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Volumn 56, Issue 7, 2013, Pages 1615-1622

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children

Author keywords

Islet autoantibody; Progression; Susceptibility genes; Type 1 diabetes

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPIDERMAL GROWTH FACTOR RECEPTOR 3; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DQ ANTIGEN; HLA DR ANTIGEN; INSULIN; INSULIN ANTIBODY; INSULINOMA ASSOCIATED ANTIGEN 2; INTERLEUKIN 10; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; UNCLASSIFIED DRUG; ZINC TRANSPORTER 8 PROTEIN;

EID: 84878847275     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2896-y     Document Type: Article
Times cited : (54)

References (45)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • 11476858 10.1016/S0140-6736(01)05415-0 1:CAS:528:DC%2BD3MXltlymsr0%3D
    • Atkinson MA, Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221-229
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 68449094246 scopus 로고    scopus 로고
    • Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    • 19590848 10.1007/s00125-009-1438-0 1:CAS:528:DC%2BD1MXpsFyrsrY%3D
    • Achenbach P, Lampasona V, Landherr U et al (2009) Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 52:1881-1888
    • (2009) Diabetologia , vol.52 , pp. 1881-1888
    • Achenbach, P.1    Lampasona, V.2    Landherr, U.3
  • 3
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • EURODIAB Study Group 19481249 10.1016/S0140-6736(09)60568-7
    • Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G, EURODIAB Study Group (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 373:2027-2033
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyurus, E.3    Green, A.4    Soltesz, G.5
  • 4
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • 15172902 10.7326/0003-4819-140-11-200406010-00009
    • Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG (2004) Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 140:882-886
    • (2004) Ann Intern Med , vol.140 , pp. 882-886
    • Hummel, M.1    Bonifacio, E.2    Schmid, S.3    Walter, M.4    Knopff, A.5    Ziegler, A.G.6
  • 5
    • 80051979794 scopus 로고    scopus 로고
    • Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: Diabetes autoimmunity study in the young
    • 21562325 10.2337/dc10-2088
    • Steck AK, Johnson K, Barriga KJ et al (2011) Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care 34:1397-1399
    • (2011) Diabetes Care , vol.34 , pp. 1397-1399
    • Steck, A.K.1    Johnson, K.2    Barriga, K.J.3
  • 6
    • 84866382555 scopus 로고    scopus 로고
    • Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
    • 22441569 10.1007/s00125-012-2523-3 1:CAS:528:DC%2BC38Xotleltro%3D
    • Parikka V, Nanto-Salonen K, Saarinen M et al (2012) Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 55:1926-1936
    • (2012) Diabetologia , vol.55 , pp. 1926-1936
    • Parikka, V.1    Nanto-Salonen, K.2    Saarinen, M.3
  • 7
    • 79958043752 scopus 로고    scopus 로고
    • Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
    • 21376535 10.1016/j.jaut.2011.02.004
    • Ziegler AG, Pflueger M, Winkler C et al (2011) Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J Autoimmun 37:3-7
    • (2011) J Autoimmun , vol.37 , pp. 3-7
    • Ziegler, A.G.1    Pflueger, M.2    Winkler, C.3
  • 8
    • 0028584260 scopus 로고
    • Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives
    • 7926304 10.2337/diabetes.43.11.1304 1:STN:280:DyaK2M%2FhtFSksA%3D%3D
    • Bingley PJ, Christie MR, Bonifacio E et al (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43:1304-1310
    • (1994) Diabetes , vol.43 , pp. 1304-1310
