Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat

Archives of Toxicology

Volumn 85, Issue 9, 2011, Pages 1045-1056

  Yamauchi, Shusuke ^a   Kiyosawa, Naoki ^a   Ando, Yosuke ^a   Watanabe, Kyoko ^a   Niino, Noriyo ^a   Ito, Kazumi ^a   Yamoto, Takashi ^a   Manabe, Sunao ^a   Sanbuissho, Atsushi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Glutathione; Liver; Microarray; Proteomics; Toxicogenomics

Indexed keywords

ALANINE AMINOTRANSFERASE; ALDO KETOSE REDUCTASE FAMILY 1 MEMBER A1; ASPARTATE AMINOTRANSFERASE; CATALASE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 1; GLUTATHIONE; MALEIC ACID DIETHYL ESTER; MESSENGER RNA; OXIDOREDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEOME; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASNS GENE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CHEMISTRY; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE SEQUENCE; GENETIC REGULATION; HMOX1 GENE; IGFBP1 GENE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MOLECULAR PROBE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEOMICS; RAT; SRXN1 GENE; TRANSCRIPTOMICS; TRIB3 GENE; TXNRD1 GENE;

ANIMALS; DOWN-REGULATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION PROFILING; GLUTATHIONE; LIVER; LIVER FUNCTION TESTS; MALE; MALEATES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME; PROTEOMICS; RATS; RATS, INBRED F344; TOXICOGENETICS; TRANSCRIPTOME; UP-REGULATION;

RATTUS;

EID: 80052710757     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0632-7     Document Type: Article

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