Islet inflammation and CXCL10 in recent-onset type 1 diabetes

Clinical and Experimental Immunology

Volumn 159, Issue 3, 2010, Pages 338-343

  Roep, B O ^a   Kleijwegt, F S ^a   Van Halteren, A G S ^a   Bonato, V ^b,c   Boggi, U ^d   Vendrame, F ^b,c   Marchetti, P ^d   Dotta, F ^b,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF SIENA   (Italy)

^c Toscana Life Science Park   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Autoreactive T cells; CXCL10; CXCR3; IP 10; Type 1 diabetes

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNITY; CASE REPORT; CHILD; CONTROLLED STUDY; ENTEROVIRUS INFECTION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPH NODE; MALE; PANCREAS ISLET BETA CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE;

ADOLESCENT; ADULT; CHEMOKINE CXCL10; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPH NODES; MALE; RECEPTORS, CXCR3; RETROSPECTIVE STUDIES; T-LYMPHOCYTES;

EID: 74549199886     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04087.x     Document Type: Article

References (34)

1. Roep BO. The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia 2003 46 : 305 321.
2. Martin S, Wolf-Eichbaum D, Duinkerken G et al. Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 2001 345 : 1036 1040.
3. Roep BO, Kallan AA, Duinkerken G et al. T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 1995 44 : 278 283.
4. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005 54 : 92 9.
5. Naik RG, Beckers C, Wentwoord R et al. Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus. J Autoimmun 2004 23 : 55 61.
6. Arif S, Tree TI, Astill TP et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 2004 113 : 451 463.
7. Tree TI, Duinkerken G, Willemen S, de Vries RR, Roep BO. HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65. Diabetes 2004 53 : 1692 1699.
8. Reijonen H, Novak EJ, Kochik S et al. Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes 2002 51 : 1375 1382.
9. van Halteren AG, Kardol MJ, Mulder A, Roep BO. Homing of human autoreactive T cells into pancreatic tissue of NOD-scid mice. Diabetologia 2005 48 : 75 82.
10. Kent SC, Chen Y, Bregoli L et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005 435 : 224 228.
11. Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 1994 24 : 1853 1857.
12. Thebault-Baumont K, Dubois-Laforgue D, Krief P et al. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest 2003 111 : 851 857.
13. Nakayama M, Abiru N, Moriyama H et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005 435 : 220 223.
14. Moriyama H, Abiru N, Paronen J et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci USA 2003 100 : 10376 10381.
15. Schloot NC, Roep BO, Wegmann D et al. Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects. Diabetologia 1997 40 : 564 572.
16. Roep BO. T-cell responses to autoantigens in IDDM. The search for the Holy Grail. Diabetes 1996 45 : 1147 1156.
17. Dotta F, Censini S, van Halteren AG et al. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci USA 2007 104 : 5115 5120.
18. Roep BO, Kallan AA, Duinkerken G et al. T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 1995 44 : 278 283.
19. Wegmann DR. The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus. Curr Opin Immunol 1996 8 : 860 864.
20. Koeleman BP, Lie BA, Undlien DE et al. Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. Genes Immun 2004 5 : 381 388.
21. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 2001 24 : 398.
22. Zimmet PZ, Tuomi T, Mackay IR et al. Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med 1994 11 : 299 303.
23. Gale EA. Latent autoimmune diabetes in adults: a guide for the perplexed. Diabetologia 2005 48 : 2195 2199.
24. Frigerio S, Junt T, Lu B et al. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med 2002 8 : 1414 1420.
25. Rhode A, Pauza ME, Barral AM et al. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. J Immunol 2005 175 : 3516 3524.
26. Nicoletti F, Conget I, Di Mauro M et al. Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease. Diabetologia 2002 45 : 1107 1110.
27. Baker MS, Chen X, Rotramel AR et al. Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients. Surgery 2003 134 : 126 133.
28. Schulthess FT, Paroni F, Sauter NS et al. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab 2009 9 : 125 139.
29. Tanaka S, Nishida Y, Aida K et al. Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes. Diabetes 2009 58 : 2285 2291.
30. Skowera A, Ellis RJ, Varela-Calvino R et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008 118 : 3390 3402.
31. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2009 155 : 173 181.
32. Spencer J, Peakman M. Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell. Clin Exp Immunol 2009 155 : 125 127.
33. Planas R, Carrillo J, Sanchez A et al. Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin Exp Immunol 2009.
34. Velthuis JH, Unger WWJ, Van der Slik AR et al. Accumulation of auto-reactive effector T-cells and allo-specific regulatory T-cells in the pancreas allograft of a type 1 diabetic recipient. Diabetologia 2009 52 : 494 503.