메뉴 건너뛰기




Volumn 49, Issue , 2015, Pages 413-438

Neural Regulatory Pathways of Feeding and Fat in Caenorhabditis elegans

Author keywords

AMP activated kinase; Fasting; Insulin; Kynurenic; Serotonin; TGF

Indexed keywords

FAT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SEROTONIN; CAENORHABDITIS ELEGANS PROTEIN; OCTOPAMINE; TYRAMINE;

EID: 84948747390     PISSN: 00664197     EISSN: 15452948     Source Type: Book Series    
DOI: 10.1146/annurev-genet-120213-092244     Document Type: Article
Times cited : (33)

References (147)
  • 2
    • 17444432931 scopus 로고    scopus 로고
    • Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system
    • Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR. 2005. Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron 46(2):247-60
    • (2005) Neuron , vol.46 , Issue.2 , pp. 247-260
    • Alkema, M.J.1    Hunter-Ensor, M.2    Ringstad, N.3    Horvitz, H.R.4
  • 3
    • 0037448528 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    • Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, et al. 2003. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421(6920):268-72
    • (2003) Nature , vol.421 , Issue.6920 , pp. 268-272
    • Ashrafi, K.1    Chang, F.Y.2    Watts, J.L.3    Fraser, A.G.4    Kamath, R.S.5
  • 4
    • 84901834303 scopus 로고    scopus 로고
    • Current status of the field of obesity
    • Atkinson RL. 2014. Current status of the field of obesity. Trends Endocrinol. Metab. 25(6):283-84
    • (2014) Trends Endocrinol. Metab , vol.25 , Issue.6 , pp. 283-284
    • Atkinson, R.L.1
  • 5
    • 0027528788 scopus 로고
    • The genetics of feeding in Caenorhabditis elegans
    • Avery L. 1993. The genetics of feeding in Caenorhabditis elegans. Genetics 133(4):897-917
    • (1993) Genetics , vol.133 , Issue.4 , pp. 897-917
    • Avery, L.1
  • 6
    • 0024743467 scopus 로고
    • Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C.elegans
    • Avery L, Horvitz HR. 1989. Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans. Neuron 3(4):473-85
    • (1989) Neuron , vol.3 , Issue.4 , pp. 473-485
    • Avery, L.1    Horvitz, H.R.2
  • 7
    • 0025063432 scopus 로고
    • Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans
    • Avery L, Horvitz HR. 1990. Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J. Exp. Zool. 253(3):263-70
    • (1990) J. Exp. Zool , vol.253 , Issue.3 , pp. 263-270
    • Avery, L.1    Horvitz, H.R.2
  • 8
    • 0043270437 scopus 로고    scopus 로고
    • Food transport in the C.elegans pharynx
    • Avery L, Shtonda BB. 2003. Food transport in the C. elegans pharynx. J. Exp. Biol. 206(14):2441-57
    • (2003) J. Exp. Biol , vol.206 , Issue.14 , pp. 2441-2457
    • Avery, L.1    Shtonda, B.B.2
  • 9
    • 84872838564 scopus 로고    scopus 로고
    • In WormBook, ed. The C.elegans Research Community
    • AveryL, You Y-J. 2012. C. elegans feeding. In WormBook, ed.The C. elegans Research Community. http:// www.wormbook.org/chapters/www-feeding/feeding.html
    • (2012) C.elegans Feeding
    • Avery, L.1    You, Y.-J.2
  • 10
    • 84867786932 scopus 로고    scopus 로고
    • Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C.elegans
    • Beets I, Janssen T, Meelkop E, Temmerman L, Suetens N, et al. 2012. Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. Science 338(6106):543-45
    • (2012) Science , vol.338 , Issue.6106 , pp. 543-545
    • Beets, I.1    Janssen, T.2    Meelkop, E.3    Temmerman, L.4    Suetens, N.5
  • 11
    • 39549086559 scopus 로고    scopus 로고
    • A Caenorhabditis elegans allatostatin/galanin-like receptorNPR-9 inhibits local search behavior in response to feeding cues
    • BendenaWG, Boudreau JR, PapanicolaouT,Maltby M, Tobe SS, Chin-Sang ID. 2008. A Caenorhabditis elegans allatostatin/galanin-like receptorNPR-9 inhibits local search behavior in response to feeding cues. PNAS 105(4):1339-42
    • (2008) PNAS , vol.105 , Issue.4 , pp. 1339-1342
    • Bendena, W.G.1    Boudreau, J.R.2    Papanicolaou, T.3    Maltby, M.4    Tobe, S.S.5    Chin-Sang, I.D.6
  • 12
    • 0023783911 scopus 로고
    • Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor
    • Birch PJ, Grossman CJ, Hayes AG. 1988. Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor. Eur. J. Pharmacol. 154(1):85-87
    • (1988) Eur. J. Pharmacol , vol.154 , Issue.1 , pp. 85-87
    • Birch, P.J.1    Grossman, C.J.2    Hayes, A.G.3
  • 13
    • 3042738924 scopus 로고    scopus 로고
    • Loss of C.elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
    • Blacque OE, Reardon MJ, Li C, McCarthy J, Mahjoub MR, et al. 2004. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 18(13):1630-42
    • (2004) Genes Dev , vol.18 , Issue.13 , pp. 1630-1642
    • Blacque, O.E.1    Reardon, M.J.2    Li, C.3    McCarthy, J.4    Mahjoub, M.R.5
  • 14
    • 0021770409 scopus 로고
    • Cloning of a yolk protein gene family from Caenorhabditis elegans
    • Blumenthal T, Squire M, Kirtland S, Cane J, Donegan M, et al. 1984. Cloning of a yolk protein gene family from Caenorhabditis elegans. J. Mol. Biol. 174(1):1-18
    • (1984) J. Mol. Biol , vol.174 , Issue.1 , pp. 1-18
    • Blumenthal, T.1    Squire, M.2    Kirtland, S.3    Cane, J.4    Donegan, M.5
  • 15
    • 0035282944 scopus 로고    scopus 로고
    • Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42
    • Brockie PJ, Madsen DM, Zheng Y, Mellem J, Maricq AV. 2001. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J. Neurosci. 21(5):1510-22
    • (2001) J. Neurosci , vol.21 , Issue.5 , pp. 1510-1522
    • Brockie, P.J.1    Madsen, D.M.2    Zheng, Y.3    Mellem, J.4    Maricq, A.V.5
  • 16
    • 70449560405 scopus 로고    scopus 로고
    • The influence of bacterial diet on fat storage in C.elegans
    • Brooks KK, Liang B,Watts JL. 2009. The influence of bacterial diet on fat storage in C. elegans. PLOS ONE 4(10):e7545
    • (2009) PLOS ONE , vol.4 , Issue.10 , pp. e7545
    • Brooks, K.K.1    Liang, B.2    Watts, J.L.3
  • 17
    • 0034699544 scopus 로고    scopus 로고
    • IRS-2 pathways integrate female reproduction and energy homeostasis
    • Burks DJ, de Mora JF, Schubert M, Withers DJ, MyersMG, et al. 2000. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407(6802):377-82
    • (2000) Nature , vol.407 , Issue.6802 , pp. 377-382
    • Burks, D.J.1    De Mora, J.F.2    Schubert, M.3    Withers, D.J.4    Myers, M.G.5
  • 18
    • 0017076266 scopus 로고
