Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays

Toxicology

Volumn 280, Issue 3, 2011, Pages 77-87

  Kojima, Hiroyuki ^a   Sata, Fumihiro ^b   Takeuchi, Shinji ^a   Sueyoshi, Tatsuya ^c   Nagai, Tadanori ^a  

^a HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Human; Mouse; Pesticide; Pregnane X receptor; Reporter gene assay

Indexed keywords

AMIDE; BUTAMIFOS; CARBAMIC ACID; CHLOROBENZILATE; CHLOROTHALONIL; DICHLOBENIL; DICOFOL; DIELDRIN; DIPHENYL ETHER; ENDOSULFAN; ENDRIN; FOLPET; HEPTACHLOR; HEPTACHLOR EPOXIDE; METHOXYCHLOR; ORGANOCHLORINE DERIVATIVE; ORGANOPHOSPHATE PESTICIDE; PENDIMETHALIN; PENTACHLOROPHENOL; PESTICIDE; PHOSALONE; PIPEROPHOS; PREGNANE X RECEPTOR; PRETILACHLOR; PROCHLORAZ; PYRETHROID; PYRIBUTICARB; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA;

ARTICLE; CELL STRAIN COS7; COMPARATIVE STUDY; GENE ACTIVATION; GENE ACTIVITY; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; KIDNEY CELL; KIDNEY CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; HUMANS; MICE; PESTICIDES; RECEPTORS, STEROID; SPECIES SPECIFICITY;

MUS; SIMIAE;

EID: 79151471362     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.11.008     Document Type: Article

References (39)

