Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254 - Exposed rats using a multifactor linear model

Toxicological Sciences

Volumn 102, Issue 2, 2008, Pages 291-309

  Silkworth, Jay B ^a   Carlson, Erik A ^a   Mcculloch, Colin ^a   Illouz, Kati ^a   Goodwin, Shirlean ^a   Sutter, Thomas R ^b  

^a GENERAL ELECTRIC COMPANY   (United States)

^b UNIVERSITY OF MEMPHIS   (United States)

Author keywords

Aroclor 1254; Liver; Microarray; PCB; TCDD; Toxic equivalency factor

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROCLOR 1254; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL CARCINOGENESIS; DOSE RESPONSE; ESTROGEN METABOLISM; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENETIC ANALYSIS; GENOTOXICITY; INDUSTRIAL WASTE; LETHAL DOSE; LIVER CANCER; LIVER CARCINOGENESIS; LIVER TOXICITY; LIVER TUMOR; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; STEROID METABOLISM;

ADMINISTRATION, ORAL; ANIMALS; AROCLOR 1254; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; LOGISTIC MODELS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX CHARACTERISTICS; TETRACHLORODIBENZODIOXIN; TOXICOGENETICS;

RATTUS; RODENTIA;

EID: 40949120956     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm313     Document Type: Article

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