Zinc transporter (ZnT)8186-194 is an immunodominant CD8 + T cell epitope in HLA-A2+ type 1 diabetic patients

Diabetologia

Volumn 55, Issue 7, 2012, Pages 2026-2031

  Scotto, M ^b   Afonso, G ^b   Larger, E ^b,c   Raverdy, C ^b,d   Lemonnier, F A ^b   Carel, J C ^b,d   Dubois Laforgue, D ^b,c   Baz, B ^b,e   Levy, D ^c   Gautier, J F ^b,e   Launay, O ^c   Bruno, G ^f   Boitard, C ^b,c   Sechi, L A ^g   Hutton, J C ^h   Davidson, H W ^h   Mallone, R ^a,b,c  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔTEL DIEU   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

^e SAINT LOUIS HOSPITAL   (France)

^f UNIVERSITY OF TURIN   (Italy)

^g UNIVERSITY OF SASSARI   (Italy)

^h UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Autoimmunity; Beta cell; Environment; Islet; SCL30A8; Type 1 diabetes

Indexed keywords

EPITOPE; HLA A2 ANTIGEN; PLASMID DNA; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8 [153-161]; ZINC TRANSPORTER 8 [186-194];

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TRANSGENIC MOUSE;

ADOLESCENT; ADULT; ANIMALS; AUTOANTIBODIES; CATION TRANSPORT PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HLA-A2 ANTIGEN; HUMANS; INFANT; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED;

EID: 84866425219     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2543-z     Document Type: Article

References (10)

1. Brezar V, Carel JC, Boitard C, Mallone R (2011) Beyond the hormone: insulin as an autoimmune target in type 1 diabetes. Endocr Rev 32:623-669
2. Wenzlau JM, Juhl K, Yu L et al (2007) The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 104:17040-17045
3. Dang M, Rockell J, Wagner R et al (2011) Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol 186:6056-6063
4. Wu X, Xu X, Gu R et al (2012) Prediction of HLA class I-restricted T cell epitopes of islet autoantigen combined with binding and dissociation assays. Autoimmunity 45:176-185
5. Mallone R, Martinuzzi E, Blancou P et al (2007) CD8+ T cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes 56:613-621
6. Skowera A, Ellis RJ, Varela-Calvino R et al (2008) CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 118:3390-3402
7. Blancou P, Mallone R, Martinuzzi E et al (2007) Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol 178:7458-7466
8. Nabozny GH, Baisch JM, Cheng S et al (1996) HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med 183:27-37
9. Martinuzzi E, Novelli G, Scotto M et al (2008) The frequency and immunodominance of islet-specific CD8+ T cell responses change after type 1 diabetes diagnosis and treatment. Diabetes 57:1312-1320
10. Masala S, Paccagnini D, Cossu D et al (2011) Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients. PLoS One 6:e26931