    • The life cycle of the nematode Caenorhabditis elegans: I Wildtype growth and reproduction
    • Byerly L, Cassada RC, Russell RL. 1976. The life cycle of the nematode Caenorhabditis elegans: I. Wildtype growth and reproduction. Dev. Biol. 51(1):23-33
    • (1976) Dev. Biol , vol.51 , Issue.1 , pp. 23-33
    • Byerly, L.1    Cassada, R.C.2    Russell, R.L.3
  • 19
    • 77953320474 scopus 로고    scopus 로고
    • Roles ofCUP-5, the Caenorhabditis elegans orthologue of humanTRPML1, in lysosome and gut granule biogenesis
    • CampbellEM,Fares H. 2010. Roles ofCUP-5, the Caenorhabditis elegans orthologue of humanTRPML1, in lysosome and gut granule biogenesis. BMC Cell Biol. 11(1):40
    • (2010) BMC Cell Biol , vol.11 , Issue.1 , pp. 40
    • Campbell, E.M.1    Fares, H.2
  • 20
    • 77951166692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
    • Chakrabarti P, English T, Shi J, Smas CM, Kandror KV. 2010. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes 59(4):775-81
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 775-781
    • Chakrabarti, P.1    English, T.2    Shi, J.3    Smas, C.M.4    Kandror, K.V.5
  • 21
    • 0348196965 scopus 로고    scopus 로고
    • Why Caenorhabditis elegans adults sacrifice their bodies to progeny
    • Chen J, Caswell-Chen EP. 2003. Why Caenorhabditis elegans adults sacrifice their bodies to progeny. Nematology 5(4):641-45
    • (2003) Nematology , vol.5 , Issue.4 , pp. 641-645
    • Chen, J.1    Caswell-Chen, E.P.2
  • 22
    • 84876694690 scopus 로고    scopus 로고
    • NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans
    • Cheong MC, Lee H-J, Na K, Joo H-J, Avery L, et al. 2012. NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans. Cell. Mol. Life Sci. 70(9):1623-36
    • (2012) Cell. Mol. Life Sci , vol.70 , Issue.9 , pp. 1623-1636
    • Cheong, M.C.1    Lee, H.-J.2    Na, K.3    Joo, H.-J.4    Avery, L.5
  • 23
    • 0037154791 scopus 로고    scopus 로고
    • Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions
    • Choi S, Jonak EM, Simpson L, Patil V, Fernstrom JD. 2002. Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions. Brain Res. 928(1-2):30-39
    • (2002) Brain Res , vol.928 , Issue.1-2 , pp. 30-39
    • Choi, S.1    Jonak, E.M.2    Simpson, L.3    Patil, V.4    Fernstrom, J.D.5
  • 24
    • 63449117482 scopus 로고    scopus 로고
    • Coordinated regulation of foraging and metabolism in C.elegans by RFamide neuropeptide signaling
    • Cohen M, Reale V, Olofsson B, Knights A, Evans P, de Bono M. 2009. Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling. Cell Metab. 9(4):375-85
    • (2009) Cell Metab , vol.9 , Issue.4 , pp. 375-385
    • Cohen, M.1    Reale, V.2    Olofsson, B.3    Knights, A.4    Evans, P.5    De Bono, M.6
  • 25
    • 84903482476 scopus 로고    scopus 로고
    • Loss of a neural AMPactivated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions
    • Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, et al. 2014. Loss of a neural AMPactivated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLOS Genet. 10(6):e1004394
    • (2014) PLOS Genet , vol.10 , Issue.6 , pp. e1004394
    • Cunningham, K.A.1    Bouagnon, A.D.2    Barros, A.G.3    Lin, L.4    Malard, L.5
  • 26
    • 84863516398 scopus 로고    scopus 로고
    • AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C.elegans
    • Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, et al. 2012. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. CellMetab. 16(1):113-21
    • (2012) CellMetab , vol.16 , Issue.1 , pp. 113-121
    • Cunningham, K.A.1    Hua, Z.2    Srinivasan, S.3    Liu, J.4    Lee, B.H.5
  • 27
    • 34548490748 scopus 로고    scopus 로고
    • Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease
    • Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, et al. 2007. Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr. Biol. 17(18):1586-94
    • (2007) Curr. Biol , vol.17 , Issue.18 , pp. 1586-1594
    • Davenport, J.R.1    Watts, A.J.2    Roper, V.C.3    Croyle, M.J.4    Van Groen, T.5
  • 28
    • 84899805654 scopus 로고    scopus 로고
    • Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans
    • de Almeida Barros AG, Bridi JC, de Souza BR, de Castro J unior C, de Lima Torres KC, et al. 2014. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. PLOS ONE 9(1):e85874
    • (2014) PLOS ONE , vol.9 , Issue.1 , pp. e85874
    • De Almeida, B.A.G.1    Bridi, J.C.2    De Souza, B.R.3    De Castro, C.4    De Lima, T.K.C.5
  • 29
    • 84858272602 scopus 로고    scopus 로고
    • Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
    • Deblon N, Bourgoin L, Veyrat-Durebex C, Peyrou M, Vinciguerra M, et al. 2012. Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br. J. Pharmacol. 165(7):2325-40
    • (2012) Br. J. Pharmacol , vol.165 , Issue.7 , pp. 2325-2340
    • Deblon, N.1    Bourgoin, L.2    Veyrat-Durebex, C.3    Peyrou, M.4    Vinciguerra, M.5
  • 30
    • 79960178819 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptionalmechanisms
    • DePina AS, IserWB, Park S-S, Maudsley S,Wilson MA,Wolkow CA. 2011. Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptionalmechanisms. BMC Physiol. 11(1):11
    • (2011) BMC Physiol , vol.11 , Issue.1 , pp. 11
    • DePina, A.S.1    Iser, W.B.2    Park, S.-S.3    Maudsley, S.4    Wilson, M.A.5    Wolkow, C.A.6
  • 31
    • 75049085233 scopus 로고    scopus 로고
    • PKA phosphorylates and inactivates AMPKαto promote efficient lipolysis
    • Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, et al. 2010. PKA phosphorylates and inactivates AMPKαto promote efficient lipolysis. EMBO J. 29(2):469-81
    • (2010) EMBO J , vol.29 , Issue.2 , pp. 469-481
    • Djouder, N.1    Tuerk, R.D.2    Suter, M.3    Salvioni, P.4    Thali, R.F.5
  • 32
    • 78649916826 scopus 로고    scopus 로고
    • Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction
    • Edmonds JW, Prasain JK,DorandD, Yang Y,Hoang HD, et al. 2010. Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction. Dev. Cell 19(6):858-71
    • (2010) Dev. Cell , vol.19 , Issue.6 , pp. 858-871
    • Edmonds, J.W.1    Prasain, J.K.2    Dorand, D.3    Yang, Y.4    Hoang, H.D.5
  • 33
    • 0022651695 scopus 로고
    • Dextrofenfluramine increases energy cost of muscular effort
    • Even P, Nicolaidis S. 1986. Dextrofenfluramine increases energy cost of muscular effort. Pharmacol. Biochem. Behav. 24(3):647-55
