburg HA. Ten-year follow- up study of islet-cell antibodies and childhood diabetes mellitus. Lancet 1989;8647:1100-1103
14. Schatz D, Krischer J, Horne G, Riley W, Spillar R, Silverstein J, Winter W, Muir A, Derovanesian D, Shah S, Malone J, Maclaren N. Islet cell antibodies predict insulin- dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest 1994; 93:2403-2407
15. LaGasse JM, Brantley MS, Leech NJ, Rowe RE, Monks S, Palmer JP, Nepom GT, McCulloch DK, Hagopian WA. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies. Diabetes Care 2002;25:505-511
16. Gullstrand C, Wahlberg J, Ilonen J, Vaarala O, Ludvigsson J. Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study. Pediatr Diabetes 2008;9:182-190 (Pubitemid 351785002)
17. Savola K, Läärä E,Vähäsalo P, Kulmala P, Åkerblom HK, Knip M. Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study. Diabetes 2001;50:2625-2632 (Pubitemid 33642784)
18. Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Hummel M, Mollenhauer U, Vordemann J, Lenz A, Standl E. On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 1993;36:402-408
19. Leslie RDG, Elliott RB. Early environmental events as a cause of IDDM: evidence and implications. Diabetes 1994;43:843-850
20. Knip M. Natural course of preclinical type 1 diabetes. Horm Res 2002;57(Suppl. 1):6-11
21. Veijola R, Vähäsalo P, Tuomilehto-Wolf E, Reijo-nen H, Kulmala P, Ilonen J, Åkerblom HK, Knip M, the Childhood Diabetes in Finland Study Group. Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Diabetes 1995;44:1021-1028
22. Bingley PJ, the ICARUS Group. Interactions of age, islet cell antibodies, insulin autoantibodies and first phase insulin response in predicting risk of progression to IDDM in relatives: the ICARUS dataset. Diabetes 1996;45:1720-1728
23. Siljander H, Simell S, Hekkala A, Lähde J, Simell T, Vähäsalo P, Veijola R, Ilonen J, Simell O, Knip M. Predictive value of diabetes- associated autoantibodies among children with HLA-conferred disease susceptibility recruited from the general population. Diabetes 2009;58:2835-2842
24. Knip M. Can we predict type 1 diabetes in the general population? Diabetes Care 2002;25:623-625
25. Gale EA, Gillespie KM. Diabetes and gender. Diabetologia 2001;44:3-15