    • Bingley, P.J.1    Christie, M.R.2    Bonifacio, E.3
  • 9
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type i diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • 8666144 10.2337/diabetes.45.7.926 1:CAS:528:DyaK28Xkt1Wqs70%3D
    • Verge CF, Gianani R, Kawasaki E et al (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3
  • 10
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study
    • 10078544 10.2337/diabetes.48.3.460 1:STN:280:DyaK1M7ns1Cgsg%3D%3D
    • Ziegler AG, Hummel M, Schenker M, Bonifacio E (1999) Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 48:460-468
    • (1999) Diabetes , vol.48 , pp. 460-468
    • Ziegler, A.G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4
  • 11
    • 0032832015 scopus 로고    scopus 로고
    • Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization
    • 10414936 10.1016/S0168-8227(99)00008-X 1:STN:280:DyaK1MzktF2jsA%3D%3D
    • Puavilai G, Chanprasertyotin S, Sriphrapradaeng A (1999) Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization. Diabetes Res Clin Pract 44:21-26
    • (1999) Diabetes Res Clin Pract , vol.44 , pp. 21-26
    • Puavilai, G.1    Chanprasertyotin, S.2    Sriphrapradaeng, A.3
  • 12
    • 41849115906 scopus 로고    scopus 로고
    • Diabetes Antibody Standardization Program: Evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2
    • 18373080 10.1007/s00125-008-0967-2 1:STN:280:DC%2BD1c3jt1Knsg%3D%3D
    • Torn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ, Laboratories P (2008) Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 51:846-852
    • (2008) Diabetologia , vol.51 , pp. 846-852
    • Torn, C.1    Mueller, P.W.2    Schlosser, M.3    Bonifacio, E.4    Bingley, P.J.5    Laboratories, P.6
  • 13
    • 78649321907 scopus 로고    scopus 로고
    • Diabetes Antibody Standardization Program: Evaluation of assays for insulin autoantibodies
    • 20871974 10.1007/s00125-010-1915-5 1:CAS:528:DC%2BC3cXhtl2isLbF
    • Schlosser M, Mueller PW, Torn C, Bonifacio E, Bingley PJ, Laboratories P (2010) Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 53:2611-2620
    • (2010) Diabetologia , vol.53 , pp. 2611-2620
    • Schlosser, M.1    Mueller, P.W.2    Torn, C.3    Bonifacio, E.4    Bingley, P.J.5    Laboratories, P.6
  • 14
    • 82755162447 scopus 로고    scopus 로고
    • Diabetes antibody standardization program: First proficiency evaluation of assays for autoantibodies to zinc transporter 8
    • 21980171 10.1373/clinchem.2011.170662 1:CAS:528:DC%2BC3MXhs1ahtrnI
    • Lampasona V, Schlosser M, Mueller PW et al (2011) Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. Clin Chem 57:1693-1702
    • (2011) Clin Chem , vol.57 , pp. 1693-1702
    • Lampasona, V.1    Schlosser, M.2    Mueller, P.W.3
  • 15
    • 10744222979 scopus 로고    scopus 로고
    • IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity
    • 12750767 10.1007/s00125-003-1164-y 1:CAS:528:DC%2BD3sXksFKlsrc%3D
    • Walter M, Albert E, Conrad M et al (2003) IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity. Diabetologia 46:712-720
    • (2003) Diabetologia , vol.46 , pp. 712-720
    • Walter, M.1    Albert, E.2    Conrad, M.3
  • 16
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • 19430480 10.1038/ng.381 1:CAS:528:DC%2BD1MXls1Cmt7c%3D
    • Barrett JC, Clayton DG, Concannon P et al (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41:703-707
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 17
    • 84867741377 scopus 로고    scopus 로고
    • A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
    • 22932816 10.1038/gene.2012.36 1:CAS:528:DC%2BC38XhsFCgtL3K