    • (1986) Pharmacol. Biochem. Behav , vol.24 , Issue.3 , pp. 647-655
    • Even, P.1    Nicolaidis, S.2
  • 34
    • 73949156856 scopus 로고    scopus 로고
    • Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans
    • Fang-Yen C, Avery L, Samuel ADT. 2009. Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans. PNAS 106(47):20093-96
    • (2009) PNAS , vol.106 , Issue.47 , pp. 20093-20096
    • Fang-Yen, C.1    Avery, L.2    Samuel, A.D.T.3
  • 35
    • 14544272858 scopus 로고    scopus 로고
    • Monogenic obesity in humans
    • Farooqi IS, O'Rahilly S. 2005. Monogenic obesity in humans. Annu. Rev. Med. 56(1):443-58
    • (2005) Annu. Rev. Med , vol.56 , Issue.1 , pp. 443-458
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 36
    • 36649019357 scopus 로고    scopus 로고
    • The development of tolerance to drugs that suppress food intake
    • Fernstrom JD, Choi S. 2008. The development of tolerance to drugs that suppress food intake. Pharmacol. Ther. 117(1):105-22
    • (2008) Pharmacol. Ther , vol.117 , Issue.1 , pp. 105-122
    • Fernstrom, J.D.1    Choi, S.2
  • 37
    • 0032852842 scopus 로고    scopus 로고
    • Tetrahydropterin-dependent amino acid hydroxylases
    • Fitzpatrick PF. 1999. Tetrahydropterin-dependent amino acid hydroxylases. Annu. Rev. Biochem. 68(1):355-81
    • (1999) Annu. Rev. Biochem , vol.68 , Issue.1 , pp. 355-381
    • Fitzpatrick, P.F.1
  • 38
    • 35848935201 scopus 로고    scopus 로고
    • Cause-specific excess deaths associated with underweight, overweight and obesity
    • Flegal KM, Graubard BI,Williamson DF, Gail MH. 2008. Cause-specific excess deaths associated with underweight, overweight and obesity. JAMA 298(17):2028-37
    • (2008) JAMA , vol.298 , Issue.17 , pp. 2028-2037
    • Flegal, K.M.1    Graubard, B.I.2    Williamson, D.F.3    Gail, M.H.4
  • 39
    • 84923295947 scopus 로고    scopus 로고
    • Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
    • Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, et al. 2015. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science 347(6217):83-86
    • (2015) Science , vol.347 , Issue.6217 , pp. 83-86
    • Folick, A.1    Oakley, H.D.2    Yu, Y.3    Armstrong, E.H.4    Kumari, M.5
  • 42
    • 0031685525 scopus 로고    scopus 로고
    • Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
    • Gems D, Sutton AJ, SundermeyerML, Albert PS, King KV, et al. 1998. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150(1):129-55
    • (1998) Genetics , vol.150 , Issue.1 , pp. 129-155
    • Gems, D.1    Sutton, A.J.2    Sundermeyer, M.L.3    Albert, P.S.4    King, K.V.5
  • 43
    • 0032734242 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte
    • Grant B, Hirsh D. 1999. Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte. Mol. Biol. Cell 10(12):4311-26
    • (1999) Mol. Biol. Cell , vol.10 , Issue.12 , pp. 4311-4326
    • Grant, B.1    Hirsh, D.2
  • 44
    • 48149109399 scopus 로고    scopus 로고
    • Neural and molecular dissection of a C.elegans sensory circuit that regulates fat and feeding
    • Greer ER, Perez CL, Van Gilst MR, Lee BH, Ashrafi K. 2008. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 8(2):118-31
    • (2008) Cell Metab , vol.8 , Issue.2 , pp. 118-131
    • Greer, E.R.1    Perez, C.L.2    Van Gilst, M.R.3    Lee, B.H.4    Ashrafi, K.5
  • 45
    • 0033841033 scopus 로고    scopus 로고
    • A Caenorhabditis elegans type I TGFβreceptor can function in the absence of type II kinase to promote larval development
    • Gunther CV, Georgi LL, Riddle DL. 2000. A Caenorhabditis elegans type I TGFβreceptor can function in the absence of type II kinase to promote larval development. Development 127(15):3337-47
    • (2000) Development , vol.127 , Issue.15 , pp. 3337-3347
    • Gunther, C.V.1    Georgi, L.L.2    Riddle, D.L.3
  • 46
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. 2012. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13(4):251-62
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , Issue.4 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 47
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms M, Seale P. 2013. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19(10):1252-63
    • (2013) Nat. Med , vol.19 , Issue.10 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 48
    • 79960642870 scopus 로고    scopus 로고
    • Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C.elegans
    • Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, et al. 2011. Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLOS ONE 6(7):e21897
    • (2011) PLOS ONE , vol.6 , Issue.7 , pp. e21897
    • Harris, G.1    Korchnak, A.2    Summers, P.3    Hapiak, V.4    Law, W.J.5
  • 49
    • 84865060770 scopus 로고    scopus 로고
    • C.elegans BLOC-1 functions in trafficking to lysosome-related gut granules
    • Hermann GJ, Scavarda E, Weis AM, Saxton DS, Thomas LL, et al. 2012. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. PLOS ONE 7(8):e43043
    • (2012) PLOS ONE , vol.7 , Issue.8 , pp. e43043
    • Hermann, G.J.1    Scavarda, E.2    Weis, A.M.3    Saxton, D.S.4    Thomas, L.L.5
  • 52
    • 0842281817 scopus 로고    scopus 로고
    • Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans
    • Hills T, Brockie PJ, Maricq AV. 2004. Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J. Neurosci. 24(5):1217-25
    • (2004) J. Neurosci , vol.24 , Issue.5 , pp. 1217-1225
    • Hills, T.1    Brockie, P.J.2    Maricq, A.V.3
  • 53
    • 33644764020 scopus 로고    scopus 로고
    • SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying
    • Hobson RJ, Hapiak VM, Xiao H, Buehrer KL, Komuniecki PR, Komuniecki RW. 2006. SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying. Genetics 172(1):159-69
    • (2006) Genetics , vol.172 , Issue.1 , pp. 159-169
    • Hobson, R.J.1    Hapiak, V.M.2    Xiao, H.3    Buehrer, K.L.4    Komuniecki, P.R.5    Komuniecki, R.W.6
  • 54
    • 77952954253 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans
    • Horikawa M, Sakamoto K. 2010. Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans. Mol. Cell. Endocrinol. 323(2):183-92
    • (2010) Mol. Cell. Endocrinol , vol.323 , Issue.2 , pp. 183-192
    • Horikawa, M.1    Sakamoto, K.2
  • 55
    • 0019977293 scopus 로고
    • Serotonin and octopamine in the nematode Caenorhabditis elegans
