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Volumn 6, Issue 3, 2011, Pages

Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; PHENOBARBITAL; CELL RECEPTOR; CYP2B10 PROTEIN, MOUSE; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

EID: 79953035873     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018216     Document Type: Article
Times cited : (71)

References (61)
  • 2
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W, (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447: 425-432.
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 3
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    • Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, et al. (2008) Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 30: 755-766.
    • (2008) Mol Cell , vol.30 , pp. 755-766
    • Mohn, F.1    Weber, M.2    Rebhan, M.3    Roloff, T.C.4    Richter, J.5
  • 4
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD, (2000) The language of covalent histone modifications. Nature 403: 41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 5
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD, (2001) Translating the histone code. Science 293: 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 6
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: patterns and paradigms
    • Cedar H, Bergman Y, (2009) Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 10: 295-304.
    • (2009) Nat Rev Genet , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 7
    • 0032732788 scopus 로고    scopus 로고
    • Relationships between chromatin organization and DNA methylation in determining gene expression
    • Jones PL, Wolffe AP, (1999) Relationships between chromatin organization and DNA methylation in determining gene expression. Semin Cancer Biol 9: 339-347.
    • (1999) Semin Cancer Biol , vol.9 , pp. 339-347
    • Jones, P.L.1    Wolffe, A.P.2
  • 8
    • 0842324785 scopus 로고    scopus 로고
    • The nucleosome: from genomic organization to genomic regulation
    • Khorasanizadeh S, (2004) The nucleosome: from genomic organization to genomic regulation. Cell 116: 259-272.
    • (2004) Cell , vol.116 , pp. 259-272
    • Khorasanizadeh, S.1
  • 9
    • 0028569618 scopus 로고
    • Inheritance of chromatin states
    • Wolffe AP, (1994) Inheritance of chromatin states. Dev Genet 15: 463-470.
    • (1994) Dev Genet , vol.15 , pp. 463-470
    • Wolffe, A.P.1
  • 10
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A, (2007) Perceptions of epigenetics. Nature 447: 396-398.
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 11
    • 73649107635 scopus 로고    scopus 로고
    • Epigenetics: molecular mechanisms and implications for disease
    • Handel AE, Ebers GC, Ramagopalan SV, (2010) Epigenetics: molecular mechanisms and implications for disease. Trends Mol Med 16: 7-16.
    • (2010) Trends Mol Med , vol.16 , pp. 7-16
    • Handel, A.E.1    Ebers, G.C.2    Ramagopalan, S.V.3
  • 12
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B, (1983) Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 13
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP, (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228: 187-190.
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 14
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M, (2009) DNA hypomethylation in cancer cells. Epigenomics 1: 239-259.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 15
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, et al. (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37: 391-400.
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3    Boix-Chornet, M.4    Espada, J.5
  • 16
    • 77953995002 scopus 로고    scopus 로고
    • Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers
    • Chi P, Allis CD, Wang GG, (2010) Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 10: 457-469.
    • (2010) Nat Rev Cancer , vol.10 , pp. 457-469
    • Chi, P.1    Allis, C.D.2    Wang, G.G.3
  • 17
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
    • Baylin SB, Ohm JE, (2006) Epigenetic gene silencing in cancer- a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6: 107-116.
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 18
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg AP, Ohlsson R, Henikoff S, (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7: 21-33.
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 19
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB, (2007) The epigenomics of cancer. Cell 128: 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 20
    • 1842817557 scopus 로고    scopus 로고
    • Perturbation of epigenetic status by toxicants
    • Bombail V, Moggs JG, Orphanides G, (2004) Perturbation of epigenetic status by toxicants. Toxicol Lett 149: 51-58.
    • (2004) Toxicol Lett , vol.149 , pp. 51-58
    • Bombail, V.1    Moggs, J.G.2    Orphanides, G.3
  • 22
    • 33847331654 scopus 로고    scopus 로고
    • Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    • Phillips JM, Yamamoto Y, Negishi M, Maronpot RR, Goodman JI, (2007) Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. Toxicol Sci 96: 72-82.
