Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 374-384

  Mathijs, Karen ^a,b   Brauers, Karen J J ^a   Jennen, Danyel G J ^a,b   Boorsma, Andre ^a,c   van Herwijnen, Marcel H M ^a   Gottschalk, Ralph W H ^a   Kleinjans, Jos C S ^a,b   van Delft, Joost H M ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Netherlands Toxicogenomics Centre   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Carcinogens; Class discrimination; Primary mouse hepatocytes; Time; Transcriptomics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AFLATOXIN B1; BENZO[A]PYRENE; CARCINOGEN; CYCLOSPORIN A; DIMETHYLNITROSAMINE; MITOMYCIN C; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; CARCINOGEN TESTING; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOTOXICITY; IMMUNOHISTOCHEMISTRY; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREDICTION; UNINDEXED SEQUENCE; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; LIVER CELL; METABOLISM; VALIDATION STUDY;

MUS; RODENTIA;

ANIMALS; CARCINOGENS; CELLS, CULTURED; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; MUTAGENS;

EID: 74949142247     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp229     Document Type: Article

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