Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

Diabetes

Volumn 61, Issue 7, 2012, Pages 1752-1759

  Kronenberg, Deborah ^a,b   Knight, Robin R ^b   Estorninho, Megan ^b   Ellis, Richard J ^b   Kester, Michel G ^c   De Ru, Arnoud ^c   Eichmann, Martin ^b   Huang, Guo C ^b   Powrie, Jake ^a   Dayan, Colin M ^d   Skowera, Ania ^a,b   Van Veelen, Peter A ^c   Peakman, Mark ^a,b  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A24 ANTIGEN; PREPROINSULIN; PREPROINSULIN[3-11]; PROINSULIN; TETRAMER; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CELL KILLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MASS SPECTROMETRY; ONSET AGE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL;

ADULT; AUTOANTIBODIES; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL LINE; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; FEMALE; GLUTAMATE DECARBOXYLASE; HLA-A24 ANTIGEN; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; PROTEIN PRECURSORS; PROTEIN SORTING SIGNALS; YOUNG ADULT;

EID: 84863222103     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1520     Document Type: Article

References (21)

1. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PG, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985;313:353-360 (Pubitemid 15046367)
2. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2009;155:173-181
3. Foulis AK, Farquharson MA, Hardman R. Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987;30:333-343 (Pubitemid 17083703)
4. Itoh N, Hanafusa T, Miyazaki A, et al. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993;92:2313-2322 (Pubitemid 23333537)
5. Skowera A, Ellis RJ, Varela-Calviño R, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope [corrected in: J Clin Invest 2009;119:2844]. J Clin Invest 2008;118:3390-3402
6. Nejentsev S, Howson JM, Walker NM, et al.; Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007;450:887-892
7. Middleton D, Williams F, Meenagh A, et al. Analysis of the distribution of HLA-A alleles in populations from five continents. Hum Immunol 2000;61:1048-1052
8. Williams F, Meenagh A, Maxwell AP, Middleton D. Allele resolution of HLA-A using oligonucleotide probes in a two-stage typing strategy. Tissue Antigens 1999;54:59-68 (Pubitemid 29326931)
9. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004;114:589-597 (Pubitemid 39572109)
10. (n): technical design and applications to peptide and protein analysis. J Sep Sci 2002;25:557-568
11. Kuzushima K, Hayashi N, Kimura H, Tsurumi T. Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay. Blood 2001;98:1872-1881
12. Burrows SR, Elkington RA, Miles JJ, et al. Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype. J Immunol 2003;171:1407-1412 (Pubitemid 36900074)
13. Lissina A, Ladell K, Skowera A, et al. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. J Immunol Methods 2009;340:11-24
14. Brochet X, Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res 2008;36(Web Server issue):W503-508
15. Kubo RT, Sette A, Grey HM, et al. Definition of specific peptide motifs for four major HLA-A alleles. J Immunol 1994;152:3913-3924 (Pubitemid 24111063)
16. Maier R, Falk K, Rötzschke O, et al. Peptide motifs of HLA-A3, -A24, and -B7 molecules as determined by pool sequencing. Immunogenetics 1994;40:306-308 (Pubitemid 24275666)
17. Velthuis JH, Unger WW, Abreu JR, et al. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010;59:1721-1730
18. Cucca F, Lampis R, Congia M, et al. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet 2001;10:2025-2037 (Pubitemid 32998815)
19. Chang L, Kjer-Nielsen L, Flynn S, et al. Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens 2003;62:408-417 (Pubitemid 37338881)
20. Toma A, Laïka T, Haddouk S, et al. Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes. Diabetes 2009;58:394-402
21. Colaert N, Helsens K, Martens L, Vandekerckhove J, Gevaert K. Improved visualization of protein consensus sequences by iceLogo. Nat Methods 2009;6:786-787