    • (2007) Toxicol Sci , vol.96 , pp. 72-82
    • Phillips, J.M.1    Yamamoto, Y.2    Negishi, M.3    Maronpot, R.R.4    Goodman, J.I.5
  • 23
    • 0036094163 scopus 로고    scopus 로고
    • Epigenetics and DNA methylation come of age in toxicology
    • Watson RE, Goodman JI, (2002) Epigenetics and DNA methylation come of age in toxicology. Toxicol Sci 67: 11-16.
    • (2002) Toxicol Sci , vol.67 , pp. 11-16
    • Watson, R.E.1    Goodman, J.I.2
  • 24
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M, (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8: 286-298.
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 25
    • 70349751583 scopus 로고    scopus 로고
    • Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology
    • Csoka AB, Szyf M, (2009) Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Med Hypotheses 73: 770-780.
    • (2009) Med Hypotheses , vol.73 , pp. 770-780
    • Csoka, A.B.1    Szyf, M.2
  • 26
    • 0015142880 scopus 로고
    • Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene
    • Peraino C, Fry RJ, Staffeldt E, (1971) Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene. Cancer Res 31: 1506-1512.
    • (1971) Cancer Res , vol.31 , pp. 1506-1512
    • Peraino, C.1    Fry, R.J.2    Staffeldt, E.3
  • 27
    • 0015677374 scopus 로고
    • Brief communication: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital
    • Peraino C, Fry RJ, Staffeldt E, (1973) Brief communication: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital. J Natl Cancer Inst 51: 1349-1350.
    • (1973) J Natl Cancer Inst , vol.51 , pp. 1349-1350
    • Peraino, C.1    Fry, R.J.2    Staffeldt, E.3
  • 28
    • 0034117990 scopus 로고    scopus 로고
    • Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis
    • Lee GH, (2000) Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis. Toxicol Pathol 28: 215-225.
    • (2000) Toxicol Pathol , vol.28 , pp. 215-225
    • Lee, G.H.1
  • 29
    • 0020335340 scopus 로고
    • Morphological classification of mouse liver tumors based on biological characteristics
    • Becker FF, (1982) Morphological classification of mouse liver tumors based on biological characteristics. Cancer Res 42: 3918-3923.
    • (1982) Cancer Res , vol.42 , pp. 3918-3923
    • Becker, F.F.1
  • 30
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, et al. (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19: 6318-6322.
    • (1999) Mol Cell Biol , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5
  • 31
    • 0037223832 scopus 로고    scopus 로고
    • The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity
    • Yamamoto Y, Kawamoto T, Negishi M, (2003) The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch Biochem Biophys 409: 207-211.
    • (2003) Arch Biochem Biophys , vol.409 , pp. 207-211
    • Yamamoto, Y.1    Kawamoto, T.2    Negishi, M.3
  • 32
    • 67650735625 scopus 로고    scopus 로고
    • The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
    • Phillips JM, Burgoon LD, Goodman JI, (2009a) The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. Toxicol Sci 110: 319-333.
    • (2009) Toxicol Sci , vol.110 , pp. 319-333
    • Phillips, J.M.1    Burgoon, L.D.2    Goodman, J.I.3
  • 33
    • 77955084537 scopus 로고    scopus 로고
    • Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo
    • Ross J, Plummer SM, Rode A, Scheer N, Bower CC, et al. (2010) Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo. Toxicol Sci 116: 452-466.
    • (2010) Toxicol Sci , vol.116 , pp. 452-466
    • Ross, J.1    Plummer, S.M.2    Rode, A.3    Scheer, N.4    Bower, C.C.5
  • 34
    • 33744802237 scopus 로고    scopus 로고
    • Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice
    • Bachman AN, Phillips JM, Goodman JI, (2006) Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice. Toxicol Sci 91: 393-405.