    • Winkler C, Krumsiek J, Lempainen J et al (2012) A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes. Genes Immun 13:549-555
    • (2012) Genes Immun , vol.13 , pp. 549-555
    • Winkler, C.1    Krumsiek, J.2    Lempainen, J.3
  • 18
    • 84950451743 scopus 로고
    • Exact inference for contingency tables with ordered categories
    • 10.1080/01621459.1990.10476220
    • Agresti A, Mehta CR, Patel NR (1990) Exact inference for contingency tables with ordered categories. JASA 85:453-458
    • (1990) JASA , vol.85 , pp. 453-458
    • Agresti, A.1    Mehta, C.R.2    Patel, N.R.3
  • 19
    • 0016355478 scopus 로고
    • A new look at the statistical model identification
    • 10.1109/TAC.1974.1100705
    • Akaike H (1974) A new look at the statistical model identification. IEEE Trans Autom Control 19:716-723
    • (1974) IEEE Trans Autom Control , vol.19 , pp. 716-723
    • Akaike, H.1
  • 20
    • 44349193971 scopus 로고    scopus 로고
    • A risk score for type 1 diabetes derived from autoantibody-positive participants in the Diabetes Prevention Trial-Type 1
    • 18000175 10.2337/dc07-1459 1:CAS:528:DC%2BD1cXktVSntr4%3D
    • Sosenko JM, Krischer JP, Palmer JP et al (2008) A risk score for type 1 diabetes derived from autoantibody-positive participants in the Diabetes Prevention Trial-Type 1. Diabetes Care 31:528-533
    • (2008) Diabetes Care , vol.31 , pp. 528-533
    • Sosenko, J.M.1    Krischer, J.P.2    Palmer, J.P.3
  • 21
    • 75149163252 scopus 로고    scopus 로고
    • Clinical applications of diabetes antibody testing
    • 19875480 10.1210/jc.2009-1365 1:CAS:528:DC%2BC3cXhtVGhsrw%3D
    • Bingley PJ (2010) Clinical applications of diabetes antibody testing. J Clin Endocrinol Metab 95:25-33
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 25-33
    • Bingley, P.J.1
  • 22
    • 0032518421 scopus 로고    scopus 로고
    • Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group
    • 9435304 10.1172/JCI119879 1:CAS:528:DyaK1cXmtF2isg%3D%3D
    • Kulmala P, Savola K, Petersen JS et al (1998) Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group. J Clin Invest 101:327-336
    • (1998) J Clin Invest , vol.101 , pp. 327-336
    • Kulmala, P.1    Savola, K.2    Petersen, J.S.3
  • 23
    • 0036460367 scopus 로고    scopus 로고
    • IA-2 autoantibodies predict impending type i diabetes in siblings of patients
    • 12488955 10.1007/s00125-002-0949-8 1:CAS:528:DC%2BD38XpsFOmsL4%3D
    • Decochez K, de Leeuw IH, Keymeulen B et al (2002) IA-2 autoantibodies predict impending type I diabetes in siblings of patients. Diabetologia 45:1658-1666
    • (2002) Diabetologia , vol.45 , pp. 1658-1666
    • Decochez, K.1    De Leeuw, I.H.2    Keymeulen, B.3
  • 24
    • 0842288452 scopus 로고    scopus 로고
    • Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    • 14747289 10.2337/diabetes.53.2.384 1:CAS:528:DC%2BD2cXhtlWhu74%3D
    • Achenbach P, Warncke K, Reiter J et al (2004) Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53:384-392
    • (2004) Diabetes , vol.53 , pp. 384-392
    • Achenbach, P.1    Warncke, K.2    Reiter, J.3
  • 25
    • 0025141413 scopus 로고
    • Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes
    • 1967440 10.1016/0140-6736(90)90013-U 1:STN:280:DyaK3c7htlKguw%3D%3D
    • Bonifacio E, Bingley PJ, Shattock M et al (1990) Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335:147-149
    • (1990) Lancet , vol.335 , pp. 147-149
    • Bonifacio, E.1    Bingley, P.J.2    Shattock, M.3
  • 26
    • 4344690190 scopus 로고    scopus 로고
    • Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    • 15314696 1:CAS:528:DC%2BD2cXmvVels74%3D
    • Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E (2004) Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 114:589-597