    • Horvitz HR, ChalfieM, Trent C, Sulston JE, Evans PD. 1982. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216(4549):1012-14
    • (1982) Science , vol.216 , Issue.4549 , pp. 1012-1014
    • Horvitz, H.R.1    Chalfie, M.2    Trent, C.3    Sulston, J.E.4    Evans, P.D.5
  • 56
    • 44249103225 scopus 로고    scopus 로고
    • Discovery of a cholecystokinin-gastrin-like signaling system in nematodes
    • Janssen T, Meelkop E, Lindemans M, Verstraelen K, Husson SJ, et al. 2008. Discovery of a cholecystokinin-gastrin-like signaling system in nematodes. Endocrinology 149(6):2826-39
    • (2008) Endocrinology , vol.149 , Issue.6 , pp. 2826-2839
    • Janssen, T.1    Meelkop, E.2    Lindemans, M.3    Verstraelen, K.4    Husson, S.J.5
  • 57
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C.elegans larval development, metabolism and life span
    • Jia K, Chen D, Riddle DL. 2004. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131(16):3897-906
    • (2004) Development , vol.131 , Issue.16 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 58
    • 66349109113 scopus 로고    scopus 로고
    • Systemic regulation of autophagy in Caenorhabditis elegans
    • Kang C, AveryL. 2009. Systemic regulation of autophagy in Caenorhabditis elegans. Autophagy 5(4):565-66
    • (2009) Autophagy , vol.5 , Issue.4 , pp. 565-566
    • Kang, C.1    Avery, L.2
  • 59
    • 58149523270 scopus 로고    scopus 로고
    • Systemic regulation of starvation response in Caenorhabditis elegans
    • Kang C, Avery L. 2009. Systemic regulation of starvation response in Caenorhabditis elegans. Genes Dev. 23(1):12-17
    • (2009) Genes Dev , vol.23 , Issue.1 , pp. 12-17
    • Kang, C.1    Avery, L.2
  • 60
    • 34548421950 scopus 로고    scopus 로고
    • Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    • Kang C, You Y, Avery L. 2007. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 21(17):2161-71
    • (2007) Genes Dev , vol.21 , Issue.17 , pp. 2161-2171
    • Kang, C.1    You, Y.2    Avery, L.3
  • 61
    • 0038192369 scopus 로고    scopus 로고
    • Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes
    • Keane J, Avery L. 2003. Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes. Genetics 164(1):153-62
    • (2003) Genetics , vol.164 , Issue.1 , pp. 153-162
    • Keane, J.1    Avery, L.2
  • 62
    • 0020724305 scopus 로고
    • Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans
    • Kimble J, Sharrock WJ. 1983. Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans. Dev. Biol. 96(1):189-96
    • (1983) Dev. Biol , vol.96 , Issue.1 , pp. 189-196
    • Kimble, J.1    Sharrock, W.J.2
  • 63
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura KD, TissenbaumHA, Liu Y, RuvkunG. 1997. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277(5328):942-46
    • (1997) Science , vol.277 , Issue.5328 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 64
    • 84878535012 scopus 로고    scopus 로고
    • A conserved role for atlastin GTPases in regulating lipid droplet size
    • Klemm RW, Norton JP, Cole RA, Li CS, Park SH, et al. 2013. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 3(5):1465-75
    • (2013) Cell Rep , vol.3 , Issue.5 , pp. 1465-1475
    • Klemm, R.W.1    Norton, J.P.2    Cole, R.A.3    Li, C.S.4    Park, S.H.5
  • 65
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. 2000. Obesity as a medical problem. Nature 404(6778):635-43
    • (2000) Nature , vol.404 , Issue.6778 , pp. 635-643
    • Kopelman, P.G.1
  • 66
    • 46749129840 scopus 로고    scopus 로고
    • FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A 4 heterologously expressed in mammalian cells
    • KubiakTM,LarsenMJ, Bowman JW,Geary TG, LoweryDE. 2008. FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Pept. Sci. 90(3):339-48
    • (2008) Pept. Sci , vol.90 , Issue.3 , pp. 339-348
    • Kubiak, T.M.1    Larsen, M.J.2    Bowman, J.W.3    Geary, T.G.4    Lowery, D.E.5
  • 67
    • 33847609962 scopus 로고    scopus 로고
    • Serotonin and energy balance: Molecular mechanisms and implications for type 2 diabetes
    • Lam DD, Heisler LK. 2007. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Rev. Mol. Med. 9(5):1-24
    • (2007) Expert Rev. Mol. Med , vol.9 , Issue.5 , pp. 1-24
    • Lam, D.D.1    Heisler, L.K.2
  • 69
    • 80053312481 scopus 로고    scopus 로고
    • Autophagy and lipid metabolism coordinately modulate life span in germline-less C.elegans
    • Lapierre LR, Gelino S, Melendez A, Hansen M. 2011. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr. Biol. 21(18):1507-14
    • (2011) Curr. Biol , vol.21 , Issue.18 , pp. 1507-1514
    • Lapierre, L.R.1    Gelino, S.2    Melendez, A.3    Hansen, M.4
  • 70
    • 0025773552 scopus 로고
    • Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds
    • Le Feuvre RA, Aisenthal L, Rothwell NJ. 1991. Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain Res. 555(2):245-50
    • (1991) Brain Res , vol.555 , Issue.2 , pp. 245-250
    • Le Feuvre, R.A.1    Aisenthal, L.2    Rothwell, N.J.3
  • 71
    • 84855179325 scopus 로고    scopus 로고
    • Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C.elegans Bardet-Biedl syndrome mutants
    • Lee BH, Liu J,WongD, Srinivasan S, AshrafiK. 2011. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLOS Biol. 9(12):e1001219
    • (2011) PLOS Biol , vol.9 , Issue.12 , pp. e1001219
    • Lee, B.H.1    Liu, J.2    Wong, D.3    Srinivasan, S.4    Ashrafi, K.5
  • 72
    • 0032959163 scopus 로고    scopus 로고
    • EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans
    • Lee RYN, Sawin ER, Chalfie M, Horvitz HR, Avery L. 1999. EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans. J. Neurosci. 19(1):159-67
    • (1999) J. Neurosci , vol.19 , Issue.1 , pp. 159-167
    • Lee, R.Y.N.1    Sawin, E.R.2    Chalfie, M.3    Horvitz, H.R.4    Avery, L.5
  • 73
    • 84924557150 scopus 로고    scopus 로고
    • Insights and challenges in using C.elegans for investigation of fat metabolism
    • Lemieux GA, Ashrafi K. 2015. Insights and challenges in using C. elegans for investigation of fat metabolism. Crit. Rev. Biochem. Mol. Biol. 50(1):69-84
    • (2015) Crit. Rev. Biochem. Mol. Biol , vol.50 , Issue.1 , pp. 69-84
    • Lemieux, G.A.1    Ashrafi, K.2
  • 74
    • 84920955894 scopus 로고    scopus 로고
    • Kynurenic acid is a nutritional cue that enables behavioral plasticity
