Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes

Archives of Toxicology

Volumn 86, Issue 11, 2012, Pages 1717-1727

  Schaap, Mirjam M ^a,b   Zwart, Edwin P ^a   Wackers, Paul F K ^a,c,d   Huijskens, Ilse ^e   Van De Water, Bob ^e   Breit, Timo M ^c,f   Van Steeg, Harry ^a,b   Jonker, Martijs J ^c,f   Luijten, Mirjam ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d Center for Biomedical Genetics   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f NETHERLANDS BIOINFORMATICS CENTRE   (Netherlands)

Author keywords

Mode of action; Non genotoxic carcinogens; Primary mouse hepatocytes; Toxicogenomics

Indexed keywords

1,1,1 TRICHLOROETHANE; 1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROCLOR 1254; ARSENITE SODIUM; BETA HEXACHLOROCYCLOHEXANE; CALYCULIN A; CARBON TETRACHLORIDE; CARCINOGEN; CLOFIBRATE; CYCLOSPORIN A; HEPTACHLOR EPOXIDE; LEAD ACETATE; METALLOID; OKADAIC ACID; PHENOBARBITAL; TACROLIMUS; UNCLASSIFIED DRUG; WYETH 14643;

ANIMAL CELL; ARTICLE; CARCINOGEN TESTING; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENOTOXICITY; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; SKIN TOXICITY; SKIN TUMOR; TRANSCRIPTOMICS; TUMOR PROMOTION;

ANIMALS; CARCINOGENS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; MUTAGENS; TOXICITY TESTS;

RODENTIA;

EID: 84871231005     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0883-6     Document Type: Article

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