1. Chrencik J.E., Orans J., Moore L.B., Xue Y., Peng L., Collins J.L., Wisely G.B., Lambert M.H., Kliewer S.A., Redinbo M.R. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol. Endocrinol. 2005, 19:1125-1134.
2. Coumoul X., Diry M., Barouki R. PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem. Pharmacol. 2002, 64:1513-1519.
3. Creusot N., Kinani S., Balaguer P., Tapie N., LeMenach K., Maillot-Maréchal E., Porcher J.M., Budzinski H., Aït-Aïssa S. Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples. Anal. Bioanal. Chem. 2010, 396:569-583.
4. Dubrac S., Elentner A., Ebner S., Horejs-Hoeck J., Schmuth M. Modulation of T lymphocyte function by the pregnane X receptor. J. Immunol. 2010, 184:2949-2957.
5. Goodwin B., Hodgson E., Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol. Pharmacol. 1999, 56:1329-1339.
6. Honkakoski P., Palvimo J.J., Penttilä L., Vepsäläinen J., Auriola S. Effects of triaryl phosphates on mouse and human nuclear receptors. Biochem. Pharmacol. 2004, 67:97-106.
7. Jacobs M.N., Nolan G.T., Hood S.R. Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol. Appl. Pharmacol. 2005, 209:123-133.
8. Jones S.A., Moore L.B., Shenk J.L., Wisely G.B., Hamilton G.A., McKee D.D., Tomkinson N.C., LeCluyse E.L., Lambert M.H., Willson T.M., Kliewer S.A., Moore J.T. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol. 2000, 14:27-39.
9. Kanetoshi A., Katsura E., Kojima H., Ueda Y., Hori Y. Concentartion of herbicides detected in river water and identification of the oxon-form of pyributicarb [in Japanese]. Report Hokkaido Inst. Pub. Health 1999, 49:63-67.
10. Kliewer S.A., Goodwin B., Willson T.M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev. 2002, 23:687-702.
11. Kojima H., Iida M., Katsura E., Kanetoshi A., Hori Y., Kobayashi K. Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities. Environ. Health Perspect. 2003, 111:497-502.
12. Kojima H., Katsura E., Takeuchi S., Niiyama K., Kobayashi K. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 2004, 112:524-531.
13. Kojima H., Takeuchi S., Uramaru N., Sugihara K., Yoshida T., Kitamura S. Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoylated metabolites in transactivation assays using Chinese hamster ovary cells. Environ. Health Perspect. 2009, 117:1210-1218.
14. Kretschmer X.C., Baldwin W.S. CAR and PXR: xenosensors of endocrine disrupters?. Chem. Biol. Interact. 2005, 155:111-128.
15. Lehmann J.M., McKee D.D., Watson M.A., Willson T.M., Moore J.T., Kliewer S.A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 1998, 102:1016-1023.
16. Lemaire G., Mnif W., Pascussi J.M., Pillon A., Rabenoelina F., Fenet H., Gomez E., Casellas C., Nicolas J.C., Cavaillès V., Duchesne M.J., Balaguer P. Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. Toxicol. Sci. 2006, 91:501-509.
17. Lemaire G., de Sousa G., Rahmani R. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem. Pharmacol. 2004, 68:2347-2358.
18. Martin M.T., Dix D.J., Judson R.S., Kavlock R.J., Reif D.M., Richard A.M., Rotroff D.M., Romanov S., Medvedev A., Poltoratskaya N., Gambarian M., Moeser M., Makarov S.S., Houck K.A. Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem. Res. Toxicol. 2010, 23:578-590.
19. Masuyama H., Hiramatsu Y., Kunitomi M., Kudo T., MacDonald P.N. Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate pregnane X receptor-mediated transcription. Mol. Endocrinol. 2000, 14:421-428.
20. Matsubara T., Noracharttiyapot W., Toriyabe T., Yoshinari K., Nagata K., Yamazoe Y. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab. Dispos. 2007, 32:728-733.
21. Mikamo E., Harada S., Nishikawa J., Nishihara T. Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor. Toxicol. Appl. Pharmacol. 2003, 193:66-72.
22. Mnif W., Pascussi J.M., Pillon A., Escande A., Bartegi A., Nicolas J.C., Cavaillès V., Duchesne M.J., Balaguer P. Estrogens and antiestrogens activate hPXR. Toxicol. Lett. 2007, 170:19-29.
23. Mnif, W., Dagnino, S., Escande, A., Pillon, A., Fenet, H., Gomez, E., Casellas, C., Duchesne, M. J., Hernandez-Raquet, G., Cavaillès, V., Balaguer, P., Bartegi, A., 2010. Biological analysis of endocrine-disrupting compounds in Tunisian sewage treatment plants. Arch. Environ. Contam. Toxicol. doi:10.1007/s00244-009-9438-0.
24. Moreau A., Vilarem M.J., Maurel P., Pascussi J.M. Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. Mol. Pharmaceutics 2008, 5:35-41.
25. Pacyniak E.K., Cheng X., Cunningham M.L., Crofton K., Klaassen C.D., Guo G.L. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicol. Sci. 2007, 97:94-102.
26. Staudinger J.L., Goodwin B., Jones S.A., Hawkins-Brown D., MacKenzie K.I., LaTour A., Liu Y., Klaassen C.D., Brown K.K., Reinhard J., Willson T.M., Koller B.H., Kliewer S.A. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:3369-3374.
27. Synold T.W., Dussault I., Forman B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 2001, 7:584-590.
28. Tabb M.M., Blumberg B. New modes of action for endocrine-disrupting chemicals. Mol. Endocrinol. 2006, 20:475-482.
29. Takeshita A., Koibuchi N., Oka J., Taguchi M., Shishiba Y., Ozawa Y. Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenbiotic receptor-mediated transcription. Eur. J. Endocrinol. 2001, 145:513-517.
30. Takeuchi S., Iida M., Kobayashi S., Jin K., Matsuda T., Kojima H. Differential effects of phthalate esters on transcriptional activities via human estrogen receptors α and β, and androgen receptor. Toxicology 2005, 210:223-233.
31. Takeuchi S., Iida M., Yabushita H., Matsuda T., Kojima H. In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides by a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-A1 induction by propanil, diuron and linuron. Chemosphere 2008, 74:155-165.
32. Takeuchi S., Matsuda T., Kobayashi S., Takahashi T., Kojima H. In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR) α and PPAR γ and quantitative analysis of in vivo induction pathway. Toxicol. Appl. Pharmacol. 2006, 217:235-244.
33. Timsit Y.E., Negishi M. CAR and PXR: the xenobiotic-sensing receptors. Steroids 2007, 72:231-246.
34. Wada T., Gao J., Xie W. PXR and CAR in energy metabolism. Trends Endocrinol. Metab. 2009, 20:273-279.
35. Watkins R., Wisely L.B., Moor L.B., Lambert M.H., Williams S.P., Wilson T.M., Kliewer S.A., Redinbo M.R. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 2001, 292:2329-2332.
36. Xie W., Evans R.M. Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 2001, 276:37739-37742.
37. Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., Waxman D.J., Evans R.M. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:3375-3380.
38. Yang D., Wang X., Chen Y., Deng R., Yan B. Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol. Appl. Pharmacol. 2009, 237:49-58.
39. Zhou C., Verma S., Blumberg B. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl. Receptor Signal. 2009, 7:1-21.