    • Lemieux GA, CunninghamKA, Lin L,Mayer F, Werb Z, AshrafiK. 2015. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell 160(1-2):119-31
    • (2015) Cell , vol.160 , Issue.1-2 , pp. 119-131
    • Lemieux, G.A.1    Cunningham, K.A.2    Lin, L.3    Mayer, F.4    Werb, Z.5    Ashrafi, K.6
  • 75
    • 84889010695 scopus 로고    scopus 로고
    • In silico molecular comparisons of C.elegans and mammalian pharmacology identify distinct targets that regulate feeding
    • Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, et al. 2013. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLOS Biol. 11(11):e1001712
    • (2013) PLOS Biol , vol.11 , Issue.11 , pp. e1001712
    • Lemieux, G.A.1    Keiser, M.J.2    Sassano, M.F.3    Laggner, C.4    Mayer, F.5
  • 76
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A. 2002. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 23(2):201-29
    • (2002) Endocr. Rev , vol.23 , Issue.2 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 77
    • 84860290521 scopus 로고    scopus 로고
    • Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C.elegans feeding regulation
    • Li Z, Li Y, Yi Y, Huang W, Yang S, et al. 2012. Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. Nat. Commun. 3:776
    • (2012) Nat. Commun , vol.3 , pp. 776
    • Li, Z.1    Li, Y.2    Yi, Y.3    Huang, W.4    Yang, S.5
  • 78
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in βcells and brain causes obesity and diabetes
    • Lin X, Taguchi A, Park S, Kushner JA, Li F, et al. 2004. Dysregulation of insulin receptor substrate 2 in βcells and brain causes obesity and diabetes. J. Clin. Investig. 114(7):908-16
    • (2004) J. Clin. Investig , vol.114 , Issue.7 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3    Kushner, J.A.4    Li, F.5
  • 79
    • 33748485820 scopus 로고    scopus 로고
    • Xenobiotic detoxification in the nematode Caenorhabditis elegans
    • Lindblom TH,Dodd AK. 2006. Xenobiotic detoxification in the nematode Caenorhabditis elegans. J. Exp. Zool. Part A 305A(9):720-30
    • (2006) J. Exp. Zool. Part A , vol.305 A , Issue.9 , pp. 720-730
    • Lindblom, T.H.1    Dodd, A.K.2
  • 80
    • 4444304350 scopus 로고    scopus 로고
    • A novel nuclear receptor/coregulator complex controls C.elegans lipid metabolism, larval development, and aging
    • Ludewig AH, Kober-Eisermann C, Weitzel C, Bethke A, Neubert K, et al. 2004. A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev. 18(17):2120-33
    • (2004) Genes Dev , vol.18 , Issue.17 , pp. 2120-2133
    • Ludewig, A.H.1    Kober-Eisermann, C.2    Weitzel, C.3    Bethke, A.4    Neubert, K.5
  • 82
    • 84858341125 scopus 로고    scopus 로고
    • New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals
    • McCormick M, Chen K, Ramaswamy P, Kenyon C. 2012. New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell 11(2):192-202
    • (2012) Aging Cell , vol.11 , Issue.2 , pp. 192-202
    • McCormick, M.1    Chen, K.2    Ramaswamy, P.3    Kenyon, C.4
  • 83
    • 67449129802 scopus 로고    scopus 로고
    • The C.elegans intestine
    • ed. The C.elegans Research Community
    • McGhee J. 2007. The C. elegans intestine. In WormBook, ed.The C. elegans Research Community. http:// www.wormbook.org/chapters/www-intestine/intestine.html
    • (2007) WormBook
    • McGhee, J.1
  • 84
    • 0035393437 scopus 로고    scopus 로고
    • Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
    • Michaud JL, Boucher F, Melnyk A, Gauthier F, Goshu E, et al. 2001. Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum. Mol. Genet. 10(14):1465-73
    • (2001) Hum. Mol. Genet , vol.10 , Issue.14 , pp. 1465-1473
    • Michaud, J.L.1    Boucher, F.2    Melnyk, A.3    Gauthier, F.4    Goshu, E.5
  • 85
    • 0032532480 scopus 로고    scopus 로고
    • Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
    • Michaud JL, Rosenquist T, May NR, Fan C-M. 1998. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 12(20):3264-75
    • (1998) Genes Dev , vol.12 , Issue.20 , pp. 3264-3275
    • Michaud, J.L.1    Rosenquist, T.2    May, N.R.3    Fan, C.-M.4
  • 86
    • 27244443371 scopus 로고    scopus 로고
    • C.elegans tubby regulates life span and fat storage by two independent mechanisms
    • Mukhopadhyay A, Deplancke B, Walhout AJM, Tissenbaum HA. 2005. C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab. 2(1):35-42
    • (2005) Cell Metab , vol.2 , Issue.1 , pp. 35-42
    • Mukhopadhyay, A.1    Deplancke, B.2    Walhout, A.J.M.3    Tissenbaum, H.A.4
  • 88
    • 84916203269 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor signaling in C.elegans
    • ed. The C.elegans Research Community
    • Murphy CT,HuPJ. 2013. Insulin/insulin-like growth factor signaling in C. elegans. InWormBook, ed.The C. elegans Research Community. http://www.wormbook.org/chapters/www-insulingrowthsignal/ insulingrowthsignal.html
    • (2013) InWormBook
    • Murphy, C.T.1    Hu, P.J.2
  • 89
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT,McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424(6946):277-83
    • (2003) Nature , vol.424 , Issue.6946 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 90
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    • NachuryMV, Loktev AV, ZhangQ,Westlake CJ, Peranen J, et al. 2007. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129(6):1201-13
    • (2007) Cell , vol.129 , Issue.6 , pp. 1201-1213
    • Nachury, M.V.1    Loktev, A.V.2    Zhang, Q.3    Westlake, C.J.4    Peranen, J.5
  • 91
    • 66349088529 scopus 로고    scopus 로고
    • Hepatic triacylglycerol accumulation and insulin resistance
    • Nagle CA, Klett EL, Coleman RA. 2008. Hepatic triacylglycerol accumulation and insulin resistance. J. Lipid Res. 50(Suppl.):S74-79
    • (2008) J. Lipid Res , vol.50 , pp. S74-79
    • Nagle, C.A.1    Klett, E.L.2    Coleman, R.A.3
  • 92
    • 84908130875 scopus 로고    scopus 로고
    • FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans
    • Nelson MD, Lee KH, Churgin MA, Hill AJ, Van Buskirk C, et al. 2014. FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans. Curr. Biol. 24(20):2406-10
    • (2014) Curr. Biol , vol.24 , Issue.20 , pp. 2406-2410
    • Nelson, M.D.1    Lee, K.H.2    Churgin, M.A.3    Hill, A.J.4    Van Buskirk, C.5
  • 93
    • 84887449305 scopus 로고    scopus 로고
    • An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C.elegans body fat