    • (2006) Toxicol Sci , vol.91 , pp. 393-405
    • Bachman, A.N.1    Phillips, J.M.2    Goodman, J.I.3
  • 35
    • 66149107971 scopus 로고    scopus 로고
    • Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice
    • Phillips JM, Burgoon LD, Goodman JI, (2009b) Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. Toxicol Sci 109: 193-205.
    • (2009) Toxicol Sci , vol.109 , pp. 193-205
    • Phillips, J.M.1    Burgoon, L.D.2    Goodman, J.I.3
  • 36
    • 64349093987 scopus 로고    scopus 로고
    • Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors
    • Phillips JM, Goodman JI, (2009) Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors. Toxicol Sci 108: 273-289.
    • (2009) Toxicol Sci , vol.108 , pp. 273-289
    • Phillips, J.M.1    Goodman, J.I.2
  • 37
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski P, Zelko I, Sueyoshi T, Negishi M, (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18: 5652-5658.
    • (1998) Mol Cell Biol , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 38
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, et al. (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37: 853-862.
    • (2005) Nat Genet , vol.37 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5
  • 39
    • 0026672926 scopus 로고
    • Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital
    • Honkakoski P, Kojo A, Lang MA, (1992) Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochem J 285 (Pt 3): 979-983.
    • (1992) Biochem J , vol.285 , Issue.Pt 3 , pp. 979-983
    • Honkakoski, P.1    Kojo, A.2    Lang, M.A.3
  • 40
    • 0030908295 scopus 로고    scopus 로고
    • Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
    • Honkakoski P, Negishi M, (1997) Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J Biol Chem 272: 14943-14949.
    • (1997) J Biol Chem , vol.272 , pp. 14943-14949
    • Honkakoski, P.1    Negishi, M.2
  • 41
    • 0028784365 scopus 로고
    • Nebulette: a 107 kD nebulin-like protein in cardiac muscle
    • Moncman CL, Wang K, (1995) Nebulette: a 107 kD nebulin-like protein in cardiac muscle. Cell Motil Cytoskeleton 32: 205-225.
    • (1995) Cell Motil Cytoskeleton , vol.32 , pp. 205-225
    • Moncman, C.L.1    Wang, K.2
  • 42
    • 77956873627 scopus 로고    scopus 로고
    • Tackling the widespread and critical impact of batch effects in high-throughput data
    • Leek JT, Scharpf RB, Bravo HC, Simcha D, Langmead B, et al. (2010) Tackling the widespread and critical impact of batch effects in high-throughput data. Nat Rev Genet 11: 733-739.
    • (2010) Nat Rev Genet , vol.11 , pp. 733-739
    • Leek, J.T.1    Scharpf, R.B.2    Bravo, H.C.3    Simcha, D.4    Langmead, B.5
  • 43
    • 5444223019 scopus 로고    scopus 로고
    • Site-specific analysis of histone methylation and acetylation
    • Umlauf D, Goto Y, Feil R, (2004) Site-specific analysis of histone methylation and acetylation. Methods Mol Biol 287: 99-120.
    • (2004) Methods Mol Biol , vol.287 , pp. 99-120
    • Umlauf, D.1    Goto, Y.2    Feil, R.3
  • 44
    • 77953628087 scopus 로고    scopus 로고
    • Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels
    • Klug M, Heinz S, Gebhard C, Schwarzfischer L, Krause SW, et al. (2010) Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol 11: R63.
    • (2010) Genome Biol , vol.11
    • Klug, M.1    Heinz, S.2    Gebhard, C.3    Schwarzfischer, L.4    Krause, S.W.5
  • 45
    • 0019417544 scopus 로고
    • Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats
    • Uchida E, Hirono I, (1981) Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats. J Cancer Res Clin Oncol 100: 231-238.
    • (1981) J Cancer Res Clin Oncol , vol.100 , pp. 231-238
    • Uchida, E.1    Hirono, I.2
  • 46
    • 0019863469 scopus 로고
    • Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally
    • Hirose M, Shirai T, Tsuda H, Fukushima S, Ogiso T, et al. (1981) Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally. Carcinogenesis 2: 1299-1302.
