Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 747, Issue 2, 2012, Pages 164-175

  Watanabe, Takashi ^a,m   Suzuki, Takayoshi ^b   Natsume, Masakatsu ^c   Nakajima, Madoka ^c   Narumi, Kazunori ^d,k   Hamada, Shuichi ^d   Sakuma, Tomohiro ^e   Koeda, Akiko ^f   Oshida, Keiyu ^g   Miyamoto, Yohei ^g   Maeda, Akihisa ^g   Hirayama, Michiasa ^h   Sanada, Hisakazu ⁱ   Honda, Hiroshi ^j   Ohyama, Wakako ^k   Okada, Emiko ^k   Fujiishi, Yohei ^k   Sutou, Shizuyo ^l   Tadakuma, Ayami ^a   Ishikawa, Yasuyoshi ^a   Kido, Mahoko ^a   Minamiguchi, Rina ^a   Hanahara, Izumi ^a   Furihata, Chie ^a,b   more..

^a AOYAMA GAKUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c Genotoxicology Laboratory Safety Assessment Unit   (Japan)

^d LSI MEDIENCE CORPORATION   (Japan)

^e JAPAN FOOD RESEARCH LABORATORIES   (Japan)

^f N   (Japan)

^g TORAY INDUSTRIES INC   (Japan)

^h FUJIFILM CORPORATION   (Japan)

ⁱ KAKEN PHARMACEUTICAL CO LTD   (Japan)

^j KAO CORPORATION   (Japan)

^k YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^l SHUJITSU UNIVERSITY   (Japan)

^m Institute of Physical and Chemical Research   (Japan)

more..

Author keywords

Gene expression; Gene network; Mouse liver; PCA; Quantitative real time PCR

Indexed keywords

1,4 DICHLOROBENZENE; 2,4 DIAMINOTOLUENE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 DIMETHYLAMINOAZOBENZENE; BIS(2 HYDROXYPROPYL)NITROSAMINE; CARCINOGEN; CHLORPHENOTANE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN G1; CYTOCHROME P450 1A2; EPIDERMAL GROWTH FACTOR RECEPTOR; EPOXIDE HYDROLASE; FURAN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH DIFFERENTIATION FACTOR 15; HEAT SHOCK PROTEIN; HEME OXYGENASE 1; HISTONE H1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; METHYL CPG BINDING PROTEIN; N (2 FLUORENYL)ACETAMIDE; NITROSOMORPHOLINE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLO LIKE KINASE 2; PROTEIN BAX; PROTEIN P53; QUINOLINE; SOMATOMEDIN BINDING PROTEIN 1; URETHAN;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; COMET ASSAY; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; GENE EXPRESSION PROFILING; GENOTOXICITY; LD 50; LIVER; LIVER CARCINOGENESIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION;

ANIMALS; CARCINOGENS; DOUBLE EFFECT PRINCIPLE; GENE EXPRESSION PROFILING; INJECTIONS, INTRAPERITONEAL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MUTAGENS; REAL-TIME POLYMERASE CHAIN REACTION;

MUS;

EID: 84863781041     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.04.011     Document Type: Article

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