    • Noble T, Stieglitz J, Srinivasan S. 2013. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell Metab. 18(5):672-84
    • (2013) Cell Metab , vol.18 , Issue.5 , pp. 672-684
    • Noble, T.1    Stieglitz, J.2    Srinivasan, S.3
  • 94
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C.elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389(6654):994-99
    • (1997) Nature , vol.389 , Issue.6654 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5
  • 95
    • 70350365111 scopus 로고    scopus 로고
    • C.elegans major fats are stored in vesicles distinct from lysosome-related organelles
    • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. 2009. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 10(5):430-35
    • (2009) Cell Metab , vol.10 , Issue.5 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.4
  • 96
    • 34248214629 scopus 로고    scopus 로고
    • Sensory ciliogenesis in Caenorhabditis elegans: Assignment of IFT components into distinct modules based on transport and phenotypic profiles
    • Ou G, Koga M, Blacque OE,MurayamaT,Ohshima Y, et al. 2007. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol. Biol. Cell 18(5):1554-69
    • (2007) Mol. Biol. Cell , vol.18 , Issue.5 , pp. 1554-1569
    • Ou, G.1    Koga, M.2    Blacque, O.E.3    Murayama, T.4    Ohshima, Y.5
  • 97
    • 78651066040 scopus 로고    scopus 로고
    • The effect of a selective octopamine antagonist, epinastine, on pharyngeal pumping in Caenorhabditis elegans
    • PackhamR,Walker RJ,Holden-DyeL. 2010. The effect of a selective octopamine antagonist, epinastine, on pharyngeal pumping in Caenorhabditis elegans. Invertebr. Neurosci. 10(1):47-52
    • (2010) Invertebr. Neurosci , vol.10 , Issue.1 , pp. 47-52
    • Packham, R.1    Walker, R.J.2    Holden-Dye, L.3
  • 98
    • 0030776478 scopus 로고    scopus 로고
    • The DAF-3 Smad protein antagonizesTGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway
    • Patterson GI, Koweek A, Wong A, Liu Y, RuvkunG. 1997. The DAF-3 Smad protein antagonizesTGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11(20):2679-90
    • (1997) Genes Dev , vol.11 , Issue.20 , pp. 2679-2690
    • Patterson, G.I.1    Koweek, A.2    Wong, A.3    Liu, Y.4    Ruvkun, G.5
  • 99
    • 84871359857 scopus 로고    scopus 로고
    • The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
    • Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, et al. 2013. The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue. Mol. Cell. Endocrinol. 365(2):260-69
    • (2013) Mol. Cell. Endocrinol , vol.365 , Issue.2 , pp. 260-269
    • Pereira, M.J.1    Palming, J.2    Rizell, M.3    Aureliano, M.4    Carvalho, E.5
  • 100
    • 50049117073 scopus 로고    scopus 로고
    • A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C.elegans
    • Perez CL, Van GilstMR. 2008. A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 8(3):266-74
    • (2008) Cell Metab , vol.8 , Issue.3 , pp. 266-274
    • Perez, C.L.1    Van Gilst, M.R.2
  • 101
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • Polak P, Cybulski N, Feige JN, Auwerx J, Ruegg MA, Hall MN. 2008. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 8(5):399-410
    • (2008) Cell Metab , vol.8 , Issue.5 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Ruegg, M.A.5    Hall, M.N.6
  • 102
    • 0028201449 scopus 로고
    • Electrical activity and behavior in the pharynx of Caenorhabditis elegans
    • Raizen DM, Avery L. 1994. Electrical activity and behavior in the pharynx of Caenorhabditis elegans. Neuron 12(3):483-95
    • (1994) Neuron , vol.12 , Issue.3 , pp. 483-495
    • Raizen, D.M.1    Avery, L.2
  • 103
    • 33744492114 scopus 로고    scopus 로고
    • A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans
    • Raizen DM, Cullison KM, Pack AI, Sundaram MV. 2006. A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans. Genetics 173(1):177-87
    • (2006) Genetics , vol.173 , Issue.1 , pp. 177-187
    • Raizen, D.M.1    Cullison, K.M.2    Pack, A.I.3    Sundaram, M.V.4
  • 104
    • 0028871952 scopus 로고
    • Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans
    • Raizen DM, Lee RY, Avery L. 1995. Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics 141(4):1365-82
    • (1995) Genetics , vol.141 , Issue.4 , pp. 1365-1382
    • Raizen, D.M.1    Lee, R.Y.2    Avery, L.3
  • 105
    • 38749092606 scopus 로고    scopus 로고
    • Lethargus is a Caenorhabditis elegans sleep-like state
    • Raizen DM, Zimmerman JE, Maycock MH, Ta UD, You Y, et al. 2008. Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451(7178):569-72
    • (2008) Nature , vol.451 , Issue.7178 , pp. 569-572
    • Raizen, D.M.1    Zimmerman, J.E.2    Maycock, M.H.3    Ta, U.D.4    You, Y.5
  • 106
    • 84919608396 scopus 로고    scopus 로고
    • Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C.elegans
    • Ratnappan R, Amrit FRG, Chen S-W, Gill H, Holden K, et al. 2014. Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans. PLOS Genet. 10(12):e1004829
    • (2014) PLOS Genet , vol.10 , Issue.12 , pp. e1004829
    • Ratnappan, R.1    Amrit, F.R.G.2    Chen, S.-W.3    Gill, H.4    Holden, K.5
  • 107
    • 84880817406 scopus 로고    scopus 로고
    • Shifts in the distribution of mass densities is a signature of caloric restriction in Caenorhabditis elegans
    • Reina A, Subramaniam AB, Laromaine A, Samuel ADT,WhitesidesGM. 2013. Shifts in the distribution of mass densities is a signature of caloric restriction in Caenorhabditis elegans. PLOS ONE 8(7):e69651
    • (2013) PLOS ONE , vol.8 , Issue.7 , pp. e69651
    • Reina, A.1    Subramaniam, A.B.2    Laromaine, A.3    Samuel, A.D.T.4    Whitesides, G.M.5
  • 108
    • 10544256181 scopus 로고    scopus 로고
    • Control of C.elegans larval development by neuronal expression of a TGF-βhomolog
    • Ren P, Lim C-S, Johnsen R, Albert PS, Pilgrim D, Riddle DL. 1996. Control of C. elegans larval development by neuronal expression of a TGF-βhomolog. Science 274(5291):1389-91
    • (1996) Science , vol.274 , Issue.5291 , pp. 1389-1391
    • Ren, P.1    Lim, C.-S.2    Johnsen, R.3    Albert, P.S.4    Pilgrim, D.5    Riddle, D.L.6
  • 109
    • 0036736214 scopus 로고    scopus 로고
    • Characterization of a tyramine receptor from Caenorhabditis elegans
    • Rex E, Komuniecki RW. 2002. Characterization of a tyramine receptor from Caenorhabditis elegans. J. Neurochem. 82(6):1352-59