    • (2004) J Clin Invest , vol.114 , pp. 589-597
    • Achenbach, P.1    Koczwara, K.2    Knopff, A.3    Naserke, H.4    Ziegler, A.G.5    Bonifacio, E.6
  • 27
    • 34249665017 scopus 로고    scopus 로고
    • GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes
    • 17325256 10.2337/db06-1715 1:CAS:528:DC%2BD2sXmtlKiu7Y%3D
    • Mayr A, Schlosser M, Grober N et al (2007) GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes. Diabetes 56:1527-1533
    • (2007) Diabetes , vol.56 , pp. 1527-1533
    • Mayr, A.1    Schlosser, M.2    Grober, N.3
  • 28
    • 84867834141 scopus 로고    scopus 로고
    • IA-2 autoantibody affinity in children at risk for type 1 diabetes
    • 23110943 10.1016/j.clim.2012.09.010 1:CAS:528:DC%2BC38Xhs1OnurnO
    • Krause S, Chmiel R, Bonifacio E et al (2012) IA-2 autoantibody affinity in children at risk for type 1 diabetes. Clin Immunol 145:224-229
    • (2012) Clin Immunol , vol.145 , pp. 224-229
    • Krause, S.1    Chmiel, R.2    Bonifacio, E.3
  • 29
    • 80054746235 scopus 로고    scopus 로고
    • Understanding type 1 diabetes through genetics: Advances and prospects
    • 22005987 10.1038/nrg3069 1:CAS:528:DC%2BC3MXhtlartrzO
    • Polychronakos C, Li Q (2011) Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 12:781-792
    • (2011) Nat Rev Genet , vol.12 , pp. 781-792
    • Polychronakos, C.1    Li, Q.2
  • 30
    • 77951926420 scopus 로고    scopus 로고
    • Etiology of type 1 diabetes
    • 20412756 10.1016/j.immuni.2010.04.001 1:CAS:528:DC%2BC3cXlslSju74%3D
    • Todd JA (2010) Etiology of type 1 diabetes. Immunity 32:457-467
    • (2010) Immunity , vol.32 , pp. 457-467
    • Todd, J.A.1
  • 31
    • 69349102624 scopus 로고    scopus 로고
    • Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    • 19701192 10.1038/ng.434 1:CAS:528:DC%2BD1MXhtVaksrnI
    • Dendrou CA, Plagnol V, Fung E et al (2009) Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 41:1011-1015
    • (2009) Nat Genet , vol.41 , pp. 1011-1015
    • Dendrou, C.A.1    Plagnol, V.2    Fung, E.3
  • 32
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • 18468463 10.1016/j.immuni.2008.03.016 1:CAS:528:DC%2BD1cXmtlagt7s%3D
    • Tang Q, Adams JY, Penaranda C et al (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28:687-697
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 33
    • 77449143100 scopus 로고    scopus 로고
    • Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T cells of type 1 diabetic subjects
    • 19875613 10.2337/db09-0694 1:CAS:528:DC%2BC3cXhvVyru74%3D
    • Long SA, Cerosaletti K, Bollyky PL et al (2010) Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T cells of type 1 diabetic subjects. Diabetes 59:407-415
    • (2010) Diabetes , vol.59 , pp. 407-415
    • Long, S.A.1    Cerosaletti, K.2    Bollyky, P.L.3
  • 34
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • 17277778 10.1038/ng1958 1:CAS:528:DC%2BD2sXitVOksbs%3D
    • Yamanouchi J, Rainbow D, Serra P et al (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39:329-337
    • (2007) Nat Genet , vol.39 , pp. 329-337
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3
  • 35
    • 56749178234 scopus 로고    scopus 로고
    • Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice
    • 18941219 1:CAS:528:DC%2BD1cXht1KrtrnF
    • Sgouroudis E, Albanese A, Piccirillo CA (2008) Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol 181:6283-6292
    • (2008) J Immunol , vol.181 , pp. 6283-6292
    • Sgouroudis, E.1    Albanese, A.2    Piccirillo, C.A.3
  • 36
    • 84868036600 scopus 로고    scopus 로고
    • Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes
    • 22891215 10.2337/db11-1694 1:CAS:528:DC%2BC38Xhsl2it7jF
    • Howson JM, Cooper JD, Smyth DJ et al (2012) Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes 61:3012-3017
    • (2012) Diabetes , vol.61 , pp. 3012-3017
    • Howson, J.M.1    Cooper, J.D.2    Smyth, D.J.3
  • 37
    • 4444296223 scopus 로고    scopus 로고
    • Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level
    • 15198994 10.1093/hmg/ddh187 1:CAS:528:DC%2BD2cXlvFGqsbc%3D
    • Kurreeman FA, Schonkeren JJ, Heijmans BT, Toes RE, Huizinga TW (2004) Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level. Hum Mol Genet 13:1755-1762
    • (2004) Hum Mol Genet , vol.13 , pp. 1755-1762
    • Kurreeman, F.A.1    Schonkeren, J.J.2    Heijmans, B.T.3    Toes, R.E.4    Huizinga, T.W.5
  • 38
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • 16699517 10.1038/ng1800 1:CAS:528:DC%2BD28XltVOhur4%3D
    • Smyth DJ, Cooper JD, Bailey R et al (2006) A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 38:617-619
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3
  • 39
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • 19264985 10.1126/science.1167728 1:CAS:528:DC%2BD1MXksVOltr8%3D
    • Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324:387-389
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 40
    • 58149091678 scopus 로고    scopus 로고
    • Shared and distinct genetic variants in type 1 diabetes and celiac disease
    • 19073967 10.1056/NEJMoa0807917 1:CAS:528:DC%2BD1cXhsFCntrfI
    • Smyth DJ, Plagnol V, Walker NM et al (2008) Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 359:2767-2777
    • (2008) N Engl J Med , vol.359 , pp. 2767-2777
    • Smyth, D.J.1    Plagnol, V.2    Walker, N.M.3
  • 41
    • 28444469783 scopus 로고    scopus 로고
    • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    • 16273109 10.1038/ng1673 1:CAS:528:DC%2BD2MXht1Ggsr%2FN
    • Vang T, Congia M, Macis MD et al (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 37:1317-1319
    • (2005) Nat Genet , vol.37 , pp. 1317-1319
    • Vang, T.1    Congia, M.2    MacIs, M.D.3
  • 42
    • 36849012027 scopus 로고    scopus 로고
    • Localization of type 1 diabetes susceptibility to the MHC class i genes HLA-B and HLA-A
    • 18004301 10.1038/nature06406 1:CAS:528:DC%2BD2sXhtl2nsrjF
    • Nejentsev S, Howson JM, Walker NM et al (2007) Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450:887-892
    • (2007) Nature , vol.450 , pp. 887-892
    • Nejentsev, S.1    Howson, J.M.2    Walker, N.M.3
  • 43
    • 66449085624 scopus 로고    scopus 로고
    • Diabetes: A virus-gene collaboration
    • 10.1038/459518a
    • von Herrath M (2009) Diabetes: a virus-gene collaboration. Nature 459:518-519
    • (2009) Nature , vol.459 , pp. 518-519
    • Von Herrath, M.1
  • 44
    • 80053548022 scopus 로고    scopus 로고
    • FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection
    • 22025780 10.2337/db11-0638 1:CAS:528:DC%2BC3MXhsVyis7zN
    • Smyth DJ, Cooper JD, Howson JM et al (2011) FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes 60:3081-3084
    • (2011) Diabetes , vol.60 , pp. 3081-3084
    • Smyth, D.J.1    Cooper, J.D.2    Howson, J.M.3
  • 45
    • 72849129001 scopus 로고    scopus 로고
    • Epigenetics: Deciphering how environmental factors may modify autoimmune type 1 diabetes
    • 19697079 10.1007/s00335-009-9213-6 1:CAS:528:DC%2BD1MXhsVyqs77N
    • MacFarlane AJ, Strom A, Scott FW (2009) Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome 20:624-632
    • (2009) Mamm Genome , vol.20 , pp. 624-632
    • MacFarlane, A.J.1    Strom, A.2    Scott, F.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.