    • (1981) Carcinogenesis , vol.2 , pp. 1299-1302
    • Hirose, M.1    Shirai, T.2    Tsuda, H.3    Fukushima, S.4    Ogiso, T.5
  • 47
    • 33745329809 scopus 로고    scopus 로고
    • The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
    • Gachon F, Olela FF, Schaad O, Descombes P, Schibler U, (2006) The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab 4: 25-36.
    • (2006) Cell Metab , vol.4 , pp. 25-36
    • Gachon, F.1    Olela, F.F.2    Schaad, O.3    Descombes, P.4    Schibler, U.5
  • 48
    • 8844262660 scopus 로고    scopus 로고
    • Principles for modulation of the nuclear receptor superfamily
    • Gronemeyer H, Gustafsson JA, Laudet V, (2004) Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 3: 950-964.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 950-964
    • Gronemeyer, H.1    Gustafsson, J.A.2    Laudet, V.3
  • 50
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • Schwartz YB, Pirrotta V, (2007) Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 8: 9-22.
    • (2007) Nat Rev Genet , vol.8 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 51
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber M, Hellmann I, Stadler MB, Ramos L, Paabo S, et al. (2007) Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 39: 457-466.
    • (2007) Nat Genet , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Paabo, S.5
  • 52
    • 34547725157 scopus 로고    scopus 로고
    • DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
    • Ooi SK, Qiu C, Bernstein E, Li K, Jia D, et al. (2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448: 714-717.
    • (2007) Nature , vol.448 , pp. 714-717
    • Ooi, S.K.1    Qiu, C.2    Bernstein, E.3    Li, K.4    Jia, D.5
  • 53
    • 70350044885 scopus 로고    scopus 로고
    • DNA demethylation in hormone-induced transcriptional derepression
    • Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, et al. (2009) DNA demethylation in hormone-induced transcriptional derepression. Nature 461: 1007-1012.
    • (2009) Nature , vol.461 , pp. 1007-1012
    • Kim, M.S.1    Kondo, T.2    Takada, I.3    Youn, M.Y.4    Yamamoto, Y.5
  • 54
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41: 178-186.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5
  • 55
    • 67650090496 scopus 로고    scopus 로고
    • Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
    • Schmidl C, Klug M, Boeld TJ, Andreesen R, Hoffmann P, et al. (2009) Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res 19: 1165-1174.
    • (2009) Genome Res , vol.19 , pp. 1165-1174
    • Schmidl, C.1    Klug, M.2    Boeld, T.J.3    Andreesen, R.4    Hoffmann, P.5
  • 56
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462: 315-322.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3    Hawkins, R.D.4    Hon, G.5
  • 57
    • 77954504873 scopus 로고    scopus 로고
    • Conserved role of intragenic DNA methylation in regulating alternative promoters
    • Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, et al. (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466: 253-257.
    • (2010) Nature , vol.466 , pp. 253-257
    • Maunakea, A.K.1    Nagarajan, R.P.2    Bilenky, M.3    Ballinger, T.J.4    D'Souza, C.5
  • 58
    • 77954842322 scopus 로고    scopus 로고
    • Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes
    • Wu H, Coskun V, Tao J, Xie W, Ge W, et al. (2010) Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329: 444-448.
    • (2010) Science , vol.329 , pp. 444-448
    • Wu, H.1    Coskun, V.2    Tao, J.3    Xie, W.4    Ge, W.5
  • 59
    • 77955059818 scopus 로고    scopus 로고
    • What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?
    • Goodman JI, Augustine KA, Cunnningham ML, Dixon D, Dragan YP, et al. (2010) What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments? Toxicol Sci 116: 375-381.
    • (2010) Toxicol Sci , vol.116 , pp. 375-381
    • Goodman, J.I.1    Augustine, K.A.2    Cunnningham, M.L.3    Dixon, D.4    Dragan, Y.P.5
  • 61
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
    • (2004) Stat Appl Genet Mol Biol , vol.3 , pp. 3
    • Smyth, G.K.1


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