    • (2002) J. Neurochem , vol.82 , Issue.6 , pp. 1352-1359
    • Rex, E.1    Komuniecki, R.W.2
  • 110
    • 9744266669 scopus 로고    scopus 로고
    • Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans
    • Rex E,Molitor SC,Hapiak V, Xiao H, HendersonM, Komuniecki R. 2004. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans. J. Neurochem. 91(5):1104-15
    • (2004) J. Neurochem , vol.91 , Issue.5 , pp. 1104-1115
    • Rex, E.1    Molitor, S.C.2    Hapiak, V.3    Xiao, H.4    Henderson, M.5    Komuniecki, R.6
  • 111
    • 0019496482 scopus 로고
    • Interacting genes in nematode dauer larva formation
    • RiddleDL, Swanson MM, Albert PS. 1981. Interacting genes in nematode dauer larva formation. Nature 290(5808):668-71
    • (1981) Nature , vol.290 , Issue.5808 , pp. 668-671
    • Riddle, D.L.1    Swanson, M.M.2    Albert, P.S.3
  • 112
    • 12744254778 scopus 로고    scopus 로고
    • Tyramine and octopamine: Ruling behavior and metabolism
    • Roeder T. 2005. Tyramine and octopamine: ruling behavior and metabolism. Annu. Rev. Entomol. 50:447-77
    • (2005) Annu. Rev. Entomol , vol.50 , pp. 447-477
    • Roeder, T.1
  • 113
    • 0023191789 scopus 로고
    • Effect of diet and fenfluramine on thermogenesis in the rat: Possible involvement of serotonergic mechanisms
    • Rothwell NJ, Stock MJ. 1987. Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms. Int. J. Obes. 11(4):319-24
    • (1987) Int. J. Obes , vol.11 , Issue.4 , pp. 319-324
    • Rothwell, N.J.1    Stock, M.J.2
  • 114
    • 84888205217 scopus 로고    scopus 로고
    • Brain regulation of energy balance and body weight
    • Rui L. 2013. Brain regulation of energy balance and body weight. Rev. Endocr.Metab. Disord. 14(4):387-407
    • (2013) Rev. Endocr. Metab. Disord , vol.14 , Issue.4 , pp. 387-407
    • Rui, L.1
  • 115
    • 33751424424 scopus 로고    scopus 로고
    • TGF-β signaling
    • ed. The C.elegans Research Community
    • Savage-Dunn C. 2005. TGF-β signaling. In WormBook, ed. The C. elegans Research Community. http://www.wormbook.org/chapters/www-tgfbsignal/tgfbsignal.html
    • (2005) WormBook
    • Savage-Dunn, C.1
  • 116
    • 0033714116 scopus 로고    scopus 로고
    • C.elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    • Sawin ER, Ranganathan R, Horvitz HR. 2000. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26(3):619-31
    • (2000) Neuron , vol.26 , Issue.3 , pp. 619-631
    • Sawin, E.R.1    Ranganathan, R.2    Horvitz, H.R.3
  • 117
    • 0030272986 scopus 로고    scopus 로고
    • Chemosensory neurons function in parallel to mediate a pheromone response in C.elegans
    • Schackwitz WS, Inoue T, Thomas JH. 1996. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17(4):719-28
    • (1996) Neuron , vol.17 , Issue.4 , pp. 719-728
    • Schackwitz, W.S.1    Inoue, T.2    Thomas, J.H.3
  • 118
    • 38549125566 scopus 로고    scopus 로고
    • Egg-laying
    • ed. The C.elegans Research Community
    • Schafer W. 2005. Egg-laying. In WormBook, ed. The C. elegans Research Community. http://www. wormbook.org/chapters/www-egglaying/egglaying.html
    • (2005) WormBook
    • Schafer, W.1
  • 119
    • 33947158693 scopus 로고    scopus 로고
    • Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle
    • Schroeder LK, Kremer S, Kramer MJ, Currie E, Kwan E, et al. 2007. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Mol. Biol. Cell 18(3):995-1008
    • (2007) Mol. Biol. Cell , vol.18 , Issue.3 , pp. 995-1008
    • Schroeder, L.K.1    Kremer, S.2    Kramer, M.J.3    Currie, E.4    Kwan, E.5
  • 120
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu H-Q. 2012. Kynurenines in the mammalian brain: when physiology meets pathology. Nat. Rev. Neurosci. 13(7):465-77
    • (2012) Nat. Rev. Neurosci , vol.13 , Issue.7 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.-Q.4
  • 121
    • 82555184793 scopus 로고    scopus 로고
    • The oogenic germline starvation response in C.elegans
    • Seidel HS, Kimble J. 2011. The oogenic germline starvation response in C. elegans. PLOS ONE 6(12):e28074
    • (2011) PLOS ONE , vol.6 , Issue.12 , pp. e28074
    • Seidel, H.S.1    Kimble, J.2
  • 123
    • 31544457058 scopus 로고    scopus 로고
    • Dietary choice behavior in Caenorhabditis elegans
    • Shtonda BB, Avery L. 2006. Dietary choice behavior in Caenorhabditis elegans. J. Exp. Biol. 209(1):89-102
    • (2006) J. Exp. Biol , vol.209 , Issue.1 , pp. 89-102
    • Shtonda, B.B.1    Avery, L.2
  • 124
    • 84857018711 scopus 로고    scopus 로고
    • Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans
    • Song B, Avery L. 2012. Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans. J. Neurosci. 32(6):1920-31
    • (2012) J. Neurosci , vol.32 , Issue.6 , pp. 1920-1931
    • Song, B.1    Avery, L.2
  • 125
    • 84879039297 scopus 로고    scopus 로고
    • Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans
    • Song B-M, Faumont S, Lockery S, Avery L. 2013. Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans. eLife 2(0):e00329
    • (2013) ELife , vol.2 , pp. e00329
    • Song, B.-M.1    Faumont, S.2    Lockery, S.3    Avery, L.4
  • 126
    • 84887264885 scopus 로고    scopus 로고
    • Genetic regulation of Caenorhabditis elegans lysosome related organelle function
    • Soukas AA, Carr CE, Ruvkun G. 2013. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLOS Genet. 9(10):e1003908
    • (2013) PLOS Genet , vol.9 , Issue.10 , pp. e1003908
    • Soukas, A.A.1    Carr, C.E.2    Ruvkun, G.3
  • 127
    • 61449244533 scopus 로고    scopus 로고
    • Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    • Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. 2009. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 23(4):496-511
    • (2009) Genes Dev , vol.23 , Issue.4 , pp. 496-511
    • Soukas, A.A.1    Kane, E.A.2    Carr, C.E.3    Melo, J.A.4    Ruvkun, G.5
  • 128
    • 84922170516 scopus 로고    scopus 로고
    • Regulation of body fat in Caenorhabditis elegans
    • Srinivasan S. 2015. Regulation of body fat in Caenorhabditis elegans. Annu. Rev. Physiol. 77(1):161-78
    • (2015) Annu. Rev. Physiol , vol.77 , Issue.1 , pp. 161-178
    • Srinivasan, S.1
  • 130
    • 0029982256 scopus 로고    scopus 로고
    • Eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling
    • Starich TA, Lee RY, Panzarella C, Avery L, Shaw JE. 1996. eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling. J. Cell Biol. 134(2):537-48
