Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Archives of Toxicology

Volumn 87, Issue 2, 2013, Pages 337-345

  Schug, Markus ^a   Stöber, Regina ^a   Heise, Tanja ^b   Mielke, Hans ^b   Gundert Remy, Ursula ^b   Godoy, Patricio ^a   Reif, Raymond ^a   Blaszkewicz, Meinolf ^a   Ellinger Ziegelbauer, Heidrun ^c   Ahr, Hans Jürgen ^c   Selinski, Silvia ^a   Günther, Georgia ^a   Marchan, Rosemarie ^a   Sachinidis, Agapios ^d   Nüssler, Andreas ^e   Oberemm, Axel ^c   Hengstler, Jan G ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^c BAYER AG   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alternative methods; Genotoxic and non genotoxic carcinogens; Hepatocyte in vitro system; In vitro pharmacokinetics; In vitro in vivo comparison

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; MEMBRANE PROTEIN; MESSENGER RNA; METHAPYRILENE; PROTEIN ABAT; RNA; SULFOTRANSFERASE 1A1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ABAT GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; GADD34 GENE; GENE; GENE EXPRESSION; HALF LIFE TIME; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER LEVEL; LIVER TOXICITY; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SULT1A1 GENE; SUPERNATANT; TOXICOGENETICS;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; ANTIGENS, DIFFERENTIATION; ARYLSULFOTRANSFERASE; CARCINOGENS; CELLS, CULTURED; GENE EXPRESSION REGULATION, NEOPLASTIC; HALF-LIFE; HEPATOCYTES; LIVER; MALE; METHAPYRILENE; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; RNA, MESSENGER;

RATTUS;

EID: 84873713806     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0999-8     Document Type: Article

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