    • (1996) J. Cell Biol , vol.134 , Issue.2 , pp. 537-548
    • Starich, T.A.1    Lee, R.Y.2    Panzarella, C.3    Avery, L.4    Shaw, J.E.5
  • 131
    • 0342680006 scopus 로고    scopus 로고
    • Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
    • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. 2000. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403(6769):560-64
    • (2000) Nature , vol.403 , Issue.6769 , pp. 560-564
    • Sze, J.Y.1    Victor, M.2    Loer, C.3    Shi, Y.4    Ruvkun, G.5
  • 132
    • 84870987975 scopus 로고    scopus 로고
    • Treat obesity as physiology, not physics
    • Taubes G. 2012. Treat obesity as physiology, not physics. Nature 492(7428):155
    • (2012) Nature , vol.492 , Issue.7428 , pp. 155
    • Taubes, G.1
  • 133
    • 84876835671 scopus 로고    scopus 로고
    • The science of obesity: What do we really know about what makes us fat
    • TaubesG. 2013. The science of obesity: What do we really know about what makes us fat?BMJ346:f1050
    • (2013) BMJ , vol.346 , pp. f1050
    • Taubes, G.1
  • 134
    • 84906091844 scopus 로고    scopus 로고
    • Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior
    • Trojanowski NF, Padovan-Merhar O, Raizen DM, Fang-Yen C. 2014. Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior. J. Neurophysiol. 112(4):951-61
    • (2014) J. Neurophysiol , vol.112 , Issue.4 , pp. 951-961
    • Trojanowski, N.F.1    Padovan-Merhar, O.2    Raizen, D.M.3    Fang-Yen, C.4
  • 135
    • 0033914588 scopus 로고    scopus 로고
    • Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats
    • Vickers SP, Benwell KR, Porter RH, Bickerdike MJ, Kennett GA, Dourish CT. 2000. Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. Br. J. Pharmacol. 130(6):1305-14
    • (2000) Br. J. Pharmacol , vol.130 , Issue.6 , pp. 1305-1314
    • Vickers, S.P.1    Benwell, K.R.2    Porter, R.H.3    Bickerdike, M.J.4    Kennett, G.A.5    Dourish, C.T.6
  • 136
    • 84912142103 scopus 로고    scopus 로고
    • Serotonin controlling feeding and satiety
    • Voigt J-P, Fink H. 2015. Serotonin controlling feeding and satiety. Behav. Brain Res. 277:14-31
    • (2015) Behav. Brain Res , vol.277 , pp. 14-31
    • Voigt, J.-P.1    Fink, H.2
  • 137
    • 78650752631 scopus 로고    scopus 로고
    • Reward, dopamine and the control of food intake: Implications for obesity
    • Volkow ND,WangG-J, Baler RD. 2011. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn. Sci. 15(1):37-46
    • (2011) Trends Cogn. Sci , vol.15 , Issue.1 , pp. 37-46
    • Volkow, N.D.1    Wang, G.-J.2    Baler, R.D.3
  • 138
    • 55849101681 scopus 로고    scopus 로고
    • Fat metabolism links germline stem cells and longevity in C.elegans
    • Wang MC, O'Rourke EJ, Ruvkun G. 2008. Fat metabolism links germline stem cells and longevity in C. elegans. Science 322(5903):957-60
    • (2008) Science , vol.322 , Issue.5903 , pp. 957-960
    • Wang, M.C.1    O'Rourke, E.J.2    Ruvkun, G.3
  • 139
    • 84865803552 scopus 로고    scopus 로고
    • The BBSome controls IFT assembly and turnaround in cilia
    • Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J. 2012. The BBSome controls IFT assembly and turnaround in cilia. Nat. Cell Biol. 14(9):950-57
    • (2012) Nat. Cell Biol , vol.14 , Issue.9 , pp. 950-957
    • Wei, Q.1    Zhang, Y.2    Li, Y.3    Zhang, Q.4    Ling, K.5    Hu, J.6
  • 140
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C.elegans life-span by insulinlike signaling in the nervous system
    • Wolkow CA, Kimura KD, Lee M-S, Ruvkun G. 2000. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290(5489):147-50
    • (2000) Science , vol.290 , Issue.5489 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.-S.3    Ruvkun, G.4
  • 141
    • 77958586133 scopus 로고    scopus 로고
    • A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods
    • Yen K, Le TT, Bansal A, Narasimhan SD, Cheng J-X, TissenbaumHA. 2010. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLOS ONE 5(9):e12810
    • (2010) PLOS ONE , vol.5 , Issue.9 , pp. e12810
    • Yen, K.1    Le, T.T.2    Bansal, A.3    Narasimhan, S.D.4    Cheng, J.-X.5    Tissenbaum, H.A.6
  • 142
    • 33645569464 scopus 로고    scopus 로고
    • Starvation activates map kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    • You Y, Kim J, Cobb M, Avery L. 2006. Starvation activates map kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metab. 3(4):237-45
    • (2006) Cell Metab , vol.3 , Issue.4 , pp. 237-245
    • You, Y.1    Kim, J.2    Cobb, M.3    Avery, L.4
  • 143
    • 39649094910 scopus 로고    scopus 로고
    • Insulin, cGMP, and TGF-βsignals regulate food intake and quiescence in C.elegans: A model for satiety
    • You Y, Kim J, Raizen DM, Avery L. 2008. Insulin, cGMP, and TGF-βsignals regulate food intake and quiescence in C. elegans: a model for satiety. Cell Metab. 7(3):249-57
    • (2008) Cell Metab , vol.7 , Issue.3 , pp. 249-257
    • You, Y.1    Kim, J.2    Raizen, D.M.3    Avery, L.4
  • 144
    • 65649147891 scopus 로고    scopus 로고
    • Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy
    • Zaghloul NA, Katsanis N. 2009. Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J. Clin. Investig. 119(3):428-37
    • (2009) J. Clin. Investig , vol.119 , Issue.3 , pp. 428-437
    • Zaghloul, N.A.1    Katsanis, N.2
  • 145
    • 84864818294 scopus 로고    scopus 로고
    • Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets
    • Zhang P, Na H, Liu Z, Zhang S, Xue P, et al. 2012. Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets. Mol. Cell. Proteomics 11(8):317-28
    • (2012) Mol. Cell. Proteomics , vol.11 , Issue.8 , pp. 317-328
    • Zhang, P.1    Na, H.2    Liu, Z.3    Zhang, S.4    Xue, P.5
  • 146
    • 78649772040 scopus 로고    scopus 로고
    • Lipid droplets as ubiquitous fat storage organelles in C.elegans
    • Zhang SO, Trimble R, Guo F, Mak HY. 2010. Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol. 11:96
    • (2010) BMC Cell Biol , vol.11 , pp. 96
    • Zhang, S.O.1    Trimble, R.2    Guo, F.3    Mak, H.Y.4
  • 147
    • 0029588435 scopus 로고
    • Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
    • Zhou Q-Y, Palmiter RD. 1995. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83(7):1197-209
    • (1995) Cell , vol.83 , Issue.7 , pp. 1197-1209
    • Zhou, Q.-Y.1    Palmiter, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.